Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Residue+85+plays+an+important+role+in+the+structure+and+function+of+SP-A+and+is+a+major+factor+for+the+differences+between+SP-A1+and+SP-A2+variants. assertion.
- assertion asSentence Mutations+in+ISPD+cause+Walker-Warburg+syndrome+and+defective+glycosylation+of+alpha-dystroglycan. assertion.
- assertion asSentence Human+primary+cementoblasts+subjected+to+compression+and+IL-1beta+stimulation+impeded+BSP+and+CEMP-1+expression%2C+proteins+that+are+associated+with+cementogenesis. assertion.
- assertion asSentence HESRG+is+a+novel%2C+sensitive+and+specific+biomarker+for+intracranial+germinoma+and+embryonal+carcinoma. assertion.
- assertion asSentence KIR2DS2%2A005+encodes+a+molecule+expressed+on+the+surface+of+natural+killer-+and+T-lymphocytes. assertion.
- assertion asSentence A+destabilizing+dinucleotide+deletion+in+the+3%27+UTR+of+CD24+mRNA+conveys+significant+protection+against+both+multiple+sclerosis+and+systemic+lupus+erythematosus. assertion.
- assertion asSentence CD24+overexpression+is+associated+with+cancer+development+and+progression. assertion.
- assertion asSentence Upregulation+of+CD24+is+associated+with+inflammatory+bowel+disease. assertion.
- assertion asSentence Combined+anticancer+agents+formestane+and+herceptin+are+active+on+a+subpopulation+of+CD44high%2FCD24low+breast+cancer+cells. assertion.
- assertion asSentence PON1+association+with+human+phosphate+binding+protein+%28HPBP%29+is+essential+for+preserving+its+active+conformation. assertion.
- assertion asSentence Pathogenic+mutations+in+KLLN+are+rare+in+breast+cancer+families+and+the+c.339_340delAG+variant+does+not+represent+a+high-penetrance+breast+cancer+risk+allele. assertion.
- assertion asSentence Oro-dental+anomalies%2C+pigmentary+disorder+and+vasculopathy+are+found+in+MOPD1+patients. assertion.
- assertion asSentence The+chromosomal+structure+in+the+region+22q11.2+predisposes+to+the+occurrence+of+microduplication+22q11.2+and+reciprocal+deletion. assertion.
- assertion asSentence Short+GC-rich+RNA+similar+to+miR+1909+and+1915+folds+in+silico+with+the+5%27-UTR+and+ORF+of+Notch+and+responders. assertion.
- assertion asSentence Short+GC-rich+RNA+similar+to+miR+1909+and+1915+folds+in+silico+with+the+5%27-UTR+and+ORF+of+Notch+and+responders. assertion.
- assertion asSentence MIR-1226+functions+as+a+tumor+suppressor+by+promoting+the+induction+of+cell+death. assertion.
- assertion asSentence High+serum+microRNA+1254+expression+is+associated+with+early-stage+non-small+cell+lung+cancer. assertion.
- assertion asSentence Oxidative+stress+induces+tyrosine+phosphorylation+and+cellular+redistribution+of+occludin-ZO-1+and+E-cadherin-beta-catenin+complexes+by+a+tyrosine-kinase-dependent+mechanism. assertion.
- assertion asSentence The+occludin+present+in+the+tight+junctions+in+HepG2+cells+. assertion.
- assertion asSentence Heat+stress-induced+increase+in+occludin+protein+expression+is+mediated+by+HSF-1+activation+and+subsequent+binding+of+HSF-1+to+the+occludin+promoter. assertion.
- assertion asSentence DEP-1+interacts+with+the+tight+junction+proteins+occludin+and+ZO-1+in+a+tyrosine+phosphorylation-dependent+manner. assertion.
- assertion asSentence Nedd4-2+interacts+with+occludin+to+inhibit+tight+junction+assembly+and+the+regulation+of+paracellular+conductance+in+the+collecting+duct. assertion.
- assertion asSentence MOST-1+is+associated+with+cell+survival%2C+proliferation+and+progression+of+breast+and+prostate+cancer+cells. assertion.
- assertion asSentence Circulating+soluble+MICA+in+cancer+patients+deactivates+natural+killer+%28NK%29+cell-mediated+NK+immunity+by+down-modulating+important+activating+and+chemokine+receptors+in+vitro+and+in+vivo. assertion.
- assertion asSentence The+association+of+MICA+alleles+with+diabetes+mellitus%2C+type+1%2C+is+in+combination+with+HLA+high-risk+haplotypes. assertion.
- assertion asSentence Polymorphic+MICA+in+HLA+Class+I+interacts+with+non-polymorphic+NKG2D+receptor+on+NK+cells. assertion.
- assertion asSentence Soluble+MICA+%28expressed+in+human+hepatocellular+carcinoma%29impairs+activation+of+natural+killer+cells+and+subsequent+dendritic+cell+function. assertion.
- assertion asSentence Microsatellite+polymorphism+of+MICA+is+a+genetic+marker+which+is+associated+with+antibody+formation+and+is+especially+important+in+early+events+of+autoimmune+reaction. assertion.
- assertion asSentence There+is+an+association+between+MICA+genes+and+an+increased+susceptibility+to+oral+squamous+cell+carcinoma+in+Japanese+patients. assertion.
- assertion asSentence MICA+is+widely+expressed+in+osteosarcoma. assertion.
- assertion asSentence Common+MICA+and+MICB+genetic+variations+are+not+associated+with+susceptibility+to+type+1+diabetes. assertion.
- assertion asSentence Estradiol+regulates+MICA+expression+in+human+endometrial+cells. assertion.
- assertion asSentence The+MICA-A9+allele+of+the+transmembrane+microsatelite+MICA+polymorphism+occurred+more+frequently+in+psoriatic+arthritis+with+psoriasis+type+II+group+%28age+of+psoriasis+onset+after+40+years%29+than+in+controls. assertion.
- assertion asSentence MICB+polymorphisms+and+haplotypes+with+MICA+and+HLA+alleles+in+Koreans. assertion.
- assertion asSentence The+genetic+polymorphism+of+MICA-129+and+sMICA+levels+are+correlated+in+ulcerative+colitis+patients+of+Hubei+Han+nationality. assertion.
- assertion asSentence Low+MICA+is+associated+with+hepatocellular+carcinoma. assertion.
- assertion asSentence HLA+and+MICA+genes+in+patients+with+tuberculosis+in+Brazil. assertion.
- assertion asSentence NF-kappaB+regulates+MICA+gene+transcription+in+endothelial+cell+through+a+genetically+inhibitable+control+site. assertion.
- assertion asSentence There+is+a+significantly+enhanced+ratio+between+the+dynorphin+A+immunoreactive+area+and+the+whole+area+of+the+entopeduncular+nucleus+in+genetically+dystonic+hamsters+compared+to+controls. assertion.
- assertion asSentence NARR+is+ubiquitously+expressed+and+resides+in+nucleoli+where+it+colocalizes+with+ribosomal+DNA+gene+clusters. assertion.
- assertion asSentence Partitioning+defective+3+homologue+%28Par3%29+and+mammalian+homologues+of+Drosophila+Lethal+%282%29+Giant+Larvae+%28Lgl1%2F2%29%2C+antagonize+each+other+in+modulating+myosin+II+activation+during+cell-cell+contact+formation+in+Madin-Darby+canine+kidney+cells. assertion.
- assertion asSentence Malignant+proliferation+in+canine+hemangiosarcomas+is+associated+with+bcl-2+and+survivin+expression. assertion.
- assertion asSentence Dynamic+changes+in+expression%2Fdistribution+of+differentially+phosphorylated+forms+of+connexin+43+in+tachycardia-induced+heart+failure. assertion.
- assertion asSentence All-trans+retinoic+acid+significantly+increased+Cx43+expression+and+gap+junction+intercellular+communication+in+canine+lens+epithelial+cells+%28LEC%29%2C+associated+with+increased+cell+differentiation. assertion.
- assertion asSentence Intrapericardial+adenine+nucleosides+induce+elevation+of+endothelin-1+concentration+in+the+pericardial+space+of+the+dog+heart. assertion.
- assertion asSentence Imerslund-Grasbeck+syndromes+due+to+an+in-frame+deletion+of+33+nucleotides+in+exon+10+of+AMN+or+a+homozygous+substitution+in+the+AMN+translation+initiation+codon+abrogate+AMN+expression+and+block+cubilin+processing+and+targeting+to+the+apical+membrane. assertion.
- assertion asSentence Both+mRNA+transcript+levels+and+the+activities+of+MMP-3+and+MMP-7+are+elevated+in+X-linked+Alport+syndrome+%28XLAS%29+kidneys+from+dogs. assertion.
- assertion asSentence The+TNF-alpha-induced+activation+of+the+ERK%2FGEF-H1%2FRhoA+pathway+in+tubular+cells+is+mediated+through+Src-+and+TACE-dependent+EGFR+activation. assertion.
- assertion asSentence No+significant+difference+in+beta-catenin+expression+or+activation+between+osteosarcoma+populations+differing+in+serum+ALP+concentration. assertion.
- assertion asSentence PKA+rapidly+enhances+proteasome+assembly+and+activity+in+in+vivo+hearts. assertion.
- assertion asSentence Ghrelin+induces+tone-dependent+constriction+of+canine+coronary+arterioles+which+is+mediated+by+a+receptor+other+than+GHS-R1a. assertion.
- assertion asSentence Pacing-induced+reduction+in+KChIP2+contributes+to+altered+repolarization+and+the+T-wave+changes+of+cardiac+memory. assertion.
- assertion asSentence Defective+domain-domain+interactions+within+the+ryanodine+receptor+as+a+critical+cause+of+diastolic+Ca2%2B+leak+in+failing+hearts. assertion.
- assertion asSentence Leptin+dilates+canine+small+mesenteric+arteries+and+veins+by+a+mechanism+involving+endothelial+release+of+nitric+oxide. assertion.
- assertion asSentence A+unique+motif+in+the+occludin+sequence+that+is+involved+in+the+regulation+of+ZO-1+binding+by+reversible+phosphorylation+of+specific+Tyr+residues. assertion.
- assertion asSentence Morphological+aspects+related+to+long-term+functional+improvement+of+the+retina+in+the+4+years+following+rAAV-mediated+gene+transfer+in+the+RPE65+null+mutation. assertion.
- assertion asSentence TIMP-1+induces+an+epithelial-mesenchymal+transition-like+phenotypic+conversion+in+MDCK+cells+independent+of+its+MMP-inhibitory+domain. assertion.
- assertion asSentence With+a+moderate+deficit+in+total+body+sodium+and+total+body+water%2C+the+renin-angiotensin-aldosterone+system+is+the+major+factor+controlling+arterial+blood+pressure. assertion.
- assertion asSentence Haplotype+sharing+excludes+orthologous+COL4A3%2C+COL4A4+or+MYH9+loci+in+hereditary+nephritis+in+bull+terriers. assertion.
- assertion asSentence Knockdown+of+occludin+caused+mislocalization+of+tricellulin+to+bTJs%2C+implying+that+occludin+supports+tricellular+localization+of+tricellulin+by+excluding+tricellulin+from+bicellular+tight+junctions. assertion.
- assertion asSentence Constitutive+expression+in+MDCK+cells%2C+GP8+endothelial+cells+nuclei+leads+to+increase+expression+of+the+M2+pyruvate+kinase%2Cincreased+proliferative+activity+and+in+MDCK+reduced+intercellular+junctional+stability. assertion.
- assertion asSentence Phenotypic+consequences+of+depleted+SERCA-gated+stores+for+epidermal+homeostasis+explain+how+depleted+SERCA2+calcium+stores+provoke+focal+lesions+rather+than+generalized+dermatoses%2C+a+reminiscent+of+the+human+genodermatosis+Darier+disease. assertion.
- assertion asSentence The+mutation+%28ABCB1-1Delta%29+renders+affected+animals+extremely+susceptible+to+toxicosis+induced+by+substrate+drugs%2C+such+as+the+macrocyclic+lactones+at+doses+well+below+those+tolerated+by+dogs+with+the+wild-type+ABCB1+gene. assertion.
- assertion asSentence Activation+of+the+small+GTPase+RhoA+plays+a+critical+role+in+the+regulation+of+force+generation+in+intact+airway+smooth+muscle+tissues+activated+by+muscarinic+stimulation. assertion.
- assertion asSentence Tumor-infiltrating+lymphocytes+isolated+from+regressing+canine+transmissible+venereal+tumor+secrete+high+concentrations+of+IL-6+and+antagonize+the+anti-lymphokine-activated+killer+activity+of+tumor+cell+transforming+growth+factor-beta+1. assertion.
- assertion asSentence Transforming+growth+factor-beta+1+secreted+by+canine+transmissible+venereal+tumor+cells+suppresses+lymphokine-activated+killer+cytotoxicity. assertion.
- assertion asSentence The+ATPase+activity+of+GRP94+is+essential+for+chaperone+activity+in+vivo+and+the+essential+protein-binding+domain+of+GRP94+is+distinct+from+the+N-terminal+domain. assertion.
- assertion asSentence Malignant+proliferation+in+canine+hemangiosarcomas+is+associated+with+bcl-2+and+survivin+expression. assertion.
- assertion asSentence Protein+kinase+A-anchoring+protein+AKAP95+binds+D-type+cyclins. assertion.
- assertion asSentence A+functional+polymorphism+%28Val-158-Met%29+at+the+Catechol-O-methyltransferase+%28COMT%29+locus+confers+a+modest+affective+vulnerability+to+psychosis. assertion.
- assertion asSentence Discoidin+domain+receptor+%28DDR%29+1a%2Fb+inhibited+collagen-induced+tyrosine+phosphorylation+of+signal+transducers+and+activators+of+transcription+%28Stat%29+1%2F3+and+cell+migration+triggered+by+alpha2beta1-integrin. assertion.
- assertion asSentence Non-Smad+transforming+growth+factor-beta+signaling+regulated+by+focal+adhesion+kinase+binding+the+p85+subunit+of+phosphatidylinositol+3-kinase. assertion.
- assertion asSentence Cadherins+play+a+crucial+role+in+beta-catenin-dependent+transcription. assertion.
- assertion asSentence Resveratrol-mediated+SIRT-1+interactions+with+p300+modulate+receptor+activator+of+NF-kappaB+ligand+%28RANKL%29+activation+of+NF-kappaB+signaling+and+inhibit+osteoclastogenesis+in+bone-derived+cells. assertion.
- assertion asSentence Exonic+SINE+insertion+in+STK38L+causes+canine+early+retinal+degeneration+. assertion.
- assertion asSentence Lyn%2C+a+member+of+the+Src+family+tyrosine+kinases+previously+implicated+in+Pseudomonas+aeruginosa+infection%2C+mediates+both+phosphatidylinositol+3%2C4%2C5-trisphosphate-enriched+cell+protrusion+formation+and+bacterial+aggregate+internalization. assertion.
- assertion asSentence Interaction+between+PAR-3+and+the+aPKC-PAR-6+complex+is+indispensable+for+apical+domain+development+of+epithelial+cells. assertion.
- assertion asSentence APC+is+a+component+of+a+cortical+template+that+guides+microtubule+network+formation. assertion.
- assertion asSentence Apical+scaffolding+protein+NHERF2+modulates+the+localization+of+alternatively+spliced+plasma+membrane+Ca2%2B+pump+2B+variants+in+polarized+epithelial+cells. assertion.
- assertion asSentence In+the+absence+of+the+stabilizing+action+of+cMyBP-C+either+as+a+consequence+of+genetic+mutation+or+dephosphorylation%2C+premature+degradation+of+thick+filaments+occurs+and+is+accompanied+by+persistent+contractile+dysfunction. assertion.
- assertion asSentence Both+Par1b+and+Dvl1+function+antagonistically+to+regulate+the+assembly+of+functional+E-cadherin-dependent+adhesion+complexes. assertion.
- assertion asSentence The+mutation+underlying+Multifocal+retinal+dysplasia+in+the+German+Spitz+is+not+allelic+with+BEST1+mutations+found+in+four+other+breeds. assertion.
- assertion asSentence Bestrophinopathies+are+a+group+of+inherited+retinal+disorders+primarily+caused+by+point+mutations+scattered+throughout+the+BEST1+gene. assertion.
- assertion asSentence RalA+and+RalB+differentially+regulate+development+of+epithelial+tight+junctions. assertion.
- assertion asSentence CXCR4+is+excluded+as+the+cause+of+trapped+neutrophil+syndrome+in+Border+Collies. assertion.
- assertion asSentence Podocalyxin+functions+in+epithelial+polarization+by+contributing+to+an+early+apical+scaffold+based+on+PDZ+domain-mediated+interactions. assertion.
- assertion asSentence sEPO-R+and+asEPO-R+transcripts+contribute+to+in+vivo+up-regulation+of+EPO-R+protein+expression+in+the+post-pneumonectomy+remaining+lung. assertion.
- assertion asSentence RNA+interference-mediated+knockdown+of+DNM2+reduces+endocannabinoid+uptake+into+neuronal+dCAD+cells. assertion.
- assertion asSentence Dynamic+interactions+between+AQP2+and+the+actin+cytoskeleton+are+critical+for+initiating+AQP2+apical+targeting. assertion.
- assertion asSentence Gene+does+not+play+a+major+role+in+the+variation+in+aggression+in+the+Golden+Retrievers. assertion.
- assertion asSentence Rap1+plays+a+role+in+the+maintenance+and+repair+of+E-cadherin+junctions+and+is+activated+via+an+%22outside-in%22+signaling+pathway+initiated+by+E-cadherin+and+mediated+at+least+in+part+by+PDZ-GEF+I. assertion.
- assertion asSentence Most+canine+high-grade+B-cell+lymphomas+correspond+to+human+diffuse+large+C-cell+lymphoma+with+no+immunohistochemical+expression+of+BCL6. assertion.
- assertion asSentence Proteinase+activated+receptor-2+%28PAR-2%29+activating+peptides+have+a+receptor+system+in+canine+coronary+arteries+that+is+distinct+from+PAR-2+itself. assertion.
- assertion asSentence Mc1r+is+epistatic+to+variation+at+Agouti+or+K+and+the+epistatic+relationship+between+Agouti+and+K+depends+on+the+alleles+being+tested. assertion.
- assertion asSentence NADPH+oxidase+subunit+p22phox+contributes+to+coronary+endothelial+dysfunction+in+the+failing+heart. assertion.
- assertion asSentence The+syntaxin+4+N+terminus+regulates+its+basolateral+targeting+by+munc18c-dependent+and+-independent+mechanisms. assertion.
- assertion asSentence The+exocyst+protein+Sec10+regulates+primary+ciliogenesis. assertion.
- assertion asSentence PKC+eta+directly+interacts+with+the+C-terminal+domain+of+occludin+and+phosphorylates+it+on+highly+conserved+T403+and+T404%2C+an+important+mechanism+of+epithelial+TJ+regulation+by+PKC+eta. assertion.
- assertion asSentence Mutant+B-spectrin+%28T+to+M%29+causes+elliptocytosis+in+canine+by+preventing+the+formation+of+spectrin+tetramers. assertion.
- assertion asSentence Cell+confluency-induced+Stat3+activation+regulates+NHE3+expression+by+recruiting+Sp1+and+Sp3+to+the+proximal+NHE3+promoter+region+during+epithelial+dome+formation. assertion.