Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Cdo+also+interacts+with+Bnip-2%2C+a+protein+that+binds+the+small+guanosine+triphosphatase+%28GTPase%29+Cdc42+and+a+negative+regulator+of+Cdc42%2C+Cdc42+GTPase-activating+protein+%28GAP%29. assertion.
- assertion asSentence Demonstrate+roles+of+the+p38alpha%2Fbeta%2Fdelta+isoforms+in+the+regulation+of+12-O-tetradecanoylphorbol+13-acetate-induced+skin+inflammation. assertion.
- assertion asSentence JIP-1+targets+MKP-7+to+dephosphorylate+JNK. assertion.
- assertion asSentence JIP+scaffold+proteins+are+critically+required+for+normal+NMDA+receptor+function. assertion.
- assertion asSentence eIF-2+kinase+increases+during+myoblast+differentiation+because+of+transactivation+by+MyoD+protein. assertion.
- assertion asSentence Both+TLR2+%28Pam3CSK4%29+and+TLR4+%28LPS%29+ligands+induced+rapid+phosphorylation+of+PKR. assertion.
- assertion asSentence The+aberrant+accumulation+of+STAT1+protein+induced+by+loss+of+PKR+regulate+osteoblast+differentiation+through+both+SLIM%2FSTAT1-dependent+and+-independent+pathways. assertion.
- assertion asSentence EIF2alpha+phosphorylation+in+vaccinia+virus+infected+cells+is+mediated+by+protein+kinase+R%28PKR%29. assertion.
- assertion asSentence PKR+plays+important+roles+in+the+differentiation+of+osteoclasts. assertion.
- assertion asSentence The+eIF2alpha+kinases+PKR+and+GCN2+promote+apoptosis. assertion.
- assertion asSentence Heme-regulated+eIF2alpha+kinase+activated+Atf4+signaling+pathway+in+oxidative+stress+and+erythropoiesis. assertion.
- assertion asSentence Mammary-derived+PRL+influences+mammary+epithelial+cell+proliferation+via+an+autocrine%2Fparacrine+mechanism%2C+establishing+a+physiologic+function+for+mammary+PRL+during+mammopoiesis. assertion.
- assertion asSentence Bmp1+processes+prl+to+a+17-kDa+anti-angiogenic+factor. assertion.
- assertion asSentence The+absence+of+prolactin+receptor+signaling+is+not+detrimental+to+male+testicular+function+and+to+fertility+in+the+mouse. assertion.
- assertion asSentence Prolactin+independent+rescue+of+mouse+corpus+luteum+life+span. assertion.
- assertion asSentence Germ+cell+nuclear+factor+acts+as+a+repressor+of+basal+transcription+on+both+the+Protamine+1+and+Protamine+2+promoters. assertion.
- assertion asSentence Prion+and+doppel+proteins+bind+to+granule+cells+of+the+cerebellum. assertion.
- assertion asSentence A+mouse+PrP+with+two+point+mutations+that+subtly+affect+the+structure+of+its+globular+domain%2C+causes+a+fully+penetrant+lethal+spongiform+encephalopathy+with+cerebral+PrP+plaques. assertion.
- assertion asSentence Deletion+of+PrP%28C%29+expression+dissociates+Abeta+accumulation+from+behavioral+impairment+in+these+AD+mice%2C+with+the+cognitive+deficits+selectively+requiring+PrP%28C%29. assertion.
- assertion asSentence A+calpain-like+activity+mediates+normal+processing+of+PrPC+in+N2a+neuroblastoma+cells. assertion.
- assertion asSentence Proteasomal+dysfunction+and+endoplasmic+reticulum+stress+enhance+trafficking+of+prion+protein+aggregates+through+the+secretory+pathway+and+increase+accumulation+of+pathologic+prion+protein. assertion.
- assertion asSentence Segment+100+to+104+regulates+conversion+of+PrP%28C%29+to+PrP%28Sc%29+in+prion-infected+neuroblastoma+cells. assertion.
- assertion asSentence A+description+of+how+PrP%28c%29+influences+oligodendrocyte+proliferation+in+the+developing+and+adult+central+nervous+system. assertion.
- assertion asSentence Oxidation+of+PrP+destabilizes+the+native+fold+of+PrP%28C%29%2C+facilitating+the+transition+to+PrP%28Sc%29. assertion.
- assertion asSentence An+important+role+for+the+aPC%2FEPCR+pathway+in+reducing+metastasis+via+inhibition+of+tumor+cell+adhesion+and+transmigration. assertion.
- assertion asSentence An+important+role+for+the+aPC%2FEPCR+pathway+in+reducing+metastasis+via+inhibition+of+tumor+cell+adhesion+and+transmigration. assertion.
- assertion asSentence EPCR+interacts+with+the+ternary+TF+coagulation+initiation+complex+to+enable+PAR1%2C2+signaling. assertion.
- assertion asSentence The+microenvironment+of+the+inflamed+fibrotic+lung+impairs+the+regenerative+capacity+of+bone+marrow-derived+prominin-1%2B+progenitor+cells+and+promotes+their+differentiation+into+pathogenic+phenotypes. assertion.
- assertion asSentence Several+components+of+the+main+GH-signaling+pathways+exhibit+enhanced+sensitivity+to+the+hormone+in+liver+and+muscle+of+Ames+dwarf+mice. assertion.
- assertion asSentence In+the+adult+mouse+hindbrain%2C+peripherin+is+expressed+in+discrete+neuronal+subpopulations+that+have+sensory%2C+motor+and+autonomic+functions. assertion.
- assertion asSentence Murine+and+human+proteinase+3+complexes+have+different+interaction+patterns+with+peptidic+substrates. assertion.
- assertion asSentence UGT1+aids+in+the+folding+of+sequential+domain-containing+proteins+such+as+prosaposin. assertion.
- assertion asSentence PS1+and+PS2+affect+caveolin+1+trafficking+in+an+indirect+manner+and+are+required+for+caveolae+formation+by+controlling+transport+of+intracellular+caveolin+1+to+the+plasma+membrane. assertion.
- assertion asSentence PS1+functions+at+multiple+levels+to+regulate+and+stabilize+intracellular+Ca%282%2B%29+levels+that+ultimately+control+neuronal+firing+behavior+and+influence+synaptic+transmission. assertion.
- assertion asSentence Met+is+processed+in+epithelial+cells+by+presenilin-dependent+regulated+intramembrane+proteolysis+%28PS-RIP%29+independently+of+ligand+stimulation. assertion.
- assertion asSentence Endogenous+wild-type+presenilin-1+is+necessary+for+proper+protein+degradation+through+the+autophagosome-lysosome+system+by+functioning+at+the+lysosomal+level. assertion.
- assertion asSentence 4-O-Methylhonokiol+attenuates+memory+impairment+in+presenilin+2+mutant+mice+. assertion.
- assertion asSentence Endogenous+wild-type+presenilin+2+is+necessary+for+proper+protein+degradation+through+the+autophagosome-lysosome+system+by+functioning+at+the+lysosomal+level. assertion.
- assertion asSentence Presenilin+2+has+the+ability+to+regulate+nectin-1+processing. assertion.
- assertion asSentence Nrf2-dependent+induction+of+proteasome+and+Pa28alphabeta+regulator+are+required+for+adaptation+to+oxidative+stress. assertion.
- assertion asSentence REGgamma+regulates+cellular+distribution+of+p53+by+facilitating+its+multiple+monoubiquitylation+and+nuclear+export. assertion.
- assertion asSentence PAFR+mediates+early+impairment+of+neutrophil+migration+toward+the+infectious+focus+during+lethal+sepsis+caused+by+cecum+ligation+and+puncture+in+mice. assertion.
- assertion asSentence PAFr+shepherds+phosphorylcholine-containing+bacterial+components+such+as+the+cell+wall+into+host+cells+from+where+the+response+ranges+from+quiescence+to+severe+pathophysiology. assertion.
- assertion asSentence Deficiency+of+platelet-activating+factor+receptor+greatly+diminishes+acute+lung+inflammation+induced+by+bacterial+lipoteichoic+acid+in+vivo. assertion.
- assertion asSentence PAFR+is+a+disease-associated+gene+and+plays+an+important+role+in+driving+neutrophil+influx+and+lung+damage+after+infection+of+mice+with+two+subtypes+of+Influenza+A. assertion.
- assertion asSentence PAFR+on+donor+leukocytes+plays+a+critical+role+in+GVHD+by+mediating+leukocyte+influx+and+cytokine+production+in+target+tissues. assertion.
- assertion asSentence Cell+cycle+regulators+are+the+predominant+functional+gene+class+altered+in+medulloblastoma+of+Ptch1+mutants. assertion.
- assertion asSentence Opposite+modifying+effects+of+HR+and+NHEJ+deficiency+on+cancer+risk+in+Ptc1+heterozygous+mouse+cerebellum. assertion.
- assertion asSentence The+cytoplasmic+tail+of+pTalpha+plays+a+critical+role+in+T+lymphocyte+development. assertion.
- assertion asSentence Loss+of+function+of+Nkx3.1+and+Pten+cooperate+in+prostate+carcinogenesis+in+mice. assertion.
- assertion asSentence Pten+is+an+important+regulator+of+stromal+cell-derived+factor-1-directed+chemotaxis+in+B+lymphocytes. assertion.
- assertion asSentence PTEN+can+partially+inhibit+the+Wnt-1-induced+mammary+tumorigenesis+in+early+neoplastic+stages+by+blocking+the+AKT+pathway+and+by+reducing+the+IGF-I+receptor+levels+in+mammary+gland. assertion.
- assertion asSentence p18Ink4c+and+Pten+cooperate+in+tumor+suppression+by+constraining+a+positive+regulatory+loop+between+cell+growth+and+cell+cycle+control+pathways. assertion.
- assertion asSentence Conditional+deletion+of+Pten+causes+bronchiolar+hyperplasia. assertion.
- assertion asSentence %28PTEN%29+tumor+suppressor+gene+as+a+target+of+MAD1. assertion.
- assertion asSentence Pten+inactivation+cooperated+with+oncogenic+K-ras+in+promoting+lung+tumorigenesis. assertion.
- assertion asSentence PTEN+is+a+critical+regulator+in+the+follicular+thyroid+cancer+progression+and+invasiveness. assertion.
- assertion asSentence Loss+of+PTEN+increases+the+side+population+phenotype+in+glioma+cells. assertion.
- assertion asSentence XIAP+acts+as+an+E3+ubiquitin+ligase+for+PTEN+and+promotes+Akt+activity+by+regulating+PTEN+content+and+compartmentalization. assertion.
- assertion asSentence Myosin+Type+V+controls+Pten+function+and+neuronal+cell+size. assertion.
- assertion asSentence Pten+overexpression+slows+enteric+nervous+system+precursor+migration. assertion.
- assertion asSentence Myeloid+cell-associated+PTEN-deficient+mice+display+less+severe+signs+of+decreased+tissue+injury+and+improved+survival+during+pneumococcal+pneumonia. assertion.
- assertion asSentence PTEN+is+dispensable+in+mouse+spermatogenesis. assertion.
- assertion asSentence PTEN+associates+with+MTF-1+in+cells+in+response+to+oxidative+stress+and+in+zinc+homeostasis. assertion.
- assertion asSentence Hydrogen+sulfide+and+L-cysteine+increase+phosphatidylinositol+3%2C4%2C5-trisphosphate+and+glucose+utilization+by+inhibiting+PTEN+protein+and+activating+PI3K%2CAKT%2C+PKCzeta%2Flambda+in+3T3l1+adipocytes. assertion.
- assertion asSentence Synaptic+inputs+from+both+the+contralateral+auditory+cortex+and+from+the+thalamus+onto+PTEN-deficient+neurons+is+enhanced+compared+with+nearby+neurons+with+normal+PTEN+expression. assertion.
- assertion asSentence L-PGDS+is+an+important+mediator+of+muscle+and+adipose+glucose+transport+which+is+modulated+by+glycemic+conditions+and+plays+a+significant+role+in+the+glucose+intolerance+associated+with+type+2+diabetes. assertion.
- assertion asSentence PGE2+is+involved+in+many+normal+and+pathological+pathways+that+are+mediated+by+four+different+E+prostanoid+receptors+%28EP1-4%29. assertion.
- assertion asSentence Unlike+the+PGE%282%29+receptors+EP2+and+EP4%2C+the+EP1+receptor+is+a+negative+regulator+that+acts+at+multiple+stages+of+the+bone+fracture+healing+process. assertion.
- assertion asSentence Together+this+supports+a+mechanism+by+which+maturation+and+increased+contractility+of+the+vessel+is+coupled+to+the+potent+smooth+muscle+dilatory+actions+of+PGE%282%29. assertion.
- assertion asSentence Potentiation+of+antigen-stimulated+degranulation+and+IL-6+cytokine+production+by+PGE2+in+bone+marrow-derived+mast+cells+is+dependent+on+the+EP3+receptor. assertion.
- assertion asSentence EP4+maintains+intestinal+homeostasis+by+keeping+mucosal+integrity+and+downregulating+immune+response. assertion.
- assertion asSentence Combined+effects+of+EP%281%29+and+EP%284%29+antagonists+on+spontaneous+polyp+formation+in+APC+knockout+mice. assertion.
- assertion asSentence PGE%282%29+inhibits+a+crucial+step+of+the+adipocyte+differentiation+process+by+acting+on+the+EP4+receptor+in+3T3-L1+cells. assertion.
- assertion asSentence EP4+receptor+mediates+the+suppressive+action+of+PGE%282%29+in+3T3-L1+adipocyte+differentiation. assertion.
- assertion asSentence An+endogenous+PGE%282%29-EP%284%29+system+in+the+tubular+epithelium+limits+the+development+of+tubulointerstitial+fibrosis+by+suppressing+inflammatory+responses. assertion.
- assertion asSentence The+prostacyclin%2FIP+pathway+suppresses+cardiac+fibrosis%2C+at+least+partly%2C+by+inducing+CREB+phosphorylation. assertion.
- assertion asSentence Endothelial+PGI+synthase-mediated+prostacyclin+contributes+to+renal+protection+against+endotoxemia-related+acute+kidney+injury. assertion.
- assertion asSentence Demonstrate+for+the+first+time+the+involvement+of+COX-1+pathway+in+A%283%29AR-mediated+contraction+via+endothelium. assertion.
- assertion asSentence Constitutive+loss+of+Cox-1+leaves+the+gastric+mucosa+more+prone+to+damage+and+slowed+repair+of+microlesions. assertion.
- assertion asSentence Niacin+evoked+platelet+COX-1-derived+PGD+biosynthesis. assertion.
- assertion asSentence Expression+of+cyclooxygenase-2+in+intestinal+goblet+cells+of+pre-diabetic+NOD+mice. assertion.
- assertion asSentence Opposite+effects+of+cyclooxygenase-1+and+-2+activity+on+the+pressor+response+to+angiotensin+II. assertion.
- assertion asSentence There+is+a+requirement+for+the+Rho+family+of+G+proteins+for+p38+MAPK+phosphorylation+and+PGHS-2+mRNA+synthesis. assertion.
- assertion asSentence COX-2-derived+prostaglandins+contribute+to+the+onset+of+parturition+after+the+decrease+in+serum+progesterone+level. assertion.
- assertion asSentence Two+competing+oxidative+enzymes+in+arachidonate+metabolism%2C+LOX+and+COX%2C+differentially+regulate+sequential+aspects+of+fibroblast+wound+closure+in+vitro. assertion.
- assertion asSentence COX-2%2C+with+a+consequent+increase+in+peroxides+and+DNA+damage%2C+contributes+to+the+dominant+oncogenicity+of+mutant+K-ras. assertion.
- assertion asSentence COX2+pathway+is+critical+for+myoblast+proliferation+in+response+to+stretch. assertion.
- assertion asSentence COX-2+functions+as+a+cellular+factor+which+induces+superoxide-mediated+cell+death+in+primary+cortical+neurons. assertion.
- assertion asSentence Intestinal+epithelial+cell+lines+up-regulated+Cox-2+expression+in+a+TLR4-+and+MyD88-dependent+fashion. assertion.
- assertion asSentence Oxidative+stress+induces+COX-2+expression+through+the+production+of+4-Hhydroxynonenal+which+activates+p38MAPKinase. assertion.
- assertion asSentence The+NF-kappaB-inducing+kinase+%28NIK%29+regulates+COX-2+gene+expression+in+macrophages+through+inducible+phosphorylation+of+PU.1. assertion.
- assertion asSentence Ox-LDL-induced+increase+in+15d-PGJ%282%29+level+through+ERK1%2F2-dependent+COX-2+expression+is+one+of+the+mechanisms+of+PPARalpha+and+PPARgamma+activation+in+macrophages. assertion.
- assertion asSentence Calcineurin-dependent+expression+of+Cox-2+is+induced+by+physiological+calcium+mobilizing+agents. assertion.
- assertion asSentence Isoliquiritigenin+inhibits+LPS-induced+iNOS+and+COX-2+expression+via+the+attenuation+of+NF-kappaB+in+RAW+264.7+macrophages. assertion.
- assertion asSentence Foxm1+protein-induced+Cox-2+promoter+activity+and+directly+bound+to+the+-2566%2F-2580+bp+region+of+human+Cox-2+promoter. assertion.
- assertion asSentence COX2+derived+both+PGE2+and+PGI2+mediate+its+function+via+EP2+and+PPARdelta+receptors+in+early+steps+of+decidualization+in+mice. assertion.
- assertion asSentence Differential+expression+of+prohibitin+and+regulation+of+apoptosis+in+wild-type+and+COX-2+null+mouse+embryonic+fibroblasts. assertion.
- assertion asSentence Transgenic+expression+of+cyclooxygenase-2+in+hepatocytes+accelerates+endotoxin-induced+acute+liver+failure. assertion.
- assertion asSentence M.+bovis+BCG+triggers+up-regulation+of+COX-2+expression+in+macrophages. assertion.