Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Protein+kinase+A+acts+at+the+basal+body+of+the+primary+cilium+to+prevent+Gli2+activation+and+ventralization+of+the+mouse+neural+tube. assertion.
- assertion asSentence PKC-alpha+modulates+LPS-induced+gene+expression+of+NF-IL6+in+the+mouse+macrophage+cell+line+RAW+264.7. assertion.
- assertion asSentence PKC-alpha+appears+not+to+play+a+major+role+in+renal+sodium+reabsorption+but%2C+consistent+with+its+expression+in+the+medullary+collecting+duct%2C+contributes+to+urinary+concentration+in+mice. assertion.
- assertion asSentence PKC+and+not+NF+kappa+B+is+the+main+target+for+phosphatidylserine+to+exert+its+NO+inhibitory+action+on+LPS-activated+macrophages. assertion.
- assertion asSentence PKCalpha+regulates+platelet+granule+secretion+and+thrombus+formation+in+mice. assertion.
- assertion asSentence The+involvement+of+phosphatidic+acid+phosphohydrolase+1+%28PAP-1%29+and+protein+kinase+C+%28PKC%29+in+the+Toll-like+receptor-4+%28TLR-4%29+activation+of+GIVA+PLA%282%29%2C+is+demonstrated. assertion.
- assertion asSentence PKC+alpha+and+PKC+theta+have+overlapping+functions+in+alloimmunoreactivity+in+vivo. assertion.
- assertion asSentence Fibroblast+growth+factor+2-induced+Rac1+activation+depends+on+the+suppression+of+RhoG+by+a+previously+uncharacterized+ternary+S4-synectin-RhoGDI1+protein+complex+and+activation+via+PKCalpha. assertion.
- assertion asSentence PKCalpha+suppresses+osteoblastic+differentiation. assertion.
- assertion asSentence Protein+kinase+C+is+associated+with+the+reduction+of+aggregated+protein+and+phosphorylation+of+CREB+in+aggregated+protein-loaded+glomeruli. assertion.
- assertion asSentence Prkcb+participates+in+growth-factor-induced+signaling+in+C3HT10-1%2F2+fibroblasts. assertion.
- assertion asSentence PKCbeta+plays+a+redundant+role+in+TCR-induced+regulation+of+IL-2+cytokine+production+and+T+cell+proliferation. assertion.
- assertion asSentence Coronary+artery+PKC-beta+II+is+not+altered+in+diabetic+mice+lacking+Gna11. assertion.
- assertion asSentence Lens+oxidative+stress+treatment+by+H%282%29O%282%29+significantly+induced+lens+opacification+%28cataract%29+in+the+PKCgamma+knockout+mice+when+compared+to+controls. assertion.
- assertion asSentence The+subcellular+localisation+of+nPKC+delta+changes+dynamically+during+the+cell+cycle+in+dependence+of+the+requirement+of+the+enzyme+at+a+particular+place+of+the+cell. assertion.
- assertion asSentence Palmitoylcarnitine+modulates+the+interaction+of+protein+kinase+C+delta+with+GAP-43. assertion.
- assertion asSentence Phosphorylation+is+required+for+PMA-+and+cell-cycle-induced+degradation+of+protein+kinase+Cdelta. assertion.
- assertion asSentence BASH-mediated+BCR+signaling+primarily+controls+B+cell+survival+and+maturation%2C+with+BAFF-R+signaling+and+its+inhibition+of+PKCdelta+acting+as+a+secondary+regulator. assertion.
- assertion asSentence Overproduction+of+DAG+in+PLCzeta-injected+eggs+can+lead+to+PKC-mediated+Ca%282%2B%29+influx+and+subsequent+overloading+of+Ca%282%2B%29+stores. assertion.
- assertion asSentence Interaction+between+PAR-3+and+the+aPKC-PAR-6+complex+is+indispensable+for+apical+domain+development+of+epithelial+cells. assertion.
- assertion asSentence Deletion+of+genes+encoding+isoforms+of+protein+kinase+C+such+as+PKC+delta+can+improve+glucose+intolerance+in+fat+fed+mice. assertion.
- assertion asSentence Activation+of+PKC-delta+promotes+tubular+cell+injury+and+death+during+albuminuria. assertion.
- assertion asSentence Insulin+promotes+neuronal+survival+via+the+alternatively+spliced+protein+kinase+CdeltaII+isoform. assertion.
- assertion asSentence Hyperglycemia+and+diabetes+can+cause+glomerular+podocyte+apoptosis+and+endothelial+dysfunction+partly+due+to+increased+PKCdelta%2Fp38+MAPK+activation+and+the+expression+of+SHP-1+to+cause+VEGF+resistance%2C+independent+of+NF-kappaB+activation. assertion.
- assertion asSentence PKCepsilon+is+recruited+by+ischemic+preconditioning+and+induces+activation+of+SK1+that+then+mediates+IPC-induced+cardioprotection+in+murine+heart. assertion.
- assertion asSentence PKCepsilon+plays+a+causal+role+in+at+least+the+early+phases+of+ethanol-induced+liver+injury+in+mice. assertion.
- assertion asSentence Prkce+deletion+ameliorates+diet-induced+glucose+intolerance. assertion.
- assertion asSentence nPKCeta+positively+regulates+agonist-induced+thromboxane+generation+with+no+effects+on+platelet+aggregation. assertion.
- assertion asSentence aPKC+signaling+is+fundamental+to+glomerular+maintenance+and+development+and+loss+in+podocytes+causes+nephrotic+syndrome+in+mice. assertion.
- assertion asSentence PKD+facilitates+contraction+of+cardiomyocytes+by+increasing+Ca%282%2B%29+sensitivity+and+by+an+increased+calcium-activated+tension+of+contraction+through+phosphorylation+of+cMyBP-C. assertion.
- assertion asSentence PKC-theta+can+both+positively+and+negatively+regulate+the+Ca2%2B+influx+that+is+critical+for+NFAT+activity. assertion.
- assertion asSentence PKC-theta+is+involved+in+the+regulation+of+multiple+T+cell+functions+necessary+for+the+development+of+autoimmune+encephalitis. assertion.
- assertion asSentence PKCtheta+is+essential+for+the+immune+response+to+leukemia+in+mice. assertion.
- assertion asSentence A+nonredundant+antagonism+between+PKC-theta+and+Cbl-b+that+regulates+T+cell+activation+responses. assertion.
- assertion asSentence Wnt5a%2FRor2+activates+JNK%2C+through+a+process+involving+filamin+A+and+PKCzeta%2C+to+regulate+polarized+cell+migration. assertion.
- assertion asSentence PKCzeta%2C+by+controlling+the+production+of+IL-6%2C+is+a+critical+signaling+molecule+in+tumorigenesis. assertion.
- assertion asSentence Basal+or+elevated+aPKC+activity+is+required+for+the+ability+of+Src-transformed+cells+to+degrade+and+invade+the+extracellular+matrix. assertion.
- assertion asSentence PKCzeta+as+a+critical+negative+regulator+of+IL-6+in+the+control+of+obesity-induced+inflammation+in+adipocytes. assertion.
- assertion asSentence Distinctive+communication+with+the+extracellular+microenvironment+depends+on+proper+localization+and+function+of+polycystin-1+in+cilia. assertion.
- assertion asSentence PC-1+polyproline+motif+interacts+with+the+SH3+domain+of+NPHP1. assertion.
- assertion asSentence Ciliary+polycystin-2+is+a+mechanosensitive+endothelial+calcium+channel+involved+in+nitric+oxide+signaling+cascades. assertion.
- assertion asSentence Pkd1l1+is+the+elusive+Pkd2+binding+partner+required+for+Left-Right+patterning. assertion.
- assertion asSentence Pkdrej+controls+the+timing+of+fertilization+in+vivo+through+effects+on+sperm+transport+and+exocytotic+competence+and+is+a+factor+in+postcopulatory+sexual+selection. assertion.
- assertion asSentence Homozygous+p21%28cip%29+loss+releases+islets+from+growth+inhibition%2C+markedly+enhancing+proliferation+in+response+to+HGF+and+placental+lactogen. assertion.
- assertion asSentence Cytosolic+phospholipase+A%282%29+in+hypoxic+pulmonary+vasoconstriction. assertion.
- assertion asSentence Stromal+cPLA%282%29+plays+a+critical+role+in+tumor+progression+by+altering+tumor-macrophage+interactions+and+cytokine+production. assertion.
- assertion asSentence J-774+cells+incubated+with+Group+V+secretory+phospholipase+A%282%29+hydrolyzed-LDL+produced+more+TNF-alpha+and+IL-6+compared+to+cells+incubated+with+control-LDL. assertion.
- assertion asSentence Plasminogen+activator+inhibitor-1+promotes+neointima+formation+in+carotid+arteries. assertion.
- assertion asSentence Corneal+angiogenesis+is+dependent+on+PAI-1. assertion.
- assertion asSentence A+proteolytic+effect+for+PAI-1+regulates+cell+invasiveness+in+desmoid+tumor+in+knockout+mice. assertion.
- assertion asSentence The+antithrombotic+effect+of+rosiglitazone+is+mediated%2C+at+least+in+part%2C+through+the+suppressive+effect+of+adiponectin+on+PAI-1+production. assertion.
- assertion asSentence Transfection+of+cells+with+galectin-7+small+interfering+RNA+inhibited+nuclear+export+of+Smad3+and+abolished+suppressive+effect+of+HGF+on+expression+of+TGF-beta-responsive+genes+such+as+COL1A2+and+plasminogen+activator+inhibitor-1. assertion.
- assertion asSentence PAI-1-mediated+regulation+of+alphavbeta3+integrin+is+critical+for+the+control+of+TGFbeta+signaling+and+the+prevention+of+fibrotic+disease. assertion.
- assertion asSentence PAI-1+is+not+rate+limiting+for+neoplastic+progression+and+vascularization+during+premalignant+progression. assertion.
- assertion asSentence PAI-1+has+a+causal+role+in+mediating+the+early+phase+of+fructose-induced+liver+damage+in+mice+through+signaling+cascades+downstream+of+Kupffer+cells+and+TNF-alpha. assertion.
- assertion asSentence Tissue-type+plasminogen+activator+is+protective+for+inflammatory+joint+disease%2C+since+its+absence+exacerbates+the+mild+arthritis+induced+by+intra-articular+injection+of+methylated+bovine+serum+albumin%2C+either+alone+or+concurrently+with+IL-1. assertion.
- assertion asSentence Plasmin-mediated+apoptosis+of+VSMC+occurs+via+plasminogen+activation+by+either+t-PA+or+u-PA+and+is+impaired+by+PAI-1. assertion.
- assertion asSentence IL-1alpha+and+TGF-beta1+interact+with+the+production+of+tPA+during+skin+wound+healing. assertion.
- assertion asSentence Exposure+of+cryptic+domains+in+the+alpha+1-chain+of+laminin-1+by+elastase+stimulates+macrophages+urokinase+and+matrix+metalloproteinase-9+expression. assertion.
- assertion asSentence Receptor-independent+role+of+the+urokinase-type+plasminogen+activator+during+arteriogenesis. assertion.
- assertion asSentence Kringle+domain+of+uPA+induces+smooth+muscle+cell+migration+through+a+G-protein-coupled+PI3-K-dependent+process+involving+both+ERK+1%2F2+and+p38%28MAPK%29+and+is+mediated+in+part+through+EGFR. assertion.
- assertion asSentence Role+of+urokinase-type+plasminogen+activator+in+mediating+brain+inflammatory+responses. assertion.
- assertion asSentence Selective+abrogation+of+the+uPA-uPAR+interaction+is+associated+with+suppression+of+fibrin-associated+inflammation. assertion.
- assertion asSentence uPA+acts+in+a+cell+signaling+manner+via+binding+to+its+receptor+uPAR+rather+than+as+a+protease. assertion.
- assertion asSentence Targeting+urokinase-type+plasminogen+activator+receptor+on+human+glioblastoma+tumors+with+diphtheria+toxin+fusion+protein+DTAT. assertion.
- assertion asSentence MMP-12+and+other+MMPs+directly+and+efficiently+cleave+uPAR+at+the+Thr86+paralal+Tyr87+peptide+bond+located+in+the+linker+region+connecting+uPAR+domains+1+and+2%2C+releasing+the+major+ligand+binding+domain+1+from+the+rest+of+the+receptor. assertion.
- assertion asSentence uPAR+overexpression+induced+stem+cell-like+properties+and+an+increase+in+breast+tumor+initiation+and+growth. assertion.
- assertion asSentence Paracellular+transmigration+of+neutrophils+is+regulated+by+CD11b%2FMac-1+and+does+not+require+the+urokinase-type+plasminogen+activator+receptor+uPAR. assertion.
- assertion asSentence GPCR+activation+of+Ras+and+PI3Kc+in+neutrophils+depends+on+PLCb2%2Fb3+and+the+RasGEF+RasGRP4. assertion.
- assertion asSentence The+pattern+of+phospholipase+Cbeta3+expression+is+unique%2C+revealing+stripes+in+three+of+the+four+transverse+zones+and+a+uniform+distribution+in+the+fourth.+and+PLCbeta3+is+restricted+to+the+zebrin+II-immunopositive+Purkinje+cell+subset. assertion.
- assertion asSentence GPCR+activation+of+Ras+and+PI3Kc+in+neutrophils+depends+on+PLCb2%2Fb3+and+the+RasGEF+RasGRP4. assertion.
- assertion asSentence The+role+of+PLCbeta4+in+thalamic+neurons+during+sleep+stages. assertion.
- assertion asSentence Phospholipase+C-gamma1+is+required+for+cell+survival+in+oxidative+stress+by+protein+kinase+C. assertion.
- assertion asSentence PLCgamma1+signalling+induces+cardiac+TNF-alpha+expression+and+myocardial+dysfunction+during+LPS+stimulation. assertion.
- assertion asSentence PLD1+is+a+target+gene+of+C%2FEBPbeta+through+the+increased+cellular+cAMP+during+early+adipocyte+differentiation+of+3T3-L1+cells. assertion.
- assertion asSentence Mutated+ras+induced+PLD1+gene+expression+through+increased+Sp1+transcription+factor. assertion.
- assertion asSentence Plectin+contributes+to+mechanical+properties+of+living+cells. assertion.
- assertion asSentence Plasmin+activity+is+required+for+myogenesis+in+vitro+and+skeletal+muscle+regeneration+in+vivo. assertion.
- assertion asSentence Role+of+pCPB+as+a+modulator+of+the+pivotal+functions+of+plasminogen+in+fibrinolysis+and+cell+migration+in+vivo. assertion.
- assertion asSentence Plasminogen+exerts+a+marked+influence+on+both+neutrophil+and+monocyte%2Fmacrophage+recruitment+to+implanted+biomaterials. assertion.
- assertion asSentence Plk+phosphorylation+regulates+the+microtubule-stabilizing+protein+TCTP. assertion.
- assertion asSentence Inhibition+of+Plk1+activity+suppresses+pX-mediated+oncogenic+transformation. assertion.
- assertion asSentence Aerobic+interval+training+enhances+cardiomyocyte+contractility+and+Ca2%2B+cycling+by+phosphorylation+of+CaMKII+and+thr-17+of+Pln. assertion.
- assertion asSentence Regulation+of+sealing+ring+formation+by+L-plastin+and+cortactin+in+osteoclasts. assertion.
- assertion asSentence The+phospholipid+transfer+protein+gene+is+a+liver+X+receptor+target+expressed+by+macrophages+in+atherosclerotic+lesions. assertion.
- assertion asSentence Absence+of+endogenous+phospholipid+transfer+protein+impairs+ABCA1-dependent+efflux+of+cholesterol+from+macrophage+foam+cells. assertion.
- assertion asSentence PML%2FRARA+mutant+exhibit+defective+arsenic+trioxide+response+in+acute+promyelocytic+leukemia. assertion.
- assertion asSentence Prx+I-%2F-+mice+have+less+reducing+activity+and+are+more+susceptible+to+the+damage+mediated+by+reactive+oxygen+species+in+vivo+than+wild-type+mice. assertion.
- assertion asSentence The+PHOX2B+can+induce+desired+neuronal+lineages+from+most+expressing+neural+progenitor+cells+by+a+mechanism+resembling+developmental+binary+cell-fate+switching. assertion.
- assertion asSentence DNA+polymerase+beta+is+not+an+essential+component+of+the+machinery+that+maintains+mtDNA+integrity. assertion.
- assertion asSentence Mutation+burden+in+wild+type+and+Polg-deficient+mice. assertion.
- assertion asSentence AgRP%2FNPY+and+POMC+neurons+each+play+mandatory+roles+in+aspects+of+leptin-regulated+energy+homeostasis. assertion.
- assertion asSentence Alpha-MSH%281-13%29+is+an+in+vivo+substrate+of+PREP. assertion.
- assertion asSentence Spatiotemporal+localization+of+MC1R+and+alpha-MSH+in+cutaneous+wounds+warrants+future+investigation+into+the+role+of+MC1R%2Falpha-MSH+signaling+in+the+inflammatory+and+fibroproliferative+responses+to+cutaneous+injury. assertion.
- assertion asSentence Cell-autonomous+role+of+InsR%2FFoxO1+signaling+in+regulating+POMC+neuron+number%2C+distinct+from+its+established+role+to+activate+Pomc+transcription. assertion.
- assertion asSentence Serum+albumin+is+as+efficient+as+paraxonase+in+the+detoxication+of+paraoxon+at+toxicologically+relevant+concentrations. assertion.
- assertion asSentence OCT1+and+OCT2+are+important+for+N-methyl-4-phenyl-1%2C2%2C3%2C6-tetrahydropyridine+%28MPTP%29+transfer+across+the+blood-brain+barrier+and+amantadine+reduces+the+blood-brain+barrier+transfer+of+MPTP+and+MPTP-induced+dopaminergic+toxicity+in+rodents. assertion.
- assertion asSentence Oct1+is+required+in+th+embryo+proper+from+late+gastrulation+stages+onwards. assertion.
- assertion asSentence Brn-3a+is+required+for+the+generation+of+proprioceptors+in+the+mesencephalic+trigeminal+tract+nucleus. assertion.
- assertion asSentence Brn3b+regulates+gene+expression+through+the+action+of+a+strong+transcriptional+activation+domain+within+its+N-terminal+sequence. assertion.