Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Smad2+and+PEA3+regulate+RGC-32+transcription+which+is+essential+for+smooth+muscle+cell+differentiation+from+neural+crest+cells. assertion.
- assertion asSentence In+knockout+mice%2C+there+is+an+attenuation+of+foreign+body+inflammation+because+of+decreased+angiogenesis. assertion.
- assertion asSentence Expression+levels+of+PECAM-1+and+SSEA-1+in+embryonic+stem+cells+correlated+closely+with+their+pluripotency+and%2For+their+ability+to+incorporate+into+the+epiblast+of+chimeric+embryos. assertion.
- assertion asSentence PECAM-1+plays+a+crucial+role+in+the+suppression+of+development+of+autoimmune+arthritis. assertion.
- assertion asSentence The+neuronal+and+behavioral+deficits+seen+in+mice+lacking+a+functional+Peg3+gene+are+mediated+by+increases+in+the+incidence+of+early+neonatal+apoptosis+in+brain. assertion.
- assertion asSentence Regulation+and+function+of+the+Rhox5+homeobox+gene. assertion.
- assertion asSentence The+Rhox5+gene+achieves+Sertoli+cell-specific+transcription+using+a+combinatorial+strategy+involving+negative+and+cooperative+positive+regulation. assertion.
- assertion asSentence Histone+H1+silences+Rhox5+transcription+by+promoting+methylation+of+one+of+its+promoters. assertion.
- assertion asSentence Lack+of+phosphatidylethanolamine+N-methyltransferase+alters+plasma+VLDL+phospholipids+and+attenuates+atherosclerosis+in+mice. assertion.
- assertion asSentence Lack+of+phosphatidylethanolamine+N-methyltransferase+decreased+liver+damage+in+Abcb4%28-%2F-%29+mice+caused+by+exposure+of+the+liver+to+excess+bile+acids. assertion.
- assertion asSentence Increase+in+ACTH+level+after+zero-maze+test+failed+to+reach+the+level+of+significance+in+Penk1%28-%2F-%29+mice. assertion.
- assertion asSentence ENKephalinergic+neurons+develop+according+to+a+rostrocaudal+and+ventrodorsal+gradient. assertion.
- assertion asSentence The+dark-like+mutation+causes+cardiomyocyte+hypertrophy+due+to+loss-of-function+of+peptidase+d+%28Pepd%29. assertion.
- assertion asSentence Mouse+embryo+fibroblasts+from+Per1%28-%2F-%29+mice+have+a+much+shorter+period+in+culture+than+do+tissues+in+the+intact+animal. assertion.
- assertion asSentence PER1-mediated+nuclear+export+of+cryptochrome+1%2F2+is+an+important+element+in+establishing+circadian+rhythm. assertion.
- assertion asSentence The+expression+of+Per1+protein+in+osteoblasts+is+regulated+by+the+sympathetic+nervous+system+and+leptin. assertion.
- assertion asSentence Disruption+of+per1%2F2+gene+expression+alters+the+inductive+effects+of+dioxin+on+the+AhR+signaling+pathway+in+the+mouse+liver. assertion.
- assertion asSentence Treatments+with+electric+convulsive+shock+or+kainic+acid+up-regulated+per1+mRNA+%26+protein+in+the+hippocampal+formation+%26+cerebral+cortex. assertion.
- assertion asSentence The+expression+of+Per1+and+Per2+genes+in+breast+tumor+tissue+decreased+in+comparison+with+their+expression+in+the+lever+and+decreased+with+age+in+both+the+liver+and+tumor+tissue. assertion.
- assertion asSentence The+circadian+gene+Period2+plays+an+important+role+in+tumor+suppression+and+DNA+damage+response+in+vivo. assertion.
- assertion asSentence Cell-autonomous+circadian+transcription+of+Per2+is+driven+by+two+transcriptional+elements%2C+one+for+rhythm+generation+and+the+other+for+phase+control. assertion.
- assertion asSentence Neuronal+PAS+protein+2-Per2+protein+is+a+heme-sensor+protein+in+which+teine-215+is+the+heme+ligand. assertion.
- assertion asSentence The+Per2+mutation+dampens+daily+GC+rhythms+in+young+adult+females. assertion.
- assertion asSentence Overexpression+of+mPer2+enhances+sensitivity+to+cisplatin+in+pancreatic+cancer. assertion.
- assertion asSentence An+acute+change+of+Per2+and+Rev-erbalpha+gene+expression+mediated+by+refeeding-induced+insulin+secretion+is+a+critical+step+mediating+the+early+phase+of+feeding-induced+entrainment+of+the+liver+clock. assertion.
- assertion asSentence Per3+as+potent+mediator+of+cell+fate+that+functions+by+altering+the+transcriptional+activity+of+PPARgamma. assertion.
- assertion asSentence Per3+is+a+key+player+in+the+mammalian+circadian+system. assertion.
- assertion asSentence Mutations+in+the+Pex7+gene+cause+impaired+neuronal+migration+and+endochondral+ossification. assertion.
- assertion asSentence Profilin+II+regulates+the+exocytosis+of+kainate+glutamate+receptors. assertion.
- assertion asSentence Perforin-dependent+cytotoxicity+constitutes+the+major+means+by+which+CD8%2B+T+cells+protect+against+Listeria+monocytogenes. assertion.
- assertion asSentence Ly49H-regulated+NK-cell+control+of+murine+CMV+infection+is+dependent+on+pfp-mediated+cytolysis. assertion.
- assertion asSentence Perforin+deficiency+attenuates+inflammation+and+tumor+growth+in+colitis-associated+cancer. assertion.
- assertion asSentence A+perforin-dependent+pathwy+plays+a+role+to+mediate+contraction+of+antigen-specific+CD8%2B+and+CD4%2B+T+cells+during+prolonged+Listeria+monocytogenes+infection. assertion.
- assertion asSentence Placental+growth+factor+is+a+survival+factor+for+tumor+endothelial+cells+and+macrophages. assertion.
- assertion asSentence PlGF+is+an+important+promoter+of+arteriogenesis. assertion.
- assertion asSentence Proangiogenic+gene+therapy+with+placental+growth+factor+improves+exercise+tolerance+of+ischaemic+rabbit+hindlimbs. assertion.
- assertion asSentence PlGF-MMP-9-expressing+cells+restore+microcirculation+and+efficacy+of+cell+therapy+in+aged+dystrophic+muscle. assertion.
- assertion asSentence PGF+is+a+secreted+factor+that+supports+hypertrophy+and+cardiac+function+during+pressure+overload+by+affecting+endothelial+cells+and+fibroblasts+that+in+turn+stimulate+and+support+the+myocytes+through+additional+paracrine+factors. assertion.
- assertion asSentence PTBP2+is+a+trans-acting+factor+that+helps+to+stabilize+Pgk2+mRNA+in+male+mouse+germ+cells. assertion.
- assertion asSentence Progesterone+regulates+CaBP-9k+gene+in+the+uterus+of+immature+mice%2C+in+addition%2C+estrogen+also+can+affect+the+expression+of+CaBP-9k+through+the+regulation+of+PR. assertion.
- assertion asSentence PRA+and+PRB+expression+in+mammary+epithelial+cells+is+temporally+and+spatially+separated+during+normal+mammary+gland+development+in+the+BALB%2Fc+mouse. assertion.
- assertion asSentence Superovulation+induced+by+GnRHa+down+regulates+the+expressions+of+ER%2C+PR+and+the+LIF+mRNA+on+the+mice+of+secretive+phase+endometrium. assertion.
- assertion asSentence Decreased+progesterone+receptor+activity+contributes+to+depression-like+behavior+in+mice. assertion.
- assertion asSentence An+active+role+of+continued+PR+expression+in+the+luminal+epithelium+for+the+initial+implantation+process. assertion.
- assertion asSentence Pharmacokinetics+of+quinacrine+efflux+from+mouse+brain+via+the+P-glycoprotein+efflux+transporter. assertion.
- assertion asSentence Mdr1a+primary+influences+the+oral+absorption+of+ezetimibe+in+mice. assertion.
- assertion asSentence CF1+mdr1a+%28-%2F-%29+mice+are+susceptible+to+Plasmodium+berghei+ANKA. assertion.
- assertion asSentence Both+P-gp+and+Bcrp1+reduce+the+brain+penetration+of+erlotinib. assertion.
- assertion asSentence Desipramine+treatment+has+minimal+effects+on+the+brain+accumulation+of+glucocorticoids+in+P-gp-deficient+and+wild-type+mice. assertion.
- assertion asSentence Differential+expression+of+prohibitin+and+regulation+of+apoptosis+in+wild-type+and+COX-2+null+mouse+embryonic+fibroblasts. assertion.
- assertion asSentence PHEX+functions+in+bone+to+coordinate+bone+mineralization+and+systemic+phosphate+homeostasis+by+directly+regulating+the+mineralization+process+and+producing+FGF23. assertion.
- assertion asSentence PHEX+and+DMP1+control+a+common+pathway+regulating+bone+mineralization+and+FGF23+production%2C+the+latter+involving+activation+of+the+FGFR+signaling+in+osteocytes. assertion.
- assertion asSentence Role+for+PICK1+in+anchoring+PKCalpha+to+mitochondria+in+a+ligand-specific+manner. assertion.
- assertion asSentence PICK1+permits+changes+in+AMPAR+subunit+composition+to+occur+in+conjunction+with+synaptic+potentiation. assertion.
- assertion asSentence Reduced+IgE%2Fantigen-mediated+passive+cutaneous+anaphylaxis+is+detected+in+mice+with+Piga-deficient+mast+cells. assertion.
- assertion asSentence Is+a+central+mediator+of+NMDA+receptor+signalling+to+MAP+kinase+%28Erk1%2F2%29%2C+Akt%2FPKB+and+CREB+in+striatal+neurones. assertion.
- assertion asSentence P110delta+is+the+dominant+PI3K+isoform+for+cytokine+secretion+by+NK+cells. assertion.
- assertion asSentence T+cell+receptor-induced+phosphoinositide-3-kinase+p110delta+activity+is+required+for+T+cell+localization+to+antigenic+tissue+in+mice. assertion.
- assertion asSentence PI3K+delta+functions+in+influencing+the+type+of+B+cell+cytokine+production+and+differentiation+response+induced+by+TLR-ligands. assertion.
- assertion asSentence The+magnitude+of+the+germinal+cell+reaction+is+controlled+by+the+activity+of+the+PI3K+pathway+in+T+follicular+helper+cells. assertion.
- assertion asSentence The+impaired+Treg+function+in+p110delta%28D910A%29+mice+can+in+part+be+explained+by+the+failure+of+CD38%28high%29+cells+to+develop. assertion.
- assertion asSentence Products+of+the+Pik3r1+gene+contribute+to+transformation+efficiency+by+BCR-ABL+and+there+is+a+role+for+PI3K+signaling+in+B-lineage+transformation+by+ABL+oncogenes. assertion.
- assertion asSentence Primary+increase+in+serum+leptin+on+the+normal+diet+play+a+role+in+the+protection+from+adiposity+in+Pik3r1%28-%2F-%29+mice. assertion.
- assertion asSentence PI3K-p85alpha+plays+a+role+in+differentiation+of+both+follicular+and+marginal+zone+B+cells. assertion.
- assertion asSentence Moreover%2C+both+PI+3-kinase+activation+and+cytoprotection+by+PrP%28C%29+appeared+to+rely+on+copper+binding+to+the+N-terminal+octapeptide+of+PrP%28C%29. assertion.
- assertion asSentence Thrombopoietin+%28TPO%29+stimulates+c-myc+expression+in+primary+megakaryocytes+through+a+PI3K-+and+MAPK-dependent+pathway+that+is+not+mediated+by+Akt%2C+PKCzeta+or+mTOR. assertion.
- assertion asSentence Insulin-stimulated+Interaction+between+insulin+receptor+substrate+1+and+p85alpha+and+activation+of+protein+kinase+B%2FAkt+require+Rab5. assertion.
- assertion asSentence PI3-kinase%2FAkt+plays+a+role+in+the+TNF-alpha-stimulated+IL-6+synthesis+mainly+independent+of+p44%2Fp42+MAP+kinase+in+osteoblasts. assertion.
- assertion asSentence Mammalian+target+of+rapamycin+is+the+key+effector+of+phosphatidylinositol-3-OH-initiated+proliferative+signals+in+the+thyroid+follicular+epithelium. assertion.
- assertion asSentence Cytokine-induced+PI3K+signaling+pathways+promote+Cdk+activation+and+override+permanent+cell+cycle+arrest+checkpoints+in+hematopoietic+cells. assertion.
- assertion asSentence Beclin+1+and+its+binding+proteins+orchestrate+the+precise+function+of+the+class+III+PI%283%29K+in+regulating+autophagy+at+multiple+steps. assertion.
- assertion asSentence The+inflammatory+response+required+recruitment+of+phosphatidylinositol-3-kinase-C2alpha+to+the+SH3-binding+site+of+PSD95. assertion.
- assertion asSentence Class+IA+phosphatidylinositol+3-kinase+in+pancreatic+beta+cells+controls+insulin+secretion+by+multiple+mechanisms. assertion.
- assertion asSentence Signaling+dynamics+of+PI3K+and+p38+and+JNK1%2F2+MAPK+assume+critical+importance+in+ESAT-6+triggered+expression+of+COX-2+in+macrophages. assertion.
- assertion asSentence Deregulated+c-MYC+and+PI3K+activity+cooperate+in+Burkitt+lymphoma+pathogenesis. assertion.
- assertion asSentence Involvement+of+p85beta+in+CD28-mediated+activation+and+differentiation+of+antigen-stimulated+T+cells. assertion.
- assertion asSentence PIKfyve-dependent+channel+degradation+is+essential+to+prevent+Ca2%2B-induced+toxicity+in+neurons. assertion.
- assertion asSentence PIP5K+is+released+from+the+membrane+during+phagosome+formation. assertion.
- assertion asSentence Pim-1+is+required+for+differentiation+into+vascular+endothelium+and+smooth+muscle+cells. assertion.
- assertion asSentence PDGF%28bb%29-induced+proliferation+of+vascular+smooth+muscle+cells+is+partly+attributed+to+transcriptionally+upregulated+Pim-1. assertion.
- assertion asSentence Combined+Rps19+insufficiency+and+Pim-1+deficiency+promote+murine+myeloid+cell+growth+through+a+deregulation+of+c-Myc+and+a+simultaneous+up-regulation+of+anti-apoptotic+Bcl+proteins. assertion.
- assertion asSentence Pim-1+expression+correlates+with+lymphocyte+proliferation+and+activation. assertion.
- assertion asSentence Type+I+PIPkinases+interact+with+and+are+regulated+by+the+retinoblastoma+susceptibility+gene+product-pRB. assertion.
- assertion asSentence PIR-B+is+critical+for+B+cell+suppression%2C+DC+maturation+and+for+balancing+T%28H%291+and+T%28H%292+immune+responses. assertion.
- assertion asSentence PIR-B+plays+a+role+in+regulating+signal+strength+in+adhesion-mediated+activation+of+myeloid+cells. assertion.
- assertion asSentence PirB+and+Nogo+receptor-1+participate+in+ligand-dependent+inhibition+of+synaptic+plasticity+in+hippocampal+slice+cultures+of+adult+mice. assertion.
- assertion asSentence Blocking+the+function+of+PirB+is+not+sufficient+to+promote+axonal+reorganization+or+functional+recovery+after+motor+cortex+injury. assertion.
- assertion asSentence Deafness+and+permanently+reduced+potassium+channel+gene+expression+and+function+in+hypothyroid+Pit1dw+mutants. assertion.
- assertion asSentence The+absolute+concentration+of+PITX2+is+important+for+normal+pituitary+cell+lineage+expansion. assertion.
- assertion asSentence An+essential+function+of+PITX2+protein+in+neural+crest+is+to+regulate+an+extrinsic+factor%28s%29+required+for+development+of+the+optic+nerve. assertion.
- assertion asSentence Functions+in+second+lineage+myocardium+revealing+that+this+cardiac+progenitor+field+is+patterned+asymmetrically. assertion.
- assertion asSentence High-fat+diet+reduces+Pitx2c+levels+in+Cited2-deficient+embryos+and+enhance+penetrance+of+left-right+patterning+defects. assertion.
- assertion asSentence Pitx3+is+specifically+required+for+the+formation+of+the+substantia+nigra+subfield+at+the+onset+of+dopaminergic+neuron+differentiation. assertion.
- assertion asSentence Nurr1+and+Pitx3+cooperatively+promote+terminal+maturation+to+the+midbrain+dopamine+neuron+phenotype+in+murine+and+human+ES+cell+cultures. assertion.
- assertion asSentence Pitx3+is+involved+in+a+mdDA+developmental+cascade+linked+to+RA+signaling. assertion.
- assertion asSentence Use+of+a+Pitx3-enhanced+green+fluorescent+protein+%28Pitx3-eGFP%29+knock-in+mouse+blastocyst-derived+embryonic+stem+%28mES%29+cell+line+and+flow+cytometry%29+to+select+and+purify+midbrain+dopamine+neurons. assertion.
- assertion asSentence PTH+regulates+MGP+via+both+PKA-+and+ERK-dependent+pathways. assertion.
- assertion asSentence Fetal+ethanol+exposure+activates+protein+kinase+A. assertion.
- assertion asSentence PDE4+inhibition+resolves+neutrophilic+inflammation+by+promoting+caspase-dependent+apoptosis+of+inflammatory+cells+by+targeting+a+PKA%2FPI3K%2FAkt-dependent+survival+pathway. assertion.
- assertion asSentence Inhibition+of+PKA+phosphorylation+of+RyR2+reduced+sarcoplasmic+reticulum+Ca%282%2B%29+leak+and+attenuated+cardiomyopathy+in+mdx+mice. assertion.