Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence E2f3a+and+E2f3b+have+largely+overlapping+functions+in+vivo+and+E2f3a+can+fully+substitute+for+E2f1+and+E2f3+in+most+murine+tissues. assertion.
- assertion asSentence EB1+coordinates+melanoma+cell+migration+through+regulating+the+balance+between+lamellipodial+and+filopodial+protrusion. assertion.
- assertion asSentence Ebf1+is+a+rare+example+of+a+transcription+factor+that+regulates+both+the+osteoblast+and+adipocyte+lineages+similarly. assertion.
- assertion asSentence Compound+haploinsufficiencies+of+Ebf1+and+Runx1+genes+impede+B+cell+lineage+progression. assertion.
- assertion asSentence Promotes+placodal+cell+fate+during+early+development+of+ectodermal+organs. assertion.
- assertion asSentence An+essential+role+is+established+for+S1P1+in+the+homing+of+IgG-secreting+plasma+cells. assertion.
- assertion asSentence The+crucial+role+of+activation+of+the+SPHK1S1PS1P1+signaling+pathway+in+response+to+inflammatory+mediators+in+endothelial+cells+in+regulating+endothelial+barrier+homeostasis. assertion.
- assertion asSentence S1P%281%29+and+S1P%283%29+receptors+act+synergistically+to+enhance+functional+network+formation+via+increased+functional+length+density. assertion.
- assertion asSentence S1P3+signaling+directs+immature+B+cells+to+a+bone+marrow+microenvironment+important+for+both+tolerance+induction+and+maturation. assertion.
- assertion asSentence S1P%281%29+and+S1P%283%29+receptors+act+synergistically+to+enhance+functional+network+formation+via+increased+functional+length+density. assertion.
- assertion asSentence Mice+deficient+in+bone+marrow+%28BM%29+S1P3+are+protected+from+kidney+ischemia-reperfusion+injury+and+have+reduced+infiltration+of+natural+killer+%28NK%29T+cells+and+neutrophils%2C+compared+with+mice+with+wild-type+BM+cells. assertion.
- assertion asSentence Endothelin-1+is+a+critical+mediator+of+myogenic+tone+in+tumor+arterioles. assertion.
- assertion asSentence ET-1%2FETAR+and+subsequent+epithelial+signals+are+sequentially+involved+in+branchial+arch+development+by+maintaining+dHAND+and+Dlx6+expression. assertion.
- assertion asSentence ET-1+mediates+oxidative+stress+in+the+spinal+cord+through+the+modulation+of+spinal+cord+blood+flow. assertion.
- assertion asSentence ET-1+functions+as+a+physiological+autocrine+regulator+of+vasopressin+action+in+the+collecting+duct. assertion.
- assertion asSentence Endothelin-1+mRNA+is+present+in+neurons+of+central+cardiorespiratory+region+and+drastically+increased+during+the+transition+from+episodic+fetal+breathing+to+continuous+postnatal+respiration+%28E18.5+to+D0.5%29. assertion.
- assertion asSentence ET-1+regulates+adiponectin+expression+and+secretion+by+two+different+signaling+pathways+in+3T3-L1+adipocytes. assertion.
- assertion asSentence ET-1+is+a+lymphangiogenic+mediator. assertion.
- assertion asSentence Inhibitory+ET-1+regulation+of+epithelial+Na%2B+channel+%28ENaC%29+via+ETB+receptors+has+a+natriuretic+effect%2C+with+loss+of+this+regulation+being+prohypertensive. assertion.
- assertion asSentence Ednra+receptor+signaling+is+crucial+for+early+neural+crest+cell+patterning%2Cbut+subsequent+Ednra+signaling+is+not+essential+for+mandible+bone+development. assertion.
- assertion asSentence Deletion+of+the+Ednrb+is+associated+with+a+reduction+in+both+central+and+peripheral+Ednra+density. assertion.
- assertion asSentence Renin-angiotensin-aldosterone+system+components+are+upregulated+under+endothelin+blockade. assertion.
- assertion asSentence A+paracrine+vasoregulatory+pathway+mediated+by+endothelial+cell-derived+ET-1+acting+on+the+vascular+smooth+muscle+ET%28A%29+receptor. assertion.
- assertion asSentence Knockout+of+ET%28A%29+receptor+protects+against+cold+temperature-induced+cardiac+hypertrophy+and+contractile+dysfunction. assertion.
- assertion asSentence Deletion+of+the+Ednrb+is+associated+with+a+reduction+in+both+central+and+peripheral+Ednra+density. assertion.
- assertion asSentence SOX10+does+not+directly+activate+Ednrb+transcription+in+the+melanocyte+lineage. assertion.
- assertion asSentence The+endothelial+cell+endothelin+B+receptor+mediates+a+tonic+vasodilator+effect+and+nonendothelial+cell+endothelin+B+receptors+are+important+for+the+regulation+of+blood+pressure. assertion.
- assertion asSentence Endothelin+B+receptor+stimulation+inhibits+suicidal+erythrocyte+death. assertion.
- assertion asSentence Eed+associates+with+the+trxG+protein+Mll+upon+brain+maturation. assertion.
- assertion asSentence During+late+embryonic+and+early+postnatal+stages%2C+elongation+factor+2+kinase+is+up-regulated+in+the+cerebral+cortex+and+hippocampal+pyramidal+cell+layer. assertion.
- assertion asSentence Resveratrol+inhibits+the+proliferation+and+migration+of+vascular+endothelial+cells+by+activating+eukaryotic+elongation+factor-2+kinase. assertion.
- assertion asSentence Bidirectional+ephrinA2-EphA2+signaling+regulates+bone+remodeling+at+the+initiation+phase. assertion.
- assertion asSentence Whole-mount+in+situ+hybridization+revealed+overlapping+expression+of+the+Epha1+receptor+and+its+high-affinity+ligands+ephrin+A1+%28Efna1%29+and+ephrin+A3+%28Efna3%29+in+the+primitive+streak+and+the+posterior+paraxial+mesoderm+during+early+mouse+development. assertion.
- assertion asSentence LIM+homeodomain+proteins+control+axon+pathways+topographic+projections+in+the+limb+through+control+of+EphA+receptors+and+ephrin-A+ligands+in+motor+neurons+and+limb+mesenchymal+cells. assertion.
- assertion asSentence EphB2+and+ephrin-B2+are+coexpressed+at+the+midline+in+the+fusing+urethral%2Fcloacal+endoderm+and+underlying+lateral+mesoderm+of+the+urorectal+septum+that+migrates+toward+the+caudal+midline+as+the+cloaca+septates. assertion.
- assertion asSentence Dorsal+and+ventral-temporal+axons+require+ephrin-B2+reverse+signalling. assertion.
- assertion asSentence Rac-GAP+alpha-chimerin+regulates+motor-circuit+formation+as+a+key+mediator+of+Efnb3+forward+signaling. assertion.
- assertion asSentence Ephrinb3+is+directly+involved+in+the+specificity+of+mesostriatal+projection. assertion.
- assertion asSentence Activation+of+m-calpain+%28calpain+II%29+by+epidermal+growth+factor+is+limited+by+protein+kinase+A+phosphorylation+of+m-calpain. assertion.
- assertion asSentence EGF+induces+expression+of+early+G%281%29+cyclins+in+mammary+epithelial+cells. assertion.
- assertion asSentence Egf+inhibition+of+c-Myc-mediated+apoptosis+through+Akt+and+Erk+involves+Bcl-xl+upregulation+in+mammary+epithelial+cells. assertion.
- assertion asSentence Enterocyte-specific+epidermal+growth+factor+prevents+barrier+dysfunction+and+improves+mortality+in+murine+peritonitis. assertion.
- assertion asSentence GH+modulates+EGF+signaling+in+the+liver. assertion.
- assertion asSentence EGF%2FEGR-1+repressed+transcriptional+activation+of+the+MMP-9+gene+by+stromal+cells. assertion.
- assertion asSentence Proprotein+convertase+PC7+enhances+the+activation+of+the+EGF+receptor+pathway+through+processing+of+the+EGF+precursor. assertion.
- assertion asSentence The+function+and+trafficking+of+the+EGF+receptor+are+modulated+by+cholesterol+depletion+in+ways+that+serve+to+enhance+EGF+receptor+signaling. assertion.
- assertion asSentence The+EGF+receptor+can+mediate+the+prevention+of+apoptosis+in+a+hematopoietic+cell+line+independently+of+both+receptor-ligand+binding+and+receptor+kinase+activity. assertion.
- assertion asSentence Syntaxin+9+interacts+specifically+with+the+epidermal+growth+factor+receptor. assertion.
- assertion asSentence Cav1+phosphorylation+is+required+for+stretch-induced+Egfr+and+Akt+activation+in+mesangial+cells. assertion.
- assertion asSentence Down-regulation+of+EGFR+protein+expression+is+associated+with+impaired+liver+regener-+ation+in+db%2Fdb+mice. assertion.
- assertion asSentence H%282%29O%282%29+increased+AA+release+and+PGE%282%29+production+by+the+upregulation+of+cPLA%282%29+and+COX-2+via+Ca%282%2B%29%2FPKC%2FMAPKs+and+EGFR+transactivation%2C+subsequently+proliferation+of+mouse+ES+cells. assertion.
- assertion asSentence Signaling+pathways+activated+by+epidermal+growth+factor+receptor+or+fibroblast+growth+factor+receptor+differentially+regulate+branching+morphogenesis+in+fetal+mouse+submandibular+glands. assertion.
- assertion asSentence Epidermal+hyperproliferation+in+mice+lacking+fatty+acid+transport+protein+4+%28FATP4%29+involves+ectopic+EGF+receptor+and+STAT+3+signaling. assertion.
- assertion asSentence A+role+for+the+USP8.STAM+complex+as+a+protective+mechanism+regulating+early+endosomal+sorting+of+EGFR+between+pathways+destined+for+lysosomal+degradation+and+recycling. assertion.
- assertion asSentence A+phosphatidic+acid-phospholipase+A1alpha-lysophosphatidic+acid-P2Y5+axis+regulates+differentiation+of+hair+follicles+via+a+tumour+necrosis+factor+alpha+converting+enzyme-transforming+growth+factor+alpha-epidermal+growth+factor+receptor+pathway. assertion.
- assertion asSentence EGFR+signaling+plays+an+essential+role+in+the+remodeling+of+growth+plate+cartilage+extracellular+matrix+into+bone+during+endochondral+ossification. assertion.
- assertion asSentence A+tight+cooperation+between+the+EGF%2FEGFR+and+mPGES-1+leads+to+a+significant+tumorigenic+gain+in+epithelial+cells. assertion.
- assertion asSentence EGR1+as+a+major+regulator+of+cell+senescence+and+previously+undescribed+upstream+%22gatekeeper%22+of+the+p53+tumor+suppressor+pathway. assertion.
- assertion asSentence Hydrogen+peroxide-induced+EGR1+expression+is+mediated+by+c-Abl. assertion.
- assertion asSentence Egr-1+acts+as+a+growth+stimulator+for+B+lymphoma+cells. assertion.
- assertion asSentence The+concerted+action+of+the+transcription+factors+Egr1+and+NFAT2+can+play+a+crucial+role+in+regulation+of+the+T+cell+differentiation+in+vitro+due+to+the+cooperative+regulation+of+Id3+and+Rag2+gene+expression. assertion.
- assertion asSentence Egr-1+is+essential+for+marginal+zone+B+cell+development+and+critical+for+functional+immune+responses+in+vivo. assertion.
- assertion asSentence Egr+transcription+factors+are+essential+for+conversion+of+the+mitogenic+signal+of+epidermal+growth+factor+into+a+proliferative+response. assertion.
- assertion asSentence EGR1+and+EGR2+involvement+in+vertebrate+tendon+differentiation. assertion.
- assertion asSentence Control+network+for+Egr-1+expression+through+a+feedback+loop+between+SHP+and+HNF4alpha. assertion.
- assertion asSentence Egr+transcription+factors+are+essential+for+conversion+of+the+mitogenic+signal+of+epidermal+growth+factor+into+a+proliferative+response. assertion.
- assertion asSentence Egr2+and+Sox10+activity+are+directly+involved+in+mediating+the+developmental+induction+of+Pmp22+expression+through+an+intronic+enhancer. assertion.
- assertion asSentence Expression+of+ALDH1A2%2C+BEX2%2C+EGR2%2C+CCL3+and+PLAU+are+upregulated+in+Toxoplasma+gondiisusceptible+C57BL%2F6+mice. assertion.
- assertion asSentence Egr1+and+Egr3+serve+redundant+roles+in+the+maintenance+of+cell+survival+during+thymocyte+differentiation+in+vivo. assertion.
- assertion asSentence Egr3-%2F-+mice+fail+to+establish+hippocampal+LTD+in+response+to+low+frequency+stimulation+and+exhibit+dysfunction+of+the+NR1%2FNR2B+NMDA+receptor+subclass. assertion.
- assertion asSentence Exp5+exports+eEF1A+via+tRNA+from+nuclei+and+synergizes+with+other+transport+pathways+to+confine+translation+to+the+cytoplasm. assertion.
- assertion asSentence Autophagy+formation+is+a+cellular+defense+mechanism+against+polyQ72-induced+ER-stress-mediated+cell+death+by+degrading+polyQ72+aggregates%2C+with+PERK%2FeIF2alpha+phosphorylation+being+involved+in+polyQ72-induced+LC3+conversion. assertion.
- assertion asSentence eIF2alpha+phosphorylation+is+a+major+player+in+the+cellular+response+to+arsenite+stress. assertion.
- assertion asSentence With+GCN2%2C+functions+to+cooperatively+regulate+eIF2alpha+phosphorylation+and+cyclin+D1+translation+after+unfolded+response+pathway+activation. assertion.
- assertion asSentence UV-induced+eIF2alpha+phosphorylation+by+activation+of+both+PERK+and+GCN2+via+oxidative+stress+and+l-arginine+starvation+signaling+pathways. assertion.
- assertion asSentence Endoplasmic+reticulum+stress+blunts+cytokine-triggered+activation+of+NF-kappaB%2C+in+part+through+PERK-+and+IRE1-mediated+preferential+induction+of+C%2FEBPbeta. assertion.
- assertion asSentence Eif2ak3+acts+as+a+metabolic+sensor+in+the+insulin-secreting+beta-cells+to+modulate+the+trafficking+and+quality+control+of+proinsulin+in+the+endoplasmic+reticulum. assertion.
- assertion asSentence Endoplasmic+reticulum+stress+response+mediated+by+the+PERK-eIF2%28alpha%29-ATF4+pathway+is+involved+in+osteoblast+differentiation+induced+by+BMP2. assertion.
- assertion asSentence The+pleiotropic+mouse+phenotype+extra-toes+spotting+is+caused+by+translation+initiation+factor+Eif3c+mutations. assertion.
- assertion asSentence Pdcd4+binding+to+eIF4A+is+linked+to+its+transformation-suppressing+activity%2C+as+Pdcd4-eIF4A+binding+and+consequent+inhibition+of+translation+are+required+for+Pdcd4+transrepression+of+AP-1. assertion.
- assertion asSentence The+inhibitory+activity+of+4E-BP1+is+a+key+mediator+of+the+negative+effects+of+reduced+mechanistic+target+of+rapamycin+signaling+on+cardiomyocyte+homeostasis+and+heart+function. assertion.
- assertion asSentence ESE-1+is+an+Ang+II-inducible+transcription+factor+that+plays+an+important+counter-regulatory+role+in+the+setting+of+vascular+inflammation+and+remodeling. assertion.
- assertion asSentence Elf3+plays+an+important+role+in+the+regulation+of+lung+cell+proliferation+and+differentiation+during+repair+of+the+injured+bronchiolar+airway+epithelium. assertion.
- assertion asSentence Elk-1+phosphorylation+downstream+from+extracellular+signal-regulated+kinase+is+a+key+molecular+event+involved+in+long-term+neuronal+and+behavioral+adaptations+to+cocaine. assertion.
- assertion asSentence A+regulator+of+angiogenesis+that+can+switch+to+an+activator+following+induction+by+pro-angiogenic+molecules. assertion.
- assertion asSentence miR-29+and+miR-15+family+miRNAs+are+involved+in+the+down-regulation+of+elastin+in+the+adult+aorta. assertion.
- assertion asSentence MMP-12+leads+to+elastin+degradation+in+eosinophilic+meningitis+caused+by+Angiostrongylus+cantonensis. assertion.
- assertion asSentence Genetic+modifiers+of+cardiovascular+phenotype+caused+by+elastin+haploinsufficiency+act+by+extrinsic+noncomplementation. assertion.
- assertion asSentence In+dendritic+cells%2C+AIMP1+enhances+toll-like+receptor+2+%28TLR2%29-mediated+immune+responses+via+the+up-regulation+of+TLR2+expression. assertion.
- assertion asSentence ROCK1%2FPAR-1b-dependent+regulation+of+basement+membrane+placement+is+required+for+the+coordination+of+tissue+polarity+and+the+elaboration+of+tissue+structure+in+the+developing+submandibular+salivary+gland. assertion.
- assertion asSentence The+tetraspan+protein+EMP2+increases+surface+expression+of+class+I+major+histocompatibility+complex+proteins+and+susceptibility+to+CTL-mediated+cell+death. assertion.
- assertion asSentence The+transcription+factor+Sp8+has+an+essential+role+in+the+molecular+and+functional+patterning+of+the+developing+telencephalon+along+the+anteroposterior+axis+by+modulating+the+expression+gradients+of+Emx2+and+Pax6. assertion.
- assertion asSentence Engrailed+homeoprotein+recruits+the+adenosine+A1+receptor+to+potentiate+ephrin+A5+function+in+retinal+growth+cones. assertion.
- assertion asSentence Physiological+downregulation+of+En-2+around+the+day+of+birth+in+normal+Purkinje+cells+%28PCs%29+is+critical+for+the+timing+of+distinct+steps+of+PC+differentiation. assertion.
- assertion asSentence En2%28-%2F-%29+mice+displayed+an+increased+susceptibility+to+kainic+acid+-induced+seizures. assertion.
- assertion asSentence Endoglin+is+upregulated+in+neoangiogenic+vessels+formed+after+myocardial+infarction. assertion.
- assertion asSentence Replacement+of+active+site+residue+glutamate-215+of+aminopeptidase+A+with+aspartate+or+alanine+leads+to+a+strong+decrease+in+the+rate+of+hydrolysis+of+the+synthetic+substrate+alpha-L-glutamyl-beta-naphthylamide. assertion.
- assertion asSentence Ymphoproliferation+caused+by+Fas+deficiency+is+dependent+on+the+transcription+factor+eomesodermin. assertion.
- assertion asSentence IL-5+production+in+memory+Th2+cells+is+regulated+by+Eomesodermin+via+the+inhibition+of+GATA3+activity. assertion.
- assertion asSentence The+hematopoietic+microenvironment+required+for+erythropoiesis+is+dynamically+regulated+by+oxygen+through+the+functions+of+HIF-2alpha+in+ECs. assertion.