Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence LPEAT2+as+an+important+enzyme+in+the+biosynthesis+of+ethanolamine-containing+phospholipids%2C+especially+in+brain. assertion.
- assertion asSentence CALHM1+polymorphism+is+not+associated+with+late-onset+Alzheimer+disease. assertion.
- assertion asSentence The+CALHM1-P86L+polymorphism+is+associated+with+Alzheimer%27s+disease+in+the+ethnic+Chinese+Han+population. assertion.
- assertion asSentence Among+the+aged+with+cognitive+impairments%2C+the+homozygous+status+for+the+A2+allele+of+the+DRD2+Taq+I+polymorphism+is+associated+with+diminished+cognitive+performance+and+increased+atrophy+in+the+striatum. assertion.
- assertion asSentence The+TaqI-A+of+the+ANKK1+gene+and+the+C957T+of+the+DRD2+gene+are+epistatically+associated+with+psychopathic+traits+in+alcohol-dependent+patients. assertion.
- assertion asSentence IBRDC2%2C+an+IBR-type+RING-finger+E3+ubiquitin+ligase%2C+regulates+the+levels+of+Bax+and+protects+cells+from+unprompted+Bax.+activation+and+cell+death. assertion.
- assertion asSentence PIR2%2C+by+being+induced+by+TAp73+and+degrading+DeltaNp73%2C+differentially+regulates+TAp73%2FDeltaNp73+stability. assertion.
- assertion asSentence Mutations+in+the+PCSK9+gene+cause+autosomal+dominant+hypercholesterolemia. assertion.
- assertion asSentence PCSK9+proximal+promoter+contains+a+functional+sterol+regulatory+element+binding+transcription+factor+%28SREBP-1c%29+located+from+335+bp+to+355+bp+upstream+of+the+ATG. assertion.
- assertion asSentence PCSK9+%28or+a+factor+acted+upon+by+PCSK9%29+is+secreted+from+transfected+cells+and+degrades+low-density+lipoprotein+receptors+both+in+transfected+and+untransfected+cells. assertion.
- assertion asSentence The+sorting+of+PCSK9+to+the+cell+surface+and+endosomes+is+required+for+PCSK9+to+fully+promote+LDLR+degradation. assertion.
- assertion asSentence The+circulating+concentrations+of+human+PCSK9+are+directly+correlated+with+LDL+and+total+cholesterol+concentrations. assertion.
- assertion asSentence The+activity+of+PCSK9+and+its+binding+affinity+on+VLDLR+and+ApoER2+does+not+depend+on+the+presence+of+LDLR. assertion.
- assertion asSentence Truncating+mutations+in+the+apoB-100+gene+are+slightly+more+common+as+the+cause+of+hypocholesterolemia+compared+to+loss-of-function+mutations+in+the+PCSK9+gene. assertion.
- assertion asSentence Multiple+metabolic+and+genetic+factors+contribute+to+variation+in+plasma+levels+of+PCSK9+in+the+general+population. assertion.
- assertion asSentence Common+and+low-frequency+genetic+variants+in+the+PCSK9+locus+influence+the+pronounced+interindividual+variation+in+circulating+PCSK9+levels+in+healthy%2C+middle-aged+white+%28predominantly+Swedish%29+subjects. assertion.
- assertion asSentence The+collagen+VI+alpha5+chain+is+selectively+localized+at+the+basement+membrane+of+myotendinous+junctions. assertion.
- assertion asSentence P48+interacts+with+the+RBP-L+and+RBP-J+subunits+primarily+through+two+short+conserved+tryptophan-containing+motifs%2C+similar+to+the+motif+of+the+Notch+intracellular+domain+%28NotchIC%29+that+interacts+with+RBP-J. assertion.
- assertion asSentence NUT+gene+rearrangement+is+associated+with+squamous+cell+carcinoma+of+the+lung+with+long+time+survival. assertion.
- assertion asSentence Dynamin+1%27s+mechanochemical+properties+on+a+membrane+surface+are+dynamically+regulated+by+its+GTPase+cycle+and+major+binding+partners. assertion.
- assertion asSentence HLTF+and+SHPRH+are+functional+homologues+of+yeast+Rad5+that+cooperatively+mediate+PCNA+polyubiquitination+and+maintain+genomic+stability. assertion.
- assertion asSentence TAB3+is+involved+in+IL-1-induced+NF-kappaB+activation+by+physically+linking+TAK1+to+TRAF6. assertion.
- assertion asSentence SVIP+is+an+endogenous+inhibitor+of+ERAD+that+acts+through+regulating+the+assembly+of+the+gp78-p97%2FVCP-Derlin1+complex. assertion.
- assertion asSentence CD59+is+physically+associated+with+NKp46+and+NKp30+and+activate+human+nk+cell-mediated+cytotoxicity. assertion.
- assertion asSentence NKp30%28high%29+cells+are+more+effective+in+preventing+infection+of+hepatitis+C+in+high+risk+intravenous+drug+addicted+individuals. assertion.
- assertion asSentence The+NKp30-B7-H6+structure+revealed+that+this+NK+cell+activating+complex+is+distinct+from+the+CTLA4-B7+and+PD-1-PD-L+T+cell+inhibitory+complexes+in+both+overall+organization+and+detailed+atomic+interactions+that+mediate+binding+and+specificity. assertion.
- assertion asSentence NKp30+chimeric+antigen+receptor-expressing+T+cells+produce+interferon+%28IFN%29-gamma+and+kill+B7-H6+ligand-expressing+tumor+cells+in+vivo. assertion.
- assertion asSentence G6f+recruits+adaptor+signalling+proteins+Grb2+and+Grb7. assertion.
- assertion asSentence SMS1+is+responsible+for+SM+synthase+activity+in+mammalian+cells+and+plays+a+critical+role+in+cell+growth+of+lymphoid+cells. assertion.
- assertion asSentence UNC80+functions+as+a+scaffold+for+Src+kinases+in+NALCN+channel+function. assertion.
- assertion asSentence Human+bitter+taste+receptors+hTAS2R8+and+hTAS2R39+display+differential+functions+to+recognize+bitter+peptides. assertion.
- assertion asSentence hTAS2R43+and+hTAS2R44+function+as+cognate+bitter+taste+receptors+and+do+not+contribute+to+the+sweet+taste+of+saccharin+and+acesulfame+K. assertion.
- assertion asSentence Activation+by+denatonium+and+6-nitrosaccharin. assertion.
- assertion asSentence TAS2R50+is+activated+by+the+natural+bitter+terpenoids+andrographolide+and+amarogentin. assertion.
- assertion asSentence NMR+assignment+of+human+ASC2%2C+a+self+contained+protein+interaction+domain+involved+in+apoptosis+and+inflammation. assertion.
- assertion asSentence Recessive+mutations+in+the+NPHP4+gene%2C+encoding+the+protein+nephroretinin%2C+in+humans+cause+nephronophthisis+type+4+and+Senior-Loken+syndrome.There+is+evolutionary+conservation+of+the+NPHP4+gene%2C+with+an+ortholog+in+C.+elegans. assertion.
- assertion asSentence The+genes+G72+is+regulate+the+glutamate+neurotransmission+in+schizophrenia. assertion.
- assertion asSentence The+G72%2FG30+complex+is+considered+as+one+of+the+most+promising+candidate+genes+for+both+schizophrenia+and+bipolar+disorder. assertion.
- assertion asSentence hSelH+overexpression+protects+cells+from+UVB+irradiation-induced+murine+hippocampal+neuronal+cell+death+by+reducing+the+superoxide+formation. assertion.
- assertion asSentence rs12979860+is+the+ideal+IL28B+single+nucleotide+polymorphism+for+genetic+testing+in+treating+patients+of+genotype-1+hepatitis+C+virus+chronic+infection. assertion.
- assertion asSentence Vitamin+D+serum+levels+are+complementary+to+the+IL-28B+rs12979860+C%2FT+polymorphism+in+enhancing+the+correct+prediction+of+the+SVR+in+treatment-naive+chronic+hepatitis+C. assertion.
- assertion asSentence The+IL28B+variants+are+also+associated+with+likelihood+of+spontaneous+clearance+of+HCV+infection. assertion.
- assertion asSentence IL28B+and+STAT1-nuclear+translocation+in+hepatocytes+are+independent+predictors+of+response+to+treatment+with+peginterferon+and+ribavirin+in+chronic+hepatitis+C+patients. assertion.
- assertion asSentence IL28B+polymorphisms+are+strongly+associated+with+with+posttransplant+diabetes+mellitus. assertion.
- assertion asSentence The+rs12979860-CC+variant+upstream+of+IL28B+gene+is+associated+with+spontaneous+clearance+of+HCV%2C+susceptible+to+IFN%2FRBV+treatment+and+increased+IL-28B+levels+in+this+Chinese+population. assertion.
- assertion asSentence The+G30+region+is+involved+in+susceptibility+to+schizophrenia+in+the+Ashkenazi+population. assertion.
- assertion asSentence H19+gene+is+imprinted%2C+with+preferential+expression+from+the+maternal+allele. assertion.
- assertion asSentence Hypomethylation+of+the+paternally+derived+H19+is+associated+with+Silver-Russell+syndrome. assertion.
- assertion asSentence Epimutations+on+chromosome+11p15+can+be+most+efficiently+detected+in+Russell-Silver+syndrome+patients+by+screening+for+DNA+methylation+defects+at+the+H19+promoter+or+the+distal+region+of+imprinting+center+ICR. assertion.
- assertion asSentence Cohesin+has+a+critical+role+in+maintaining+CTCF-mediated+chromatin+conformation+at+the+at+the+IGF2-H19+locus+locus+and+disruption+of+this+conformation+coincides+with+changes+in+IGF2+expression. assertion.
- assertion asSentence Consistent+with+imprinting%2C+common+polymorphic+variation+in+fetal+H19+alleles+transmitted+only+from+the+mother+are+associated+with+birth+weight+and+other+markers+of+size+at+birth. assertion.
- assertion asSentence betaGT3+and+betaGT4%2C+that+are+able+to+transfer+GalNAc+to+GlcNAc+in+beta1%2C4-linkage+display+the+necessary+glycoprotein+specificity+in+vivo. assertion.
- assertion asSentence Molecular+basis+for+protein-specific+transfer+of+N-acetylgalactosamine+to+N-linked+glycans+by+the+glycosyltransferases+beta1%2C4-N-acetylgalactosaminyl+transferase+3+%28beta4GalNAc-T3%29+and+beta4GalNAc-T4. assertion.
- assertion asSentence Oncoprotein+Cot1+represses+kinase+suppressors+of+Ras1%2F2+and+1%2C25-dihydroxyvitamin+D3-induced+differentiation+of+human+acute+myeloid+leukemia+cells. assertion.
- assertion asSentence Reflux+laryngitis+is+associated+with+down-regulation+of+mucin+gene+expression. assertion.
- assertion asSentence Exposure+of+cryptic+domains+in+the+alpha+1-chain+of+laminin-1+by+elastase+stimulates+macrophages+urokinase+and+matrix+metalloproteinase-9+expression. assertion.
- assertion asSentence High-expression+of+hHSS1+is+associated+high-grade+gliomas. assertion.
- assertion asSentence The+docking+domain+of+WDR62+interacts+with+all+JNK+isoforms+through+a+D+domain+motif+located+at+the+C-terminus. assertion.
- assertion asSentence The+different+patterns+of+aberrant+methylation+of+the+CAGE-1+gene+in+the+various+histopathological+cancer+types+of+the+urinary+bladder+point+to+a+role+in+tumor+cell+differentiation. assertion.
- assertion asSentence FAM83H+mutations+in+families+with+autosomal-dominant+hypocalcified+amelogenesis+imperfecta+demonstrate+that+FAM83H+is+required+for+proper+dental-enamel+calcification. assertion.
- assertion asSentence Mutation+of+BARA%2FLIN-9+restores+the+expression+of+E2F+target+genes. assertion.
- assertion asSentence The+repressor+complex+that+Mip%2FLIN-9+forms+with+p107+takes+functional+precedence+over+the+transcriptional+activation+linked+to+the+Mip%2FLIN-9+and+B-Myb+interaction. assertion.
- assertion asSentence The+KLHL-10+gene+is+not+a+major+contributor+to+azoospermia%2C+oligospermia+or+asthenospermia+in+Chinese+population. assertion.
- assertion asSentence In+syngeneic+human+breast-derived+cell+lines%2C+one+diploid+and+non-transformed%2C+the+other+derived+from+a+ductal+carcinoma%2C+the+loss+of+H3+phosphorylation+is+significantly+more+sensitive+to+cAMP+concentration+in+the+transformed+cell+line. assertion.
- assertion asSentence Downregulated+by+zinc+and+upregulated+by+docosahexaenoate+in+a+neuroblastoma+cell+line. assertion.
- assertion asSentence Niacin-mediated+activation+of+GP109A+in+liver+lowers+ABCA1+expression+leading+to+reduced+hepatic+cholesterol+efflux+to+high+density+lipoprotein. assertion.
- assertion asSentence Agonist-stimulated+GPR120S+and+GPR120L+receptors+both+recruited+beta-arrestin2+and+underwent+robust+internalization. assertion.
- assertion asSentence Because+14-3-3+proteins+are+ubiquitous%2C+they+are+expected+to+control+the+duration+of+calcineurin-mediated+TRESK+activation+in+all+the+cell+types+that+express+the+channel%2C+depending+on+the+phosphorylation+state+of+serine+264. assertion.
- assertion asSentence A+role+for+TRESK+in+the+pathogenesis+of+typical+migraine+with+aura. assertion.
- assertion asSentence Molecular+basis+for+protein-specific+transfer+of+N-acetylgalactosamine+to+N-linked+glycans+by+the+glycosyltransferases+beta1%2C4-N-acetylgalactosaminyl+transferase+3+%28beta4GalNAc-T3%29+and+beta4GalNAc-T4. assertion.
- assertion asSentence Peptide-specific+transfer+of+N-acetylgalactosamine+to+O-linked+glycans+by+the+glycosyltransferases+beta1%2C4-N-acetylgalactosaminyl+transferase+3+%28beta4GalNAc-T3%29+and+beta4GalNAc-T4. assertion.
- assertion asSentence Liver+sinusoidal+endothelial+cell+lectin%2C+LSECtin%2C+negatively+regulates+hepatic+T-cell+immune+response. assertion.
- assertion asSentence TFAP2E+hypermethylation+is+associated+with+clinical+nonresponsiveness+to+chemotherapy+in+colorectal+cancer. assertion.
- assertion asSentence One+mutation%2C+the+D173N+allele%2C+is+present+in+42%25+of+Hartnup+chromosomes+from+apparently+unrelated+families+from+both+Australia+and+North+America. assertion.
- assertion asSentence 6-mercaptopurine+decreased+iNOS+expression+and+increased+MRP5+mRNA+levels. assertion.
- assertion asSentence Reduced+Rspo-2+levels+in+osteoarthritis+osteoblasts+are+responsible%2C+at+least+in+part%2C+for+their+reduced+Wnt%2Fbeta-catenin+signaling+and+abnormal+mineralization. assertion.
- assertion asSentence Expressed+widely+in+ER+of+all+tissues%2C+especially+highly+in+lung%2C+thymus%2C+skeleton+muscle%2C+colon+and+ovary. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+the+AMACO+gene+are+associated+with+dominant+protection+against+Type+1A+diabetes+in+an+Arab+family. assertion.
- assertion asSentence Both+ATXN1+and+BOAT1+bind+to+the+promoter+region+of+Hey1+and+inhibit+the+transcriptional+output+of+Notch+through+direct+interactions+with+CBF1%2C+a+transcription+factor+that+is+crucial+for+the+Notch+pathway. assertion.
- assertion asSentence The+retinopathy-associated+RD3+protein+is+part+of+subnuclear+protein+complexes+involved+in+diverse+processes%2C+such+as+transcription+and+splicing. assertion.
- assertion asSentence Human+FCRL6+receptor%2C+selectively+expressed+by+cytotoxic+T+and+natural+killer+%28NK%29+cells%2C+directly+binds+the+major+histocompatibility+complex+%28MHC%29+class+II+molecule+HLA-DR. assertion.
- assertion asSentence IRGM+is+significantly+associated+with+Crohn+disease. assertion.
- assertion asSentence Small+insertion%2Fdeletion+polymorphisms+in+the+promoter+and+5%27+untranslated+region+of+IRGM+are%2C+together+with+the+copy+number+variation%2C+strongly+associated+with+Crohn%27s+disease. assertion.
- assertion asSentence LRRTM1+on+chromosome+2p12+is+a+maternally+suppressed+gene+that+is+associated+paternally+with+handedness+and+schizophrenia. assertion.
- assertion asSentence PAPS+transporters+play+a+role+in+the+proliferation+of+colorectal+carcinoma+cells+themselves+and+take+part+in+a+desmoplastic+reaction+to+support+cancer+growth+by+controlling+their+sulfation+status. assertion.
- assertion asSentence RBPMS3+transcripts+are+up-regulation+in+colons+of+patients+with+chronic+psuedo+obstruction+syndrome. assertion.
- assertion asSentence Cx31.3+is+localized+to+the+gray+matter+along+small+myelinated+fibers+and+is+co-expressed+with+Cx32+in+oligodendrocytes. assertion.
- assertion asSentence Mutations+in+the+Cx29+gene+do+not+play+a+role+in+the+causation+of+non+syndromic+hearing+impairment+in+Indian+population. assertion.
- assertion asSentence Nogo-66+receptor+homolog+1+signaling+regulates+activity-dependent+synaptic+strength+and+neuronal+plasticity. assertion.
- assertion asSentence Cloning%2C+gene+organization+and+expression+of+peptidylarginine+deiminase+type+6. assertion.
- assertion asSentence ANKRD37+is+a+direct+HIF-1+target+that+is+highly+induced+in+hypoxia. assertion.
- assertion asSentence Both+the+amount+and+intrinsic+activity+of+complex+I+are+decreased+in+inherited+complex+I+deficiency%2C+ehich+can+be+increased+by+Trolox. assertion.
- assertion asSentence Epithelial+keratin%2C+K1b%2C+is+exclusively+expressed+in+luminal+duct+cells+of+eccrine+sweat+glands. assertion.
- assertion asSentence The+down-regulation+of+beta3Gn-T8+caused+significant+inhibition+of+tumor+cell+growth+in+vitro. assertion.
- assertion asSentence SVBP%28CCDC23%29acts+as+a+secretory+chaperone+for+VASH1. assertion.
- assertion asSentence CERKL+mutations+are+associated+with+widespread+retinal+degeneration+with+prominent+maculopathy. assertion.
- assertion asSentence High+expression+level+of+MAST4+in+most+normal+human+tissues%2C+with+an+exception+of+in+testis%2C+small+intestine%2C+colon+and+peripheral+blood+leukocyte. assertion.
- assertion asSentence Rab15+effector+protein+is+a+binding+partner+for+Rab15-GTP. assertion.
- assertion asSentence NTPDase8+is+the+canalicular+ecto-ATPase%2FATPDase+and+is+responsible+for+the+main+hepatic+NTPDase+activity. assertion.
- assertion asSentence Maps+within+the+critical+region+of+Williams-Beuren+syndrome. assertion.