Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Mthfd1+is+an+essential+gene+in+mice+and+alters+biomarkers+of+impaired+one-carbon+metabolism. assertion.
- assertion asSentence Foxp1+is+critical+for+monocyte+differentiation+and+macrophage+functions+in+vivo. assertion.
- assertion asSentence Alpha-Synuclein-deficient+mice+display+a+prominent+downregulation+of+Foxp1+transcript+sustained+since+postnatal+age+and+throughout+the+brain. assertion.
- assertion asSentence Loss+of+Foxp1%2F4+in+the+developing+lung+and+in+postnatal+secretory+epithelium+leads+to+ectopic+activation+of+the+goblet+cell+fate+program%2C+in+part%2C+through+de-repression+of+the+protein+disulfide+isomerase+anterior+gradient+2+%28Agr2%29. assertion.
- assertion asSentence HkRP1+%28A430106J12Rik%29+is+involved+in+the+process+of+tubulation+of+sorting+nexin-1+positive+membranes+from+early+endosome+subdomains. assertion.
- assertion asSentence Chimaerin%2C+one+of+the+Rho+GTPase+activating+proteins%2C+is+transcriptionally+up-regulated+after+exposure+to+neurotrophins+in+post-natal+cerebellar+neurons. assertion.
- assertion asSentence Impaired+sexual+behavior+in+male+mice+deficient+for+the+beta1-3+N-acetylglucosaminyltransferase-I+gene. assertion.
- assertion asSentence IRAK-2+mediates+pathology+in+a+CD4+T+cell+specific+manner+by+promoting+Th17+cell+development+through+enhancement+of+IL-1beta-induced+activation+of+transcription+factors+RORgammat+and+BATF. assertion.
- assertion asSentence Overexpression+of+E2F8+significantly+slows+down+the+proliferation+of+primary+mouse+embryonic+fibroblasts. assertion.
- assertion asSentence The+RNA-binding+motif+protein+15B+%28RBM15B%2FOTT3%29+acts+as+cofactor+of+the+nuclear+export+receptor+NXF1. assertion.
- assertion asSentence GAC63+is+a+physiologically+relevant+part+of+the+p160+coactivator+signaling+pathway+that+mediates+transcriptional+activation+by+nuclear+receptors. assertion.
- assertion asSentence Reveal+myomasp%2FLRRC39+as+a+previously+unrecognized+component+of+an+M-band-associated+signaling+pathway+that+regulates+cardiomyocyte+gene+expression+in+response+to+biomechanical+stress. assertion.
- assertion asSentence E106+residues+in+wild-type+ORAI1+are+positioned+to+form+a+Ca%282%2B%29+binding+site+in+the+channel+pore+and+E190+interacts+less+directly+with+ions+traversing+the+pore. assertion.
- assertion asSentence Orai1+co-localizes+with+inositol+1%2C4%2C5-triphosphate+type+3+receptors+%28IP3Rs%29+in+the+apical+pole+of+pancreatic+acinar+cells%2C+even+in+IP3-deficient+knockout+mice. assertion.
- assertion asSentence Heterozygote+in+fertility+phenotype+varies+with+the+genetic+background. assertion.
- assertion asSentence The+despites+a+lower+level+of+expression%2C+UPIa+maintain+its+plaque+association+in+urothelial+preneoplastic+lesions. assertion.
- assertion asSentence Levels+of+expression+altered+in+fetuses+from+pregnant+dams+on+a+protein-restricted+diet. assertion.
- assertion asSentence Sidesteam+tobacco+smoke+exposure+in+early+life+increases+NPY+tracheal+innervation+and+alters+pulmonary+function+and+these+changes+are+mediated+through+the+NGF. assertion.
- assertion asSentence Ankyrin-B+regulates+Kir6.2+membrane+expression+and+function+in+heart. assertion.
- assertion asSentence Both+beta-arrestin-1+and+-2+directly+inhibit+the+1-phosphatidylinositol+3-kinase+p110alpha+catalytic+subunit+in+vitro. assertion.
- assertion asSentence Expression+of+LPP+in+smooth+muscle+is+mediated+by+an+alternative+promoter+that+is+regulated+by+SRF%2Fmyocardin. assertion.
- assertion asSentence The+prostaglandin+E2+receptor%2C+EP2%2C+stimulates+keratinocyte+proliferation+in+mouse+skin+by+G+protein-dependent+and+%7Bbeta%7D-arrestin1-dependent+signaling+pathways. assertion.
- assertion asSentence Beta-arrestin-1+plays+a+role+in+metabolism+regulation. assertion.
- assertion asSentence Beta-arrestin-1+protein+represses+adipogenesis+and+inflammatory+responses+through+its+interaction+with+peroxisome+proliferator-activated+receptor-gamma+%28PPARgamma%29. assertion.
- assertion asSentence Examine+the+different+contributions+of+beta-arrestin1-+and+beta-arrestin2-mediated+regulation+of+the+mu-opioid+receptor+by+comparing+MOR+agonists+in+cells+that+lack+expression+of+individual+or+both+beta-arrestins. assertion.
- assertion asSentence Dia1+is+required+for+the+formation+of+the+actin+coat+around+endosomes+downstream+of+RhoB%2C+connecting+membrane+trafficking+with+the+regulation+of+actin+dynamics. assertion.
- assertion asSentence The+Akt+and+Erk+MAP+kinase+signaling+pathways+are+activated+in+androgen-independent+lesions+of+these+mice. assertion.
- assertion asSentence B-Raf%2FMKK%2FERK+provides+a+permissive+environment+for+melanoma+genesis+by+modulating+plexin+B1. assertion.
- assertion asSentence Rap1A+plays+role+in+the+regulation+of+integrins. assertion.
- assertion asSentence HPK1+associates+with+SKAP1+to+negatively+regulate+Rap1-mediated+B-lymphocyte+adhesion. assertion.
- assertion asSentence DEK+is+a+neuroblastoma+tumor+antigen. assertion.
- assertion asSentence Overexpression+of+the+cellular+DEK+protein+promotes+epithelial+transformation+in+vitro+and+in+vivo. assertion.
- assertion asSentence The+hallmark+of+translocation+in+acutte+myeloid+leukemiaa+is+the+expression+of+the+DEK%2FCAN+fusion+protein. assertion.
- assertion asSentence T+cells+in+cryptopatch+aggregates+are+clonally+related+to+T+cell+receptor+gamma+delta+chain-expressing+intestinal+epithelial+lymphocytes. assertion.
- assertion asSentence Most+TCRJdelta+segments+contain+amino+acid+sequences+at+their+5%27+ends+that+resemble+their+own+D+segments. assertion.
- assertion asSentence Raf-1-induced+Rok-alpha+inhibition+allows+the+phosphorylation+of+STAT3+and+Myc+expression+and+promotes+dedifferentiation+in+Ras-induced+tumors. assertion.
- assertion asSentence Rok-alpha+inhibition+by+Raf-1+relies+on+an+intermolecular+interaction+between+the+Rok-alpha+kinase+domain+and+the+cysteine-rich+Raf-1+regulatory+domain+%28Raf-1reg%29. assertion.
- assertion asSentence Protein+kinase+C+epsilon+regulates+translocator+protein+Tspo+gene+expression+through+a+proto-oncogene+protein+Raf-1-MAP-kinase+signal+transduction+pathway%2C+acting+at+least+in+part+through+c-Jun+and+STAT3+transcription+factors. assertion.
- assertion asSentence A+critical+role+of+BI-1+as+a+stress+integrator+that+modulates+autophagy+levels+and+other+interconnected+homeostatic+processes. assertion.
- assertion asSentence The+C+terminus+of+Bax+inhibitor-1+forms+a+Ca2%2B-permeable+channel+pore. assertion.
- assertion asSentence Methionine+oxidation+of+alpha-crystallin+in+combination+with+loss+of+MsrA+repair+causes+loss+of+alpha-crystallin+chaperone+function. assertion.
- assertion asSentence A+low+pKa+cysteine+at+the+active+site+of+mouse+methionine+sulfoxide+reductase+A. assertion.
- assertion asSentence Bcr-Abl+oncoprotein+requires+the+IL-3+receptor%2FJak2%2FStat5+pathways+for+oncogenic+transformation+of+NIH+3T3+fibroblasts. assertion.
- assertion asSentence Cerebral+GRK2+has+an+important+endogenous+neuroprotective+role+in+ischemic+cerebral+damage. assertion.
- assertion asSentence Regulator+of+coordinated+integrin+and+G-protein-coupled+receptor-directed+epithelial+cell+migration. assertion.
- assertion asSentence Absence+of+GRK2+before+coronary+artery+ligation+prevented+maladaptive+postinfarction+remodeling+and+preserved+betaAR+responsiveness. assertion.
- assertion asSentence MicroRNA-126+modulates+endothelial+SDF-1+expression+and+mobilization+of+Sca-1%28%2B%29%2FLin%28-%29+progenitor+cells+in+ischaemia. assertion.
- assertion asSentence Activation+of+phospholipase+C+and+alternative+splicing+of+pre-mRNA+encoding+the+editing+enzymes+ADAR1+and+ADAR2+have+both+overlapping+and+specific+roles+in+modulating+5-HT2CR+editing+phenotypes. assertion.
- assertion asSentence An+essential+role+for+Rgnef+in+RhoA+regulation+downstream+of+integrins+in+control+of+cell+migration. assertion.
- assertion asSentence Expression+of+Lmx1a+and+Isl1+begins+in+the+otocyst+stage%2C+with+Lmx1a+exclusively+in+the+non-sensory+and+Isl1+in+the+prosensory+epithelia. assertion.
- assertion asSentence The+Lmx1a+can+induce+desired+neuronal+lineages+from+most+expressing+neural+progenitor+cells+by+a+mechanism+resembling+developmental+binary+cell-fate+switching. assertion.
- assertion asSentence A+subset+of+type+1+diabetes+susceptibility+%28Idd7%29+genes+located+outside+the+histocompatibility+complex+of+NOD+mice+interactively+impairs+the+negative+selection+of+diabetogenic+CD8%2B+T+cells. assertion.
- assertion asSentence Learning+impairments+displayed+by+Rsk2-deficient+mice. assertion.
- assertion asSentence Investigating+signal+tranduction+pathway+involved+in+skeletal+muscle+atrophy+in+Rps6ka2+knockout+mice. assertion.
- assertion asSentence RSK2+is+required+for+growth+factor-mediated+attenuation+of+GPCR+signaling. assertion.
- assertion asSentence The+JAK-Stat5B+defective+pathway+in+NOD+mice+along+with+other+defective+factors+is+associated+with+the+pathogenesis+of+autoimmune+type+1+diabetes+in+NOD+mice. assertion.
- assertion asSentence Gpc3+is+activated+in+the+regenerating+liver+in+an+Afr2-dependent+manner. assertion.
- assertion asSentence Within+the+physiologic+range+of+aldosterone+concentrations%2C+sodium+transport+is+predicted+to+be+controlled+by+MR+occupancy+during+circadian+cycles+and+by+MR+and+GR+occupancy+during+salt+restriction+or+acute+stress. assertion.
- assertion asSentence Whrn+connects+to+the+Usher+protein+network+in+the+cochlea+and+retina+by+direct+association+with+USH2A+and+VLGR1. assertion.
- assertion asSentence C%2FEBP+epsilon+gene+as+an+important+transcription+factor+required+for+normal+function+and+development+of+macrophages. assertion.
- assertion asSentence Expression+of+CTLA-2alpha+mRNA+is+predominantly+neuronal+in+mouse+brain. assertion.
- assertion asSentence Normal+developmental+changes+in+nicotinic+signaling+and+dendritic+morphology+in+prefrontal+cortex+depend+on+alpha5-comprising+nicotinic+acetylcholine+receptors. assertion.
- assertion asSentence Tonic+inhibitory+conductance+in+hippocampal+pyramidal+neurons+generated+by+alpha5+subunit-containing+GABA%28A%29+receptors+is+highly+sensitive+to+low+concentrations+of+the+volatile+anesthetic+isoflurane. assertion.
- assertion asSentence Depending+on+cell+type%2C+Gabra5+and+delta+subunits+are+the+principal+GABA+A+receptor+subunits+regulating+tonic+inhibition+in+hippocampal+neurons. assertion.
- assertion asSentence Slc8a2+has+critical+and+non-redundant+roles+in+the+local+control+of+neuronal+calcium+ions+%5BCa2%2B%5D+essential+for+the+development+of+synaptic+plasticity+associated+with+learning+and+memory. assertion.
- assertion asSentence Disruption+of+murine+NHE4+leads+to+metabolic+acidosis+with+inappropriate+urinary+ammonia+excretion+and+decreases+the+ability+of+the+thick+ascending+limb+to+absorb+ammonia+and+to+build+the+corticopapillary+ammonia+gradient. assertion.
- assertion asSentence An+imbalance+in+IL-1%2FIL-1Ra+signaling+at+the+IL-1R1+level+modulates+the+severity+of+cardiac+remodeling+after+acute+myocardial+infarction+in+the+mouse. assertion.
- assertion asSentence The+overall+high+number+of+mutations+in+these+genes+demonstrates+their+central+role+in+the+maintenance+of+lens+transparency. assertion.
- assertion asSentence Elevated+levels+of+CEA+are+associated+with+pancreatic+cancer+and+new-onset+diabetes. assertion.
- assertion asSentence A+kappa+recombination+signal+sequence+and+its+flanks+support+six-+to+nine-fold+higher+levels+of+recombination+than+a+lambda+counterpart. assertion.
- assertion asSentence IFN-alpha+and+IFN-beta+can+act+in+an+autocrine+manner+to+activate+DCs. assertion.
- assertion asSentence IFN-alphabeta+alone+induces+tyrosine+phosphorylation+of+STAT4+in+murine+splenocytes+of+different+mouse+strains. assertion.
- assertion asSentence Both+interferon-alpha+and+-beta+genes+are+required+in+the+regenerative+capabilities+of+the+hemopoietic+system+under+the+pressure+of+Pneumocystis+infection. assertion.
- assertion asSentence Nuclear+transport+and+phosphorylation+states+of+Mop3+are+regulated+by+a+circadian+clock. assertion.
- assertion asSentence On+the+nonautoimmune+C57BL%2F6+background%2C+Sle3+affects+Ig+VHDJH+junctional+diversity+and+Ig+variable+region+heavy+chain+mutational+diversity+and+leads+to+recombinational+activation+of+allelically+excluded+Ig+heavy+chain+genes+in+the+periphery. assertion.
- assertion asSentence Mice+of+the+B6.NZMSle1%2FSle2%2FSle3+%28Sle1%2C2%2C3%29+lupus-prone+strain+also+express+an+interferon+%28IFN%29+signature+compared+with+non-autoimmune+C57BL%2F6+mice. assertion.
- assertion asSentence Loss+of+PHD1+provided+tolerance+of+hepatocytes+to+acute+hypoxia+and+protected+them+against+ischemia%2Freperfusion+damage. assertion.
- assertion asSentence Perturbation+in+salt+and+acid-base+metabolism+in+CLDN16+knockout+mice+has+its+origin+in+the+defective+cation+permeability+selectivity+of+the+thick+ascending+limb+of+the+nephron. assertion.
- assertion asSentence Altered+ultrasonic+vocalization+in+mice+with+a+disruption+in+the+Foxp2+gene. assertion.
- assertion asSentence FoxP2+is+highly+expressed+in+virtually+all+Purkinje+cells+in+cerebellum+at+and+before+postnatal+day+6%2C+except+for+those+in+the+flocculus+and+small+parts+of+the+nodulus. assertion.
- assertion asSentence Foxp2%28R552H%29+knock-in+mouse+pups+exhibit+impaired+ultrasonic+vocalization+and+poor+dendritic+development+in+Purkinje+cells. assertion.
- assertion asSentence Kisspeptin+and+its+receptor+are+expressed+in+the+human%2C+rat+and+mouse+heart+and+kisspeptins+possess+potent+positive+inotropic+activity. assertion.
- assertion asSentence The+recruitment%2C+infiltration+and+accumulation+of+bone+marrow-derived+LYVE-1-expressing+macrophages+are+crucial+for+the+formation+of+the+dense+vascular+network+in+adipose+tissue. assertion.
- assertion asSentence The+down-regulation+of+CLIC1+enhanced+proliferative+activity. assertion.
- assertion asSentence Involvement+of+the+TIP39%2FPTH2-R+system+in+the+pathways+involved+in+the+successful+development+of+the+pups. assertion.
- assertion asSentence Arthritis-promoting+locus+Cia9+partly+overcomes+the+inhibitory+effect+of+Cia2. assertion.
- assertion asSentence RAD51C+has+a+late+role+in+meiotic+recombination. assertion.
- assertion asSentence Macrophage%2Fmicroglia-specific+protein+Iba1+enhances+membrane+ruffling+and+Rac+activation+via+phospholipase+C-gamma+-dependent+pathway. assertion.
- assertion asSentence AATF+is+an+endogenous+antagonist+of+Par-4+activity+and+an+effective+inhibitor+of+aberrant+amyloid+beta+1-42+production+and+secretion+under+apoptotic+conditions. assertion.
- assertion asSentence Cooperation+between+Par-4+and+PTEN+as+relevant+for+the+development+of+prostate+cancer+and+implicate+the+NF-kappaB+pathway+as+a+critical+event+in+prostate+tumorigenesis. assertion.
- assertion asSentence Overproduction+of+DAG+in+PLCzeta-injected+eggs+can+lead+to+PKC-mediated+Ca%282%2B%29+influx+and+subsequent+overloading+of+Ca%282%2B%29+stores. assertion.
- assertion asSentence Cygb+expression+is+correlated+with+reactive+oxygen+species+scavenging. assertion.
- assertion asSentence Vsx1+is+required+for+cone+bipolar+cell+differentiation+and+regulates+photopic+vision+perception. assertion.
- assertion asSentence Transcription+factor+visual+system+homeobox+1+homolog+%28Vsx1%29+controls+specific+aspects+of+visual+function+in+the+neural+circuitry+of+the+mammalian+retina. assertion.
- assertion asSentence Required+for+presynaptic+long-term+potentiation. assertion.
- assertion asSentence Cyclic+AMP+rescue+of+priming+defects+caused+by+Munc13-1+deficiency+signaling+pathways+requires+downstream+Munc13-1-Rim2+interaction. assertion.
- assertion asSentence PRELP+has+a+role+in+skeletal+remodeling. assertion.
- assertion asSentence The+metastasis-associated+protein-1+gene+encodes+a+host+permissive+factor+for+schistosomiasis%2C+a+leading+global+cause+of+inflammation+and+cancer. assertion.
- assertion asSentence Severe+impairment+of+interleukin-1+and+Toll-like+receptor+signalling+in+mice+lacking+IRAK-4. assertion.
- assertion asSentence The+induction+of+IL-6+gene+expression+in+macrophages+via+Tlr4+is+TIRAP-dependent. assertion.