Matches in Nanopublications for { ?s ?p "Intratumoral hypoxia and genetic alterations can lead to HIF-1a overexpression, which has been associated with increased patient mortality in several cancer types. In preclinical studies, inhibition of HIF-1 activity has marked effects on tumour growth. Efforts are underway to identify inhibitors of HIF-1 and to test their efficacy as anticancer therapeutics." ?g. }
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- _4 value "Intratumoral hypoxia and genetic alterations can lead to HIF-1a overexpression, which has been associated with increased patient mortality in several cancer types. In preclinical studies, inhibition of HIF-1 activity has marked effects on tumour growth. Efforts are underway to identify inhibitors of HIF-1 and to test their efficacy as anticancer therapeutics." provenance.
- _4 value "Intratumoral hypoxia and genetic alterations can lead to HIF-1a overexpression, which has been associated with increased patient mortality in several cancer types. In preclinical studies, inhibition of HIF-1 activity has marked effects on tumour growth. Efforts are underway to identify inhibitors of HIF-1 and to test their efficacy as anticancer therapeutics." provenance.