Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence HIF-1+and+HIF-2+can+individually+arrest+the+cell+cycle+independent+from+hypoxia. assertion.
- assertion asSentence HIF-2alpha+plays+a+crucial+role+in+maintaining+iron+balance+in+the+organism+by+directly+regulating+the+transcription+of+the+gene+encoding+divalent+metal+transporter+1+%28DMT1%29%2C+the+principal+intestinal+iron+transporter. assertion.
- assertion asSentence Both+HIF-1+and+-2+are+important+transcriptional+effectors+regulating+the+responses+of+macrophages+to+a+period+of+hypoxia. assertion.
- assertion asSentence Activation+of+P2X7R+by+ATP+induces+CD44+shedding. assertion.
- assertion asSentence Activation+of+P2Y1+and+P2Y2+receptors+induces+chloride+secretion+via+calcium-activated+chloride+channels+in+kidney+inner+medullary+collecting+duct+cells. assertion.
- assertion asSentence Involved+in+the+influx+of+neutrophils+into+the+lungs+after+sepsis. assertion.
- assertion asSentence Eosinophil+accumulation%2C+a+distinctive+feature+of+lung+allergic+inflammation%2C+is+defective+in+ovalbumin+%28OVA%29-treated+P2Y2+receptor-deficient+mice+compared+with+OVA-treated+wild+type+animals. assertion.
- assertion asSentence Activation+of+P2Y1+and+P2Y2+receptors+induces+chloride+secretion+via+calcium-activated+chloride+channels+in+kidney+inner+medullary+collecting+duct+cells. assertion.
- assertion asSentence Palladin+is+expressed+in+podocytes+and+plays+an+important+role+in+actin+dynamics. assertion.
- assertion asSentence EPAB+is+necessary+for+oogenesis%2C+folliculogenesis+and+female+fertility+in+mice. assertion.
- assertion asSentence Tetrahydrobiopterin+protects+PAH+activity+in+vivo. assertion.
- assertion asSentence Pak1+functions+as+a+linker+between+insulin+and+Wnt+signaling+pathways+in+the+intestine. assertion.
- assertion asSentence Rac1+is+crucial+for+Ras-dependent+skin+tumor+formation+by+controlling+Pak1-Mek-Erk+hyperactivation+and+hyperproliferation+in+vivo. assertion.
- assertion asSentence Pak1-knockout+hearts+have+reduced+recovery+of+myocardial+performance+after+global+I%2FR+injury+concomitant+with+changes+in+troponin-T+and+MLC2+phosphorylation+and+protein+association. assertion.
- assertion asSentence Specific+suppression+of+insulin+signaling+is+achieved+via+the+spatiotemporal+regulation+of+SKIP+through+the+scaffolding+function+of+Pak1. assertion.
- assertion asSentence PAK3+is+a+key+regulator+of+synapse+formation+and+plasticity+in+the+hippocampus. assertion.
- assertion asSentence Pax3+binds+to+a+sequence+3%27+of+the+Fgfr4+gene+that+directs+Pax3-dependent+expression+at+sites+of+myogenesis+in+transgenic+mouse+embryos. assertion.
- assertion asSentence Folate+deficiency+increases+the+risk+of+neural+tube+defects+by+loss+of+Pax3+function. assertion.
- assertion asSentence miR-27b+regulates+Pax3+protein+levels+and+this+down-regulation+ensures+rapid+and+robust+entry+into+the+myogenic+differentiation+program. assertion.
- assertion asSentence Pitx2c+modulates+Pax3%2B%2FPax7%2B+cell+populations+and+regulates+Pax3+expression+by+repressing+miR27+expression+during+myogenesis. assertion.
- assertion asSentence Pax5-deficient+B-cell+progenitors+efficiently+differentiate+in+vitro+into+CD4%2BCD8%2B+alphabeta+and+gammadelta+T+cells+upon+coculture+with+OP9+stromal+cells. assertion.
- assertion asSentence Pax5-mediated+gene+repression+is+essential+for+normal+homeostasis+of+hematopoietic+development. assertion.
- assertion asSentence Pax5+recruitment+to+the+pro-B+cell-specific+hypersensitive+site+1+%28HS1%29+of+the+Igh+locus+correlates+with+immunoglobulin+heavy+chain+rearrangement+during+B+cell+development. assertion.
- assertion asSentence Pax5-null+progenitors+can+give+rise+to+additional+hematopoietic+lineages. assertion.
- assertion asSentence In+the+absence+of+Pax5%2C+the+function+of+the+proximal+Ebf1+promoter+and+accumulation+of+EBF1+protein+are+impaired+and+the+replication+timing+and+subcellular+localization+of+the+Ebf1+locus+are+altered. assertion.
- assertion asSentence Splicing+as+a+pivotal+factor+regulating+the+potent+neurogenic+role+of+Pax6. assertion.
- assertion asSentence Pax6+delimits+the+appropriate+proliferative+zone+for+GABA+interneurons+and+regulates+their+numbers+and+distributions+by+repressing+the+ventral+fates+of+dorsal+telencephalon+progenitors+and+progeny. assertion.
- assertion asSentence The+Pax-Eya-Six-Dach+network+is+at+best+only+partly+conserved+during+lens+and+nasal+placode+development. assertion.
- assertion asSentence Pax6+transcripts+are+6-10+times+more+prevalent+than+Pax6%285a%29+transcripts+early+in+neurogenesis+in+the+murine+telencephalon%2C+diencephalon+and+hindbrain+and+the+ratio+later+falls+significantly+to+about+3%3A1+in+these+regions. assertion.
- assertion asSentence Timed+genetic+removal+of+Pax6+appeared+to+unmask+a+cryptic+divergence+of+retinal+progenitor+cells+into+qualitatively+divergent+progenitor+pools. assertion.
- assertion asSentence Cdc42-mTOR+signaling+pathway+controls+Hes5+and+Pax6+expression+in+retinoic+acid-dependent+neural+differentiation. assertion.
- assertion asSentence Ventral+telencephalic+Pax6+is+important+for+formation+of+the+Islet1-expressing+corridor+and+the+thalamic+and+cortical+axons+that+grow+through. assertion.
- assertion asSentence Pax6+is+pivotal+for+initiation+of+the+lens+fiber+differentiation+program+in+the+mammalian+eye. assertion.
- assertion asSentence Defects+in+iridocorneal+angle+formation+are+caused+by+non-autonomous+mechanisms+due+to+Pax6+haploinsufficiency+in+lens+or+corneal. assertion.
- assertion asSentence Pax6+plays+a+role+in+regulating+the+orientation+and+mode+of+cell+division+of+progenitors+in+the+mouse+cerebral+cortex. assertion.
- assertion asSentence The+expression+of+Pax6+severely+impairs+tumor+propagation+by+inducing+a+reduction+of+cell+proliferation+and+the+acquisition+of+differentiation+traits+in+tumor-initiating+cells. assertion.
- assertion asSentence Decreasing+the+levels+of+Pax3%2FPax7+RNA+leads+to+a+marked+and+selective+decrease+in+Myf5%2C+MyoD+and+Desmin+expression. assertion.
- assertion asSentence A+crucial+role+for+Pax2+and+Pax8+in+nephron+differentiation+and+branching+morphogenesis+of+the+metanephros. assertion.
- assertion asSentence During+pancreatic+islet+formation%2C+Pax6+expression+becomes+dependent+upon+Pbx1+and+Pbx2+function. assertion.
- assertion asSentence Role+of+Pbx1+in+the+maintenance+of+a+functional+adrenal+cortex+mediated+by+synergistic+actions+of+Pbx1+and+Sf-1+in+the+transcriptional+regulation+of+the+critical+effector+of+adrenocortical+differentiation%2C+the+ACTH+receptor. assertion.
- assertion asSentence Pbx1+critically+functions+at+a+stage+between+hematopoietic+stem+cell+development+and+B-cell+commitment+and%2C+therefore%2C+is+one+of+the+earliest-acting+transcription+factors+that+regulate+de+novo+B-lineage+lymphopoiesis. assertion.
- assertion asSentence Pbx1+makes+a+crucial+contribution+to+distinct+regulatory+pathways+in+cardiovascular+development. assertion.
- assertion asSentence Pbx+genes+share+overlapping+functions+and+Pbx1+and+Emx2+genetically+interact+in+pelvic+formation. assertion.
- assertion asSentence In+Pbx1-deficient+dopaminergic+neurons%2C+the+high+affinity+netrin-1+receptor%2C+deleted+in+colon+cancer%2C+is+down-regulated. assertion.
- assertion asSentence Despite+wide+Pbx2+expression%2C+mice+homozygous+mutant+for+Pbx2+are+born+at+the+expected+Mendelian+frequencies+and+exhibit+no+detectable+abnormalities+in+development+and+organogenesis+or+reduction+of+long-term+survival. assertion.
- assertion asSentence TALE+proteins+are+critical+downstream+effectors+within+an+essential+homeoprotein+network+that+serves+a+rate-limiting+regulatory+role+in+MLL+leukemogenesis. assertion.
- assertion asSentence Alpha4+%28Igbp1%29+plays+a+required+role+in+regulating+the+assembly+and+maintenance+of+adaptive+PP2A+phosphatase+complexes. assertion.
- assertion asSentence HDAC4+and+PCAF+bind+to+cardiac+sarcomeres+and+play+a+role+in+regulating+myofilament+contractile+activity. assertion.
- assertion asSentence Nuclear+receptors+bind+to+retinoic+acid+response+elements+%28RAREs%29+in+the+PEPCK+promoter+in+liver. assertion.
- assertion asSentence Synapsin+I+is+a+major+endogenous+substrate+for+Pcmt1+in+the+mouse+brain. assertion.
- assertion asSentence Pcna+is+a+direct+downstream+target+of+Hoxc8. assertion.
- assertion asSentence The+expression+of+Pcp4+in+naive+resting+mature+B+cells+is+dependent+upon+tonic+stimulation+from+the+CR1%2FCR2+proteins+via+a+C3+ligand. assertion.
- assertion asSentence Prohormone+convertase+1+plays+a+key+role+in+the+processing+of+multiple+neuroendocrine+peptide+precursors. assertion.
- assertion asSentence Expression+of+PCSK1+in+mouse+small+intestine. assertion.
- assertion asSentence Phenotypic+differences+between+the+7B2+and+PC2+nulls+and+play+a+life-or-death+role+in+the+ACTH+hypersecretion+syndrome+present+in+both+129+nulls. assertion.
- assertion asSentence 7B2+possesses+chaperone+activity+that+blocks+partially+unfolded+pro-PC2+forms+from+losing+catalytic+competence+and+then+aggregating. assertion.
- assertion asSentence PC2+alone+is+responsible+for+catalyzing+the+conversion+of+pFE%2822%29+to+pFQ%287%29+and+pSE%2814%29%2C+all+peptides+implicated+in+regulation+of+suckling-induced+prolactin+release. assertion.
- assertion asSentence PC+furin+is+a+major+IGF-1+receptor+convertase. assertion.
- assertion asSentence Kinesin+adapter+JLP+links+PIKfyve+to+microtubule-based+endosome-to-trans-Golgi+network+traffic+of+furin. assertion.
- assertion asSentence Furin+is+the+major+processing+enzyme+of+the+cardiac-specific+growth+factor+bone+morphogenetic+protein+10. assertion.
- assertion asSentence Latent+transforming+growth+factor+beta-binding+proteins-2+and+-3+inhibit+the+proprotein+convertase+5%2F6A. assertion.
- assertion asSentence A+variant+in+PCSK6+is+strongly+associated+with+protection+against+pain+in+knee+osteoarthritis. assertion.
- assertion asSentence PD-1+plays+an+important+role+in+T+cell+tolerance+at+the+effector+phase+and+the+blockade+of+the+PD-1+pathway+can+augment+antiviral+immunity. assertion.
- assertion asSentence Genetic+engineering+of+T+cells+to+express+PD-1+constitutively+has+only+a+mild+impact+on+allograft+survival. assertion.
- assertion asSentence A+major+role+for+the+B7-H1%2FPD-1+axis+and+TGF-beta+as+synergistic+suppressive+mechanisms+in+tumor+draining+lymph+nodes. assertion.
- assertion asSentence Splenic+dendritic+cells+are+capable+of+inducing+conversion+of+naive+CD4%28%2B%29+T+cells+to+adaptive+Foxp3%28%2B%29CD4%28%2B%29+regulatory+T+cells+%28aTreg%29+in+the+presence+of+TGF-beta. assertion.
- assertion asSentence PD-L1%2C+a+ligand+for+programmed+death+1+%28PD-1%29%2C+delivers+a+negative+costimulatory+signal+to+T+cells+and+plays+a+critical+role+in+the+regulation+of+peripheral+transplantation+tolerance. assertion.
- assertion asSentence PD-1%2FPD-L1+interaction+is+essential+for+the+induction+and+maintenance+of+Invariant+NKT+cell+anergy. assertion.
- assertion asSentence Diabetes+susceptibility+in+NOD+mice+is+associated+with+altered+PD-1%2FPD-L1+availability. assertion.
- assertion asSentence LAG-3+acts+synergistically+with+PD-1+and%2For+other+immunoregulatory+genes+to+prevent+autoimmunity+in+mice. assertion.
- assertion asSentence PD-1+has+an+important+role+in+downregulating+proatherogenic+T-cell+responses. assertion.
- assertion asSentence The+interaction+between+programmed+cell+death+1+ligand+1+%28PD-L1%29+on+dendritic+cells+%28DCs%29+and+programmed+death+1+%28PD-1%29+on+CD8+T+cells+contributes+to+ligand-induced+TCR+down-modulation. assertion.
- assertion asSentence PD-1+has+a+key+role+in+regulating+B-1b+cell+responses+and+long-lived+antibody+production+against+T+cell-independent+type+2+antigens. assertion.
- assertion asSentence miR-21+regulates+PDCD4+expression+after+LPS+stimulation. assertion.
- assertion asSentence Genetic+variations+in+DISC1+influence+formation+of+biochemical+complex+with+PDE4+and+GSK-3+and+strengthen+the+possibility+of+synergistic+interactions+between+these+proteins. assertion.
- assertion asSentence One+mechanism+accounting+for+the+PDGF+induction+of+Glut4+translocation+is+the+suppression+of+the+Munc18c+negative+regulation+of+Syntaxin+4+function. assertion.
- assertion asSentence Endothelial+and+nonendothelial+sources+of+PDGF-B+regulate+pericyte+recruitment+and+influence+vascular+pattern+formation+in+tumors. assertion.
- assertion asSentence VEGF-C+regulates+lymphangiogenesis+and+capillary+stability+by+regulation+of+PDGF-B. assertion.
- assertion asSentence A+tightly+regulated+expression+of+PDGF+during+embryogenesis+is+required+for+normal+brain+development+and+function+in+mice. assertion.
- assertion asSentence PDGFRalpha+plays+an+essential%2C+cell-autonomous+role+in+the+development+of+cardiac+and+cephalic+neural+crest+cells. assertion.
- assertion asSentence In+response+to+demyelination%2C+oligodendrocyte+progenitor+amplification+is+significantly+reduced+and+subsequent+oligodendroglial+repopulation+of+lesions+is+impaired+in+PDGFalpha+receptor-deficient+mice. assertion.
- assertion asSentence PDGFRalpha-ip+cells+are+basic+cellular+elements+throughout+the+gastrointestinal+musculature+and+are+involved+in+the+gastrointestinal+functions. assertion.
- assertion asSentence Role+for+Pdgfralpha+in+transduction+pathways+that+lead+to+repression+of+Nkx2.5+and+WT1+during+development+of+posterior+heart+field-derived+cardiac+structures. assertion.
- assertion asSentence Sp1+is+a+key+regulator+of+the+PDGF+beta-receptor+transcription. assertion.
- assertion asSentence The+most+significant+direct+role+of+PDGFRbeta+is+to+mediate+responses+that+involve+cell+migration+rather+than+proliferation. assertion.
- assertion asSentence Apigenin+and+luteolin+impair+smooth+muscle+cell+migration+and+VEGF+expression+through+inhibition+of+PDGFR-beta+phosphorylation. assertion.
- assertion asSentence PDGFR-beta+plays+an+important+role+in+cognitive+and+socioemotional+functions. assertion.
- assertion asSentence PDK2+activity+is+essential%2C+even+at+rest%2C+in+regulation+of+carbohydrate+oxidation+and+production+of+reducing+equivalents+for+the+electron+transport+chain. assertion.
- assertion asSentence Correction+of+bone+mineralization+abnormalities+in+knockout+mice+null+for+both+the+TNAP+%28Akp2%29+and+PC-1+%28Enpp1%29+genes. assertion.
- assertion asSentence Crystal+of+Enpp1+belonged+to+space+group+P3%281%29%2C+with+unit-cell+parameters+a+%3D+b+%3D+105.3%2C+c+%3D+173.7+A. assertion.
- assertion asSentence Non-conserved+roles+for+ATX+during+neural+development+and+organogenesis. assertion.
- assertion asSentence Reduction+of+functional+PDK1+leads+to+impairment+of+intestinal+absorption+and+renal+reabsorption+of+amino+acids. assertion.
- assertion asSentence PDK1+is+essential+for+Notch-mediated+trophic+and+proliferative+responses+in+thymocytes. assertion.
- assertion asSentence Deficient+activity+of+PDK1+leads+to+a+marked+increase+of+gastric+acid+secretion. assertion.
- assertion asSentence The+deacetylase+SIRT1+promotes+membrane+localization+and+activation+of+Akt+and+PDK1+during+tumorigenesis+and+cardiac+hypertrophy. assertion.
- assertion asSentence Biphasic+induction+of+Pdx1+also+drives+differentiation+of+mouse+embryonic+stem+cells+into+pancreatic+beta-cells. assertion.
- assertion asSentence Recapitulation+of+pancreatic+neuroendocrine+tumors+in+human+multiple+endocrine+neoplasia+type+I+syndrome+via+Pdx1-directed+inactivation+of+Men1. assertion.
- assertion asSentence The+diabetes+gene+Pdx1+regulates+the+transcriptional+network+of+pancreatic+endocrine+progenitor+cells+in+mice. assertion.
- assertion asSentence Increase+in+ACTH+level+after+zero-maze+test+failed+to+reach+the+level+of+significance+in+Pdyn%28-%2F-%29+mice. assertion.
- assertion asSentence Etv4+is+positively+regulated+by+Ret+signaling+in+the+ureteric+bud+tips. assertion.