Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Brn-3b+suppresses+the+role+of+DLX1%2F2+through+physical+interaction+and+biases+the+competent+precursors+toward+retinal+ganglion+cell+fates. assertion.
- assertion asSentence Oct4+can+dimerize+onto+DNA+in+a+distinct+conformational+arrangement. assertion.
- assertion asSentence Transcriptional+repression+of+Oct-3%2F4+is+followed+by+a+pronounced+increase+in+histone+H3+methylation+on+Lys+9+that+is+mediated+by+the+SET-containing+protein%2C+G9a. assertion.
- assertion asSentence Pluripotent+stem+cell+marker+Oct-4+and+the+embryonic+stem+cell+marker+Rex-1+are+spontaneously+expressed+by+untreated+mesenchymal+stem+cells. assertion.
- assertion asSentence STAT3+and+Oct-3%2F4+maintain+silencing+of+differentiation-associated+genes+through+up-regulation+of+Eed+in+self-renewing+ES+cells. assertion.
- assertion asSentence Histone+methylation+and+acetylation+regulate+Pou5f1+and+Gfra1+in+male+germ+cell. assertion.
- assertion asSentence Suppression+of+MyoD+gene+expression+by+Oct4+is+required+for+the+initial+reprogramming+step+in+the+development+of+iPSCs+from+myoblasts. assertion.
- assertion asSentence Cited2+controls+ESC+pluripotency+and+differentiation+via+direct+regulation+of+Oct4+gene+expression. assertion.
- assertion asSentence Stabilization+of+retinoid+X+receptor+alpha+in+the+presence+of+peroxisome+proliferator-activated+receptor+alpha. assertion.
- assertion asSentence Regulates+transcription+in+mouse+liver. assertion.
- assertion asSentence PPAR-alpha+activation+increases+intracellular+concentrations+of+ROS%2C+through+the+activation+of+NADPH+oxidase. assertion.
- assertion asSentence There+is+a+muscle-specific+mechanism+to+enhance+binding+of+the+receptor+to+the+response+element+to+ensure+action+of+peroxisome+proliferator-activated+receptor+alpha+on+the+heart-type+fatty+acid+binding+protein+gene+promoter. assertion.
- assertion asSentence PPARalpha+activation+prevents+inflammation+in+white+adiopse+tissue+and+dual+activation+of+PPARalpha+and+-gamma+enhances+the+action+of+adiponectin. assertion.
- assertion asSentence The+level+of+the+%28E%29-isomer+of+phytol+increased+significantly+in+the+liver+of+PPARalpha+deficient+mice+compared+with+wild-type+mice. assertion.
- assertion asSentence Tumor+necrosis+factor+has+little+effect+on+PPAR-alpha+activity+and+fatty+acid+oxidation+rates+in+cultured+ventricular+myocytes. assertion.
- assertion asSentence N-3+fatty+acids+protect+from+high-fat+diet-induced+hepatic+insulin+resistance+in+a+PPAR-alpha-and+diacylglycerol-dependent+manner. assertion.
- assertion asSentence Lipopolysaccharides+induce+transient+lipid+accumulation+and+expression+of+ADRP+in+the+liver+through+inhibition+of+fatty+acid+oxidation+by+downregulation+of+the+PPARalpha-related+transcriptional+mechanism. assertion.
- assertion asSentence PPARalpha+behaves+as+a+modulator+of+systemic+inflammation+in+the+actue+phase+response+and+of+the+associated+vascular+response. assertion.
- assertion asSentence PAR-5359%2C+a+well-balanced+PPARalpha%2Fgamma+dual+agonist%2C+exhibits+equivalent+antidiabetic+and+hypolipidemic+activities+in+vitro+and+in+vivo. assertion.
- assertion asSentence Prostacyclin+induces+the+translocation+of+PPAR-alpha+from+the+cytosol+into+the+nucleus+and+attenuates+NF-kappaB-induced+TNF-alpha+activation+following+renal+ischemia-reperfusion+injury. assertion.
- assertion asSentence PPAR-alpha+response+is+generated+by+unbound+fatty+acids+released+locally+by+lipase+activity+and+not+by+circulating+plasma+fatty+acids. assertion.
- assertion asSentence Upon+ageing%2C+PPARalpha+plays+a+crucial+role+in+regulating+the+total+numbers%2C+compositions+and+functions+of+immune+cells+in+both+lymphoid+and+non-lymphoid+immune+organs+of+mice. assertion.
- assertion asSentence PPARalpha%2Fgamma+and+their+agonists+positively+control+megalin+expression. assertion.
- assertion asSentence PPAR-alpha+deficiency+exacerbates+doxorubicin-related+renal+injury%2C+in+part%2C+due+to+increased+podocyte+apoptosis. assertion.
- assertion asSentence Inhibition+of+c-Jun-N-terminal+kinase+increases+cardiac+peroxisome+proliferator-activated+receptor+alpha+expression+and+fatty+acid+oxidation+and+prevents+lipopolysaccharide-induced+heart+dysfunction. assertion.
- assertion asSentence S6K2+regulates+hepatic+energy+homeostasis+by+repressing+PPARalpha+activity. assertion.
- assertion asSentence Absence+of+MED1+in+the+liver+diminishes+Dex-induced+hepatic+steatosis+by+altering+the+GR-+and+CAR-dependent+gene+functions. assertion.
- assertion asSentence MED1+has+a+critical+role+in+regulating+hair%2Fepidermal+proliferation+and+differentiation. assertion.
- assertion asSentence ArgI+is+a+key+marker+of+the+alternative+program+triggered+by+PPAR+in+macrophages. assertion.
- assertion asSentence Ligand+activation+of+peroxisome+proliferator-activated+receptor+beta%2Fdelta+%28PPARbeta%2Fdelta%29+attenuates+carbon+tetrachloride+hepatotoxicity+by+downregulating+proinflammatory+gene+expression. assertion.
- assertion asSentence Cardiomyocyte-restricted+PPARdelta+deficiency+in+mice+led+to+substantially+diminished+cardiac+expression+of+Mfn2+transcript+and+protein+compared+to+that+of+controls. assertion.
- assertion asSentence Curcumin+can+induce+apoptosis+of+HT-29+colonic+neoplasm+cells+and+down-regulate+the+expression+of+PPARdelta. assertion.
- assertion asSentence Combining+ligand+activation+of+PPARbeta%2Fdelta+with+inhibition+of+COX-2+activity+can+inhibit+chemically+induced+skin+tumor+progression+by+modulating+differentiation. assertion.
- assertion asSentence PPAR-delta+serves+as+an+important+molecular+brake+for+the+control+of+central+nervous+system+autoimmune+inflammation. assertion.
- assertion asSentence Expression+of+peroxisome+proliferator-activated+nuclear+receptor+beta%2Fdelta+is+lower+in+human+and+Apc%28%2B%2FMin-FCCC%29+mouse+colon+tumors+than+in+corresponding+normal+tissue. assertion.
- assertion asSentence Peroxisome+proliferator-activated+receptor+delta+downregulates+the+expression+of+the+receptor+for+advanced+glycation+end+products+and+pro-inflammatory+cytokines+in+the+kidney+of+streptozotocin-induced+diabetic+mice. assertion.
- assertion asSentence A+PML-PPAR-delta+pathway+for+fatty+acid+oxidation+regulates+hematopoietic+stem+cell+maintenance. assertion.
- assertion asSentence Regulation+of+phosphodiesterase+3B+gene+expression+by+peroxisome+proliferator-activated+receptor+gamma. assertion.
- assertion asSentence Loss+of+muscle-expressed+pparg+in+the+mouse+leads+to+adiposity+and+insulin+resistance. assertion.
- assertion asSentence Mutant+thyroid+hormone+receptor+beta+represses+the+expression+and+transcriptional+activity+of+peroxisome+proliferator-activated+receptor+gamma+during+thyroid+carcinogenesis. assertion.
- assertion asSentence PPARgamma+is+essential+for+the+in+vivo+survival+of+mature+adipocytes%2Cin+transgenic+mice. assertion.
- assertion asSentence Inflammation-triggered+cell+growth+and+emphysema+during+lysosomal+acid+lipase+deficiency+are+partially+caused+by+peroxisome+proliferator-activated+receptor-gamma+inactivation. assertion.
- assertion asSentence PDK1+can+function+as+a+PPARgamma1+coactivator+independently+of+its+catalytic+activity+and+establishes+an+important+mechanistic+link+between+adipocyte+differentiation+and+the+insulin+signaling+pathway. assertion.
- assertion asSentence Ox-LDL-induced+increase+in+15d-PGJ%282%29+level+through+ERK1%2F2-dependent+COX-2+expression+is+one+of+the+mechanisms+of+PPARalpha+and+PPARgamma+activation+in+macrophages. assertion.
- assertion asSentence ArgI+is+a+key+marker+of+the+alternative+program+triggered+by+PPAR+in+macrophages. assertion.
- assertion asSentence SPPARgammaM5+induced+an+attenuated+PPARgamma-regulated+gene+expression+profile+in+fully+differentiated+3T3-L1+adipocytes+and+white+adipose+tissue+of+chronically+treated+db%2Fdb+mice. assertion.
- assertion asSentence ERbeta-deficiency+protects+against+diet-inducedinsulin+resistance+and+glucose+intolerance+which+involves+an+augmented+PPARgamma+signaling+in+adipose+tissue. assertion.
- assertion asSentence Green+tea+seed+oil+reduces+weight+gain+in+C57BL%2F6J+mice+and+influences+adipocyte+differentiation+by+suppressing+peroxisome+proliferator-activated+receptor-gamma. assertion.
- assertion asSentence CRBP-III+is+a+PPARgamma+target+gene+and+plays+a+role+in+lipid+and+whole+body+energy+metabolism. assertion.
- assertion asSentence SIRT2+suppresses+adipogenesis+by+deacetylating+FOXO1+to+promote+FOXO1%27s+binding+to+PPARgamma+and+subsequent+repression+on+PPARgamma+transcriptional+activity. assertion.
- assertion asSentence Deletion+of+PPARgamma+in+follicular+stem+cells+in+mice+causes+a+skin+and+hair+phenotype+that+emulates+scarring+alopecia. assertion.
- assertion asSentence The+basal+channel+opening+of+P2X7R+receptor+in+cultured+mouse+astrocytes+is+at+least+in+part+regulated+by+PPAR+gamma. assertion.
- assertion asSentence PPAR+gamma+is+differentially+expressed+in+F4%2F80%28hi%29+versus+F4%2F80%28low%29+adipose+tissue+macrophages+subsets+and+its+deficiency+favors+a+predominance+of+M1+markers+in+white+adipose+tissue. assertion.
- assertion asSentence Bscl2+is+required+for+PPARgamma%27s+full+activation+to+initiate+the+adipogenesis+transcription+program. assertion.
- assertion asSentence The+therapeutic+effect+of+PPARgamma+in+asthma+is+exerted+via+the+down-regulation+of+interleukin+%28IL%29-17+expression. assertion.
- assertion asSentence Nocturnin%2C+is+markedly+upregulated+with+Pparg+activation+in+adipocytes+and+bone+marrow+stromal+cells. assertion.
- assertion asSentence Noc+plays+a+unique+role+in+the+regulation+of+mesenchymal+stem-cell+lineage+allocation+by+modulating+PPAR-gamma+activity+through+nuclear+translocation. assertion.
- assertion asSentence Colon+OCTN2+gene+expression+is+up-regulated+by+peroxisome+proliferator-activated+receptor+gamma+in+humans+and+mice+and+contributes+to+local+and+systemic+carnitine+homeostasis. assertion.
- assertion asSentence PPARgamma+plays+a+pivotal+role+in+controlling+placental+vascular+proliferation+and+contributes+to+its+termination+in+late+pregnancy. assertion.
- assertion asSentence HSL+modulates+adipose+metabolism+is+by+providing+intrinsic+ligands+or+pro-ligands+for+PPARgamma. assertion.
- assertion asSentence PPARgamma+activation+inhibits+T-lymphocyte-+derived+adipose+tissue+inflammation%2C+attenuating+the+systemic+development+of+insulin+resistance. assertion.
- assertion asSentence CAAT%2Fenhancer+binding-protein+beta+%28C%2FEPBbeta%29+signaling+through+the+IL-17A+receptor+promoted+adipogenic+transdifferentiation+of+myoblast+cells+by+activating+peroxisome+proliferator-activated+receptor+gamma+%28PPARgamma%29. assertion.
- assertion asSentence PPAR-gamma+negatively+regulates+IFN-beta+production+in+TLR3-+and+4-stimulated+macrophages+by+preventing+IRF3+binding+to+the+IFN-beta+promoter. assertion.
- assertion asSentence PPARalpha%2Fgamma+and+their+agonists+positively+control+megalin+expression. assertion.
- assertion asSentence Activation+of+PPARgamma+in+myeloid+cells+promotes+lung+cancer+progression+and+metastasis. assertion.
- assertion asSentence PGC-1alpha+mediates+the+ligand-dependent+activation+of+FXR+and+transcription+of+SHP+gene. assertion.
- assertion asSentence PGC-1+alpha+is+vital+for+the+heart+to+meet+increased+demands+for+ATP+and+work+in+response+to+physiological+stimuli. assertion.
- assertion asSentence The+PGC-1alpha+protein+acetylation+by+GCN5+turns+off+the+transcriptional+and+biological+function+of+this+metabolic+coactivator. assertion.
- assertion asSentence Palmitate+reduces+PGC-1alpha+expression+in+skeletal+muscle+cells+through+a+mechanism+involving+MAPK-ERK+and+NF-kappaB+activation. assertion.
- assertion asSentence PGC-1alpha+as+a+critical+regulator+of+skeletal+muscle+fuel+stores. assertion.
- assertion asSentence The+molecular+mechanism+of+thyroid+hormone+regulation+of+PGC-1alpha%2C+is+investigated. assertion.
- assertion asSentence Coactivator+PGC-1alpha+regulates+the+fasting+inducible+xenobiotic-metabolizing+enzyme+CYP2A5+in+mouse+primary+hepatocytes. assertion.
- assertion asSentence Dual+modulation+of+both+lipid+oxidation+and+synthesis+by+peroxisome+proliferator-activated+receptor-gamma+coactivator-1alpha+and+-1beta+in+cultured+myotubes. assertion.
- assertion asSentence NO%2Fprotein+kinase+G+%28PKG%29-dependent+downregulation+of+PGC-1+alpha+and+the+ROS+detoxification+system+in+endothelial+cells+are+mediated+by+the+PI3K%2FAkt+signaling+pathway+and+subsequent+inactivation+of+transcription+factor+Foxo3a. assertion.
- assertion asSentence The+transcriptional+coactivators%2C+PGC-1alpha+and+beta%2C+cooperate+to+maintain+cardiac+mitochondrial+function+during+the+early+stages+of+insulin+resistance. assertion.
- assertion asSentence NT-PGC-1alpha+protein+is+sufficient+to+link+AR+beta+3+activation+to+transcriptional+and+physiological+components+of+thermogenesis. assertion.
- assertion asSentence Cell+surface+expression+of+the+major+amyloid-beta+peptide+%28Abeta%29-degrading+enzyme%2C+neprilysin%2C+depends+on+phosphorylation+by+mitogen-activated+protein+kinase%2Fextracellular+signal-regulated+kinase+kinase+%28MEK%29+and+dephosphorylation+by+protein+phosphatase+1a. assertion.
- assertion asSentence PP1gamma2+is+involved+in+sperm+tail+morphogenesis. assertion.
- assertion asSentence DARPP-32+increases+interactions+between+epidermal+growth+factor+receptor+and+ERBB3+to+promote+tumor+resistance+to+gefitinib. assertion.
- assertion asSentence PPp2ca+interacts+with+Jak2. assertion.
- assertion asSentence Treating+C2C12+myotubes+with+adiponectin+promoted+APPL1+interaction+with+protein+phosphatase+2A+%28PP2A%29+and+protein+kinase+Czeta+%28PKCzeta%29%2C+leading+to+the+activation+of+PP2A+and+subsequent+dephosphorylation+and+inactivation+of+PKCzeta. assertion.
- assertion asSentence PP2A%2FC+provides+a+dual+inhibitory+effect+on+Bcl2%27s+survival+function+by+both+dephosphorylating+Bcl2+and+enhancing+p53-Bcl2+binding. assertion.
- assertion asSentence Peroxisome+proliferator-activated+receptor+beta+stimulation+induces+rapid+cardiac+growth+and+angiogenesis+via+direct+activation+of+calcineurin. assertion.
- assertion asSentence A+part+of+polysaccharides+from+the+stem+and+leaves+of+Panax+ginseng+exhibits+immunopotentiation+effects+on+murine+spleen+lymphocytes+by+the+Ca2%2B-calcineurin-NFAT-IL-2+signaling+pathway. assertion.
- assertion asSentence Estrogen+attenuates+left+ventricular+and+cardiomyocyte+hypertrophy+by+an+estrogen+receptor-dependent+pathway+that+increases+calcineurin+degradation. assertion.
- assertion asSentence Deactivation+of+calcineurin%2FNFAT+pathway-induced+pathological+hypertrophy+is+a+preferential+mechanism+by+which+exercise+training+leads+to+the+cardiac+anti-remodelling+effect+in+heart+failure. assertion.
- assertion asSentence Nup88+is+up-regulated+in+response+to+hypertonic+stress+and+acts+to+retain+TonEBP+in+the+nucleus%2C+activating+transcription+of+critical+osmoprotective+genes. assertion.
- assertion asSentence The+cytoplasmic+and+membrane-associated+POP+have+distinct+roles+in+different+types+of+placental+cells. assertion.
- assertion asSentence Histamine+and+serotonin+storage+in+mast+cells+is+dependent+on+serglycin+proteoglycan. assertion.
- assertion asSentence Serglycin+proteoglycan+is+dispensable+for+normal+secretion+and+activity+of+mast+cell+proteases+in+response+to+peritoneal+infection+with+T.+gondii. assertion.
- assertion asSentence Major+basic+protein+decreases+epithelial+barrier+function+and+in+this+manner+contributes+to+the+pathogenesis+of+inflammatory+bowel+diseases. assertion.
- assertion asSentence In+R70Qgamma1-expressing+mice%2C+there+is+an+increase+in+muscle+glycogen+synthase+activity+associated+with+an+increase+in+exercise+capacity. assertion.
- assertion asSentence Joining+of+DNA+ends+during+CSR+does+not+require+DNA-PKcs+and+can+occur+by+an+alternative+repair+pathway+to+that+used+for+V%28D%29J+recombination. assertion.
- assertion asSentence Lack+of+DNA-PKcs+is+accompanied+by+an+increase+in+the+protein+level+of+one+of+the+catalytic+isozymes+of+protein+kinase+CK2%2C+i.e.%2C+CK2alpha%27+and+a+concomitant+increase+in+CK2+activity. assertion.
- assertion asSentence Ablation+of+CGKI+in+Purkinje+cells+of+the+cerebellum+leads+to+impairment+of+long-term+depression+and+cerebellar+learning+in+knockout+mice. assertion.
- assertion asSentence Posttranslational+modification+of+PKGI+critically+influences+the+nuclear+translocation+of+PKGI+and+activities+of+cGMP+in+SMCs. assertion.
- assertion asSentence TGF-beta%281%29+decreased+sGC+and+PKGI+expression+in+pulmonary+artery+and+aortic+smooth+muscle+cells+from+adult+rats+and+mice. assertion.
- assertion asSentence Basal%2Fmoderately+elevated+PKG+activity+protects+against+high%2Fpathological-level+nitric+oxide-induced+apoptosis+and+promotes+DNA+synthesis%2Fproliferation+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence cGK+II+is+induced+in+granulosa+cells+of+preovulatory+follicles+by+LH-+and+PR-dependent+mechanisms. assertion.
- assertion asSentence p38+beta+MAP+kinase+mediates+the+effects+of+carbon+monoxide+on+cytoprotection+and+Hsp70+regulation. assertion.