Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence COX-2-dependent+production+of+8-iso-PGF2alpha%2C+by+activating+TP+receptors%2C+participates+in+hypoxia-induced+hyperreactivity+of+pulmonary+arteries. assertion.
- assertion asSentence COX-2+can+be+degraded+via+the+endoplasmic+reticulum-associated+and+substrate-dependent+pathway. assertion.
- assertion asSentence COX-2+is+more+preferentially+involved+in+the+generation+of+endogenous+anti-adipogenic+prostanoids+during+the+maturation+phase+of+adipocytes. assertion.
- assertion asSentence Absence+of+COX-2+increased+sensitivity+to+PTH. assertion.
- assertion asSentence Parp-1+can+bind+to+the+inhibitory+element+-655%2F-632+in+the+promoter+region+of+mouse+Cyclooxygenase-2+both+in+vitro+and+in+vivo. assertion.
- assertion asSentence 4-Nonylphenol+induced+COX-2+protein+and+gene+expression+in+murine+macrophage+RAW264.7+cells. assertion.
- assertion asSentence The+development+of+chronic+pancreatitis+does+not+depend+considerably+on+COX-2. assertion.
- assertion asSentence The+structural+basis+of+endocannabinoid+oxygenation+by+cyclooxygenase-2. assertion.
- assertion asSentence MyD88+and+Cox-2+signaling+play+roles+in+intestinal+fibrosis+during+Salmonella-induced+enterocolitis. assertion.
- assertion asSentence Periostin+is+a+PTH+regulated+extracellular+matrix+protein%2C+partly+co-localizing+with+collagen+1a1. assertion.
- assertion asSentence PTH+is+able+to+modulate+the+anomalies+of+Fgf23+knockout+mice+by+controlling+serum+1%2C25%28OH%292D+and+calcium+levels. assertion.
- assertion asSentence Disturbed+tooth+development+in+parathyroid+hormone-related+protein+%28PTHrP%29-gene+knockout+mice. assertion.
- assertion asSentence PTHrP+and+Indian+hedgehog+control+differentiation+of+growth+plate+chondrocytes+at+multiple+steps. assertion.
- assertion asSentence Both+Indian+hedgehog+%28IHH%29+and+parathyroid+hormone-related+protein+%28PTHrP%2C+PTHLH%29+negatively+regulate+the+transition+from+preosteoblastic+progenitors+to+osteoblasts. assertion.
- assertion asSentence Upregulation+of+PTH%2FPTHrP+receptor+mRNA+expression+in+the+developing+growth+plate. assertion.
- assertion asSentence Ihh+has+both+PTHrP-dependent+and+-independent+functions+during+postnatal+endochondral+bone+development. assertion.
- assertion asSentence PYK2+is+closely+involved+in+receptor-+or+ischemia-activated+signaling+events+which+modulate+endothelial+nitrix+oxide+synthase-mediated+vasodilation+and+angiogenesis. assertion.
- assertion asSentence PTP-PEST+controls+Pyk2+activity+and+is+a+positive+regulator+of+secondary+T+cell+activation. assertion.
- assertion asSentence Nonreceptor+tyrosine+kinase+Pyk2+has+an+important+role+in+the+integrin-mediated+activation+of+neutrophils+that+contributes+to+normal+degranulation+responses+required+for+efficient+host+defense+to+Staphylococcus+aureus+infection. assertion.
- assertion asSentence Compensatory+function+of+Pyk2+protein+in+the+promotion+of+focal+adhesion+kinase+%28FAK%29-null+mammary+cancer+stem+cell+tumorigenicity+and+metastatic+activity. assertion.
- assertion asSentence Ptn-deficient+mice+do+not+display+detectable+defects+in+endochondral+and+intramembranous+ossification+and+intramembranous+ossification+or+bone+remodeling. assertion.
- assertion asSentence Pleiotrophin+is+secreted+from+fibroblasts+and+has+an+antiapoptotic+effect+in+these+cells+and+in+embryonic+stem+cells. assertion.
- assertion asSentence Attenuation+of+leptin+action+and+regulation+of+obesity+by+protein+tyrosine+phosphatase+1B. assertion.
- assertion asSentence PTP1B+is+a+modulator+of+brown+fat+adipogenesis+and+adipocyte+differentiation+requires+regulated+expression+of+PTP1B. assertion.
- assertion asSentence Adipocyte-specific+PTP1B+deletion+does+not+beneficially+manipulate+signaling+pathways+regulating+glucose+homeostasis%2C+lipid+metabolism+or+adipokine+secretion+in+adipocytes. assertion.
- assertion asSentence Role+of+SHP-2+in+fibroblast+growth+factor+receptor-mediated+suppression+of+myogenesis+in+C2C12+myoblasts. assertion.
- assertion asSentence SHP-2+transduces+extracellular+matrix+stimuli+to+intracellular+signaling+pathways+to+promote+skeletal+muscle+growth. assertion.
- assertion asSentence Shp2+is+a+common+signal+transducer+for+pre-TCR+and+TCR+in+promoting+T+cell+maturation+and+proliferation. assertion.
- assertion asSentence SIRPalpha+and+PZR+serve+as+scaffolds+that+facilitate+plasma+membrane+recruitment+and+signaling+of+NS-associated+SHP-2+mutants. assertion.
- assertion asSentence Leukemogenic+Ptpn11+causes+fatal+myeloproliferative+disorder+via+cell-autonomous+effects+on+multiple+stages+of+hematopoiesis. assertion.
- assertion asSentence Shp2+acts+as+a+signal+coordinator+in+beta-cells%2C+orchestrating+multiple+pathways+controlling+insulin+biosynthesis+to+maintain+glucose+homeostasis. assertion.
- assertion asSentence SHP2+is+a+positive+effector+of+Fc%28epsilon%29RI-induced+activation+of+Fyn%2FGrb2-associated+binder+2%2FAkt+and+Ras%2FErk+pathways+leading+to+TNF-alpha+release+from+mast+cells. assertion.
- assertion asSentence Protein-tyrosine+phosphatase+SHP2+contributes+to+GDNF+neurotrophic+activity+through+direct+binding+to+phospho-Tyr687+in+the+RET+receptor+tyrosine+kinase. assertion.
- assertion asSentence Loss+of+Ptpn11+in+murine+hematopoietic+cells+leads+to+bone+marrow+aplasia+and+lethality. assertion.
- assertion asSentence Shp2+acts+to+mediate+expression+of+thyroid+transcription+factor+1+%28TTF1%29+and+ATP-binding+cassette+subfamily+A+member+3+%28ABCA3%29+in+type+II+alveolar+epithelial+cells. assertion.
- assertion asSentence PTP-PEST+plays+an+essential+function+in+early+embryogenesis. assertion.
- assertion asSentence PTP-PEST+actively+contributes+to+the+cellular+apoptotic+response+and+reveal+the+importance+of+caspases+as+regulators+of+PTPs+in+apoptosis. assertion.
- assertion asSentence MKP-1+plays+an+essential+role+in+adipocyte+differentiation+through+down-regulation+of+p42%2Fp44+MAPK+activity. assertion.
- assertion asSentence NH%282%29+terminus+of+MKP-1+plays+roles+in+nuclear+targeting+and+transcriptional+regulation. assertion.
- assertion asSentence Anandamide-induced+rapid+MKP-1+expression+switches+off+MAPK+signal+transduction+in+microglial+cells+activated+by+stimulation+of+pattern+recognition+receptors. assertion.
- assertion asSentence DUSP1+mRNA+and+protein+levels+are+lower+in+Mat1a+knockout+livers+and+fall+rapidly+in+cultured+hepatocytes. assertion.
- assertion asSentence Generation+of+ROS+by+Nox4+mediates+TGF-beta1-induced+PAI-1+gene+expression+at+least+in+part+through+oxidative+modification+and+inhibition+of+MKP-1+leading+to+a+sustained+activation+of+JNK+and+p38+MAPKs. assertion.
- assertion asSentence miR-101+regulates+the+innate+immune+responses+of+macrophages+to+LPS+through+targeting+MKP-1. assertion.
- assertion asSentence MKP-1+knockout+does+not+prevent+glucocorticoid-induced+bone+disease+in+mice. assertion.
- assertion asSentence GR+dimerization+inhibits+JNK2+through+MKP1+and+protects+from+TNF-induced+apoptosis+and+lethal+inflammation. assertion.
- assertion asSentence Integrin+alpha%281%29beta%281%29+functions+as+a+negative+regulator+of+epidermal+growth+factor+receptor+%28EGFR%29+signalling+through+the+activation+of+a+protein+tyrosine+phosphatase. assertion.
- assertion asSentence High+fat+fed+Ptpn2%2B%2F-+mice+exhibit+lower+fasted+blood+glucose+and+decreased+hepatic+glucose+output. assertion.
- assertion asSentence STEP+increases+the+sensitivity+of+neurons+to+status+epilepticus-induced+excitotoxicity+by+specifically+blocking+a+latent+neuroprotective+response+initiated+by+the+mitogen-activated+protein+kinase+pathway. assertion.
- assertion asSentence The+size+of+the+T+cell+zone+and+number+of+resident+CD4-positive+T+cells+in+the+spleen+are+markedly+reduced+in+the+spleen+of+SIRPalpha+mutant+mice. assertion.
- assertion asSentence SIRPalpha+demonstrates+an+indispensable+role+for+protective+immunity+in+Salmonella+infection. assertion.
- assertion asSentence BCR+ligation+of+Cd45-%2F-+B+cells+failed+to+activate+phosphatidylinositol-3-OH+kinase%2C+NF-kappaB%2C+Erk1+or+Erk2+kinases+or+to+upregulate+cell+survival+proteins+and+instead+induced+apoptosis. assertion.
- assertion asSentence In+a+natural+killer+cell+subset%2C+B200+cells+depended+primarily+on+interleukin+15+and+common+cytokine+receptor+gamma+chain+signaling+for+their+development. assertion.
- assertion asSentence The+endogenous+GOAT-ghrelin-growth+hormone+secretagogue+receptor+system+is+not+essential+for+the+maintenance+of+euglycemia+during+prolonged+calorie+restriction. assertion.
- assertion asSentence Calsarcin-2+skeletal+muscle+specific+protein+deficiency+increases+execrcise+capacity+in+mice+through+calcineurin%2FNFAT+activation. assertion.
- assertion asSentence FGF23+transgenic+mice+display+differentially+expressed+transcript+levels+of+several+genes+%28Npt2a%2C+Pdzk1%2C+Atp1a2%29+essential+in+renal+Pi+regulation. assertion.
- assertion asSentence EDF-1+is+required+for+PPARgamma+transcriptional+activation+during+preadipocyte+differentiation. assertion.
- assertion asSentence Mule+regulates+the+ATM-p53+axis+to+maintain+B+cell+homeostasis+under+both+steady-state+and+stress+conditions. assertion.
- assertion asSentence Histone+H3+arginine+methylation+by+CARM1+in+ES+cells+allows+epigenetic+modulation+of+pluripotency. assertion.
- assertion asSentence Phosphorylation+at+Ser%28217%29+serves+as+a+molecular+switch+for+controlling+CARM1+enzymatic+activity+during+the+cell+cycle. assertion.
- assertion asSentence Dact1+regulates+adipogenesis+through+coordinated+effects+on+gene+expression+that+selectively+alter+intracellular+and+paracrine%2Fautocrine+components+of+the+Wnt%2Fbeta-catenin+signaling+pathway. assertion.
- assertion asSentence Stk25+is+a+genetic+modifier+of+Tau+phosphorylation+in+Dab1-mutant+mice. assertion.
- assertion asSentence EVC+and+LBN+protein+colocalize+at+the+tip+of+the+primary+atrial+septum+during+murine+cardiac+development. assertion.
- assertion asSentence Skeletal+muscle+JP1%2F2+damage+is+significantly+associated+with+early+%280-3+days%29+strength+deficits+after+performance+of+eccentric+contractions. assertion.
- assertion asSentence Single+residues+in+a+gamma-secretase+component+besides+presenilin+are+able+to+differentially+affect+amyloid+precursor+protein+and+Notch+processing. assertion.
- assertion asSentence The+chemokine+receptor+D6+limits+the+inflammatory+response+in+vivo. assertion.
- assertion asSentence Chemokine+decoy+receptor+D6+limits+CC-chemokine-dependent+pathogenic+inflammation+and+is+required+for+adequate+cardiac+remodeling+after+myocardial+infarction. assertion.
- assertion asSentence A33+antigen-deficient+mice+have+defective+colonic+mucosal+repair. assertion.
- assertion asSentence Claudin-15+knockout+leads+to+Na%28%2B%29+deficiency+and+glucose+malabsorption+in+the+mouse+adult+small+intestine. assertion.
- assertion asSentence Toxoplasma+gondii+ROP5+binding+alters+the+conformation+of+the+Irga6+active+site. assertion.
- assertion asSentence Breast+adenocarcinoma+cells+genetically+modified+with+the+IL-21+gene+induce+strong+immune+rejection+responses+and+specific+immunity+in+syngeneic+mice. assertion.
- assertion asSentence IL-21+achieves+its+stimulatory+effect+by+inducing+the+development+of+mature+natural+killer+%28NK%29+cells+into+a+large+granular+lymphocyte+phenotype+with+heightened+effector+function. assertion.
- assertion asSentence A+previously+unappreciated+role+for+T+follicular+helper+cells+in+the+formation+of+the+germinal+center+and+isotype+switching+through+a+CD4%28%2B%29+T+cell-intrinsic+requirement+for+IL-21. assertion.
- assertion asSentence IL-21+acts+directly+on+B+cells+and+is+crucially+required+for+virus-like+particle-specific+immunoglobulin+G+%28IgG%29+responses. assertion.
- assertion asSentence IL-21+signaling+is+essential+for+follicular+T+helper-like+cell-mediated+IgG+production+and+concomitant+IL-21-dependent+IgG+responses. assertion.
- assertion asSentence The+PD-1%3APD-L1+pathway+down-regulates+alloreactive+CD4+T+cells+during+cardiac+allograft+rejection%2C+particularly+in+the+absence+of+CD28+costimulation. assertion.
- assertion asSentence PD-L1+interacts+with+programmed+cell+death+1+%28PD-1%29+protein+to+form+part+of+a+common+pathway+to+selectively+maintain+tolerance+within+the+target+tissues. assertion.
- assertion asSentence PD-1%2FPD-L+pathway+has+an+important+role+in+downregulating+proatherogenic+T+cell+response+and+atherosclerosis+by+limiting+APC-dependent+T+cell+activation. assertion.
- assertion asSentence PPAR+gamma-induced+CD8-positive+T+cell+tolerance+is+mediated+by+the+combined+action+of+increased+cross-presentation+and+enhanced+signaling+via+the+coinhibitory+molecule+B7H1. assertion.
- assertion asSentence B7-H1%2FCD80+interaction+is+required+for+the+induction+and+maintenance+of+peripheral+T-cell+tolerance. assertion.
- assertion asSentence Essential+role+of+B7-H1+in+double-stranded+RNA-induced+augmentation+of+an+asthma+phenotype+in+mice. assertion.
- assertion asSentence High+PDL1+expression+in+nonhematopoietic+donor+cells+is+associated+with+acquired+intolerance+to+vascularized+cardiac+allografts. assertion.
- assertion asSentence Graft+tissue+expression+of+B7-H1+plays+a+critical+role+in+regulating+inflammatory+responses+during+liver+transplantation-induced+hepatic+ischemia%2Freperfusion+injury. assertion.
- assertion asSentence Upregulation+of+B7-H1+on+primed+T+cells+helps+effector+T+cells+survive+the+contraction+phase+and+consequently+generate+optimal+protective+immunity. assertion.
- assertion asSentence PD-L1+delivers+an+immunoinhibitory+signal%2C+suppressing+T+cell+activation. assertion.
- assertion asSentence Hematopoietic+stem+cells+of+Fancg-%2F-+mice+Impaired+functionality+and+homing. assertion.
- assertion asSentence The+different+genetic+defects+in+Actn4+produce+a+spectrum+of+glomerular+morphologic+lesions+depending+on+the+specific+combination+of+normal+and%2For+defective+alleles. assertion.
- assertion asSentence Auditory+function+declined+over+several+weeks+in+Kcnq4-%2F-+mice+and+over+several+months+in+mice+carrying+the+dominant+negative+allele. assertion.
- assertion asSentence K%28v%297.4+and+K%28v%297.5+are+expressed+in+different+regions+of+the+murine+gastrointestinal+tract+and+blockers+of+K%28v%297+channels+augment+inherent+contractile+activity. assertion.
- assertion asSentence CMO1+is+the+key+enzyme+for+vitamin+A+production+in+mice+and+alters+lipid+metabolism. assertion.
- assertion asSentence The+role+of+conserved+catalytic+site+aromatic+residues+in+the+catalytic+mechanism+of+BCMO1+is+consistent+with+the+formation+of+a+substrate+carbocation+intermediate+and+cation-pi+stabilization. assertion.
- assertion asSentence In+Bcmo1-deficient+mice%2C+Fzd6+AND+Cthrc1+genes+are+upregulated. assertion.
- assertion asSentence TRPV3+and+TRPV4+are+ion+channels+activated+by+modest+increases+in+ambient+temperature. assertion.
- assertion asSentence TRPV4+is+required+for+normal+thermal+responsiveness+in+vivo. assertion.
- assertion asSentence TRPV4+is+required+for+PAR%282%29-induced+mechanical+hyperalgesia+and+excitation+of+colonic+afferent+neurons. assertion.
- assertion asSentence Cables+is+a+relevant+target+of+the+chromosome+18q+deletions+frequently+seen+in+human+colorectal+cancer. assertion.
- assertion asSentence Coordinated+regulation+of+fat-specific+and+liver-specific+glycerol+channels%2C+aquaporin+adipose+and+aquaporin+9. assertion.
- assertion asSentence Aquaporin-9+protein+is+the+primary+route+of+hepatocyte+glycerol+uptake+for+glycerol+gluconeogenesis+in+mice. assertion.
- assertion asSentence The+Nesprin-1+is+essential+for+the+interaction+with+a+C-terminal+region+in+SUN1+protein. assertion.
- assertion asSentence The+KASH-domain-containing+proteins+Syne-1+and+Syne-2+play+crucial+roles+in+anchoring+both+synaptic+and+non-synaptic+myonuclei+that+are+important+for+proper+motor+neuron+innervation+and+respiration. assertion.
- assertion asSentence NG+is+expressed+by+principal+cells+in+different+neocortical+layers+and+in+the+hippocampus+by+granule+cells+of+the+dentate+gyrus+and+pyramidal+neurons+of+CA1-CA3. assertion.