Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence SV2+action+modulates+synaptic+networks+by+ensuring+that+low-frequency+neurotransmission+is+faithfully+conveyed. assertion.
- assertion asSentence Perp+is+a+key+effector+in+the+p63+developmental+program. assertion.
- assertion asSentence Perp+is+requered+throughout+adult+life+for+proper+epithelial+homeostasis+and+function. assertion.
- assertion asSentence SMOC-2+contributes+to+cell+cycle+progression+by+maintaining+ILK+activity+during+G1. assertion.
- assertion asSentence The+expression+domains+of+ChM-I+and+TeM+during+vertebrate+development+incorporate+the+typical+avascular+regions+of+the+mesenchymal+tissues. assertion.
- assertion asSentence Endogenous+RalB+plays+a+negative+role+in+the+ingestion+process+of+Fc+gamma+receptor-mediated+macrophage+phagocytosis. assertion.
- assertion asSentence An+intimate+association+between+MLL+and+RNA+pol+II+occurs+at+MLL+target+genes+in+vivo+that+is+required+for+normal+initiation+and%2For+transcriptional+elongation. assertion.
- assertion asSentence Loss+of+synaptic+vesicle+glycoprotein+2b+is+associated+with+inhibition+of+tetanus+neurotoxin+into+central+neurons. assertion.
- assertion asSentence A+different+functional+role+for+the+TRPV6-ankyrin+repeat+domain+than+in+the+paralogous+thermosensitive+TRPV1+channel. assertion.
- assertion asSentence Genetic+elimination+of+neuroglobin+evokes+an+increased+behavioural+response+to+light+concomitant+with+increased+Per1+gene+expression+in+the+suprachiasmatic+nucleus. assertion.
- assertion asSentence mPGES-1+expression+is+required+for+bleomycin-induced+skin+fibrogenesis. assertion.
- assertion asSentence SIRT2+suppresses+adipogenesis+by+deacetylating+FOXO1+to+promote+FOXO1%27s+binding+to+PPARgamma+and+subsequent+repression+on+PPARgamma+transcriptional+activity. assertion.
- assertion asSentence SIRT2+is+a+tumor+suppressor+through+its+role+in+regulating+mitosis+and+genome+integrity. assertion.
- assertion asSentence Calorie+restriction+reduces+oxidative+stress+by+SIRT3-mediated+SOD2+activation. assertion.
- assertion asSentence Regulation+of+the+mPTP+by+SIRT3-mediated+deacetylation+of+CypD+at+lysine+166+suppresses+age-related+cardiac+hypertrophy. assertion.
- assertion asSentence Mitochondrial+deacetylase+SIRT3%28-%2F-%29+mice+are+protected+from+acetaminophen+hepatotoxicity%2C+that+mitochondrial+aldehyde+dehydrogenase+2+is+a+direct+SIRT3+substrate. assertion.
- assertion asSentence Inpp5e+mutations+cause+primary+cilium+signaling+defects%2C+ciliary+instability+and+ciliopathies+in+the+mouse. assertion.
- assertion asSentence Osteoblastic+bone+formation+is+a+potent+modulator+of+FGF23+production+and+release+into+the+circulation. assertion.
- assertion asSentence FGF-23%2FKlotho+signaling+is+not+essential+for+the+phosphaturic+and+anabolic+functions+of+PTH. assertion.
- assertion asSentence Drmkn+and+Krtdap+are+the+highest+differentially+expressed+genes+in+epidermis+embryonic+development+in+mice. assertion.
- assertion asSentence TSC1+heterozygotes+%28mice%29develop+kidney+cystadenomas+and+liver+hemangiomas+at+high+frequency%2C+with+the+latter+more+common%2C+more+severe+and+lethal+in+females+than+in+males. assertion.
- assertion asSentence Loss+of+Tsc1%2FTsc2+activates+mTOR+and+disrupts+PI3K-Akt+signaling+through+downregulation+of+PDGFR. assertion.
- assertion asSentence Phosphorylation+of+S6K1+is+controlled+by+the+Tsc1-Tsc2+complex. assertion.
- assertion asSentence DAP3+is+critical+for+TCR-mediated+induction+of+apoptosis+at+the+downstream+of+Nur77. assertion.
- assertion asSentence Wnt%2Fbeta-catenin%2FTCF7L2+pathway+is+preferentially+able+to+alter+the+transcriptional+regulation+of+the+TGF-beta-target+gene%2C+TMEPAI. assertion.
- assertion asSentence Cellular+up-regulation+of+Nedd4+family+interacting+protein+1+%28Ndfip1%29+using+low+levels+of+bioactive+cobalt+complexes. assertion.
- assertion asSentence The+interaction+of+Asb-4+with+IRS4+in+cell+lines+mediates+the+degradation+of+IRS4+and+decreases+insulin+signaling. assertion.
- assertion asSentence Phosphorylation+of+KLC1+at+serine+460+modulates+binding+and+trafficking+of+calsyntenin-1. assertion.
- assertion asSentence Eplin-alpha+transcription+is+regulated+by+actin-MAL-SRF+signalling. assertion.
- assertion asSentence Junctate-1+in+the+heart+is+closely+linked+to+the+homeostasis+of+E-C+coupling+proteins+and+a+sustained+increase+of+junctate-1+expression+leads+to+a+severe+cardiac+remodeling+and+arrhythmias. assertion.
- assertion asSentence Specific+deletion+of+KLF4+led+to+IFITM3+overexpression+in+colon+mucosa+in+Villin-Cre%2B+%3BKlf4+fl%2Ffl+mice. assertion.
- assertion asSentence S-palmitoylation+and+ubiquitination+differentially+regulate+interferon-induced+transmembrane+protein+3+%28IFITM3%29-mediated+resistance+to+influenza+virus. assertion.
- assertion asSentence The+H%28%2B%29+vacuolar+ATPase+maintains+neural+stem+cells+in+the+developing+mouse+cortex. assertion.
- assertion asSentence BCCIP+and+its+anti-replication+stress+functions+are+essential+for+normal+neural+development+by+maintaining+an+orderly+proliferation+of+neural+progenitors. assertion.
- assertion asSentence Smad2+and+PEA3+regulate+RGC-32+transcription+which+is+essential+for+smooth+muscle+cell+differentiation+from+neural+crest+cells. assertion.
- assertion asSentence Consistent+with+the+phenotypes+of+loss+of+other+members+of+the+TIP60-p400+complex%2C+Dmap1%28-%2F-%29+mice+died+during+preimplantation+in+both+Dnmt1%28%2B%2F%2B%29+and+Dnmt1%28V%29%28%2F%29%28V%29+backgrounds. assertion.
- assertion asSentence The+mouse+Ca2%2B%2Fcalmodulin+kinase+II+inhibitor+alpha+%28CaMKIINalpha%29+gene+encodes+a+2.9kb+brain-specific+transcript+whose+expression+is+downregulated+in+mouse+brain+during+Japanese+encephalitis+virus+and+rabies+virus+infection. assertion.
- assertion asSentence Deficiency+of+the+transcriptional+regulator+Kruppel-like+factor+15+%28Klf15%29+in+mice+leads+to+both+heart+failure+and+aortic+aneurysm+and+Klf15+concentrations+are+markedly+reduced+in+failing+human+hearts+and+in+human+aortic+aneurysm+tissues. assertion.
- assertion asSentence Tumor+necrosis+factor+promotes+Runx2+degradation+through+up-regulation+of+Smurf1+and+Smurf2+in+osteoblasts. assertion.
- assertion asSentence E3+ubiquitin-protein+ligase+constitutive+photomorphogenesis+protein+1+is+needed+for+COP1+for+degradation+via+the+ubiquitin-proteasome+pathway. assertion.
- assertion asSentence SLN+overexpression+inhibits+SERCA2a+through+stabilization+of+SERCA2a-phospholamban+interaction+in+the+absence+of+PLN. assertion.
- assertion asSentence Pcp4l1+encodes+a+polypeptide+with+significant+sequence+similarity+to+the+Purkinje+cell+protein+4+gene+%28Pcp40%3Bit+is+expressed+during+mouse+development. assertion.
- assertion asSentence miR-484+attenuate+Fis1+and+mitochondrial+fission+by+binding+to+N-terminal+of+Fis1+and+inhibiting+its+translation. assertion.
- assertion asSentence Hepatic+Hamp2+expression+displays+considerable+strain-+and+sex-dependent+variation+in+mice. assertion.
- assertion asSentence XIAP-TAB1-TAK1+complex+is+dependent+on+NRAGE+for+IKK-alpha%2Fbeta+phosphorylation+and+NF-kappaB+activation. assertion.
- assertion asSentence O-GlcNAcylation+of+TAB1+is+required+for+full+TAK1+activation+upon+stimulation+with+IL-1%2Fosmotic+stress. assertion.
- assertion asSentence Antagonization+of+p193+and+p53+activity+relaxes+the+otherwise+stringent+regulation+of+cardiomyocyte+cell+cycle+reentry+in+the+injured+adult+heart. assertion.
- assertion asSentence Cul7+forms+a+heterodimeric+complex+with+Cul1+in+a+manner+dependent+on+Fbxw8. assertion.
- assertion asSentence Complex+synergistic+interactions+occur+between+Zfhx1+transcription+factor+genes+Sip1+and+delta+EF1+during+mouse+embryogenesis. assertion.
- assertion asSentence Lix1+knockout+mouse+does+not+exhibit+spinal+muscular+atrophy+phenotype. assertion.
- assertion asSentence Leucine-rich+repeat+motif+5+%28LRR5%29+of+PLAP-1%2Fasporin%2C+plays+an+important+role+in+the+PLAP-1%2Fasporin-BMP-2+interaction. assertion.
- assertion asSentence p62+localizes+to+the+endoplasmic+reticulum+%28ER%29-associated+autophagosome+formation+site+independently+of+LC3+localization+to+membranes. assertion.
- assertion asSentence GRAIL+in+the+liver+is+essential+for+maintenance+of+normal+glucose+and+lipid+metabolism+in+living+animals. assertion.
- assertion asSentence Endogenous+GRAIL+regulates+general+cell+cycle+and+proliferation+of+primary+naive+CD4+T+cells. assertion.
- assertion asSentence CIIA+functions+as+a+molecular+switch+for+the+GEF+activity+of+SOS1%2C+directing+this+activity+toward+Rac1. assertion.
- assertion asSentence Overexpression+of+morgana%2FCHP-1+in+NIH3T3+cells+leads+to+the+increased+stress+resistance+of+the+cells. assertion.
- assertion asSentence BAF180+is+critical+for+coronary+vessel+formation. assertion.
- assertion asSentence Mouse+Scotin+induces+apoptosis+and+developmental+defects+when+overexpressed+in+Drosophila. assertion.
- assertion asSentence Germ+cell+depletion+2+%28gcd2%29+is+a+chemically+induced+recessive+mutation+that+causes+infertility+in+male+and+female+mice. assertion.
- assertion asSentence Inhibition+of+beta-catenin+signaling+in+articular+chondrocytes+causes+increased+cell+apoptosis+and+articular+cartilage+destruction+in+Col2a1-ICAT-+transgenic+mice. assertion.
- assertion asSentence Expression+of+the+Herc5-mediated+ubiquitin-like+protein+ISGylation+system+can+distinctly+potentiate+interferon-beta-induced+antiviral+effects+against+influenza+A+virus. assertion.
- assertion asSentence The+SWI%2FSNF+chromatin+remodeling+complex+regulates+myocardin-induced+smooth+muscle-specific+gene+expression. assertion.
- assertion asSentence In+vitro+nona-arginine-GRIM19+treatment+of+constitutively+activated+STAT3+%28STAT3c%29+cancer+cells+significantly+reduced+STAT3-dependent+transcription. assertion.
- assertion asSentence Overexpression+of+UBE2T+in+NIH3T3+cells+significantly+promoted+colony+formation+in+mouse+cell+cultures. assertion.
- assertion asSentence CKIP-1+functions+as+the+first+auxiliary+factor+to+enhance+the+activation+of+Smurf1. assertion.
- assertion asSentence Socs4+is+a+hydroxylation+substrate+of+FIH+and+promotes+vascular+differentiation+via+an+oxygen-dependent+mechanism. assertion.
- assertion asSentence Interactions+with+JAM-B+and+-C+are+essential+for+development+of+cutaneous+inflammation. assertion.
- assertion asSentence JAM-B+is+an+active+player+in+the+maintenance+of+the+bone+marrow+stromal+microenvironment. assertion.
- assertion asSentence Neurotensin+knock-out+mice+do+not+differ+from+their+wild-type+or+heterozygous+littermates+in+either+baseline+or+acute+cocaine-stimulated+locomotor+activity. assertion.
- assertion asSentence Mouse+RetSat+catalyzes+the+stereospecific+saturation+of+the+C13-C14+double+bond+of+all-trans-retinol+to+produce+%2813R%29-all-trans-13%2C14-dihydroretinol. assertion.
- assertion asSentence A+mechanism+by+which+LC3B%2C+through+interactions+with+Cav-1+and+Fas%2C+can+regulate+apoptosis. assertion.
- assertion asSentence CGI-58+plays+a+critical+role+in+limiting+hepatic+steatosis+and+maintaining+hepatic+glycerophospholipid+homeostasis+and+in+promoting+high-fat-diet-induced+obesity+and+insulin+resistance. assertion.
- assertion asSentence Scavenger+receptor+class+B+type+I+mediates+biliary+cholesterol+secretion+independent+of+ATP-binding+cassette+transporter+g5%2Fg8+in+mice. assertion.
- assertion asSentence MATE1+mediates+the+efflux+of+cisplatin+and+is+involved+in+cisplatin-induced+nephrotoxicity. assertion.
- assertion asSentence Despite+forming+the+Atg12-Atg5-Atg16L2+complex%2C+Atg16L2+is+not+recruited+to+phagophores+and+is+mostly+present+in+the+cytosol. assertion.
- assertion asSentence CCPG+is+a+bona+fide+coactivator+and+promotes+adipogenesis+in+a+PPARgamma-dependent+manner. assertion.
- assertion asSentence Acheron+regulates+vascular+endothelial+proliferation+and+angiogenesis+together+with+Id1+during+wound+healing. assertion.
- assertion asSentence MKP3+has+a+negative+feedback+action+on+the+MAPK%2FERK-mediated+FGF8+pathway+in+the+mouse+neuroepithelium. assertion.
- assertion asSentence SPACA1-deficient+male+mice+are+infertile+with+abnormally+shaped+sperm+heads+reminiscent+of+globozoospermia. assertion.
- assertion asSentence Both+P-TEFb+activity+and+H1+phosphorylation+are+necessary+for+the+full+differentiation+of+C2C12+myoblasts+into+myotubes. assertion.
- assertion asSentence The+CMG-1+serves+as+a+transcriptional+regulator+of+proliferation+and+adhesion-associated+genes+in+early+stage+male+germ-line+cells+in+the+testis. assertion.
- assertion asSentence Berberine+impairs+mitochonidrial+function+stimulating+the+expression+of+atrogin-1+without+affecting+phosphorylation+of+forkhead+transcription+factors. assertion.
- assertion asSentence Complex+contribution+of+cyclophilin+D+to+Ca2%2B-induced+permeability+transition+in+brain+mitochondria%2C+with+relation+to+the+bioenergetic+state. assertion.
- assertion asSentence Chd8+promotes+the+association+of+beta-catenin+and+histone+H1%2C+with+formation+of+the+trimeric+complex+on+chromatin+being+required+for+inhibition+of+beta-catenin-dependent+transactivation. assertion.
- assertion asSentence DAG-induced+PKCepsilon+activation+plays+a+major+role+in+nonalcoholic+fatty+liver+disease+%28NAFLD%29-associated+hepatic+insulin+resistance. assertion.
- assertion asSentence DGAT2+is+capable+of+catalyzing+TG+synthesis+and+promote+its+storage+in+cytosolic+lipid+droplets+independent+of+its+localization+in+the+ER. assertion.
- assertion asSentence The+interaction+of+PTPIP51+with+14-3-3beta%2C+especially+in+trained+individuals%2C+hints+to+an+involvement+of+PTPIP51+in+the+downstream+regulation+of+insulin+action. assertion.
- assertion asSentence Mouse+and+human+RPL4+enhance+MoMLV+gag-pol+readthrough. assertion.
- assertion asSentence Synectin+selectively+regulates+arterial+branching+morphogenesis. assertion.
- assertion asSentence GIPC1-MyoGEF+complex+formation+plays+an+important+role+in+regulating+MDA-MB-231+breast+cancer+cell+polarization+and+invasion. assertion.
- assertion asSentence Cav1.4alpha1+is+required+for+proper+targeting+of+the+presynaptic+PMCA1+complex+in+retinal+photoreceptors. assertion.
- assertion asSentence ATP2B1+plays+important+roles+in+the+regulation+of+blood+pressure+through+alteration+of+calcium+handling+and+vasoconstriction+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence CHD1L+promotes+hepatocellular+carcinoma+progression+and+metastasis+in+mice+and+is+associated+with+these+processes+in+human+patients. assertion.
- assertion asSentence DLC2-mutant+mice+display+enhanced+angiogenic+responses. assertion.
- assertion asSentence Protein+expression%2C+expressing+profile+and+subcellular+localization+of+AK078438+gene+set+the+basis+for+further+exploration+of+its+functions. assertion.
- assertion asSentence Syntaxin+9+interacts+specifically+with+the+epidermal+growth+factor+receptor. assertion.
- assertion asSentence Expressed+in+both+B-cell+lines+and+primary+B-lymphocytes. assertion.
- assertion asSentence GPIHBP1+is+located+at+the+basolateral+surface+of+capillary+endothelial+cells+and+actively+transports+LPL+across+endothelial+cells. assertion.
- assertion asSentence Wy-14%2C643+treatment+upregulated+expression+of+the+adiponectin+receptor+%28AdipoR%29-1+and+AdipoR2. assertion.
- assertion asSentence Adipo1+and+2+serve+as+the+predominant+receptors+for+adiponectin+in+vivo+and+play+important+roles+in+the+regulation+of+glucose+and+lipid+metabolism%2C+inflammation+and+oxidative+stress+in+vivo. assertion.