Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Relationship+between+dilation+of+endoplasmic+reticulum+and+decreased+levels+of+the+FBXO11+gene+in+vitiligo+melanocytes. assertion.
- assertion asSentence CtIP+counteracts+Rb-mediated+G%281%29+restraint. assertion.
- assertion asSentence CtIP+binds+to+switch-region+DNA+and+plays+a+physiological+role+in+microhomology-mediated+end+joining+in+a+C-NHEJ-proficient+environment. assertion.
- assertion asSentence Phenylalanine+169+in+the+second+extracellular+loop+of+the+human+histamine+H4+receptor+is+responsible+for+the+difference+in+agonist+binding+between+human+and+mouse+H4+receptors. assertion.
- assertion asSentence Therapeutic+H4R+antagonism+can+significantly+ameliorate+allergen+induced%2C+Th2+cytokine+driven+pathologies+such+as+lung+remodeling+and+airway+dysfunction+in+asthma. assertion.
- assertion asSentence Evi3+misexpression+initiates+tumorigenesis+by+perturbing+B-cell+development+via+an+interaction+with+Early+B-cell+Factor+%28EBF%29. assertion.
- assertion asSentence Zfp521+is+an+important+PTHrP+target+gene+that+regulates+growth+plate+chondrocyte+proliferation+and+differentiation. assertion.
- assertion asSentence The+TRIF+pathway+is+critical+for+lipopolysaccharide+to+increase+effector+T+cell+accumulation+into+nonlymphoid+tissues+such+as+liver+and+lung. assertion.
- assertion asSentence Either+rod+or+cone+PDE6+can+effectively+couple+to+the+cone+phototransduction+pathway+to+mediate+visual+signaling. assertion.
- assertion asSentence CatSper-null+mutant+spermatozoa+are+unable+to+ascend+beyond+the+oviductal+reservoir. assertion.
- assertion asSentence Immunization+with+B-cell+epitopes+in+transmembrane+domains+and+pore+region+of+CatSper1+can+cause+significant+antifertility+effects+in+male+mice. assertion.
- assertion asSentence RIN1+is+an+ABL+tyrosine+kinase+activator+and+a+regulator+of+epithelial-cell+adhesion+and+migration. assertion.
- assertion asSentence The+EphA4+receptor+is+required+for+synaptic+plasticity+in+the+amygdala%2C+raising+the+possibility+that+an+underlying+mechanism+of+Rin1+function+in+amygdala+is+to+down-regulate+EphA4+signaling+by+promoting+its+endocytosis. assertion.
- assertion asSentence Modulation+of+TRPM6+and+Na%28%2B%29%2FMg%282%2B%29+exchange+in+mammary+epithelial+cells+in+response+to+variations+of+magnesium+availability. assertion.
- assertion asSentence Dmrt2+is+associated+with+embryonic+myogensis. assertion.
- assertion asSentence The+transcription+factor%2C+GLIS3%2C+has+both+repressor+and+activation+functions. assertion.
- assertion asSentence The+anti-tumorigenic+properties+of+peroxisomal+proliferator-activated+receptor+alpha+are+arachidonic+acid+epoxygenase-mediated. assertion.
- assertion asSentence Cyp2c44+functions+as+an+high+potassium-inducible+antihypertensive+enzyme+responsible+for+inhibiting+ENaC+activity+and+Na+absorption+in+the+aldosterone-sensitive+distal+nephron. assertion.
- assertion asSentence Zfp281+plays+bifunctional+roles+in+regulating+gene+expression+within+the+network. assertion.
- assertion asSentence Mice+with+reduced+expression+of+laminin+gamma1+in+Schwann+cells+also+exhibit+a+reduction+in+laminin+alpha2+and+beta1+and+exhibit+motor+defects+which+lead+to+hind+leg+paralysis+and+tremor. assertion.
- assertion asSentence Deletion+of+Atf6alpha+has+a+profound+effect+on+the+transcriptional+program+elicited+by+endoplasmic+reticulum+stress%2C+revealing+a+broader+than+anticipated+role+for+Atf6alpha+in+this+signaling+network. assertion.
- assertion asSentence In+mice%2C+Elys+maintains+genome+stability+in+intestinal+epithelial+progenitor+cells%2C+independent+of+its+role+in+NPC+assembly+in+zebrafish. assertion.
- assertion asSentence Loss+of+vasohibin-2+is+associated+with+deficient+angiogenesis+in+the+termination+sprouting+front+of+endothelial+cells. assertion.
- assertion asSentence Plays+an+important+role+in+controlling+the+dynamics+of+GABAA+receptor+phosphorylation+through+protein+phosphatase+1+binding. assertion.
- assertion asSentence Activation+of+GPBAR1+receptors+by+hydrophobic+bile+salts+leads+to+the+opening+of+potassium+K%28ATP%29+channels. assertion.
- assertion asSentence TGR5+activation+yields+a+significant+immune+modulating+function+in+the+prevention+of+atherosclerosis. assertion.
- assertion asSentence DNA-PKcs+and+Artemis+open+AAV+inverted+terminal+repeat+%28ITR%29+hairpin+loops+in+a+tissue-dependent+manner. assertion.
- assertion asSentence ARTEMIS+stabilizes+the+genome+and+modulates+proliferative+responses+in+multipotent+mesenchymal+cells. assertion.
- assertion asSentence T+cell+and+B+Cell+immunity+can+be+reconstituted+with+mismatched+hematopoietic+stem+cell+transplantation+without+alkylator+therapy+in+artemis-deficient+mice+using+anti-natural+killer+cell+antibody+and+photochemically+treated+sensitized+donor+T+cells. assertion.
- assertion asSentence Sin1-mTORC2+suppresses+rag1%2C2+and+il7r+gene+expression+through+Akt2+in+B+cells. assertion.
- assertion asSentence Actin+remodeling+by+endogenous+gelsolin+or+analogues+protects+neurons+from+apoptosis+mediated+by+mitochondria+and+caspase-3. assertion.
- assertion asSentence Gelsolin+plays+a+pro-survival+and+apoptotic+role+in+pancreatic+beta-cells. assertion.
- assertion asSentence Presence+of+P2X3+receptor+is+demonstrated+for+the+first+time+in+mouse+otic+neurons. assertion.
- assertion asSentence Modulator+of+cellular+signaling+pathways+involving+Wnt+proteins%2C+bone+morphogenetic+proteins%2C+fibroblast+growth+factors+and+sonic+hedgehog+homolog. assertion.
- assertion asSentence The+gene+encoding+MEGF7%2FLRP4%2C+a+member+of+the+low-density+lipoprotein+receptor+family%2C+plays+an+essential+role+in+the+process+of+digit+differentiation. assertion.
- assertion asSentence IPS-1+is+the+sole+adapter+in+both+retinoic+acid-inducible+gene+%28RIG-I%29+and+melanoma+differentiation-associated+gene+5+%28Mda5%29+signaling+that+mediates+effective+responses+against+a+variety+of+RNA+viruses. assertion.
- assertion asSentence Emodin+induces+BV-2+cell+apoptosis+through+TRB3+and+consequently+eliminates+inflammatory+microglia. assertion.
- assertion asSentence Mice+genetically+altered+to+carry+the+equivalent+of+STX16del4-6+contributing+to+pseudohypoparathyroidism+type+1b. assertion.
- assertion asSentence The+existence+of+an+SLC17A9-dependent+ATP-enriched+vesicular+pool+in+biliary+epithelium+that+undergoes+regulated+exocytosis+to+initiate+purinergic+signaling. assertion.
- assertion asSentence hnRNP+A3+is+a+major+liver+nuclear+protein+binding+to+age+related+increase+element+of+the+factor+IX+gene. assertion.
- assertion asSentence UV-induced+eIF2alpha+phosphorylation+by+activation+of+both+PERK+and+GCN2+via+oxidative+stress+and+l-arginine+starvation+signaling+pathways. assertion.
- assertion asSentence Endoplasmic+reticulum+stress+response+mediated+by+the+PERK-eIF2%28alpha%29-ATF4+pathway+is+involved+in+osteoblast+differentiation+induced+by+BMP2. assertion.
- assertion asSentence KAT+III+inhibited+by+equimolar+methionine+and+half-life+is+3.9+minutes+at+65+degree+C. assertion.
- assertion asSentence Lgp2+acts+as+a+negative+feedback+regulator+of+antiviral+signaling+by+sequestering+double-stranded+RNA+from+retinoic+acid-inducible+gene-I+%28RIG-I%29. assertion.
- assertion asSentence The+activation+of+RIG-I+occurs+through+an+RNA-+and+ATP-driven+structural+switch+in+the+SF2+domain. assertion.
- assertion asSentence Shb+binds+directly+to+FAK+and+regulates+its+phosphorylation+leading+to+enhanced+cell+spreading+in+a+Src-dependent+manner. assertion.
- assertion asSentence Zcchc11+fine+tunes+IL-6+production+by+uridylating+miR-26a. assertion.
- assertion asSentence MCPIP+has+therapeutic+values+to+protect+heart+from+inflammatory+pathologies. assertion.
- assertion asSentence The+upregulation+of+left+ventricular+atrial+natriuretic+peptide+%28ANP%29+serves+as+a+molecular+marker+of+cardiac+hypertrophy. assertion.
- assertion asSentence ANP+and+AT1+receptor+blockade+attenuate+angiotensin+II-induced+renomedullary+interstitial+cells+proliferation+and+extracellular+matrix+synthesis+more+efficiently+in+the+absence+of+neutral+endopeptidase. assertion.
- assertion asSentence NPPA-AS+isoform+is+capable+of+down-regulating+the+intron-retained+NPPA+mRNA+variant. assertion.
- assertion asSentence ACE2+regulates+renal+ANP+via+the+generation+of+Ang-%281-7%29. assertion.
- assertion asSentence TDP-43-induced+death+is+associated+with+altered+regulation+of+BIM+and+Bcl-xL+and+attenuated+by+caspase-mediated+TDP-43+cleavage. assertion.
- assertion asSentence Progranulin+deficiency+in+mice+leads+to+reduced+survival+in+adulthood+and+increased+cellular+ageing+accompanied+by+hyperphosphorylation+of+TDP-43. assertion.
- assertion asSentence BTLA-herpesvirus+entry+mediator+%28HVEM%29+interactions+are+functionally+involved+in+T+cell+regulation+during+Plasmodium+berghei+strain+ANKA+blood-stage+malaria+and+regulate+sequestration+of+T+cells+in+brain+capillaries. assertion.
- assertion asSentence B+and+T+lymphocyte+attenuator+employs+a+conserved+binding+mode+for+herpesvirus+entry+mediator+recognition. assertion.
- assertion asSentence NFAT+negatively+regulates+TR2+expression+in+activated+T+cells. assertion.
- assertion asSentence Signaling+through+herpesvirus+entry+mediator+promoted+HIF-1alpha+activity+in+the+kidney+and+subsequently+facilitated+renal+Epo+production+and+erythropoiesis+in+vivo+under+normoxic+conditions. assertion.
- assertion asSentence Efferent+protection+from+acoustic+injury+is+mediated+via+alpha9+nicotinic+acetylcholine+receptors+on+outer+hair+cells. assertion.
- assertion asSentence Inhibition+of+N-type+Ca%282%2B%29+channel+channels+by+Vc1.1+and+RgIA+conotoxins+is+not+mediated+by+the+expression+of+alpha9+nAChRs+in+dorsal+root+ganglia+neurons. assertion.
- assertion asSentence The+interaction+between+CHFR+and+PARP-1+plays+an+important+role+in+cell+cycle+regulation+and+cancer+therapeutic+strategies. assertion.
- assertion asSentence Obif+plays+an+essential+role+in+bone+formation+through+regulating+osteoblastogenesis. assertion.
- assertion asSentence Mdm20+is+highly+expressed+in+the+developing+mouse+brain. assertion.
- assertion asSentence CYP26B1+maintains+low+levels+of+retinoic+acid+in+the+developing+testes+that+blocks+entry+into+meiosis+and+acts+as+a+survival+factor+to+prevent+apoptosis+of+male+germ+cells. assertion.
- assertion asSentence GAT-1+plays+a+prominant+role+in+both+tonic+and+phasic+GABA%28A%29+receptor+inhibition%2C+in+particular+during+systained+neuronal+activity. assertion.
- assertion asSentence Increased+Trypanosoma+cruzi+invasion+and+heart+fibrosis+associated+with+high+transforming+growth+factor+beta+levels+in+mice+deficient+in+alpha%282%29-macroglobulin. assertion.
- assertion asSentence p190RhoGAP+links+integrins+and+caveolin-1%2Fcaveolae+to+RhoA+in+a+mechanotransduction+cascade+that+participates+in+endothelial+adaptation+to+flow. assertion.
- assertion asSentence Negative+feedback+role+for+Siglec-F+in+regulating+the+pathogenesis+of+human+eosinophil-mediated+disorders. assertion.
- assertion asSentence alpha2%2C3-linked+sialic+acid-containing+glycoprotein+Siglec-F+ligands+and+the+enzymes+required+for+their+synthesis+are+constitutively+expressed+in+lungs%2C+especially+by+airway+epithelium. assertion.
- assertion asSentence Synemin+gene+encodes+proteins+belonging+to+the+intermediate+filament+which+confer+resistance+to+mechanical+stress+and+modulate+cell+shape. assertion.
- assertion asSentence Alpha-+and+beta-synemin+transcripts+and+their+encoded+proteins+colocalize+in+neurons%2C+especially+in+the+midbrain+and+pons. assertion.
- assertion asSentence GDPD5+is+a+glycerophosphocholine+phosphodiesterase+that+osmotically+regulates+the+osmoprotective+organic+osmolyte+glycerophosphocholine. assertion.
- assertion asSentence The+CK2+phospho-dependent+interaction+between+TEL2+and+the+R2TP+complex+affects+phosphatidylinositol+3-kinase-related+kinase+functions+and+is+essential+for+mTOR+and+SMG1+stability+in+vivo. assertion.
- assertion asSentence Fus1+establishes+its+immune-+and+tumour-suppressive+activities+via+regulation+of+mitochondrial+homeostasis. assertion.
- assertion asSentence Ghrelin-GOAT+system+as+a+signaling+pathway+that+alerts+the+central+nervous+system+to+the+presence+of+dietary+calories%2C+rather+than+to+their+absence+as+is+commonly+accepted. assertion.
- assertion asSentence PLC+gamma+2+is+not+required+for+platelet+aggregation. assertion.
- assertion asSentence PLCgamma1+and+PLCgamma2+play+nonredundant+and+obligatory+roles+in+NK+cell+ontogeny+and+in+its+effector+functions. assertion.
- assertion asSentence Plays+an+important+role+in+pre-B+cell+receptor-mediated+early+B-cell+development. assertion.
- assertion asSentence MLK4+is+a+negative+regulator+of+TLR4+signaling. assertion.
- assertion asSentence Mbd3l1+and+Mbd3l2+are+not+involved+in+genome-wide+demethylation+of+paternal+genomes+in+mouse+zygotes+and+are+dispensable+for+normal+development. assertion.
- assertion asSentence Loss+of+Plzf+correlates+with+increased+punctate+distribution+of+trimethylated+H3-K9+and+H4-K20+in+spermatogonia+at+the+expense+of+perinuclear+localization. assertion.
- assertion asSentence PLZF-positive+T+cells%2C+via+IL-4+production%2C+regulate+the+size+of+the+memory-phenotype+CD8-positive+T-cell+pool. assertion.
- assertion asSentence Tethering+DNA+damage+checkpoint+mediator+proteins+topoisomerase+IIbeta-binding+protein+1+%28TopBP1%29+and+Claspin+to+DNA+activates+ataxia-telangiectasia+mutated+and+RAD3-related+%28ATR%29+phosphorylation+of+checkpoint+kinase+1+%28Chk1%29. assertion.
- assertion asSentence LARG+plays+a+critical+role+in+plexin-B1+signaling+to+stimulate+Rho+activation+and+cytoskeletal+reorganization. assertion.
- assertion asSentence B-Raf%2FMKK%2FERK+provides+a+permissive+environment+for+melanoma+genesis+by+modulating+plexin+B1. assertion.
- assertion asSentence Deletion+of+the+SCAP%2FSREBP+pathway+in+respiratory+epithelial+cells+altered+lung+lipid+homeostasis+and+induced+compensatory+lipid+accumulation+and+synthesis+in+lung+lipofibroblasts. assertion.
- assertion asSentence GPR119+engages+multiple+complementary+pathways+for+control+of+glucose+homeostasis. assertion.
- assertion asSentence Nox1+stimulates+cell+proliferation+in+actively+cycling+cells+by+reducing+the+requirement+for+growth+factors+to+maintain+expression+of+cyclin+D1. assertion.
- assertion asSentence The+sex+difference+in+TNF-alpha+expression+is+estrogen-dependent+and+mediated+via+Rac1+dependent+NADPH+oxidase%2FERK1%2F2+and+p38+MAPK+pathway+in+lipopolysaccharide-stimulated+hearts. assertion.
- assertion asSentence LPS+induced+Nox1+mRNA+expression+and+reactive+oxygen+species+generation+in+Raw264.7+cells. assertion.
- assertion asSentence Reactive+oxygen+species+derived+from+NOX1%2FNADPH+oxidase+oxidize+and+inactivate+PTEN+to+positively+regulate+the+Akt%2FFOXO4%2Fp27%28kip1%29+signaling+pathway. assertion.
- assertion asSentence Central+NPFF1+and+NPFF2+receptors+control+in+an+opposite+manner+the+body+temperature+in+mice. assertion.
- assertion asSentence LRRC10+exhibits+dynamic+intracellular+expression+patterns+in+cardiomyocytes. assertion.
- assertion asSentence NPC1L1+is+essential+for+phytosterols+to+enter+the+body+in+mice. assertion.
- assertion asSentence A+PLCbeta%2FPI3Kgamma-GSK3+signaling+pathway+regulates+cofilin+phosphatase+slingshot2+and+neutrophil+polarization+and+chemotaxis. assertion.
- assertion asSentence The+lack+of+PHOSPHO1+affected+ATP+hydrolysis+via+a+secondary+reduction+in+the+levels+of+TNAP+in+PHOSPHO1-deficient+matrix+vesicles. assertion.
- assertion asSentence Phospho1%28-%2F-%29+bones+are+hypomineralized+and%2C+consequently%2C+are+softer+and+more+flexible. assertion.
- assertion asSentence Mutation+in+the+Fscn2+gene+underlies+the+early+onset+progressive+hearing+loss+of+DBA%2F2J+mice+attributed+to+the+ahl8+locus. assertion.
- assertion asSentence Lipid+peroxidation+and+oxidative+stress+regulate+hepatic+Apopb+degradation+and+VLDL+production. assertion.
- assertion asSentence ApoB48%2C+not+ApoB100%2C+is+the+preferred+protein+for+the+gut+to+coat+chylomicrons+to+ensure+efficient+chylomicron+formation+and+lipid+absorption. assertion.