Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence CTCF+functions+as+a+switch-like+molecule+between+the+insulin+signaling+and+the+regulations+of+Pax6+and+glucagon+expression+in+pancreatic+islet+alpha-cells. assertion.
- assertion asSentence Treatment+of+embryoid+bodies+grown+from+pluripotent+murine+embryonic+stem+%28ES%29+cells+with+cardiotrophin+1+significantly+stimulated+cardiomyogenesis+and+increased+nuclear+expression+of+the+proliferation+marker+Ki-67. assertion.
- assertion asSentence Hypoxia+increased+cardiotrophin-1+levels+in+cardiac+cells+through+a+direct+regulation+of+CT-1+promoter+by+HIF-1alpha%2C+protecting+cells+from+apoptosis. assertion.
- assertion asSentence Prostaglandin+15-deoxy-Delta12%2C14-PGJ2+%2815d-PGJ2%29+inactivates+CCTalpha+by+inducing+generation+of+reactive+oxidant+species+and+the+appearance+of+a+cross-linked+CCTalpha+dimer+in+cells. assertion.
- assertion asSentence In+proteolipid+protein+transgenic+mice+cathepsin+B+is+upregulated+primarily+in+microglia%2Fmacrophages+of+white+matter. assertion.
- assertion asSentence CysC+regulates+soluble+Abeta+and+Abeta-associated+neuronal+deficits+through+inhibiting+CatB-induced+Abeta+degradation. assertion.
- assertion asSentence Aspartyl+protease+substrate+myoglobin+requires+cathepsin+D+activity+for+presentation+to+T+cells. assertion.
- assertion asSentence Cathepsin+G+and+neutrophil+elastase+contribute+to+lung-protective+immunity+against+mycobacterial+infections+in+mice. assertion.
- assertion asSentence Free+cholesterol+accumulation+in+macrophage+membranes+activates+Toll-like+receptors+and+p38+mitogen-activated+protein+kinase+and+induces+cathepsin+K. assertion.
- assertion asSentence Dilated+cardiomyopathy+in+mice+deficient+for+the+lysosomal+cysteine+peptidase+cathepsin+L. assertion.
- assertion asSentence Prevents+atrophy+of+seminiferous+tubules+and+promotes+the+formation+of+preleptotene+spermatocytes+and+the+differentiation+of+these+meiotic+cells+into+pachytene+spermatocytes. assertion.
- assertion asSentence A+cathepsin+L+isoform+devoid+of+a+signal+peptide+loalizes+to+the+nucleus+in+S+phase+and+processes+the+CDP%2FCux+transcription+factor. assertion.
- assertion asSentence CTSL+regulates+cardiac+repair+and+remodelling+post-myocardial+infarction+through+a+mechanism+with+multiple+pathways. assertion.
- assertion asSentence Defects+in+DNA+repair+associated+with+53BP1+deficiency+upon+loss+of+A-type+lamins+are+due+to+upregulation+of+CTSL. assertion.
- assertion asSentence Cathepsin+S+contributes+to+angiogenesis+by+microvascular+endothelial+cells. assertion.
- assertion asSentence Plays+role+in+migration+and+activation+of+microglia+to+protect+facial+motoneurons+against+axotomy-induced+injury. assertion.
- assertion asSentence A+short+splicing+variant+of+missing+in+metastasis+binds+poorly+to+cortactin+in+vitro+and+is+unable+to+enhance+actin+polymerization. assertion.
- assertion asSentence MLCK+is+essential+for+the+translocation+and+association+of+cortactin+and+p47phox. assertion.
- assertion asSentence CUGBP1+associates+with+GU-rich+elements+to+regulate+decay+of+a+wide+range+of+mRNAs. assertion.
- assertion asSentence Activation+of+PAR2+triggers+a+signaling+cascade+that+culminates+with+the+stimulation+of+p110+CUX1+DNA+binding+and+the+transcriptional+activation+of+target+genes. assertion.
- assertion asSentence Loss+of+Cux1+transcriptional+activity+during+dextran+sulfate+sodium+%28DSS%29-induced+colitis+leads+to+a+severe+increase+of+colonic+inflammation. assertion.
- assertion asSentence Cux-2+control+the+development+of+Reelin+expressing+cortical+interneurons. assertion.
- assertion asSentence CX3CR1+mediates+direct+recruitment+of+bone+marrow-derived+monocytes%2Fmacrophages+which+release+profibrotic+and+angiogenic+mediators. assertion.
- assertion asSentence CCR2-+and+CX3CR1-expressing+macrophages+exhibit+opposite+activities+in+angiogenesis. assertion.
- assertion asSentence CX%283%29CR1-fractalkine+%28FKN%29+interaction+in+vivo+is+essential+for+smooth+muscle+cell+differentiation+of+bone+marrow-derived+progenitor+cells+at+the+vessel+wall+level. assertion.
- assertion asSentence CX3CR1+signaling+promoted+T%28H%292+survival+in+the+inflamed+lungs. assertion.
- assertion asSentence During+a+CD4%28%2B%29+T-cell-induced+colitis%2C+CX3CR1%28lo%29+cells+accumulate+in+the+inflamed+mucosa+and+upregulate+the+expression+of+pro-inflammatory+cytokines+and+triggering+receptor+expressed+on+myeloid+cells-1+%28TREM-1%29. assertion.
- assertion asSentence Signaling+via+CX3CR1+promotes+the+generation+of+Dendritic+Cells+and+other+myeloid+cell+subsets+under+steady-state+conditions+and+contributes+to+compensatory+expansion+of+the+Dendritic+Cell+pool. assertion.
- assertion asSentence Intestinal+CX%283%29C+chemokine+receptor+1%28high%29+%28CX%283%29CR1%28high%29%29+CD11b%28%2B%29+CD11c%28%2B%29+cells+are+responsible+for+prevention+of+intestinal+inflammation. assertion.
- assertion asSentence During+a+specific+temporal+window%2C+CAR+expression+on+cardiomyocytes+is+essential+for+normal+cardiac+development. assertion.
- assertion asSentence A+function+for+CAR+in+testis+morphogenesis+and+in+migration+of+germ+cells+across+the+blood-testis+barrier+during+spermatogenesis. assertion.
- assertion asSentence Activation+of+STAT1+protein+is+an+early+event+in+coxsackievirus-induced+myocarditis+preceding+enhanced+CAR+expression+during+tissue+reorganization. assertion.
- assertion asSentence CAR+activation+dramatically+improves+fatty+liver+and+ameliorates+hyperglycemia. assertion.
- assertion asSentence Mice+deficient+in+the+NADPH+oxidase+subunit+gp91%28phox%29+exhibited+significantly+blunted+platelet+and+leukocyte+recruitment+responses+to+a+hypercholesterolemic+diet. assertion.
- assertion asSentence The+gp91phox+subunit+of+NADPH+oxidase+is+not+necessary+for+pressure+overload-induced+hypertrophy+in+the+mouse. assertion.
- assertion asSentence Ang+II+impairs+functional+hyperemia+by+Activating+AT1+receptors+and+inducing+ROS+production+via+a+gp91phox+containing+NADPH+oxidase. assertion.
- assertion asSentence Gp91%28phox%29+subunit+of+NAD%28P%29H+oxidase+mediates+O2-+production+through+the+activation+of+NAD%28P%29H+oxidase+and+attenuation+of+nitric+oxide-dependent+control+of+myocardial+oxygen+consumption+by+ANG+II. assertion.
- assertion asSentence Phosphodiesterase+2+mediates+redox-sensitive+endothelial+cell+proliferation+and+angiogenesis+by+thrombin+via+Rac1+and+NADPH+oxidase+2. assertion.
- assertion asSentence NOX2+deficiency+decreases+beta-cell+destruction+and+preserves+islet+function+in+streptozotocin-induced+diabetes+by+reducing+reactov+oxygen+species+production. assertion.
- assertion asSentence alpha1AMP-activated+protein+kinase+preserves+endothelial+function+during+chronic+angiotensin+II+treatment+by+limiting+Nox2+upregulation. assertion.
- assertion asSentence Monocyte-specific+expression+of+the+NOX2+regulatory+component%2C+NCF1%2C+protects+mice+from+lethal+infections+with+staphylococci+and+Burkholderia+cepacia. assertion.
- assertion asSentence Nox2-containing+NADPH+oxidase+deficiency+protects+against+age-dependent+impairment+of+neovascularization. assertion.
- assertion asSentence The+course+of+etoposide-induced+apoptosis+from+damage+to+DNA+and+p53+activation+to+mitochondrial+release+of+cytochrome+c. assertion.
- assertion asSentence Both+neurons+and+cancer+cells+strictly+inhibit+cytochrome+c-mediated+apoptosis+by+a+mechanism+dependent+on+glucose+metabolism. assertion.
- assertion asSentence High+concentration+glucose+administration+caused+significantly+increased+expression+of+NF-kappaB%2C+Bax+and+cytochrome+C. assertion.
- assertion asSentence Resveratrol+induces+p53-independent%2C+X-linked+inhibitor+of+apoptosis+protein+%28XIAP%29-mediated+Bax+protein+oligomerization+on+mitochondria+to+initiate+cytochrome+c+release+and+caspase+activation. assertion.
- assertion asSentence SF-1+and+AP-1+cooperate+to+activate+CYP11A1+transcription+in+vitro+and+in+vivo. assertion.
- assertion asSentence Prenatal+exposure+to+ethanol+increased+expressions+of+StAR+and+P450scc+in+maternal+adrenal+and+decreased+them+in+fetal+adrenal. assertion.
- assertion asSentence Aromatase+activity+is+critical+for+normal+autonomic+control+of+the+heart+and%2C+hence%2C+for+reducing+the+deleterious+effects+of+high+BP+variability. assertion.
- assertion asSentence PGF%282alpha%29+decreases+luteal+P450arom+mRNA+levels+at+the+end+of+pregnancy+in+rodents+by+inhibiting+cyp19+expression. assertion.
- assertion asSentence From+the+structural+and+transcriptional+points+of+view%2C+the+efferent+ductules+of+Ar%28-%2F-%29+mice+are+indistinguishable+from+those+of+WT+mice. assertion.
- assertion asSentence FXR+is+able+to+compete+with+steroidogenic+factor+1+in+binding+to+a+common+sequence+present+in+the+aromatase+promoter+region+interfering+negatively+with+its+activity. assertion.
- assertion asSentence Reduced+availability+of+heme+limits+the+incorporation+of+P450s+into+brain+endoplasmic+reticulum. assertion.
- assertion asSentence Overexpression+of+CYP1A1+shifts+the+balance+of+the+metabolic+activities+in+the+skin+of+AhRR%28-%2F-%29+mice+in+favor+of+the+detoxification+of+carcinogens. assertion.
- assertion asSentence CYP1A2+is+not+required+for+TCDD-induced+immunosuppression+in+the+mouse. assertion.
- assertion asSentence In+rodents%2C+aristolochic+acid+demethylation%2C+mediated+by+CYP1A2%2C+is+a+primary+pathway+of+aristolochic+acid+detoxication. assertion.
- assertion asSentence In+the+developing+mouse+embryo+Cyp1b1+exhibits+asymmetric+expression+along+the+axes+of+development. assertion.
- assertion asSentence Cyp26a1%28-%2F-%29+mouse+fetuses+have+lethal+morphogenetic+phenotypes+mimicking+those+generated+by+excess+retinoic+acid+administration. assertion.
- assertion asSentence Expression+of+CYP26A1+in+endometrial+epithelial+cells+is+regulated+by+progesterone+and+not+significantly+influenced+by+co-administration+of+estrogen. assertion.
- assertion asSentence Activity+of+CYP26A1+and+CYP26C1+is+required+for+correct+A-P+patterning+and+production+of+migratory+cranial+neural+crest+cells+in+the+developing+mammalian+brain. assertion.
- assertion asSentence Coactivator+PGC-1alpha+regulates+the+fasting+inducible+xenobiotic-metabolizing+enzyme+CYP2A5+in+mouse+primary+hepatocytes. assertion.
- assertion asSentence Chestnut+inner+shell+extract+treatment+with+ethanol+decreased+CYP2E1+expression+and+increased+activities+of+catalase+and+superoxide+dismutase. assertion.
- assertion asSentence Predominantly+neuronal+expression+of+cytochrome+P450+isoforms+CYP3A11+and+CYP3A13+in+mouse+brain. assertion.
- assertion asSentence Midlozam+metabolism+in+Cyp3a+knockout+mice+can+be+attributed+to+up-regulated+Cyp2c+enzymes. assertion.
- assertion asSentence Cyp3a11+plays+a+crucial+role+in+directing+drug+action+to+hormonal+response+within+the+limbic+system+of+mouse+brain+in+drug-hormone+crosstalk. assertion.
- assertion asSentence A+deletion+of+the+hepatocyte+nuclear+factor-4alpha+binding+motif+in+liver+changes+the+expression+of+Cyp3a11. assertion.
- assertion asSentence Leptin+suppresses+renal+gene+overexpression+for+1+alpha-hydroxylase+and+24-hydroxylase+and+corrects+increased+serum+concentrations+of+calcium+and+phosphate+in+ob%2Fob+mice. assertion.
- assertion asSentence Increased+CYP4B1+mRNA+is+associated+with+the+inhibition+of+dextran+sulfate+sodium-induced+colitis+by+caffeic+acid+in+mice. assertion.
- assertion asSentence Demethylation+of+lanosterol+to+FF-MAS+by+the+acrosomal+lanosterol+14+alpha-demethylase+enzyme+complex+demonstrates+for+the+first+time+the+ability+of+ejaculate+sperm+to+synthesize+meiosis-activating+sterols. assertion.
- assertion asSentence Cyp7a1+deficiency+in+APOE%2A3-Leiden+mice+decreases+the+VLDL+particle+production+rate%2C+as+a+consequence+of+a+strongly+reduced+bile+acid+biosynthesis%2C+leading+to+a+decrease+in+plasma+triglycerides. assertion.
- assertion asSentence In+the+intercross+between+C57BL%2F6J+and+CASA%2FRk+mice%2C+Cyp8b1+is+not+responsible+for+biliary+bile+acid+composition. assertion.
- assertion asSentence DAB1+is+a+nucleocytoplasmic+shuttling+protein. assertion.
- assertion asSentence The+distribution+pattern+of+corticospinal+tract+neurons+of+the+reelin%2FDab1-compound+mutant+mouse+differs+from+those+of+either+of+the+reeler+or+yotari+counterparts. assertion.
- assertion asSentence Daf1+expression+is+closely+associated+with+CD4%2B+T+cell+activation+and+the+accumulation+of+CD44%28high%29%28activated%2Fmemory%29%2CCD4%2B+T+cells+in+both+spontaneous+and+induced+systemic+autoimmune+disease. assertion.
- assertion asSentence Murine+cytomegalovirus+infection+augments+morbidity+and+mortality+post-allo-bone+marrow+transplantion+by+reducing+surface+DAF+expression. assertion.
- assertion asSentence Interactions+involving+alpha-dystroglycan+%28a-DG%29+influence+the+strength+of+attachment+of+granule+neurons+to+the+a-DG-expressing+Bergmann+glial+cells+that+guide+granule+neuron+migration+in+the+cerebellum. assertion.
- assertion asSentence Mice+with+epiblast-specific+loss+of+dystroglycan+develop+brain+and+eye+defects+that+resemble+the+clinical+spectrum+of+the+human+Walker-Warburg+syndrome. assertion.
- assertion asSentence DG+is+necessary+for+the+formation+of+the+glial+endfoot+architecture. assertion.
- assertion asSentence The+C-terminal+domain+%28NLS2+motif%29of+ZIPK+of+murine+is+nonfunctional+for+transport. assertion.
- assertion asSentence Changes+in+innate+and+acquired+immune+responses+in+mice+with+targeted+deletion+of+the+dopamine+transporter+gene. assertion.
- assertion asSentence DAT+is+constitutively+internalized+and+sorted+in+a+ubiquitination-independent+manner+to+late+endosomes%2Flysosomes+and+in+part+to+a+Rab4+positive+short+loop+recycling+pathway. assertion.
- assertion asSentence IFN-alpha-induced+up-regulation+and+nuclear+translocation+of+Daxx+are+completely+abrogated+in+the+absence+of+tyk2. assertion.
- assertion asSentence Daxx+participates+in+myocardial+ischemia%2Freperfusion+proapoptotic+signaling+in+vivo. assertion.
- assertion asSentence Overexpressed+WT+human+DJ-1+prevents+Daxx+translocation+and+abolishes+cytotoxicity+in+mouse+Neuro-2a+cells. assertion.
- assertion asSentence Both+Daxx+and+macrophage+Ste20-like+kinase+%28MST%291+are+key+mediators+of+microglial+cell+death+induced+by+the+proinflammatory+cytokine+interferon+%28IFN%29-gamma. assertion.
- assertion asSentence Dazl+contributes+to+the+differentiation+of+embryonic+stem+cells+into+germ+cells. assertion.
- assertion asSentence PPRE+in+intron+1+of+the+ACBP+gene+is+a+bona+fide+PPARgamma-response+element. assertion.
- assertion asSentence A+functionally+active+recombinant+ACBP+with+amino+acid+sequence+identical+to+the+native+protein+interacts+preferentially+with+anionic+phospholipid-rich%2C+highly+curved+membranes+to+facilitate+transfer+of+ACBP-bound+ligands. assertion.
- assertion asSentence Endogenously+overexpressed+DBI+impairs+hippocampus-dependent+learning+without+anxiety+or+proconflict+behavior. assertion.
- assertion asSentence Deficiency+of+SH3P7%2FmAbp1+in+mouse+mutants+is+associated+with+tissue+abnormalities+and+impaired+vesicle+transport+and+their+constricted+physical+capabilities+and+disturbed+neuromotoric+behaviour. assertion.
- assertion asSentence Genomic+organization+underlying+the+splice+variants+of+DCLK+and+the+expression+profile+of+two+splice+variants+affecting+the+kinase+domain+of+DCLK+and+CPG16+%28candidate+plasticity+gene+16%29. assertion.
- assertion asSentence The+microtubule-associated+proteins+doublecortin+and+doublecortin-like+are+differentially+expressed%2C+particularly+during+early+corticogenesis%2C+consistent+with+their+different+functional+roles. assertion.
- assertion asSentence DCC+performs+dual+roles+both+as+a+cell+surface+receptor+that+modulates+intracellular+signaling+pathways+and+as+a+transcriptional+coactivator+that+relies+on+gamma-secretase-dependent+production+and+nuclear+translocation+of+the+cytoplasmic+domain. assertion.
- assertion asSentence In+pre+B-cell+leukemia+transcription+factor+1-deficient+dopaminergic+neurons%2C+the+high+affinity+netrin-1+receptor%2C+deleted+in+colon+cancer%2C+is+down-regulated. assertion.
- assertion asSentence Decorin+has+a+primary+role+in+regulating+fibril+assembly%2C+a+function+that+can+be+fine-tuned+by+biglycan+during+early+development. assertion.
- assertion asSentence DCoH+acts+as+a+cofactor+for+HNF1+that+stabilizes+the+dimeric+HNF1+complex. assertion.
- assertion asSentence Dcpp+is+highly+expressed+in+the+oviductal+lumen+in+the+presence+of+preimplantation+embryos. assertion.
- assertion asSentence Doublecortin-like+kinase+%28Dclk%29+gene+functions+in+a+partially+redundant+pathway+with+Dcx+in+the+formation+of+axonal+projections+across+the+midline+and+migration+of+cortical+neurons. assertion.
- assertion asSentence Loss+of+CREB+function+in+a+cell-autonomous+manner+impairs+dendritic+development%2C+decreases+the+expression+of+DCX. assertion.
- assertion asSentence Transgenic+ablation+of+doublecortin-expressing+cells+suppresses+adult+neurogenesis+and+worsens+stroke+outcome+in+mice. assertion.