Matches in Nanopublications for { ?s ?p "PI3K-Akt-GSK3b pathway Glycogen-synthase kinase 3b (GSK3b) is a distinct substrate of Akt1 that has been shown to modulate hypertrophy. GSK3b activity is inhibited by Akt1 phosphorylation [65] (Fig. 1). Expression of a dominantnegative, kinase-inactive form of GSK3b induces dramatic hypertrophy in skeletal myotubes [6]. In cardiac hypertrophy, GSK3b phosphorylation is also evident [66], and expression of a dominant-negative form of GSK3b can induce cardiac hypertrophy [66]." ?g. }
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- _6 value "PI3K-Akt-GSK3b pathway Glycogen-synthase kinase 3b (GSK3b) is a distinct substrate of Akt1 that has been shown to modulate hypertrophy. GSK3b activity is inhibited by Akt1 phosphorylation [65] (Fig. 1). Expression of a dominantnegative, kinase-inactive form of GSK3b induces dramatic hypertrophy in skeletal myotubes [6]. In cardiac hypertrophy, GSK3b phosphorylation is also evident [66], and expression of a dominant-negative form of GSK3b can induce cardiac hypertrophy [66]." provenance.