Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Gadda+inhibits+the+T-cell+alternative+p38+activation+pathway. assertion.
- assertion asSentence Hematopoietic+cells+from+Gadd45a-deficient+mice+are+sensitized+to+genotoxic-stress-+induced+apoptosis. assertion.
- assertion asSentence Gadd45a%2C+Gadd45b+and+Gadd45g+expression+during+mouse+embryonic+development. assertion.
- assertion asSentence CHOP+directly+activates+ERO1alpha+and+GADD34+in+the+endoplasmic+reticulum+of+stressed+cells. assertion.
- assertion asSentence C%2FEBPzeta+functions+as+negative+regulator+of+IL-6+expression+in+B+cells. assertion.
- assertion asSentence Coxsackievirus+B3+infection+induces+apoptosis+through+downregulation+of+p58IPK+and+activation+of+CHOP+and+SREBP1. assertion.
- assertion asSentence SPSB1+and+SPSB4+bind+strongly+to+both+Par-4+and+VASA+peptides. assertion.
- assertion asSentence DEAD-box+RNA+helicase+subunits+are+required+for+recognition+of+a+subset+of+primary+miRNAs+in+mDrosha-mediated+processing. assertion.
- assertion asSentence Solution+structures+of+the+double-stranded+RNA-binding+domains+from+RNA+helicase+A. assertion.
- assertion asSentence Wnt+signaling%2Fbeta-catenin+is+absolutely+required+and+sufficient+for+Dermo1+expression+and+dermal+cell+identity+in+the+cranium. assertion.
- assertion asSentence Effects+of+desmin+gene+knockout+on+mice+heart+mitochondria. assertion.
- assertion asSentence Increased+insulin+and+leptin+sensitivity+in+mice+lacking+acyl+CoA%3Adiacylglycerol+acyltransferase+1. assertion.
- assertion asSentence DGAT1+deficiency+protected+against+hepatic+steatosis+by+reducing+synthesis+and+increasing+the+oxidation+of+fatty+acids. assertion.
- assertion asSentence G-actin+regulates+rapid+induction+of+actin+nucleation+by+mDia1+to+restore+cellular+actin+polymers. assertion.
- assertion asSentence Loss+of+mDia1+is+associated+with+impaired+T-cell+interaction+and+T-cell+stimulation+in+lymph+nodes. assertion.
- assertion asSentence D1+playing+an+important+role+in+iodide+conservation+by+serving+as+a+scavenger+enzyme+in+peripheral+tissues+and+the+thyroid. assertion.
- assertion asSentence Dkk1+controls+the+degree+of+Wnt-7b+signalling+in+the+papilla+to+coordinate+kidney+organogenesis. assertion.
- assertion asSentence Beta-catenin+causes+renal+dysplasia+via+upregulation+of+Tgfbeta2+and+Dkk1. assertion.
- assertion asSentence PSD-95+binding+can+recruit+Kv+channels+into+lipid+rafts. assertion.
- assertion asSentence DHHC5+interacts+with+PDZ+domain+3+of+post-synaptic+density-95+%28PSD-95%29+protein+and+plays+a+role+in+learning+and+memory. assertion.
- assertion asSentence SAP90+is+involved+in+the+molecular+mechanisms+of+halothane+anesthesia+with+a+decrease+in+minimum+alveolar+concentration+in+knock-out+mice. assertion.
- assertion asSentence The+inflammatory+response+required+recruitment+of+phosphatidylinositol-3-kinase-C2alpha+to+the+SH3-binding+site+of+PSD95. assertion.
- assertion asSentence PSD-95%2FNR2B+interaction+is+more+sensitive+to+disruption+by+Tat-NR2B9c+than+PSD-95%2FNR2A+coupling+in+live+cultured+hippocampal+neurons. assertion.
- assertion asSentence Dlk1+gene%2C+like+the+human+ortholog%2C+is+imprinted%2C+with+preferential+expression+from+the+paternal+allele. assertion.
- assertion asSentence Pref-1+secretion+controls+fat+cell+differentiation+and+adipose+tissue+development. assertion.
- assertion asSentence In+preadipocytes+Foxa-2+inhibits+adipocyte+differentiation+by+activating+transcription+of+the+Pref-1+gene. assertion.
- assertion asSentence Dlk1+is+required+to+prevent+premature+expression+of+Dat+in+meso-diencephalic+dopamine+neuronal+precursors+as+part+of+the+multifaceted+process+of+neuronal+differentiation+driven+by+Nurr1+and+Pitx3. assertion.
- assertion asSentence Transcriptional+activation+of+pref-1+is+stimulated+by+E2F1+protein+in+adipocytes. assertion.
- assertion asSentence Delta-like+1+increases+dopamine+progenitor+cell+proliferation+in+ventral+midbrain. assertion.
- assertion asSentence DLL1+is+a+critical+endothelial+Notch+ligand+required+for+maintaining+arterial+identity+during+mouse+fetal+development. assertion.
- assertion asSentence Dll3+has+a+unique+function+during+T-cell+development+that+is+distinct+from+the+role+played+by+the+other+DSL+ligands+of+Notch. assertion.
- assertion asSentence Genes+act+as+forebrain-specific+factors+linking+general+neuron-inducing+signals+to+region-specific+neuron+differentiation+programs. assertion.
- assertion asSentence Dlx-1+and+-2+regulate+parallel+molecular+pathways+that+are+required+for+the+generation+of+olfactory+bulb+interneurons. assertion.
- assertion asSentence Genes+act+as+forebrain-specific+factors+linking+general+neuron-inducing+signals+to+region-specific+neuron+differentiation+programs. assertion.
- assertion asSentence Dlx2+acts+potently+neurogenic+in+adult+lateral+subependymal+zone+cells+in+vitro. assertion.
- assertion asSentence AP-2+gamma+and+Dlx+3%2C+together+with+an+additional+transcription+factor%28s%29+that+are+conserved+between+humans+and+mice%2C+are+required+for+trophoblast-specific+expression+of+3+beta-HSD+VI. assertion.
- assertion asSentence The+MYC+promoter+is+specifically+activated+by+overexpression+of+DLX5. assertion.
- assertion asSentence Ochratoxin+A+induces+craniofacial+malformation+in+mice+acting+on+Dlx5+gene+expression. assertion.
- assertion asSentence Ultraconserved+cis-regulatory+element%2C+I56i%2C+is+involved+in+regulating+Dlx5%2FDlx6+homeobox+gene+expression+in+the+developing+forebrain. assertion.
- assertion asSentence Msx1%2FDlx5+interaction+is+crucial+for+osteogenic+induction+during+frontal+bone+development. assertion.
- assertion asSentence DMPK+has+a+modulatory+role+in+the+control+of+intracellular+Ca2%2B+concentration+in+mouse+ventricular+cardiomyocytes%2C+loss+of+which+contributes+to+cardiac+dysfunction+in+myotonic+dystrophy. assertion.
- assertion asSentence Dmc1%28Mei11%29+exposes+a+sex+difference+in+recombination+in+that+a+significant+portion+of+female+oocytes+can+compensate+for+DMC1+deficiency+to+undergo+crossing-over+and+complete+gametogenesis. assertion.
- assertion asSentence In+mdx+mice+grafted+with+progenitor+muscle+cells+from+hindlimb+muscle+of+syngeneic+C57Bl%2F10+animals%2C+the+number+of+dystrophin-positive+fibers+increases+logarithmically+with+the+number+of+grafted+cells. assertion.
- assertion asSentence Dystrophin+protein+complex+is+required+for+the+proper+expression+and+function+of+Na%28v%291.5+in+mice. assertion.
- assertion asSentence The+dystrophin-deficient+heart+displays+early+alterations+in+energy+metabolism+that+precede+overt+cardiomyopathy. assertion.
- assertion asSentence Absence+of+members+of+the+dystrophin-associated+glycoprotein+complex+constitutes+a+permissive+environment+for+spontaneous+development+of+embryonal+rhabdomyosarcoma+associated+with+mutation+of+p53+and+mutation+or+altered+splicing+of+Mdm2. assertion.
- assertion asSentence In+striated+muscles%2C+dystrophin+is+involved+in+orchestrating+proper+development+and+organization+of+myofibers+as+contractile+units. assertion.
- assertion asSentence In-frame+dystrophin+following+exon+51-skipping+improves+muscle+pathology+and+function+in+the+exon+52-deficient+mdx+mouse. assertion.
- assertion asSentence Utrophin+plays+a+central+role+in+the+regulation+of+Na%28v%291.5+in+dystrophin-deficient+mice. assertion.
- assertion asSentence Gelsolin+regulates+cardiac+remodeling+after+myocardial+infarction+through+DNase+I-mediated+apoptosis. assertion.
- assertion asSentence Endocytosis+of+murine+norovirus+1+into+murine+macrophages+is+dependent+on+dynamin+II. assertion.
- assertion asSentence Impact+of+Dnmt1+deficiency%2C+with+and+without+low+folate+diets%2C+on+tumor+numbers+and+DNA+methylation+in+Min+mice. assertion.
- assertion asSentence Transcription+of+Dnmt1+is+regulated+by+both+E2F-Rb-HDAC-dependent+and+-independent+pathways. assertion.
- assertion asSentence Regulates+DNA+methylation. assertion.
- assertion asSentence TCR+signal+is+sufficient+for+transcriptional+activation+of+Foxp3+in+the+absence+of+maintenance+DNA+methylation+and+TGF-beta+facilitates+Foxp3+induction+in+part+by+opposing+cell+cycle-dependent+Dnmt1+recruitment%2C+leading+to+locus+inactivation. assertion.
- assertion asSentence DNMT1+participates+in+epigenetic+reprogramming+through+its+ability+to+distinguish+different+categories+of+methylated+sequences. assertion.
- assertion asSentence In+mouse+embryonic+stem+cells%2C+the+genes+upregulated+after+deletion+of+the+H3K9+methyltransferase+Setdb1+are+distinct+from+those+derepressed+in+mESC+deficient+in+the+Dnmt1%2C+with+the+exception+of+a+small+number+of+primarily+germline-specific+genes. assertion.
- assertion asSentence DNA+methyltransferase+1+and+DNA+methylation+patterning+contribute+to+germinal+center+B-cell+differentiation. assertion.
- assertion asSentence DNA+recognition+by+the+Dnmt1+DNA+methyltransferase. assertion.
- assertion asSentence Both+interfaces+of+Dnmt3a+are+necessary+for+the+heterochromatic+localization+of+the+enzyme+in+cells. assertion.
- assertion asSentence In+mouse+embryonic+stem+cells%2C+the+genes+upregulated+after+deletion+of+the+H3K9+methyltransferase+Setdb1+are+distinct+from+those+derepressed+in+mESC+deficient+in+the+Dnmt3a%2C+with+the+exception+of+a+small+number+of+primarily+germline-specific+genes. assertion.
- assertion asSentence Transcripts+are+at+their+highest+levels+in+type+A+spermatogonia%2C+decrease+dramatically+in+type+B+spermatogonia+and+preleptotene+spermatocytes+and+rise+again+in+leptotene%2Fzygotene+spermatocytes. assertion.
- assertion asSentence Lsh+is+required+for+establishment+of+DNA+methylation+patterns+at+stem+cell+genes+during+differentiation%2C+in+part+by+regulating+access+of+Dnmt3b+to+its+genomic+targets. assertion.
- assertion asSentence DOK1+and+DOK2+interact+with+the+Tec+protein+tyrosine+kinase. assertion.
- assertion asSentence Dok-2+is+critical+in+tumor+suppression+and+control+of+the+hematopoietic+compartment+homeostasis. assertion.
- assertion asSentence PGD2+is+produced+in+articular+tissue+during+the+development+of+collagen-induced+arthritis+and+plays+an+antiinflammatory+role%2C+acting+through+the+DP1+receptor. assertion.
- assertion asSentence Clustered+charged+amino+acids+of+human+adenosine+deaminase+comprise+a+functional+epitope+for+binding+the+adenosine+deaminase+complexing+protein+CD26%2Fdipeptidyl+peptidase+IV. assertion.
- assertion asSentence Developmental+changes+in+mRNA+expression+reliably+translate+into+changes+in+protein+levels+in+fetal+and+aging+brain. assertion.
- assertion asSentence Early+consolidation+of+aversive+memory+requires+D1+activation+selectively+in+the+nucleus+accumbens+core. assertion.
- assertion asSentence Dopaminergic+D%281%29R+and+D%282%29R+are+essential+for+the+wakefulness+induced+by+modafinil. assertion.
- assertion asSentence D2R+mediated+neurotransmission+is+important+to+effect+OF+A2AAR+on+behavioral+activationf+p50+KO+mice. assertion.
- assertion asSentence D2R-induced+vulnerability+in+Huntington+disease+is+critically+linked+to+the+activation+of+the+Rho%2FROCK+signalling+pathway. assertion.
- assertion asSentence Both+dopamine+depletion+and+Park7+protein%2FDJ-1+deletion+induce+a+rearrangement+in+the+high-voltage+activated+calcium+channel+profile%2C+specifically+involving+those+channels+that+are+selectively+modulated+by+D2+receptors. assertion.
- assertion asSentence NT+acutely+regulates+D2+autoreceptor+function+and+DA+neuron+excitability+through+PKC-mediated+phosphorylation+of+the+D2R%2C+leading+to+heterologous+receptor+desensitization. assertion.
- assertion asSentence In+commonly+used+inbred+mouse+strains+that+are+hemizygous+for+the+Drd2+transgene%2C+the+Drd2-eGFP+bacterial+artificial+chromosome+%28BAC%29+transgene+does+not+alter+striatal+gene+expression%2C+physiology%2C+or+motor+behavior. assertion.
- assertion asSentence D3+dopamine+receptor+is+found+to+be+expressed+in+the+subcommissural+organ+%28SCO%29%2C+an+ependymal+brain+gland+that+is+located+in+the+roof+of+the+third+ventricle. assertion.
- assertion asSentence Dopamine+D3+receptors+are+downregulated+in+methamphetamine-induced+sensitization. assertion.
- assertion asSentence Amphetamine+can+produce+significant+conditioned+place+preference+in+dopamine+D3+receptor+knock-out+mice. assertion.
- assertion asSentence A+single+bilateral+intrastriatal+BDNF+infusion+is+sufficient+to+rescue+the+reduced+expression+of+dopamine+receptor+D3R. assertion.
- assertion asSentence Drd4+activation+is+required+for+normal+expression+of+adenylyl+cyclase+type+1+and+for+regulation+of+its+catalytic+activity+by+light. assertion.
- assertion asSentence D5+dopamine+receptor+is+found+to+be+expressed+in+the+subcommissural+organ+%28SCO%29%2C+an+ependymal+brain+gland+that+is+located+in+the+roof+of+the+third+ventricle. assertion.
- assertion asSentence There+is+a+role+of+renal+D%285%29+receptors+in+blood+pressure+homeostasis+and+the+pathogenesis+of+hypertension+in+mice. assertion.
- assertion asSentence By+contributing+to+CD4%28%2B%29+T+cell+activation+and+differentiation+to+Th17+phenotype%2C+D5R+expressed+on+DCs+is+able+to+modulate+the+development+of+an+autoimmune+response+in+vivo. assertion.
- assertion asSentence A+palmitoylated+pool+of+Bright+is+diverted+to+lipid+rafts+of+resting+B+cells+where+it+associates+with+signalosome+components. assertion.
- assertion asSentence Atrophin-1+and+the+short+form+of+Atrophin-2+can+act+as+potent+and+evolutionarily+conserved+transcriptional+activators. assertion.
- assertion asSentence Expression+of+desmoglein+1+compensates+for+genetic+loss+of+desmoglein+3+in+keratinocyte+adhesion. assertion.
- assertion asSentence Dvl1+mediates+a+conserved+mammalian+PCP+pathway+to+regulate+convergent+extension+during+neurulation. assertion.
- assertion asSentence Both+Par1b+and+Dvl1+function+antagonistically+to+regulate+the+assembly+of+functional+E-cadherin-dependent+adhesion+complexes. assertion.
- assertion asSentence Loss+of+CYLD+instigates+tumor+growth+in+human+cylindromatosis+through+a+mechanism+in+which+hyperubiquitination+of+polymerized+Dvl+drives+enhancement+of+Wnt3%2Fbeta-catenin+responses. assertion.
- assertion asSentence p114-RhoGEF+and+Lfc+are+critically+involved+in+Wnt-3a-+and+Dvl-induced+RhoA+activation+and+neurite+retraction+in+N1E-115+cells. assertion.
- assertion asSentence Mice+heterozygous+for+Dyrk1A+exhibit+decreased+brain+size%2C+motor+abnormalities+and+cognitive+deficits+in+the+adult. assertion.
- assertion asSentence DYRK1A+and+DYRK3+promote+cell+survival+through+phosphorylation+and+activation+of+SIRT1. assertion.
- assertion asSentence Up-regulation+of+Dyrk1A+contributes+to+altered+neuronal+proliferation+in+DS+through+specific+phosphorylation+of+p53+at+Ser-15+and+subsequent+p21%28CIP1%29+induction. assertion.
- assertion asSentence Cirp+functions+to+fine-tune+the+proliferation+of+undifferentiated+spermatogonia+by+interacting+with+Dyrk1b. assertion.
- assertion asSentence Contribute+to+the+ectopic+proliferation+of+postmitotic+neuronal+cells+and+E2F1+is+unique+in+mediating+apoptosis+in+both+Rb%28-%2F-%29+lenses+and+retinas. assertion.
- assertion asSentence BIN1+is+transcriptionally+activated+by+E2F1+and+mediates+E2F1-induced+apoptosis+in+response+to+DNA+damage. assertion.
- assertion asSentence E2F1+and+E2F3+function+has+no+impact+on+Myc-mediated+lymphomagenesis. assertion.
- assertion asSentence In+vivo+E2F1+expression+significantly+increases+the+insulin+content+and+function+of+adult+beta-cells%2C+making+it+a+strategic+target+for+therapeutic+manipulation+of+beta-cell+function. assertion.
- assertion asSentence E2F1+is+an+essential+transcription+factor+for+tapasin. assertion.
- assertion asSentence Functions+for+E2f1-3+at+distinct+stages+of+myeloid+development+in+vivo%2C+first+as+repressors+in+cell+survival+and+then+as+activators+in+cell+proliferation. assertion.