Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Sel+K-deficient+T+cells+exhibit+decreased+chemokine+receptor-mediated+calcium+flux. assertion.
- assertion asSentence IkappaBzeta+is+essential+for+natural+killer+cell+activation+in+response+to+IL-12+and+IL-18+and+antiviral+host+defense+responses. assertion.
- assertion asSentence In+conventional+mice+with+normal+bacterial+colonization+of+the+intestinal+tract%2C+GPR109A+and+SLC5A8+are+expressed+on+the+apical+membrane+of+epithelial+cells+lining+the+ileum+and+colon. assertion.
- assertion asSentence Lung+epithelial+cells+secrete+AMCase+via+an+EGFR-dependent+pathway+that+is+activated+by+ADAM17+and+mediates+its+effects+via+Ras. assertion.
- assertion asSentence Notch1+intracellular+domain+plays+the+role+of+a+negative+regulator+in+AICD+signaling+via+the+disruption+of+the+AICD-Fe65-Tip60+trimeric+complex. assertion.
- assertion asSentence Fe65+and+its+interaction+with+APP+play+an+important+role+in+the+response+to+DNA+damage+by+assisting+the+recruitment+of+Tip60-TRRAP+to+DNA+damage+sites. assertion.
- assertion asSentence Partial+Tip60+loss+increased+Rora+and+Rora-mediated+gene+expression+and+delayed+ATXN1%5B82%5D-mediated+cerebellar+degeneration+during+mid-stage+disease+progression. assertion.
- assertion asSentence JDP2+inhibited+both+the+acetylation+of+histone+H3+in+the+promoter+of+the+gene+for+C%2FEBPdelta+and+transcription+from+this+promoter. assertion.
- assertion asSentence Differential+involvement+of+type+I+IFN+in+TLR4-+and+TLR9-stimulated+dendritic+cell+activation. assertion.
- assertion asSentence Autographa+californica+nuclear+polyhedrosis+virus+activates+immune+cells+via+the+Toll-like+receptor+9+%28TLR9%29%2FMyD88-dependent+signaling+pathway. assertion.
- assertion asSentence IRAK-1+is+a+specific+regulator+for+TLR7-+and+TLR9-mediated+IFN-alpha+induction+in+plasmacytoid+dendritic+cells. assertion.
- assertion asSentence Adiponectin+inhibits+Tlr9-induced+signaling. assertion.
- assertion asSentence Hepatic+stellate+cells+TLR9%2C+a+pattern+recognition+receptor+that+is+activated+by+CpG+motifs+present+specifically+in+bacterial+DNA. assertion.
- assertion asSentence TLR9+and+TLR2+cooperatively+induce+cytokine+production+during+herpes+simplex+virus+%28HSV%29-2+infection+in+vivo. assertion.
- assertion asSentence Rather+than+inducing+tolerance%2C+LPS+pretreatment+primes+the+inflammatory+response+%28e.g.%2C+tumor+necrosis+factor+production%29+of+mouse+bone+marrow-derived+macrophages+to+the+TLR9+ligand%2C+cytosine-phosphate+diester-guanine+%28CpG%29+DNA. assertion.
- assertion asSentence TLR9+signaling+plays+an+important+role+in+the+development+of+robust+protective+immunity%2C+proper+recruitment+and+function+of+effector+cells+%28lymphocytes+and+macrophages%29%2C+and%2C+ultimately%2C+effective+cryptococcal+clearance+from+the+infected+lungs. assertion.
- assertion asSentence Systemic+infection+with+Salmonella+typhimurium+causes+shedding+of+CD62L+and+the+consequent+focusing+of+B+cell+migration+via+TLR9+to+the+spleen+and+away+from+lymph+nodes. assertion.
- assertion asSentence CD14+is+a+coreceptor+of+Toll-like+receptors+7+and+9. assertion.
- assertion asSentence Passive+adoptive+transfer+of+autoimmune+encephalomyelitis+into+female+C57BL%2F6+Tlr9-deficient+mice. assertion.
- assertion asSentence Cathelicidin+signaling+via+the+Toll-like+receptor+%28TLR9%29+protects+against+colitis+in+mice. assertion.
- assertion asSentence Activation+of+dendritic+cells+via+TLR9+is+essential+for+the+induction+of+lymph+node+hypertrophy+in+leishmaniasis. assertion.
- assertion asSentence Sf3b1+and+Polycomb+group+%28PcG%29+proteins+interaction+is+essential+for+true+PcG-mediated+repression+of+Hox+genes. assertion.
- assertion asSentence KLB+and+FGFR1+form+a+1%3A1+heterocomplex+independent+of+the+galectin+lattice+that+transitions+to+a+1%3A2+complex+upon+the+addition+of+FGF21. assertion.
- assertion asSentence A+role+for+SSeCKS+in+mitogen-induced+cytoskeletal+reorganization. assertion.
- assertion asSentence tauCstF-64+promotes+germ-cell-specific+patterns+of+polyadenylation+by+binding+to+different+downstream+sequence+elements. assertion.
- assertion asSentence Pancreatic+Ucn+III+acting+through+CRFR2+is+involved+in+the+local+regulation+of+glucagon+and+insulin+secretion. assertion.
- assertion asSentence CRFR2beta+selective+Ucn-II+or+Ucn-III+will+protect+cardiomyocytes+and+the+ex+vivo+Langendorff+perfused+rat+heart+from+ischemia+reperfusion+injury+by+activation+of+ERK1%2F2-p42%2C+44. assertion.
- assertion asSentence IL-23%2C+particularly+the+N-glycosylation+site+mutant+IL-23N220L%2C+is+an+effective+and+long-lasting+genetic+adjuvant+of+DNA+vaccine+for+the+induction+of+durable+antigen-specific+T+cell+immunity. assertion.
- assertion asSentence Absence+of+the+IL-23+p19+subunit+has+little+effect+on+disease+progression+during+both+early+and+chronic+Mycobacterium+tuberculosis+infection+of+the+lung. assertion.
- assertion asSentence IL-23R+expression+is+crucial+for+generation+of+encephalitogenic+Th17+cells. assertion.
- assertion asSentence Establishment+of+the+existence+a+regulatory+IL-17%2FIL-23+axis+in+histoplasmosis+in+mice. assertion.
- assertion asSentence MyD88-dependent+Toll-like+receptor+signaling+induces+IL-23+p19+gene+expression+through+both+MAPKs+and+NF-kappaB. assertion.
- assertion asSentence Expressing+a+mutant+Ndel1+lacking+key+phosphorylation+sites+shuts+down+organelle+transport+completely+in+axons. assertion.
- assertion asSentence Salmonella+typhimurium+induces+ROS+through+a+pathway+that+requires+both+triggering+receptor+expressed+on+myeloid+cells+2+%28TREM2%29+and+DAP12. assertion.
- assertion asSentence Reperfusion+injury+of+proximal+kidney+tubules+causes+a+reduction+of+Chrdl1+expression. assertion.
- assertion asSentence CHAMP+acts+as+an+inhibitor+of+cell+proliferation+and+cardiomyocyte+hypertrophy. assertion.
- assertion asSentence BCAP-%28L%29+%28but+not+BCAP-%28S%29%29+is+a+negative+regulator+of+the+TLR-mediated+host+defense+system+in+macrophages. assertion.
- assertion asSentence TEX14+prevents+the+completion+of+cytokinesis+by+altering+the+destiny+of+CEP55+from+a+nidus+for+abscission+to+an+integral+component+of+the+intercellular+bridge. assertion.
- assertion asSentence Otoferlin+is+essential+for+a+high-affinity+Ca%282%2B%29+sensor+function+that+allows+efficient+and+linear+encoding+of+low-intensity+stimuli+at+the+vestibular+hair+cell+synapse. assertion.
- assertion asSentence In+cell+migration+WAVE1+is+essential+in+MMP-dependent+migration+in+extracellular+matrix+and+WAVE2+is+for+leading+edge+extension+for+directed+migration+in+general. assertion.
- assertion asSentence Nap1+mutant+phenotypes+define+the+crucial+roles+of+Nap1%2FWAVE-mediated+actin+regulation+in+tissue+organization+and+establishment+of+the+body+plan+of+the+mammalian+embryo. assertion.
- assertion asSentence KLF2+and+TOB1+activate+the+mouse+Dpp2+promoter. assertion.
- assertion asSentence Activation+of+the+mGlu7+receptor+produces+anxiolytic-like+effects+via+the+modulation+of+the+gamma-aminobutyric+acid+system. assertion.
- assertion asSentence In+vivo+Nedd4-2+is+a+critical+regulator+of+ENaC+activity+and+blood+pressure. assertion.
- assertion asSentence Neural+precursor+cell-expressed+developmentally+down-regulated+protein+4-2+%28Nedd4-2%29+regulation+by+14-3-3+protein+binding+at+canonical+serum+and+glucocorticoid+kinase+1+%28SGK1%29+phosphorylation+sites. assertion.
- assertion asSentence Trps1+interacts+with+the+activator+form+of+Gli3. assertion.
- assertion asSentence Role+for+endothelial+cell+JAM-C+in+mediating+leukocyte+adhesion+and+transmigration+in+response+to+I%2FR+injury. assertion.
- assertion asSentence At+the+cellular+level%2C+SK1-like+immunoreactivity+is+primarily+localized+to+somatic+and+dendritic+structures+in+the+mouse+brain. assertion.
- assertion asSentence Macul+densa+cells+can+sense+alterations+in+local+tissue+metabolism+via+accumulation+of+tubular+succinate+and+GPR91+signaling. assertion.
- assertion asSentence Regulatory+defects+in+liver+and+intestine+implicate+abnormal+hepcidin+and+Cybrd1+expression+in+hemochromatosis. assertion.
- assertion asSentence IL-6+mediates+anemia+of+inflammation+by+inducing+the+synthesis+of+HEPC. assertion.
- assertion asSentence Soluble+hemojuvelin+is+not+the+sole+factor+responsible+for+hepcidin+downregulation+by+chronic+bleeding. assertion.
- assertion asSentence Combined+deletion+of+Hfe+and+transferrin+receptor+2+in+mice+leads+to+marked+dysregulation+of+hepcidin+and+iron+overload. assertion.
- assertion asSentence In+conditions+of+iron+overload%2C+hemojuvelin+is+essential+for+transferrin-dependent+and+transferrin-independent+hepcidin+expression. assertion.
- assertion asSentence There+is+a+dramatic+induction+of+Inhbb+mRNA%2C+encoding+the+activin+beta%28B%29-subunit%2C+in+liver+challenged+with+lipopolysaccharide%2C+slightly+preceding+an+increase+in+Smad1%2F5%2F8+phosphorylation+and+Hamp+mRNA. assertion.
- assertion asSentence Hes7+oscillation+is+initiated+by+Fgf+signaling+and+propagated%2Fmaintained+anteriorly+by+Notch+signaling. assertion.
- assertion asSentence Cytochrome+c+oxidase+subunit+IV+is+essential+for+assembly+and+respiratory+function+of+the+enzyme+complex. assertion.
- assertion asSentence A+phosphatidic+acid-phospholipase+A1alpha-lysophosphatidic+acid-P2Y5+axis+regulates+differentiation+of+hair+follicles+via+a+tumour+necrosis+factor+alpha+converting+enzyme-transforming+growth+factor+alpha-epidermal+growth+factor+receptor+pathway. assertion.
- assertion asSentence T+cell+receptor+stimulation+induces+IL-24+expression+in+T+helper+type+%28Th%292+cells+by+the+coordinate+action+of+Stat6+and+c-Jun+transcription+factors+at+the+transcriptional+level. assertion.
- assertion asSentence Rbfox2+protein+controls+a+post-transcriptional+program+required+for+proper+brain+development. assertion.
- assertion asSentence Casein+kinase+1+alpha%2C+a+relevant+double+minute+2+%28MDMX%29-binding+protein%2C+plays+an+important+role+in+regulating+p53+activity+in+the+absence+or+presence+of+stress. assertion.
- assertion asSentence Dlk1+is+required+to+prevent+premature+expression+of+Dat+in+meso-diencephalic+dopamine+neuronal+precursors+as+part+of+the+multifaceted+process+of+neuronal+differentiation+driven+by+Nurr1+and+Pitx3. assertion.
- assertion asSentence Targeted+disruption+of+Glrx1+regulates+the+lung+proinflammatory+response+via+histone+acetylation+specifically+by+activation+of+IKKalpha+in+response+to+cigarette+smoke+exposure. assertion.
- assertion asSentence OCIL+is+a+physiological+negative+regulator+of+bone. assertion.
- assertion asSentence Par3%2C+in+conjunction+with+Tiam1%2C+controls+%22front-rear%22+polarity+during+the+persistent+migration+of+freely+migrating+keratinocytes. assertion.
- assertion asSentence Interaction+between+PAR-3+and+the+aPKC-PAR-6+complex+is+indispensable+for+apical+domain+development+of+epithelial+cells. assertion.
- assertion asSentence Inhibition+of+SIRT1+function+in+cells+without+HIC1+abolishes+the+resistance+to+apoptosis. assertion.
- assertion asSentence Deacetylation+of+NBS1+by+SIRT1+plays+a+key+role+in+the+dynamic+regulation+of+the+DNA+damage+response+and+in+the+maintenance+of+genomic+stability. assertion.
- assertion asSentence SIRT1+is+an+in+vitro+and+in+vivo+deacetylase+binding+partner+for+retinoblastoma+tumor+suppressor+protein+and+its+family+members+p107+and+p130. assertion.
- assertion asSentence SIRT1+acts+as+a+major+repressor+of+ucp3+gene+expression+in+response+to+glucocorticoids. assertion.
- assertion asSentence The+effect+of+SIRT1+on+insulin+resistance+is+mediated+by+repressing+PTP1B+transcription+at+the+chromatin+level. assertion.
- assertion asSentence SIRT1+makes+mES+cells+sensitive+to+ROS+and+inhibits+p53-mediated+suppression+of+Nanog+expression. assertion.
- assertion asSentence Icariin+enhances+neuronal+survival+after+oxygen+and+glucose+deprovation+by+increasing+Sirt1. assertion.
- assertion asSentence Role+of+the+Sirt1-Foxo3+axis+in+cellular+adaptation+to+hypoxia%2C+delineate+a+molecular+mechanism+of+the+caloric+restriction-mediated+antiaging+effect. assertion.
- assertion asSentence Sirt1+activation+protects+the+mouse+renal+medulla+from+oxidative+injury. assertion.
- assertion asSentence SIRT1+deacetylated+two+specific+lysine+residues+%28K265%2FK268%29+in+PIP5Kgamma+and+enhanced+PIP5Kgamma+enzyme+activity. assertion.
- assertion asSentence Mechanism+triggered+by+mechanical+stretch+of+skeletal+muscle+cells+that+leads+to+an+EGR1-dependent+transcriptional+activation+of+the+Sirt1+gene. assertion.
- assertion asSentence Sirt1+inhibition+induces+tissue+factor+expression+and+arterial+thrombus+formation+in+vivo. assertion.
- assertion asSentence The+inhibition+of+SIRT1+by+mTOR+fosters+survival+of+DNA+damage-induced+prematurely+senescent+SCC+cells+via+Bfl-1%2FA1+in+the+absence+of+functional+p53. assertion.
- assertion asSentence WldS+enhances+insulin+transcription+and+secretion+via+a+SIRT1-dependent+pathway+and+improves+glucose+homeostasis. assertion.
- assertion asSentence SIRT1+deacetylates+the+brain-specific+helix-loop-helix+transcription+factor+NHLH2+on+lysine+49+to+increase+its+activation+of+the+MAO-A+promoter. assertion.
- assertion asSentence SIRT1+responds+to+alpha-synuclein+aggregation-induced+stress+by+activating+molecular+chaperones+to+protect+against+disease. assertion.
- assertion asSentence Smarca5+is+a+key+regulator+of+global+chromatin+structure. assertion.
- assertion asSentence Stbm%2FVangl2+functions+to+maintain+cortical+progenitors+and+regulates+mitotic+spindle+orientation+during+asymmetric+divisions. assertion.
- assertion asSentence Degradation+of+MEPE+and+DMP-1+and+release+of+ASARM+peptides+are+chiefly+responsible+for+the+HYP+mineralization+defect+and+changes+in+osteoblast-osteoclast+differentiation. assertion.
- assertion asSentence Wnt3a+stimulates+Mepe+transcription+directly+by+a+canonical+Wnt+signaling+pathway+through+beta-catenin+and+Lef-1+and+indirectly+through+the+activation+of+a+Bmp-2+autocrine+loop. assertion.
- assertion asSentence Deletion+of+DOCK2%2C+a+regulator+of+the+actin+cytoskeleton+in+lymphocytes%2C+suppresses+cardiac+allograft+rejection. assertion.
- assertion asSentence PI3K+and+Src-ELMO-Dock2+pathways+work+in+parallel+to+activate+Rac2+and+modulate+chemotaxis+in+response+to+a+CXCL8+gradient+in+neutrophils. assertion.
- assertion asSentence Zfp423+controls+proliferation+and+differentiation+of+neural+precursors+in+cerebellar+vermis+formation. assertion.
- assertion asSentence Zfp423%28-%2F-%29+hemisphere+malformations+are+shaped+by+both+genetic+and+non-genetic+factors+to+produce+distinct+phenotypes. assertion.
- assertion asSentence Cbp+down-regulation+is+primarily+mediated+by+epigenetic+histone+modifications+via+oncogenic+MAPK%2FPI3K+pathways+in+a+subset+of+cancer+cells. assertion.
- assertion asSentence The+coiled+tail+of+the+round-headed+spermatozoa+appears+during+epididymal+passage+in+Gopc-deficient+mice. assertion.
- assertion asSentence The+immune+modulator+FTY720+targets+sphingosine+1-phosphate+receptors. assertion.
- assertion asSentence Cloning+of+the+NBCn2-A+transcript+demonstrates+that+it+is+dominant+in+the+subcortex+and+medulla+of+mouse+brain. assertion.
- assertion asSentence Dysbindin+regulates+prefrontal+cortex+function+by+facilitating+D2-mediated+modulation+of+GABAergic+function. assertion.
- assertion asSentence Dysbindin+and+its+associated+complex+sort+cargoes+from+cell+bodies+to+the+synapse. assertion.
- assertion asSentence NRAGE+plays+an+important+role+in+apoptotic-signaling+in+vivo. assertion.
- assertion asSentence MAGED1+binds+to+nuclear+receptor+RORalpha+to+bring+about+positive+and+negative+effects+on+core+clock+genes+of+Bmal1%2C+Rev-erbalpha+and+E4bp4+expression+through+the+Rev-Erbalpha%2FROR+responsive+elements+%28RORE%29. assertion.
- assertion asSentence LoxL2+is+not+expressed+in+MC3T3-E1+cells. assertion.
- assertion asSentence TAZ+is+a+coactivator+for+Pax8+and+TTF-1+and+plays+a+role+in+the+control+of+genes+involved+in+thyroid+development+and+differentiation. assertion.