Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence APPL1+plays+a+key+role+in+coordinating+the+vasodilator+and+vasoconstrictor+effects+of+insulin+by+modulating+Akt-dependent+NO+production+and+ERK1%2F2-mediated+ET-1+secretion+in+the+endothelium. assertion.
- assertion asSentence The+action+of+1%2C25%28OH%29%282%29D%283%29+on+colon+carcinoma+cells+depends+on+the+dual+action+of+VDR+as+a+transcription+factor+and+a+nongenomic+activator+of+RhoA-ROCK+and+p38MAPK-MSK1. assertion.
- assertion asSentence By+suppression+of+both+NF-kappaB+and+ERK1%2F2-MSK1+signaling%2C+DMF+inhibits+maturation+of+DCs+and+subsequently+Th1+and+Th17+cell+differentiation. assertion.
- assertion asSentence Cortactin+regulates+cell+movement+through+activation+of+N-WASP. assertion.
- assertion asSentence beta1+integrins+regulate+fibroblast+chemotaxis+through+control+of+N-WASP+stability. assertion.
- assertion asSentence Paxillin+and+N-WASP+are+involved+in+the+reorganization+of+actin+cytoskeleton+driving+motility+of+LPS-stimulated+cells. assertion.
- assertion asSentence Phosphorylation+of+NFATc4+by+p38+mitogen-activated+protein+kinases. assertion.
- assertion asSentence NFATc4+and+ATF3+function+as+negative+regulators+of+adiponectin+gene+expression+in+3T3+adipocytes. assertion.
- assertion asSentence Set7%2F9+is+dispensable+for+p53+function+in+the+mouse. assertion.
- assertion asSentence The+response+to+hyperglycemia+in+vascular+endothelial+cells+involves+Set7+mediated+changes+in+chromatin+remodeling+and+gene+expression. assertion.
- assertion asSentence REDD2+is+enriched+in+skeletal+muscle+and+inhibits+mTOR+signaling+in+response+to+leucine+and+stretch. assertion.
- assertion asSentence Whrn+connects+to+the+Usher+protein+network+in+the+cochlea+and+retina+by+direct+association+with+USH2A+and+VLGR1. assertion.
- assertion asSentence The+morphology+of+cochlear+hair+cell+stereocilia+in+double+mutants+reflects+a+dominance+of+the+more+severe+Myo15+%28sh2%2Fsh2%29+phenotype+over+the+Whrn+%28wi%2Fwi%29+phenotype. assertion.
- assertion asSentence IkappaBeta+regulates+the+NF-kappaB-mediated+transcription+of+a+wide+variety+of+proinflammatory+genes%2C+playing+a+crucial+role+in+the+regulation+of+innate+immune+responses. assertion.
- assertion asSentence Role+of+IL-1+receptor-associated+kinase-M+%28IRAK-M%29+in+priming+of+immune+and+inflammatory+responses+by+nitrogen+bisphosphonates. assertion.
- assertion asSentence Hip-1+and+Hippi+cooperate+to+induce+neuronal+apoptosis+in+a+caspase-8-dependent+manner. assertion.
- assertion asSentence Colocalizing+with+the+versican+V2+isoform+at+the+nodes+of+Ranvier+in+developing+and+adult+mouse+central+nervous+systems. assertion.
- assertion asSentence Mitochondrial+fragmentation+in+acute+kidney+injury+involves+the+activation+of+mitochondrial+fission+via+Drp1. assertion.
- assertion asSentence The+homozygous+deletion+in+exon+4+of+the+ALS2+gene+%28553delA%29. assertion.
- assertion asSentence Mice+deficient+in+the+Rab5+guanine+nucleotide+exchange+factor+ALS2%2Falsin+exhibit+age-dependent+neurological+deficits+and+altered+endosome+trafficking. assertion.
- assertion asSentence Homozygous+Traf3ip1+mutants+are+not+viable+and+have+both+neural+developmental+defects+and+polydactyly%2C+phenotypes+typical+of+mutants+with+ciliary+assembly+defects. assertion.
- assertion asSentence Dies1+is+a+necessary+factor+of+BMP4+signaling+and+its+suppression+sustains+mESC+self-renewal. assertion.
- assertion asSentence GRIP1+scaffolding+protein+is+required+for+the+formation+and+integrity+of+the+dermo-epidermal+junction+and+reveal+the+importance+of+PDZ+domains+in+the+organization+of+supramolecular+structures+essential+for+mammalian+embryonic+development. assertion.
- assertion asSentence Glutamate-receptor-interacting+protein+GRIP1+directly+steers+kinesin+to+dendrites. assertion.
- assertion asSentence Phospholipase+C+epsilon+acts+downstream+of+the+epidermal+growth+factor+receptor+in+controlling+semilunar+valvulogenesis+through+inhibition+of+bone+morphogenetic+protein+signaling. assertion.
- assertion asSentence Conserved+intramolecular+disulfide+bond+is+critical+to+trafficking+and+fate+of+ATP-binding+cassette+%28ABC%29+transporters+ABCB6+and+sulfonylurea+receptor+1+%28SUR1%29%2FABCC8. assertion.
- assertion asSentence Foxp1%2F2%2F4-NuRD+interactions+regulate+gene+expression+and+epithelial+injury+response+in+the+lung+via+regulation+of+interleukin-6. assertion.
- assertion asSentence Enhanced+growth+of+blood+vessels+in+Robo4%28-%2F-%29+endothelium+is+due+to+activation+of+vascular+endothelial+growth+factor+%28VEGF%29-R2+signaling+through+the+Src+and+FAK+kinases. assertion.
- assertion asSentence Maternal+FXIII+plays+a+critical+role+in+uterine+hemostasis+and+maintenance+of+the+placenta+during+gestation. assertion.
- assertion asSentence Absence+of+TRIC-A+leads+to+instability+of+Ca%282%2B%29+movement+across+the+sarcoplasmic+reticulum+membrane. assertion.
- assertion asSentence GDE5+negatively+regulates+skeletal+muscle+development. assertion.
- assertion asSentence CYLD+can+both+positively+and+negatively+regulate+signal+transduction+and+homeostasis+of+B+cells+in+vivo%2C+depending+on+the+expression+of+CYLD+splice+variants. assertion.
- assertion asSentence Inactivation+of+the+CYLD+deubiquitinase+by+HPV+E6+mediates+hypoxia-induced+NF-kappaB+activation. assertion.
- assertion asSentence Impaired+nutrient+signaling+and+body+weight+control+in+a+Na%2B+neutral+amino+acid+cotransporter+%28Slc6a19%29-deficient+mouse. assertion.
- assertion asSentence Targeted+disruption+of+the+CREB+coactivator+Crtc2+increases+insulin+sensitivity. assertion.
- assertion asSentence Rictor%2FmTORC2+in+fat+cells+plays+an+important+role+in+whole-body+energy+homeostasis+by+mediating+signaling+necessary+for+the+regulation+of+glucose+and+lipid+metabolism+in+fat+cells. assertion.
- assertion asSentence Deletion+of+Rac1+in+primary+cells+using+an+inducible-Cre%2FLox+approach+inhibits+basal+and+growth-factor+activation+of+both+mTORC1+and+mTORC2. assertion.
- assertion asSentence Reduced+dosage+of+the+modifiers+of+epigenetic+reprogramming+Dnmt1%2C+Dnmt3L%2C+SmcHD1+and+Foxo3a+has+no+detectable+effect+on+mouse+telomere+length+in+vivo. assertion.
- assertion asSentence Complex+raptor+phosphorylation+functions+as+a+biochemical+rheostat+that+modulates+mTORC1+signaling+in+accordance+with+environmental+cues. assertion.
- assertion asSentence Sphingomyelin+synthase+%28SMS%292+deficiency+in+the+macrophages+reduces+atherosclerosis+in+mice. assertion.
- assertion asSentence exoc3l2+silencing+inhibits+VEGF+receptor+2+phosphorylation+and+VEGFA-directed+migration+of+cultured+endothelial+cells. assertion.
- assertion asSentence TAF7L+replaces+TAF7+as+a+TFIID+subunit+in+late+pachytene+spermatocytes+and+in+haploid+cells. assertion.
- assertion asSentence SPSB1+and+SPSB4+bind+strongly+to+both+Par-4+and+VASA+peptides. assertion.
- assertion asSentence Insulin+induces+REDD1+expression+through+hypoxia-inducible+factor+1+activation+in+adipocytes. assertion.
- assertion asSentence Elevation+of+Dig2%2FRTP801%2FREDD1+contributes+to+the+induction+of+autophagy. assertion.
- assertion asSentence Seladin-1-dependent+cholesterol+synthesis+is+involved+in+lowering+Abeta+levels. assertion.
- assertion asSentence DHCR24+plays+important+roles+for+normal+development+of+epidermis+and+hair+follicle+even+in+postnatal+life. assertion.
- assertion asSentence Type+Ia+phosphoinositide+3-kinase+%28PI3K%29+p110beta+isoform+has+a+key+role+in+regulating+the+formation+and+stability+of+integrin+alpha%28IIb%29beta%283%29+adhesion+bonds%2C+necessary+for+shear+activation+of+platelets. assertion.
- assertion asSentence Support+the+role+for+NKLAM+in+NK+function+both+in+vitro+and+in+vivo. assertion.
- assertion asSentence Expression+of+Etnk1+in+the+mouse+hippocampus+is+modulated+by+a+sequence+variant+%28B2+SINE+indel%29+in+the+3%27+UTR+of+Comt+%28catechol-O-methyltransferase%29. assertion.
- assertion asSentence Regions+upstream+of+the+promoter+repress+transcription+more+effectively+in+a+non-malignant+breast+cell+line+as+compared+to+breast+cancer+cell+lines. assertion.
- assertion asSentence Phosphorylation+of+eIF4B+on+Ser422+by+p90+ribosomal+protein+S6+kinase+%28RSK%29+and+S6K+is+physiologically+significant%2C+as+it+increases+the+interaction+of+eIF4B+with+the+eukaryotic+translation+initiation+factor+3. assertion.
- assertion asSentence Smurf1+is+a+negative+feedback+regulator+for+IFN-gamma+signaling+by+targeting+STAT1+for+ubiquitination+and+proteasomal+degradation. assertion.
- assertion asSentence Liver+sinusoidal+endothelial+cell+lectin%2C+LSECtin%2C+negatively+regulates+hepatic+T-cell+immune+response. assertion.
- assertion asSentence DOCK8+regulates+interstitial+DC+migration+by+controlling+Cdc42+activity+spatially. assertion.
- assertion asSentence Rapgef2+deficiency+led+to+embryonic+lethality+at+E11.5+due+to+severe+yolk+sac+vascular+defects. assertion.
- assertion asSentence Tbx18+controls+the+formation+of+the+SAN+head+from+mesenchymal+precursors+on+which+Tbx3+subsequently+imposes+the+pacemaker+gene+program. assertion.
- assertion asSentence The+lithogenic+diet+induced+biliary+hyperplasia+and+reduced+bile+salt+transporter+ABCC3+expression+in+C57L+mice. assertion.
- assertion asSentence Abcc3+transports+MTX+and+7OH-MTX+back+from+the+liver+into+the+circulation%2C+leading+to+increased+plasma+levels+and+urinary+excretion. assertion.
- assertion asSentence InsP%283%29R2-mediated+Ca%282%2B%29+signals+enhance+organic+anion+secretion+into+bile+by+targeting+Mrp2+to+the+canalicular+membrane. assertion.
- assertion asSentence MsrA+and+MsrB2%2C+the+two+proteins+with+similar+function+in+antioxidant+protein+repair%2C+have+different+effects+on+aging+in+fruit+flies. assertion.
- assertion asSentence PPP1R3G+plays+a+major+role+to+control+postprandial+glucose+homeostasis+during+the+fasting-feeding+transition+via+its+regulation+on+liver+glycogenesis. assertion.
- assertion asSentence Regional+immobilization+of+CLASP2+allows+MT+stabilization+and+promotes+directionally+persistent+motility+in+fibroblasts. assertion.
- assertion asSentence The+different+spatiotemporal+expression+of+IL-34+and+CSF-1+allows+for+complementary+activation+of+the+CSF-1R+in+developing+and+adult+tissues. assertion.
- assertion asSentence The+ciliary+protein+IFT46+has+a+specific+function+in+chondrocytes+and+is+also+essential+for+normal+development+of+vertebrates. assertion.
- assertion asSentence In+skeletal+muscle+the+disruption+of+Tdn%2FCASQ+link+has+a+more+profound+effect+on+jSR+architecture+and+myoplasmic+Ca%282%2B%29+regulation+than+Jct%2FCASQ+association. assertion.
- assertion asSentence GPR30+is+indispensable+for+thymocyte+apoptosis+that+preferentially+occurs+in+T-cell+receptor+beta+chain+double-positive+thymocytes. assertion.
- assertion asSentence GPER+is+the+first+estrogen+receptor+with+inhibitory+activity+on+endothelium-dependent+contractility. assertion.
- assertion asSentence Catsper3+and+Catsper4+knockout+male+mice+are+completely+infertile+due+to+a+quick+loss+of+motility+and+a+lack+of+hyperactivated+motility+under+capacitating+conditions. assertion.
- assertion asSentence Loss+of+ceramide+synthase+2+alters+lipid+metabolic+pathways+by+inhibiting+very+long+acyl+chain+ceramide+synthesis. assertion.
- assertion asSentence Atg16L1+deficiency+confers+protection+in+vivo+to+the+host+against+both+acute+and+latent+uropathic+Escherichia+coli+infection. assertion.
- assertion asSentence Syne-2%2C+SUN1+and+SUN2+play+critical+roles+during+interkinetic+nuclear+migration+and+photoreceptor+cell+migration+in+the+mouse+retina+development. assertion.
- assertion asSentence IL-33+and+ST2+form+a+complex+with+IL-1R+accessory+protein+%28IL-1RAcP%29%2C+a+signaling+receptor+subunit+that+is+also+a+member+of+the+IL-1R+complex. assertion.
- assertion asSentence IL-33+is+a+critical+proinflammatory+cytokine+for+inflammatory+joint+disease. assertion.
- assertion asSentence Full+length+IL-33+and+its+N-terminal+caspase+3+breakdown+product+translocate+to+the+nucleus. assertion.
- assertion asSentence Il-33%2C+expressed+in+differentiated+osteoblasts%2C+inhibits+osteoclastogenesis+and+consequently+bone+resorption. assertion.
- assertion asSentence The+dual+function+cytokine+IL-33+interacts+with+the+transcription+factor+NF-kappaB+to+dampen+NF-kappaB-stimulated+gene+transcription. assertion.
- assertion asSentence Rab35+regulates+phagosome+formation+through+recruitment+of+ACAP2+in+macrophages+during+FcgammaR-mediated+phagocytosis. assertion.
- assertion asSentence The+PRELI+domain+containing+2+gene+is+involved+in+mouse+embryonic+development. assertion.
- assertion asSentence TRIM+is+dispensable+for+T-cell+development+and+peripheral+immune+functions. assertion.
- assertion asSentence In+bone+marrow-derived+dendritic+cells+lacking+SLAP+and+closely+related+SLAP2%2C+downregulation+of+the+granulocyte-macrophage+colony-stimulating+factor+%28GM-CSF%29beta+receptor+is+impaired. assertion.
- assertion asSentence LBH+is+aberrantly+overexpressed+in+mammary+tumors+of+mouse+mammary+tumor+virus+%28MMTV%29-Wnt1-transgenic+mice+and+in+aggressive+basal+subtype+human+breast+cancers+that+display+Wnt%2Fbeta-catenin+hyperactivation. assertion.
- assertion asSentence A+physiological+role+of+NUAK1+is+to+suppress+glucose+uptake+through+negative+regulation+of+insulin+signaling+in+oxidative+muscle. assertion.
- assertion asSentence VAD1.3+interacts+with+beta-actin+and+syntaxin+1+in+vitro. assertion.
- assertion asSentence Dimerization+of+Cul7+and+Parc+is+not+required+for+all+Cul7+functions+and+mouse+development. assertion.
- assertion asSentence Moreover%2C+on+high-fat+access+days+the+alternating+NT-4+mutants+significantly+increased+caloric+intake+by+9%25+compared+to+alternating+wild+types. assertion.
- assertion asSentence The+enhancing+effects+of+treadmill+training+on+axon+regeneration+include+NT-4+5+in+the+proximal+stump. assertion.
- assertion asSentence Plays+an+important+role+in+the+formation%2Ffunction+of+the+placenta. assertion.
- assertion asSentence GPR124%2C+an+orphan+G+protein-coupled+receptor%2C+is+required+for+CNS-specific+vascularization+and+establishment+of+the+blood-brain+barrier. assertion.
- assertion asSentence Rab35+regulates+phagosome+formation+through+recruitment+of+ACAP2+in+macrophages+during+FcgammaR-mediated+phagocytosis. assertion.
- assertion asSentence Rictor%2FmTORC2+in+fat+cells+plays+an+important+role+in+whole-body+energy+homeostasis+by+mediating+signaling+necessary+for+the+regulation+of+glucose+and+lipid+metabolism+in+fat+cells. assertion.
- assertion asSentence PI3K%2FAKT+signaling+through+mTORC2%2FpAKT-S473+plays+a+key+role+in+maintaining+normal+beta-cell+mass. assertion.
- assertion asSentence VSIG1+is+required+for+the+establishment+of+glandular+versus+squamous+epithelia+in+the+stomach. assertion.
- assertion asSentence TSC22D4+is+stably+upregulated+by+hyperosmolality+in+mIMCD3+cells+and+increased+in+renal+papilla+compared+with+cortex. assertion.
- assertion asSentence Dissociation+of+inositol-requiring+enzyme+%28IRE1alpha%29-mediated+c-Jun+N-terminal+kinase+activation+from+hepatic+insulin+resistance+in+conditional+X-box-binding+protein-1+%28XBP1%29+knock-out+mice. assertion.
- assertion asSentence Development+of+homozygous+embryos+lacking+Lias+is+retarded. assertion.
- assertion asSentence Apobec3+promotes+the+release+of+substantial+levels+of+noninfectious+virions+in+the+plasma+during+acute+Friend+virus+infection. assertion.
- assertion asSentence Essential+requirement+for+the+Wwox+tumor+suppressor+in+proper+steroidogenesis. assertion.
- assertion asSentence Structural+basis+for+the+exclusive+association+of+Slac2-a+with+the+Rab27+subfamily. assertion.
- assertion asSentence Allelic+divergence+of+Nkrp1b%2Fc+gene+products+helps+explain+a+longstanding+confusion+regarding+the+strain-specific+NK1.1+alloantigen+reactivity+of+mouse+natural+killer+cells. assertion.