Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence SYT6+is+hypermethylated+in+renal+cell+carcinoma. assertion.
- assertion asSentence Synaptotagmin+must+be+dephosphorylated+at+a+specific+window+of+time+and+phosphorylated+synaptotagmin+has+an+active+role+at+early+stages+of+the+acrosomal+exocytosis. assertion.
- assertion asSentence IL-23+receptor+%28IL-23R%29+gene+protects+against+pediatric+Crohn%27s+disease. assertion.
- assertion asSentence The+association+of+IL23R+and+ankylosing+spondylitis+that+is+seen+in+Caucasian+patients+is+not+present+in+Korean+patients+with+this+disease. assertion.
- assertion asSentence IL23R+polymorphism+influences+certain+subtypes+of+gastric+cancer+according+to+clinical+and+pathological+features. assertion.
- assertion asSentence Interleukin-23+receptor+polymorphism+is+a+risk+factor+in+patients+developing+oral+neoplasms. assertion.
- assertion asSentence Alternative+costimulation+via+CD5%2C+rather+than+classic+costimulation+via+CD28%2C+primes+naive+T+cells+for+stable+Th17+development+through+promoting+the+expression+of+IL-23R. assertion.
- assertion asSentence IL-23R+variants+are+not+associated+with+ankylosing+spondylitis+in+East+Asian+population. assertion.
- assertion asSentence A+missense+mutation+in+WD-repeat+domain+65+%28WDR65%29+in+an+individual+with+Van+der+Woude+syndrome. assertion.
- assertion asSentence SIK1+links+LKB1+to+p53-dependent+anoikis+and+suppresses+metastasis. assertion.
- assertion asSentence AIF+maintains+the+transformed+state+of+colon+cancer+cells+through+its+NADH+oxidase+activity%2C+by+mechanisms+that+involve+complex+I+function. assertion.
- assertion asSentence AIFM3+is+a+direct+target+of+miR-210+in+human+hepatoma+cells. assertion.
- assertion asSentence COMMD1+accelerates+the+ubiquitination+and+degradation+of+NF-kappaB+subunits+through+its+interaction+with+a+multimeric+ubiquitin+ligase+containing+Elongins+B+and+C%2C+Cul2+and+SOCS1+%28ECS%28SOCS1%29%29. assertion.
- assertion asSentence COMMD1+%28copper+metabolism+MURR1+domain-containing+protein+1%29+regulates+Cullin+RING+ligases+by+preventing+CAND1+%28Cullin-associated+Nedd8-dissociated+protein+1%29+binding. assertion.
- assertion asSentence BTLA+is+constitutively+expressed+on+most+CD4%2B+and+CD8%2B+T+cells+and+its+expression+progressively+decreases+upon+T+cell+activation. assertion.
- assertion asSentence BTLA+is+an+inhibitory+coreceptor+of+the+B+cell+receptor+%28BCR%29+signaling+pathway+that+attenuates+B+cell+activation+by+targeting+the+downstream+signaling+molecules+Syk+and+B+cell+linker+protein+%28BLNK%29. assertion.
- assertion asSentence BTLA-HVEM+interactions+impair+minor+histocompatibiility+antigen-specific+T+cell+functionality%2C+providing+a+rationale+for+BTLA+signaling+blockade+in+post-stem+cell+transplantation. assertion.
- assertion asSentence PP4R2%2C+a+regulatory+subunit+of+PP4%2C+mediates+the+DNA+damage-dependent+association+between+RPA2+and+the+PP4C+catalytic+subunit. assertion.
- assertion asSentence KLB-silencing+in+Huh7+cells+decreased+cell+proliferation+and+suppressed+FGFR4+downstream+signaling. assertion.
- assertion asSentence The+2.4+A+PP2Cm+structure+reveals+a+central+beta-sandwich+with+two+bound+metal+ions+in+the+active-site+cleft. assertion.
- assertion asSentence hDAB2IP+methylation+frequently+is+present+in+breast+cancer+and+plays+a+key+role+in+hDAB2IP+inactivation. assertion.
- assertion asSentence Both+internalization+and+ASK1-interacting+protein-1+association+are+required+for+TNFR2-dependent+JNK+and+apoptotic+signaling+in+endothelial+cells. assertion.
- assertion asSentence CNKSR3%2C+a+homologue+of+scaffold+proteins+involved+in+MAPK+pathway+regulation%2C+is+a+direct+target+of+MR+and+is+required+for+the+maintenance+of+transepithelial+sodium+transport+in+the+kidney. assertion.
- assertion asSentence Organization+of+the+gene+includes+a+unique+transcriptional+start+site%2C+a+coding+region+with+six+translated+exons+and+a+3%27+UTR+containing+at+least+two+used+polyadenylation+sites. assertion.
- assertion asSentence C9orf14+is+a+candidate+tumor-suppressor+for+nevus+development+and+late+stage+melanoma+at+9p21%2C+a+region+frequently+deleted+in+different+types+of+human+cancers. assertion.
- assertion asSentence TILRR%2C+an+isoform+encoded+by+an+alternatively+spliced+FREM1+mRNA%2C+is+an+IL-1RI+co-receptor+that+associates+with+the+signaling+receptor+complex+to+enhance+recruitment+of+MyD88+and+control+Ras-dependent+amplification+of+NF-kappaB+and+inflammatory+responses. assertion.
- assertion asSentence Low-affinity+transporter+SMCT2+initiates+lactate+absorption+in+the+early+parts+of+the+proximal+tubule+followed+by+the+participation+of+the+high-affinity+transporter+SMCT1+in+the+latter+parts+of+the+proximal+tubule. assertion.
- assertion asSentence Dendritic-cell+%28DC%29-associated+C-type+lectin+receptors+%28CLRs%29+take+up+antigens+to+present+to+T+cells+and+regulate+DC+functions. assertion.
- assertion asSentence Sodium-coupled+electrogenic+transport+of+pyroglutamate+%285-oxoproline%29+via+SLC5A8%2C+a+monocarboxylate+transporter. assertion.
- assertion asSentence SLC5A8+nuclear+translocation+and+loss+of+expression+are+associated+with+poor+outcome+in+pancreatic+ductal+adenocarcinoma. assertion.
- assertion asSentence Four+DGKH+markers+are+linked+to+adult+attention-hyperactivity+disorder+and+seven+to+unipolar+depression%2C+making+DGKH+a+risk+factor+gene+for+bipolar+disorder%2C+unipolar+depression+and+adult+attention-deficit+hyperactivity+disorder. assertion.
- assertion asSentence Downregulation+of+TMEM30B+is+associated+with+recurrence+in+meningiomas. assertion.
- assertion asSentence DYX1C1+interacts+with+both+ERs+in+the+presence+of+17beta-estradiol+in+neurons. assertion.
- assertion asSentence Interaction+of+FGFRL1+with+Spred1+increases+the+proportion+of+the+receptor+at+the+plasma+membrane. assertion.
- assertion asSentence 3D+structure+of+a+complex+comprising+the+interaction+domains+of+FOG1+and+GATA1+reveals+how+zinc+fingers+can+act+as+protein+recognition+motifs+and+provides+a+molecular+explanation+for+how+GATA-1+mutations+contribute+to+distinct%2C+related+genetic+diseases. assertion.
- assertion asSentence NAGS+deficiency+in+humans+leads+to+hyperammonemia+and+can+be+primary%2C+due+to+mutations+in+the+NAGS+gene+or+secondary+due+to+other+mitochondrial+aberrations+that+interfere+with+the+normal+function+of+the+same+enzyme. assertion.
- assertion asSentence hSAS6+depletion+hindered+STIL+targeting+to+the+procentriole%2C+implying+that+STIL+and+hSAS6+are+mutually+dependent+for+their+centriolar+localization. assertion.
- assertion asSentence The+importance+of+TMPRSS6+trafficking+at+the+plasma+membrane+in+the+regulation+of+hepcidin+expression%2C+an+event+that+is+essential+for+iron+homeostasis. assertion.
- assertion asSentence Mutation+in+BBS12+accounts+for+Bardet-Biedl+syndrome+and+termination+of+pregnancy+of+a+fetus. assertion.
- assertion asSentence SMS2+regulates+subcellular+pools+of+diacylglycerol-binding+proteins+in+the+Golgi+apparatus. assertion.
- assertion asSentence Chief+cells+emerge+from+the+Mist. assertion.
- assertion asSentence Diaphonospondylodysostosis+is+caused+by+loss+of+BMPER+function. assertion.
- assertion asSentence The+C-terminal+domain+of+human+ZnT8+contains+at+least+two+discrete+epitopes%2C+one+of+which+is+critically+dependent+upon+the+arginine+residue+at+position+325. assertion.
- assertion asSentence SLC30A8+provides+an+important+additional+and+independent+predictive+marker+for+T1+diabetes+mellitus. assertion.
- assertion asSentence Kv11.1+%28ERG1%29+K%2B+channels+localize+in+cholesterol+and+sphingolipid+enriched+membranes+and+are+modulated+by+membrane+cholesterol. assertion.
- assertion asSentence Lissencephaly+or+mental+retardation+is+caused+by+ARX+mutations+without+the+involvement+of+other+genetic+factors. assertion.
- assertion asSentence Contractions+in+the+second+polyA+tract+of+ARX+are+rare%2C+non-pathogenic+polymorphisms. assertion.
- assertion asSentence Expression+of+dendritic+cell+markers+CD11c%2FBDCA-1+and+CD123%2FBDCA-2+in+coronary+artery+disease+upon+activation+in+whole+blood. assertion.
- assertion asSentence Human+C-type+lectin+domain+family+4%2C+member+C+%28CLEC4C%2FBDCA-2%2FCD303%29+is+a+receptor+for+asialo-galactosyl-oligosaccharides. assertion.
- assertion asSentence GIMAP1+and+GIMAP4+genes+are+up-regulated+by+IL-12+and+other+Th1+differentiation-inducing+cytokines+in+cells+induced+to+differentiate+toward+Th1+lineage+and+down-regulated+by+IL-4+in+cells+induced+to+Th2. assertion.
- assertion asSentence Mutations+of+the+polycomb-associated+gene+ASXL1+is+associated+with+myelodysplastic+syndromes+and+acute+myeloid+leukemia. assertion.
- assertion asSentence ASXL1+associates+with+the+PRC2+and+loss+of+ASXL1+in+vivo+collaborates+with+NRASG12D+to+promote+myeloid+leukemogenesis. assertion.
- assertion asSentence BerEP4+labeling+is+not+reliable+in+superficial+biopsies+of+basal+cell+carcinoma+with+squamoid+features. assertion.
- assertion asSentence The+peptide-binding+motif+of+HLA-DR8+shares+important+structural+features+with+other+type+1+diabetes-associated+alleles. assertion.
- assertion asSentence miR-5787+represses+cell+growth%2C+in+part%2C+by+targeting+eIF5. assertion.
- assertion asSentence There+is+a+high+prevalence+of+CIC+fusion+with+double-homeobox+%28DUX4%29+transcription+factors+in+EWSR1-negative+undifferentiated+small+blue+round+cell+sarcomas. assertion.
- assertion asSentence Aberrantly+expressed+miR-125b+contributes+to+HEC1B+cells+invasion+partly+through+directly+down-regulating+ERBB2+protein+expression+in+endometrioid+endometrial+cancer. assertion.
- assertion asSentence Thiazolidinediones+modulate+the+expression+of+beta+catenin+and+other+cell+cycle+proteins+by+targeting+UBR1+independently+of+PPARG. assertion.
- assertion asSentence E3+ubiquitin+ligase+is+an+essential+downstream+component+of+the+RAS+signal+transduction+pathway. assertion.
- assertion asSentence NLRP7+mutations+do+not+represent+a+major+cause+of+complete+hydatidiform+moles+of+proven+androgenetic+origin. assertion.
- assertion asSentence Human+Freud-2%2FCC2D1B+binds+to+the+5-HT1A+dual+repressor+element+and+represses+the+human+5-HT1A+receptor+gene+to+regulate+its+expression+in+non-serotonergic+cells+and+neurons. assertion.
- assertion asSentence mTORC2+signaling+promotes+GBM+growth+and+survival+and+activates+NF-kappaB. assertion.
- assertion asSentence A+single-point+mutation+in+SIV+Vpx+%28H82A%29+abrogated+binding+to+APOBEC3A+and+single-round+infection+of+monocytes+by+HIV-1. assertion.
- assertion asSentence Only+the+C-terminal+domain+of+APOBEC3F+and+-3G+dictates+the+retroviral+minus+strand+5%27-TC+and+5%27-CC+dinucleotide+hypermutation+preferences. assertion.
- assertion asSentence Polynucleotide+kinase+and+aprataxin-like+forkhead-associated+protein+%28PALF%29+acts+as+both+a+single-stranded+DNA+endonuclease+and+a+single-stranded+DNA+3%27+exonuclease+and+can+participate+in+DNA+end+joining+in+a+biochemical+system. assertion.
- assertion asSentence PIKfyve+is+a+potent+stimulator+of+ClC-2-activity+and+contributes+to+SGK1-dependent+regulation+of+ClC-2. assertion.
- assertion asSentence Coexpression+of+PIKfyve+is+followed+by+a+marked+increase+of+glutamate+induced+currents+in+EAAT2+expressing+oocytes. assertion.
- assertion asSentence Loss+of+Spred-2+inhibits+bone+growth+in+transgenic+mice+by+inhibiting+chondrocyte+differentiation+through+up-regulation+of+the+MAPK+signaling+pathway. assertion.
- assertion asSentence The+selective+localization+of+OSTalpha+and+OSTbeta+to+the+basolateral+plasma+membrane+of+epithelial+cells+responsible+for+bile+acid+and+sterol+reabsorption. assertion.
- assertion asSentence Stra13+protects+muscle+cells+from+oxidative+damage. assertion.
- assertion asSentence MHF1+and+MHF2+form+a+compact+tetramer+to+which+FANCM-F+binds+through+a+%27dual-V%27+shaped+structure. assertion.
- assertion asSentence A+role+for+Munc13-4+as+a+component+of+the+secretory+machinery+in+neutrophils. assertion.
- assertion asSentence Hemophagocytic+lymphohistiocytosis+with+MUNC13-4+gene+mutation+or+reduced+natural+killer+cell+function+prior+to+onset+of+childhood+leukemia. assertion.
- assertion asSentence Adm+and+APM-1+protect+endothelium-dependent+vascular+relaxation+in+sepsis. assertion.
- assertion asSentence 2%27-phosphodiesterase+is+a+mitochondrial+protein+that+specifically+removes+poly%28A%29+extensions+from+mitochondrial+mRNAs+both+in+vitro+and+in+mitochondria+of+cultured+cells. assertion.
- assertion asSentence TIGIT+can+inhibit+T+cell+functions+by+competing+with+CD226+and+can+also+directly+inhibit+T+cells+in+a+T+cell-intrinsic+manner. assertion.
- assertion asSentence cDNA+subtraction+revealed+increased+expression+of+alpha3-tubulin+in+the+taxol-resistant+cell+line. assertion.
- assertion asSentence The+C9orf72+hexanucleotide+repeat+expansion+in+Amyotrophic+Lateral+Sclerosis+and+Frontotemporal+Dementia. assertion.
- assertion asSentence NAIF1+is+down-regulated+in+gastric+cancer. assertion.
- assertion asSentence A+high-capacity+imino+acid+carrier+localized+at+the+small+intestinal+luminal+membrane+that+transports+nutrients+and+amino+acids+and+imino+acids. assertion.
- assertion asSentence The+proteolytic+activity+of+oligomeric+Tysnd1+is+in+turn+controlled+by+self-cleavage+of+Tysnd1+and+degradation+of+Tysnd1+cleavage+products+by+PsLon. assertion.
- assertion asSentence A+1+bp+deletion+in+the+dual+reading+frame+deafness+gene+LRTOMT+causes+a+frameshift+from+the+first+into+the+second+reading+frame. assertion.
- assertion asSentence ATOH7+is+significantly+associated+with+open-angle+glaucoma. assertion.
- assertion asSentence GlialCAM%2C+an+immunoglobulin-like+cell+adhesion+molecule+is+expressed+in+glial+cells+of+the+central+nervous+system. assertion.
- assertion asSentence hnRNPUL1+and+-2+function+downstream+of+MRN+and+CtBP-interacting+protein+%28CtIP%29+to+promote+recruitment+of+the+BLM+helicase+to+DNA+breaks. assertion.
- assertion asSentence C13Orf3+%28now+termed+Ska3%29+localizes+to+the+spindle+and+kinetochore+throughout+mitosis+and+its+depletion+markedly+delays+anaphase+transition. assertion.
- assertion asSentence Ska3+functions+to+coordinate+checkpoint+signaling+from+the+microtubule+binding+sites+within+a+kinetochore+by+laterally+linking+the+individual+binding+sites. assertion.
- assertion asSentence UV+photoreceptor+in+human+beings+OPN5+triggers+a+UV-sensitive+Gi-mediated+signaling+pathway+in+the+mammalian+tissues. assertion.
- assertion asSentence Dishevelled-DEP+domain+interacting+protein+is+a+negative+regulator+of+the+canonical+Wnt+signaling. assertion.
- assertion asSentence Mutations+in+RSPH9+leads+to+ultrastructural+cilia+defects+and+ciliary+dyskinesia. assertion.
- assertion asSentence Use+of+KIF6+genotyping+to+guide+statin+therapy+is+not+warranted+in+this+heart+protection+trial%2C+since+no+impact+is+found+on+KIF6+genotype%2C+vascular+risk+or+statin+response. assertion.
- assertion asSentence Single-nucleotide+polymorphism+of+rs10486567+in+JAZF1+is+associated+with+prostate+cancer. assertion.
- assertion asSentence RFX6+is+a+winged+helix+transcription+factor+expressed+almost+exclusively+in+the+pancreatic+islets. assertion.
- assertion asSentence On+the+basis+of+its+nuclear+magnetic+resonance+%28NMR%29+nucleic+acid+structure%2C+a+boranophosphonate-modified%2C+fully+R%28P%29+BH%283%29+DNA%2FRNA+hybrid+is+predicted+not+to+be+a+substrate+for+RNase+H1. assertion.
- assertion asSentence MYAS1+is+a+HLA-linked+locus+associated+with+myasthenia+gravis. assertion.
- assertion asSentence The+suppressive+capacity+of+inducible+regulatory+T+%28Treg%29+cells+is+sustained+with+IL-27+and+interferon+%28IFN%29-gamma. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+interleukin+27+is+associated+with+nasopharyngeal+carcinoma. assertion.
- assertion asSentence IL-27+blocks+the+proximal+steps+of+TNF-alpha+signaling+by+downregulating+cell-surface+expression+of+signaling+receptors+p55+and+p75. assertion.
- assertion asSentence Maps+to+11q22%2C+mainly+expressed+in+adult+human+heart. assertion.
- assertion asSentence RanGAP1+remains+associated+with+RanBP2%2FNup358+and+the+SUMO+E2-conjugating+enzyme+Ubc9+in+mitosis. assertion.