Matches in Nanopublications for { ?s ?p "TGF? stimulates PTHrP secretion without appearing to increase PTHrP mRNA levels. PTHrP stimulates the production of RANK ligand (RANKL) in osteoblasts, which in turn promotes the differentiation of osteoclast precursors and bone resorption. Administration of anti-PTHrP neutralizing antibodies inhibits TGF?-dependent osteolytic bone metastasis in mice (Kakonen et al., 2002)." ?g. }
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- _5 value "TGF? stimulates PTHrP secretion without appearing to increase PTHrP mRNA levels. PTHrP stimulates the production of RANK ligand (RANKL) in osteoblasts, which in turn promotes the differentiation of osteoclast precursors and bone resorption. Administration of anti-PTHrP neutralizing antibodies inhibits TGF?-dependent osteolytic bone metastasis in mice (Kakonen et al., 2002)." provenance.