Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence UGRP1+is+downregulated+in+inflamed+airways%2C+such+as+allergic+asthmatics. assertion.
- assertion asSentence Tiarp+is+stimulated+by+tumor+necrosis+factor-alpha+in+adipocytes. assertion.
- assertion asSentence Plays+a+critical+role+in+protecting+the+heart+from+doxorubicin-induced+cardiomyopathy. assertion.
- assertion asSentence At+the+cellular+level%2C+SK2-like+immunoreactivity+is+primarily+localized+to+somatic+and+dendritic+structures+in+mouse+brain. assertion.
- assertion asSentence SK2+channels+regulate+hippocampal+synaptic+plasticity+and+play+a+critical+role+in+modulating+mechanisms+of+learning+and+memory. assertion.
- assertion asSentence Formation+of+cellular+projections+in+neural+progenitor+cells+depends+on+SK3+channel+activity. assertion.
- assertion asSentence Minisatellite+locus+UPS29+can+regulate+an+activity+of+CENTB5%2C+SCNN1D+and+ACOT7+in+nervous+system+cells. assertion.
- assertion asSentence Wdr5+accelerates+osteoblast+differentiation+in+association+with+activation+of+the+canonical+Wnt+pathway. assertion.
- assertion asSentence Subtype+switching+of+vesicular+glutamate+transporters+at+parallel+fibre-Purkinje+cell+synapses+in+developing+mouse+cerebellum. assertion.
- assertion asSentence VGluT2+is+the+only+vesicular+glutamate+transporter+expressed+in+ventral+tegmental+area%2Fsubstantia+nigra+dopamine+neurons+in+vivo. assertion.
- assertion asSentence VGLUT2+is+a+major+mediator+of+nociception+in+primary+afferents%2C+implying+that+glutamate+is+the+key+somatosensory+neurotransmitter. assertion.
- assertion asSentence Npt2a+and+Npt2c+in+mice+play+distinct+and+synergistic+roles+in+inorganic+phosphate+metabolism+and+skeletal+development. assertion.
- assertion asSentence Variation+in+the+T1R3+receptor+influenced+peripheral+taste+responsiveness+over+a+wide+range+of+sweetener+concentrations. assertion.
- assertion asSentence TLR3+signaling+mediates+external+polyinosinic-polycytidylic+acid-induced+nuclear+factor-kappaB+%28NF-kappaB%29+and+IRF-3+activation+and+beta-cell+apoptosis. assertion.
- assertion asSentence Toll-like+receptor+3+activation+induces+antiviral+immune+responses+in+mouse+sertoli+cells. assertion.
- assertion asSentence Free+cholesterol+accumulation+in+macrophage+membranes+activates+Toll-like+receptors+and+p38+mitogen-activated+protein+kinase+and+induces+cathepsin+K. assertion.
- assertion asSentence Complementary+roles+for+MDA5+and+TLR3+in+poly%28I%3AC%29-mediated+NK+cell+activation. assertion.
- assertion asSentence Tlr3-mediated+immunity+during+gestation+inhibits+cortical+neurogenesis+and+causes+behavioral+disturbances. assertion.
- assertion asSentence Unexpected+protective+role+for+Toll-like+receptor+3+in+the+arterial+wall. assertion.
- assertion asSentence TLR9+and+TLR3+agonist+CpG-oligodeoxynucleotide+%28ODN%29+induces+Paneth+cell+degranulation. assertion.
- assertion asSentence The+TLR3-TRIF+mediated+antiviral+response+is+important+for+protection+against+poliovirus+infection+in+poliovirus+receptor+transgenic+mice. assertion.
- assertion asSentence Osx-mediated+inhibition+of+osteoblast+proliferation+is+a+consequence+of+the+Osx-mediated+control+of+Wnt%2Fbeta-catenin+activity. assertion.
- assertion asSentence Programmed+-1+ribosomal+frameshifting+in+mouse+and+human+Peg10+genes. assertion.
- assertion asSentence Different+expression+levels+of+inhibitory+natural+killer+%28NK%29+receptor+Ly49Q+define+sequential+developmental+stages+of+murine+plasmacytoid+dendritic+cells+in+bone+marrow. assertion.
- assertion asSentence IKKalpha+is+a+unique+molecule+involved+in+TLR7%2F9-MyD88-dependent+type+I+IFN+production+through+dendritic+cell+subset-specific+mechanisms. assertion.
- assertion asSentence Toll-like+receptor+7+stimulation+promotes+autoimmune+diabetes+in+the+NOD+mouse. assertion.
- assertion asSentence TLR7+recognizes+retroviruses+and+regulates+the+antibody+response+to+infection. assertion.
- assertion asSentence TLR7%2C+a+receptor+recognizing+self-nucleic+acid+complexes%2C+is+protective+in+atherosclerosis. assertion.
- assertion asSentence Poly-thymidine+oligonucleotides+act+in+synergy+with+TLR7%2F8+agonists+to+induce+strong+TLR7-dependent+cytokine+production+in+glial+cells. assertion.
- assertion asSentence Presence+of+a+Na%28%2B%29-Ca%282%2B%29+exchanger+in+podocytes+and+its+regulation+by+PKC. assertion.
- assertion asSentence Regulation+of+NHE3+depends+on+the+nature+of+the+NHERF+family+member+associating+with+NHE3+and+the+accompanying+NHE3+complexes. assertion.
- assertion asSentence Interleukin+6+enhances+glycolysis+through+expression+of+the+glycolytic+enzymes+hexokinase+2+and+6-phosphofructo-2-kinase%2Ffructose-2%2C6-bisphosphatase-3. assertion.
- assertion asSentence Inducible+PFKFB3+is+required+for+increased+growth%2C+metabolic+activity+and+is+regulated+through+active+JAK2+and+STAT5. assertion.
- assertion asSentence PUMA+plays+a+critical+role+in+the+maintenance+of+genomic+integrity+of+spermatogonial+stem+cell+precursors. assertion.
- assertion asSentence Deletion+of+proapoptotic+Puma+selectively+protects+hematopoietic+stem+and+progenitor+cells+against+high-dose+radiation. assertion.
- assertion asSentence The+pivotal+position+of+Puma+as+mediator+of+apoptosis+in+cortical+neurons+is+because+of+the+availability+of+at+least+three+independent+signalling+pathways+that+ensure+its+activation. assertion.
- assertion asSentence Bim+and+Puma+expression+is+induced+by+endogenous+ROS+in+a+SIRT1-dependent+manner. assertion.
- assertion asSentence Function+of+DC-SIGN+as+an+antigen-capturing+receptor+of+HIV-1. assertion.
- assertion asSentence Mouse+DC-SIGN+homologue+SIGNR3+makes+a+unique+contribution+to+protection+of+the+host+against+a+pulmonary+bacterial+pathogen. assertion.
- assertion asSentence The+extracellular+domain+of+Crb1+positively+regulates+pituitary+tumor+transforming+gene+1+%28Pttg1%29+transcript+levels. assertion.
- assertion asSentence PGC1beta+is+an+essential+mediator+for+the+PPARgamma+stimulation+of+osteoclastogenesis+by+targeting+both+PPARgamma+itself+and+ERRalpha. assertion.
- assertion asSentence The+expression+of+ASIC3+in+dorsal+root+ganglion+%28DRG%29+neurons. assertion.
- assertion asSentence Tim-1+is+induced+on+germinal+centre+B+cells+through+BCR+signaling. assertion.
- assertion asSentence Tim1+and+Tim3+are+not+essential+for+the+induction+of+the+type-2+response+in+lung+allergy. assertion.
- assertion asSentence Tim-1+functions+in+pathways+that+suppress+recruitment+of+inflammatory+cells+into+the+airways+and+the+generation+or+activity+of+CD4%2B+T+cells. assertion.
- assertion asSentence Host+homeostatic+mechanism+mediated+by+Gal-9%2FTim-3+interaction+on+CD8%28%2B%29+T+cells+can+influence+the+outcome+of+HSV-1+latent+infection. assertion.
- assertion asSentence The+Tim-3+and+PD-L1-mediated+signaling+can+significantly+reduce+pathologies+in+the+upper+genital+tract+without+suppressing+immunity+against+chlamydial+infection. assertion.
- assertion asSentence Activity+of+the+neuronal+cold+sensor+TRPM8+is+regulated+by+phospholipase+C+via+the+phospholipid+phosphoinositol+4%2C5-bisphosphate. assertion.
- assertion asSentence An+anion+transporter+expressed+on+the+apical+surface+of+renal+proximal+tubule+cells+and+capable+of+mediating+Cl%28-%29-formate+exchange. assertion.
- assertion asSentence An+essential+role+for+the+scaffolding+protein+PDZK1+in+apical+membrane+expression+of+SLC26A6%2C+is+demonstarted. assertion.
- assertion asSentence Multiple+modes+of+anion+exchange+mediated+by+Slc26a6+are+negatively+regulated+by+PKC-delta+activation. assertion.
- assertion asSentence The+selective+CRF2+agonist+prevented+enhanced+defecation. assertion.
- assertion asSentence Structural+basis+for+the+exclusive+association+of+Slac2-a+with+the+Rab27+subfamily. assertion.
- assertion asSentence Developmental+ablation+of+interdigital+webbing+on+mouse+paws+and+normal+lymphocyte+homeostasis+require+the+cooperative+activity+of+Bim+and+Bmf. assertion.
- assertion asSentence Dicer+plays+a+specific+role+in+regulating+lung+epithelial+morphogenesis+independent+of+its+requirement+in+cell+survival. assertion.
- assertion asSentence Dicer+influences+vesicular+stomatitis+virus+replication+by+a+mechanism+distinct+from+RNA+interference-+or+interferon-mediated+responses. assertion.
- assertion asSentence The+ooplasm+of+primary+oocytes+contains+DICER1-dependent+factors+that+are+crucial+for+chromosome+segregation+and+meiotic+maturation. assertion.
- assertion asSentence Binding+of+Dicer+to+TRBPs+is+critical+for+RNAi+function. assertion.
- assertion asSentence Global+reduction+of+miRNA+processing+by+silencing+Dicer+enhances+tumor+proliferation+and+invasion. assertion.
- assertion asSentence Dicer+and+Dicer-dependent+small+RNAs+are+imperative+regulators+of+haploid+spermatid+differentiation+and+essential+for+male+fertility. assertion.
- assertion asSentence Wnt5a%2FRor2+activates+JNK%2C+through+a+process+involving+filamin+A+and+PKCzeta%2C+to+regulate+polarized+cell+migration. assertion.
- assertion asSentence Filamin+A+is+required+for+osteoclastogenesis+by+regulating+actin+dynamics+via+Rho+GTPases+that+control+monocyte+migration. assertion.
- assertion asSentence Filamin+A+interacts+with+Big2+and+overexpression+of+Filamin+A+interfers+with+neuronal+migration. assertion.
- assertion asSentence Foxl2+expression+partly+depends+of+Rspo1+signalisation. assertion.
- assertion asSentence The+antibacterial+protein+SWAM2+is+constitutively+expressed+in+tongue+and+inhibits+the+growth+of+both+Escherichia+coli+and+Staphylococcus+aureus+at+an+IC90+of+10+microM. assertion.
- assertion asSentence Prominin-2+is+widely+and+abundantly+expressed+along+the+epithelia+of+various+segments+of+the+adult+male+genitourinary+tract. assertion.
- assertion asSentence Bhc80+is+indispensable+for+the+survival+of+neonatal+pups. assertion.
- assertion asSentence Xiaotan+Sanjie+Decoction+XTSJD+can+decrease+the+protein+expressions+of+IL-8+and+its+receptors+CXCR1%2FCXCR2+in+tumor+xenografts+and+gastric+tissue+adjacent+to+the+tumor. assertion.
- assertion asSentence CSN3+and+CSN5+are+involved+in+oocyte+meiosis+by+regulating+degradation+of+Cyclin+B1+and+Securin+via+APC%2FC. assertion.
- assertion asSentence Impaired+insulin+and+IGF-1+signaling+promotes+L-proline+metabolism+to+generate+a+reactive+oxygen+species+signal+for+the+adaptive+induction+of+endogenous+stress+defense+to+extend+life+span. assertion.
- assertion asSentence Macrophage+migration%2C+cell+polarization+and+antigen+presentation+to+T-cells+require+n-cofilin+mediated+F-actin+remodelling. assertion.
- assertion asSentence The+Proto-Oncogene+Proteins+p21%28ras%29downstream+effector+pathways+in+tumorigenesis. assertion.
- assertion asSentence Alcohol-fermented+soybean+increases+the+production+of+NO+and+TNF-alpha+through+the+activation+of+Rip2%2FIKK-beta+in+rIFN-gamma-primed+macrophages. assertion.
- assertion asSentence EGF-induced+MAPK+signaling+inhibits+hemidesmosome+formation+through+phosphorylation+of+the+integrin+beta+4. assertion.
- assertion asSentence The+mTRPV1+cation+channel+has+a+molecular+pharmacological+profile+more+akin+to+rat+TRPV1+than+either+human+or+guinea+pig+TRPV1. assertion.
- assertion asSentence A+significant+proportion+of+the+insulin+receptor-expressing+cells+also+expressed+TRPV1. assertion.
- assertion asSentence TRPV1+contributes+to+the+beneficial+effects+of+preconditioning+against+ischemia+reperfusion+injury+through+release+substance+P+and+calcitonin+gene-related+peptide+%28CGRP%29. assertion.
- assertion asSentence Demonstrate+a+role+for+TRPV1+in+chemo-+and+mechanosensation+of+gastroesophageal+afferents. assertion.
- assertion asSentence Elevated+pressure+induces+an+influx+of+extracellular+Ca%282%2B%29+in+retinal+microglia+that+precedes+the+activation+of+NFkappaB+and+the+subsequent+production+and+release+of+IL-6+and+is+at+least+partially+dependent+on+the+activation+of+TRPV1. assertion.
- assertion asSentence TRPV1+gene+required+for+thermosensory+transduction+and+anticipatory+secretion+from+vasopressin+neurons+during+hyperthermia. assertion.
- assertion asSentence At+the+level+of+DRG%2C+approximately+40%25+of+articular+afferents+from+these+joints+express+TRPV1+and+the+majority+of+them+are+peptidergic%2C+as+revealed+by+simultaneous+immunostaining+for+the+neuropeptide+calcitonin+gene-related+peptide. assertion.
- assertion asSentence Increased+heat+sensitivity+in+TRPV1-negative+polymodal+C-fibers+alone+following+inflammation+is+insufficient+for+the+induction+of+heat+hyperalgesia. assertion.
- assertion asSentence Clear+differences+are+revealed+between+lumbar+splanchnic+neuron+and+pelvic+nerve+sensory+pathways+in+TRPA1+and+TREK-1+gene+expression+and+in+the+gene+expression+of+potassium+two-pore+domain+channels+in+TRPV1-expressing+neurons. assertion.
- assertion asSentence In+TRPV1+knockout+mice%2C+paracetamol+induced+hypothermia+to+the+same+extent+as+in+wild-type+mice. assertion.
- assertion asSentence Absence+or+blocking+of+TRPV1+suppressed+inflammation+and+fibrosis%2Fscarring+during+healing+of+alkali-burned+mouse+cornea. assertion.
- assertion asSentence Inducible+HSP70.1+and+HSP70.3+are+required+for+late-phase+protection+against+myocardial+infarction+following+ischemia+preconditioning+in+mice. assertion.
- assertion asSentence Helix+C+is+involved+in+the+self-association+of+Hsp72. assertion.
- assertion asSentence Grhl+genes+are+highly+expressed+in+the+developing+epidermis. assertion.
- assertion asSentence Important+regulator+of+the+desmoglein+1+genes+in+the+context+of+hair+anchorage+and+epidermal+differentiation. assertion.
- assertion asSentence The+Fbxo40+is+muscle+specific+in+expression+and+is+upregulated+during+differentiation. assertion.
- assertion asSentence Murine+cells+have+evolved+mechanisms+to+ensure+the+functional+redundancy+of+Pif1+or+Nbs1+in+the+regulation+of+chromosome+healing. assertion.
- assertion asSentence BTLA+plays+an+important+role+in+the+maintenance+of+immune+tolerance+and+the+prevention+of+autoimmune+diseases. assertion.
- assertion asSentence Dot1L+and+H3K79%28+lysine+79+of+histone+H3%29+methylation+play+important+roles+in+heterochromatin+formation+and+in+embryonic+development. assertion.
- assertion asSentence Roles+of+Dot1L+and+53Bp1+in+gene+expression+and+the+control+of+DNA+double-strand+repair+pathways+in+the+context+of+chromatin. assertion.
- assertion asSentence Cbl+proteins+play+a+critical+role+in+establishing+the+MHC-dependent+CD4%28%2B%29+and+CD8%28%2B%29+T+cell+development+programs. assertion.
- assertion asSentence A+nonredundant+antagonism+between+PKC-theta+and+Cbl-b+that+regulates+T+cell+activation+responses. assertion.
- assertion asSentence Cbl-b+is+a+critical+factor+in+maintaining+lung+homeostasis+upon+environmental+exposure+to+aeroallergens. assertion.
- assertion asSentence HNF4alpha+has+a+role+in+controlling+the+acute+phase+response+of+the+liver+induced+by+ER+stress+by+regulating+expression+of+CrebH. assertion.
- assertion asSentence CREBH+plays+a+crucial+role+in+the+regulation+of+hepatic+glucose+metabolism+in+mammals. assertion.
- assertion asSentence HDAC4%2Fmyogenin+positive+feedback+loop+that+coordinates+gene+induction+and+repression+underlying+muscle+phenotypic+changes+after+muscle+denervation. assertion.