Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Nha-oc+is+expressed+by+terminally+differentiated+osteoclasts. assertion.
- assertion asSentence Increased+HMGB2+expression+is+associated+with+squamous+cell+carcinoma+of+skin. assertion.
- assertion asSentence The+G59S+mutation+in+p150%28glued%29+protein+abrogates+the+normal+function+of+the+protein+and+accelerates+motor+neuron+degeneration. assertion.
- assertion asSentence Double+heterozygote+deletion+of+NKCC1+with+alpha%282%29-Na%2CK-ATPase+demonstrates+a+striking+preservation+of+hearing+threshold+both+initially+and+with+age. assertion.
- assertion asSentence FGF23+transgenic+mice+display+differentially+expressed+transcript+levels+of+several+genes+%28Npt2a%2C+Pdzk1%2C+Atp1a2%29+essential+in+renal+Pi+regulation. assertion.
- assertion asSentence ACTH-induced+hypertension+is+dependent+on+the+ouabain-binding+site+of+the+alpha2-Na%2B-K%2B-ATPase+subunit. assertion.
- assertion asSentence Norepinephrine+release+from+the+ischemic+heart+is+greatly+enhanced+in+mice+lacking+histamine+H3+receptors. assertion.
- assertion asSentence Cul4A+is+required+for+efficient+cell+proliferation%2C+control+of+centrosome+amplification+and+genome+stability. assertion.
- assertion asSentence The+primary+spermatocytes+in+Cul4A-%2F-+mice+are+deficient+in+progression+through+late+prophase+I%2C+a+time+point+when+expression+of+the+X-linked+Cul4B+gene+is+silenced+due+to+meiotic+sex+chromosome+inactivation. assertion.
- assertion asSentence A+positive+and+negative+feed-forward+circuit+between+Tbx5+and+Sall4+ensures+precise+patterning+of+embryonic+limb+and+heart+and+provides+a+unifying+mechanism+for+heart%2Fhand+syndromes. assertion.
- assertion asSentence Bmi1+is+a+target+gene+for+Sall4+in+hematopoietic+cells. assertion.
- assertion asSentence Sall4+plays+a+diverse+role+in+regulating+stem+cell+pluripotency+during+early+embryonic+development+through+integration+of+transcriptional+and+epigenetic+controls. assertion.
- assertion asSentence Affects+plasma+LDL+cholesterol+levels+by+altering+LDL+receptor+protein+levels+via+a+post-transcriptional+mechanism. assertion.
- assertion asSentence ADP-ribosylhydrolase+3+%28ARH3%29%2C+not+poly%28ADP-ribose%29+glycohydrolase+%28PARG%29+isoforms%2C+is+responsible+for+degradation+of+mitochondrial+matrix-associated+poly%28ADP-ribose%29. assertion.
- assertion asSentence Mindin-integrin+interactions+play+a+key+role+in+regulating+Rho+GTPase+expression+in+DCs+and+DC+priming+of+T+lymphocytes. assertion.
- assertion asSentence Fatty+acid+oxidation+in+the+adipocytes+of+Acc2-%2F-+mutant+mice%2C+combined+with+a+higher+level+of+glucose+oxidation+and+a+higher+rate+of+lipolysis%2C+are+major+factors+leading+to+efficient+maintenance+of+insulin+sensitivity+and+leaner+Acc2-%2F-+mutant+mice. assertion.
- assertion asSentence Inhibition+of+acetyl-CoA+carboxylase+2+enhances+skeletal+muscle+fatty+acid+oxidation+and+improves+whole-body+glucose+homeostasis+in+db%2Fdb+mice. assertion.
- assertion asSentence Emilin-1+produced+by+vascular+smooth+muscle+cells+acts+as+a+main+regulator+of+resting+blood+pressure+levels+by+controlling+the+myogenic+response+in+resistance+arteries+through+TGF-beta. assertion.
- assertion asSentence Tpp1+is+required+for+the+protective+function+of+Pot1+proteins. assertion.
- assertion asSentence A+critical+role+of+Ada3+in+embryogenesis+and+cell+cycle+progression+as+an+essential+component+of+HAT+complex. assertion.
- assertion asSentence NLRp6+function+in+maintaining+intestinal+homeostasis+to+prevent+the+development+of+aberrant+inflammation+and+tumor+development+within+the+colon. assertion.
- assertion asSentence Potassium+and+ANO1%2F+TMEM16A+chloride+channel+profiles+distinguish+atypical+and+typical+smooth+muscle+cells+from+interstitial+cells+in+the+renal+pelvis. assertion.
- assertion asSentence Reveal+myozap+as+a+previously+unrecognized+component+of+a+Rho-dependent+signaling+pathway+that+links+the+intercalated+disc+to+cardiac+gene+regulation. assertion.
- assertion asSentence A+role+is+established+for+B7-H3+in+the+costimulation+of+T+cell-mediated+tumor+immunity+in+vivo. assertion.
- assertion asSentence Bbs4-null+mice+develop+both+motile+and+primary+cilia%2C+demonstrating+that+Bbs4+is+not+required+for+global+cilia+formation. assertion.
- assertion asSentence Overexpression+of+murine+ApoF+significantly+reduced+total+cholesterol+levels+by+28%25%2C+high+density+lipoproteins+by+27%25+and+phospholipid+levels+by+19%25. assertion.
- assertion asSentence Nur77+gene+knockout+alters+dopamine+neuron+biochemical+activity+and+dopamine+turnover. assertion.
- assertion asSentence Haploinsufficiency+of+Fig4+does+not+impose+risks+in+rodents+to+develop+neuronal+degeneration+in+either+naive+or+traumatic+conditions. assertion.
- assertion asSentence Crm1+inhibition+promotes+accumulation+of+p65+NF-kB+in+nuclei+of+poly%28ADP-ribose%29+polymerase-1-deficient+cells+and+reverses+expression+of+NF-kappaB-dependent+genes+upon+Toll-like+receptor+%28TLR%294+stimulation. assertion.
- assertion asSentence Transcription-independent+role+of+Bach1+in+mitosis+through+a+nuclear+exporter+Crm1-dependent+mechanism. assertion.
- assertion asSentence Glucokinase+is+an+integral+component+of+the+insulin+secretory+granule+and+does+not+translocate+during+glucose+stimulation. assertion.
- assertion asSentence Glucokinase+plays+a+key+role+in+the+neuroendocrine+regulation+of+metabolic+economy. assertion.
- assertion asSentence The+hepatic+abundance+of+glucokinase+is+reduced+in+Phosphoinositide-dependent+kinase-1+deficient+mice. assertion.
- assertion asSentence Role+of+a+bound+glucokinase+protein+fraction+in+the+regulation+of+insulin+granule+movement+along+tubulin+filaments. assertion.
- assertion asSentence Fed+LiRiKO+mice+displayed+loss+of+Akt+Ser473+phosphorylation+and+reduced+glucokinase+and+SREBP1c+activity+in+the+liver. assertion.
- assertion asSentence The+p53-cathepsin+axis+is+the+quintessential+framework+underlying+necrotic+cell+death. assertion.
- assertion asSentence Synaptojanin+1+function+is+needed+for+the+progression+of+recycling+vesicles+to+the+functional+synaptic+vesicle+pool. assertion.
- assertion asSentence Synaptopodin+directly+binds+to+IRSp53+and+suppresses+Cdc42%3AIRSp53%3AMena-initiated+filopodia+formation+by+blocking+the+binding+of+Cdc42+and+Mena+to+IRSp53. assertion.
- assertion asSentence HGF+protects+podocytes+from+a+loss+of+nephrin%2C+at+least+in+part%2C+through+maintaining+synaptopodin+in+nephritic+mice+with+albuminuria. assertion.
- assertion asSentence Increasing+27-hydroxycholesterol+concentrations+by+genetic+means+alters+bone+mineral+density. assertion.
- assertion asSentence ERM+is+a+transcription+factor+in+the+ets+family%2C+within+which+it+forms+the+PEA3+group. assertion.
- assertion asSentence The+blood-testis+barrier+%28Sertoli-Sertoli+tight+junctional+complex%29+is+abnormal+in+the+Etv5%28-%2F-%29+mouse. assertion.
- assertion asSentence Induced+only+in+the+presence+of+IL-4. assertion.
- assertion asSentence Production+of+Ym1%2F2+in+response+to+interleukin-13+promotes+T+helper+type+%28Th%292+cell+cytokine+production+and+allergic+airway+inflammation+by+inhibiting+the+production+of+12%28S%29-hydroxyeicosatetraenoic+acid+%28HETE%29+by+12%2F15%28S%29-lipoxygenase+%28LOX%29. assertion.
- assertion asSentence Emi1+is+stabilized+in+mitotic+cells+from+b-TrCP-deficient+%28knockout%29+mice. assertion.
- assertion asSentence In+the+developing+diencephalon%2C+Caspase3+acts+downstream+of+Barhl2+in+limiting+neuroepithelial+cell+proliferation+by+inhibiting+beta-catenin+activation. assertion.
- assertion asSentence Central+NPFF1+and+NPFF2+receptors+control+in+an+opposite+manner+the+body+temperature+in+mice. assertion.
- assertion asSentence Mice+lacking+NHE3+have+impairment+in+their+water+balance+and+urine+osmolality. assertion.
- assertion asSentence ClC-5+plays+an+essential+role+in+exocytosis+of+NHE3. assertion.
- assertion asSentence Mmrn2+interacts+with+anthrax+protective+antigen. assertion.
- assertion asSentence The+CYPD+component+of+the+mPTP+is+required+by+myocardial+ischemic+preconditioning+%28IPC%29+to+generate+mitochondrial+ROS+and+phosphorylate+Akt+and+Erk1%2F2%2C+major+steps+in+the+IPC+signalling+pathway. assertion.
- assertion asSentence Phr1+is+required+for+formation+of+major+CNS+axon+tracts+via+a+mechanism+that+is+both+cell-nonautonomous+and+independent+of+DLK. assertion.
- assertion asSentence Scribble+functions+downstream+of+beta-catenin+to+cluster+synaptic+vesicles+at+developing+synapses. assertion.
- assertion asSentence PKB+is+required+for+the+positive+effects+of+insulin+on+lipid+storage+and+regulation+of+PDE3B+and+AMPK+by+PKB+is+important+for+these+effects. assertion.
- assertion asSentence AMPK+regulates+glucocorticoid+actions+on+carbohydrate+metabolism+by+targeting+the+glucocorticoid+receptor+%28GR%29+and+modifying+transcription+of+glucocorticoid-responsive+genes+in+a+tissue-+and+promoter-specific+fashion. assertion.
- assertion asSentence Control+of+insulin+granule+dynamics+by+AMPK+dependent+KLC1+phosphorylation. assertion.
- assertion asSentence Endothelium-specific+AMPK+activation+is+sufficient+to+protect+against+diabetes+mellitus-induced+aggravation+of+vascular+injury+by+promoting+endothelial+function+and+reendothelialization+via+upregulation+of+heme+oxygenase-1+and+SDF-1alpha. assertion.
- assertion asSentence CARMA3%2FBcl10%2FMALT1-dependent+NF-kappaB+activation+mediates+angiotensin+II-responsive+inflammatory+signaling+in+hepatocytes. assertion.
- assertion asSentence Expression+of+Eaf2+is+developmentally+regulated. assertion.
- assertion asSentence Peli1+is+a+ubiquitin+ligase+needed+for+the+transmission+of+TRIF-dependent+TLR+signals. assertion.
- assertion asSentence Tnfaip8+expression+is+associated+with+susceptibility+to+Staphylococcus+aureus+sepsis. assertion.
- assertion asSentence PI3K+signaling+through+the+dual+GTPase-activating+protein+ARAP3+is+essential+for+developmental+angiogenesis. assertion.
- assertion asSentence LRP16+gene+causes+insulin+resistance+in+C2-C12+cells+by+inhibiting+the+IRS-1+signaling+and+the+transcriptional+activity+of+PPARgamma. assertion.
- assertion asSentence Leupaxin+functions+as+a+paxillin+counterpart+that+potently+suppresses+the+tyrosine+phosphorylation+of+paxillin+during+integrin+signaling. assertion.
- assertion asSentence Mutation+in+Sec15l1+causes+anemia+in+hemoglobin+deficit+mice. assertion.
- assertion asSentence UNC5B-mediated+signaling+is+a+specific+and+autonomous+component+of+fetal-placental+angiogenesis. assertion.
- assertion asSentence Disruption+of+Gpr48+causes+anterior+segment+dysgenesis+through+down-regulation+of+the+Pitx2+gene. assertion.
- assertion asSentence LGR4+is+required+for+cell+survival+of+the+peripheral+mesenchyme+at+the+embryonic+stages+of+nephrogenesis. assertion.
- assertion asSentence Osr2+plays+important+roles+in+cell+proliferation+and+development. assertion.
- assertion asSentence Mice+lacking+both+Osr2+and+Pax9+exhibited+early+tooth+developmental+arrest+with+significantly+reduced+Bmp4+and+Msx1+mRNA+expression+in+the+developing+tooth+mesenchyme. assertion.
- assertion asSentence ML-7%2C+an+MLCK+inhibitor%2C+enhances+activity+of+human+pulmonary+arterial+endothelial+cells+induced+by+LPS+and+reduces+expression+of+p-MLCK. assertion.
- assertion asSentence MLCK+is+essential+for+the+translocation+and+association+of+cortactin+and+p47phox. assertion.
- assertion asSentence Molecular+mechanism+of+telokin-mediated+disinhibition+of+myosin+light+chain+phosphatase+and+cAMP%2FcGMP-induced+relaxation+of+gastrointestinal+smooth+muscle. assertion.
- assertion asSentence Nod1-dependent+responses+play+a+critical+role+in+host+resistance+against+Trypanosoma+cruzi+infection%2C+regardless+of+Toll-like+receptor+activation+and+MyD88+signaling. assertion.
- assertion asSentence Ptdsr+is+localized+in+the+cell+nucleus+via+multiple+nuclear+localization+signals. assertion.
- assertion asSentence Mgat5+modification+of+complex-type+N-glycans+on+CNS+glycoproteins+is+involved+in+the+regulation+of+depression-like+behavior.+as+seen+in+knockout+mice. assertion.
- assertion asSentence Mi-2beta+is+essential+for+the+reprogramming+of+basal+cells+to+the+follicular+and%2C+subsequently%2C+hair+matrix+fates. assertion.
- assertion asSentence The+atypical+cadherin+Celsr3+regulates+the+development+of+the+axonal+blueprint. assertion.
- assertion asSentence DDB2+is+involved+in+global+repair+in+mouse+epithelial+cells. assertion.
- assertion asSentence The+involvement+of+the+beta4+nAChR+subunit+in+both+core+body+temperature+homeostasis+and+nicotine-elicited+thermo-alterations+in+mice. assertion.
- assertion asSentence CA+box+is+critical+for+beta4+promoter+activity+in+vivo. assertion.
- assertion asSentence Corticosteroid+hormone+induced+factor+%28CHIF%29+is+a+small+epithelial-specific+protein+regulated+by+aldosterone+and+K%2B+intake. assertion.
- assertion asSentence Interaction+of+calcium%2Fcalmodulin-dependent+protein+kinase+IIdeltaC+with+sorcin+indirectly+modulates+ryanodine+receptor+function+in+cardiac+myocytes. assertion.
- assertion asSentence In+the+hippocampus+of+mGluR2+knockout+mice%2C+there+is+a+compensatory+upregulation+of+other+glutamate+receptors+and+a+downregulation+of+glutamate+transporter+expression. assertion.
- assertion asSentence Isolation+rearing+causes+an+increase+in+mGluR2+receptors+in+prefrontal+cortex+and+hippocampus. assertion.
- assertion asSentence Activation+of+both+mGluR1+and+mGluR5+subtypes+of+group+I+mGluRs+are+required+for+the+DHPG-induced+increase+in+the+phosphorylation+of+Akt+and+mTOR+in+hippocampal+area+CA1. assertion.
- assertion asSentence Activation+of+mGlu5+receptors+sustains+the+increase+in+c-Myc+induced+by+leukemia+inhibitory+factor+in+embryonic+stem+cells+by+inhibiting+both+glycogen+synthase+kinase-3beta+and+phosphatidylinositol+3-kinase. assertion.
- assertion asSentence Demonstrate+diverse+effects+of+mGlu5+receptor+antagonists+MPEP+and+MTEP+on+gene+expression+in+the+frontal+cortex. assertion.
- assertion asSentence Long-term+exposure+to+a+noncytotoxic+concentration+of+dieldrin+causes+NMDA+receptor+internalization+and+mGLUR5+downregulation+in+cultured+cortical+neurons. assertion.
- assertion asSentence PICK1+binding+to+the+C-terminal+region+of+mGluR7a+is+crucial+for+agonist-triggered+presynaptic+signaling+in+vivo. assertion.
- assertion asSentence GRM7+is+expressed+in+the+hair+cells+and+in+spiral+ganglion+cells+of+the+inner+ear+of+human+and+mouse. assertion.
- assertion asSentence LOX-1+inactivation+leads+to+upregulation+of+immunoglobulins+in+cardiomyocytes+upon+challenge+with+Ang+II. assertion.
- assertion asSentence LOX-1+upregulation+has+a+central+role+in+cardiomyocyte+hypertrophy+response+to+angiotensin+II. assertion.
- assertion asSentence Reciprocal+regulation+between+adiponectin+and+LOX-1+amplifies+oxidative+stress+and+oxidized+LDL+uptake%2C+leading+to+endothelial+dysfunction+in+atherosclerosis. assertion.
- assertion asSentence AMP+activated+protein+kinase-alpha2+regulates+expression+of+estrogen-related+receptor-alpha%2C+a+metabolic+transcription+factor+related+to+heart+failure+development. assertion.
- assertion asSentence Deletion+of+AMPKalpha2+through+p52-Skp2-mediated+ubiquitination+%26+degradation+of+p27%28Kip1%29+accentuates+neointimal+hyperplasia+in+response+to+wire+injury. assertion.
- assertion asSentence Rac1%2C+along+with+IRSp53+and+Abi1%2C+is+involved+in+a+more+complex+and+tight+regulation+of+WAVE2+than+one+operating+solely+through+membrane+localization. assertion.
- assertion asSentence Osteoclasts+require+their+entire+integrin+repertoire+to+be+regulated+by+kindlin-3+to+orchestrate+bone+homeostasis. assertion.
- assertion asSentence Connection+of+XRCC4+and+the+nonhomologous+end+joining+DNA+repair+pathway+to+immunoglobulin+class+switch+recombination. assertion.
- assertion asSentence Overall%2C+transcriptional+inhibition+is+related+to+the+integrated+effect+of+O-GlcNAc+by+direct+modification+of+critical+elements+of+the+transcriptome+and+indirectly+through+O-GlcNAc+modification+of+the+proteasome. assertion.