Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Hydrogen-saturated+saline+decreases+athero-susceptibility+in+apoB-containing+lipoprotein+and+aortic+atherosclerosis+in+apoE-%2F-+mice+and+improves+HDL+functionality+in+C57BL%2F6J+mice. assertion.
- assertion asSentence Choroid+plexus+relationships+using+normal+and+Gdf7+%28Bmp12%29+transgenic+embryos+to+fate+map+or+ablate+dorsal+midline+cells. assertion.
- assertion asSentence The+association+of+AKAP150+with+TREK+channels+integrates+them+into+a+postsynaptic+scaffold+where+both+G-protein-coupled+membrane+receptors+and+TREK-1+dock+simultaneously. assertion.
- assertion asSentence AKAP150+acts+as+a+key+regulator+in+the+two+cAMP+pathways+to+control+PKB%2FAkt+phosphorylation. assertion.
- assertion asSentence OGR1+induces+an+increase+in+Ca%28i%29+in+response+to+acidic+medium+and+is+a+prime+candidate+for+an+osteoblast+proton+sensor. assertion.
- assertion asSentence PDE4D3%2C+like+protein+kinase+A+and+protein+phosphatase+1%2C+is+recruited+to+the+I%28Ks%29+channel+via+AKAP-9+and+contributes+to+its+critical+regulation+by+cAMP. assertion.
- assertion asSentence CTRP9+protects+against+acute+cardiac+injury+following+ischemia-reperfusion+via+an+AMPK-dependent+mechanism. assertion.
- assertion asSentence Synb+is+co-expressed+with+Cebpa+and+Gcm1+in+basal+cells+in+contact+with+the+allantois. assertion.
- assertion asSentence Mrp4+does+not+affect+irinotecan+or+SN-38+plasma+pharmacokinetics. assertion.
- assertion asSentence Absence+of+Adamts-12+is+associated+with+the+increase+in+angiogenic+response+and+tumor+invasion+into+host+tissue. assertion.
- assertion asSentence Decreased+miRNA+stability+in+cells+lacking+Ago2. assertion.
- assertion asSentence Expression+of+T-type+calcium+channels+increases+during+perinatal+development+in+various+brain+regions+and+in+the+spinal+cord. assertion.
- assertion asSentence Verification+of+the+function+of+Gb3+in+the+pathogenesis+of+hemolytic-uremic+syndrome+as+the+cellular+receptor+responsible+for+cytotoxicity+caused+by+verotoxin+%28VT%29+elaborated+by+Shigella+and+certain+strains+of+E.coli. assertion.
- assertion asSentence Changes+in+Muc19%2FSmgc+gene+expression+delineate+multiple+stages+of+salivary+mucous+cell+cytodifferentiation+and+subsequent+maturation+during+embryonic+gland+development+through+the+first+4+weeks+of+postnatal+life. assertion.
- assertion asSentence MRTF-B+plays+a+critical+role+in+regulating+differentiation+of+cardiac+neural+crest+cells+into+smooth+muscle. assertion.
- assertion asSentence RIM-BP3+plays+an+essential+role+in+manchette+development+and+function+through+its+interaction+with+Hook1. assertion.
- assertion asSentence A+subset+of+mammalian+SWI%2FSNF+complexes%2C+specifically+containing+ARID1B%2C+is+required+for+efficient+cell+cycle+re-entry+and+for+association+of+activation+factors+with+the+c-myc+promoter. assertion.
- assertion asSentence Conserved+role+for+Dact2+protein+in+kinase-regulated+biochemistry+involving+Vangl+and+Dvl. assertion.
- assertion asSentence The+GAP+activity+of+synGAP+and+its+association+with+PSD-95+are+important+for+normal+regulation+of+spine+and+synapse+formation+in+hippocampal+neurons. assertion.
- assertion asSentence Constitutive+SynGAP+reduction+increases+vigor+in+the+execution+of+learned+operant+behavior+without+compromising+its+temporal+control%2C+yielding+effects+readily+distinguishable+from+NMDAR+blockade. assertion.
- assertion asSentence Malt1+is+an+essential+positive+mediator+of+IgE+receptor+Fc+epsilon+RI-dependent+mast+cell+activation+that+selectively+uncouples+NF-kappa+B-induced+proinflammatory+cytokine+production+from+degranulation+and+leukotriene+synthesis. assertion.
- assertion asSentence TCR-+CARMA1%2FBcl10%2FMalt1+-dependent+signals+are+essential+to+commit+immature+thymocytes+to+the+nTreg+lineage. assertion.
- assertion asSentence Hearing+loss+in+the+ethylnitrosourea+%28ENU%29-induced+samba+mouse+line+is+caused+by+a+mutation+in+Loxhd1. assertion.
- assertion asSentence Kcnv2+is+a+strong+functional+candidate+for+epilepsy+modifier. assertion.
- assertion asSentence Sulf1+and+Sulf2+differentially+contribute+to+the+generation+of+organ-specific+sulfation+patterns+of+heparan+sulfate. assertion.
- assertion asSentence GITRL-costimulation+augments+both+effector+and+regulatory+functions+of+CD4%28%2B%29+T+cells. assertion.
- assertion asSentence TRAIL-+and+GITRL-activated+pathways+synergise+in+the+development+of+SCI-related+inflammatory+damage. assertion.
- assertion asSentence In+cultured+renal+cells%2C+the+PKHD1+gene+product+colocalized+with+polycystin-2%2C+the+gene+product+of+autosomal+dominant+polycystic+disease+type+2. assertion.
- assertion asSentence The+product+of+the+Pkhd1+gene+is+required+for+normal+tubulomorphogenesis+of+mouse+inner+medullary+collecting+duct+%28IMCD%29+cell+lines+via+extracellular-regulated+kinase+%28ERK%29+and+focal+adhesion+kinase+%28FAK%29+signaling. assertion.
- assertion asSentence Neu4+is+a+functional+component+of+the+ganglioside-metabolizing+system%2C+contributing+to+the+postnatal+development+of+the+brain+and+other+vital+organs. assertion.
- assertion asSentence Neu4+is+not+the+only+sialidase+contributing+to+the+metabolic+bypass+in+Hexa%28-%2F-%29+mice. assertion.
- assertion asSentence Caspr5-2+disruption+leads+to+dysfunction+at+the+cellular+level+rather+than+at+the+level+of+organ+development. assertion.
- assertion asSentence Ralgps1+is+both+necessary+and+sufficient+for+the+inhibition+of+myeloid+differentiation+by+Ras. assertion.
- assertion asSentence d2+protein+displayed+association+with+membranes+and+the+localization+in+lysosomes+and+antigen-containing+endosomes. assertion.
- assertion asSentence MEF2+and+MITF+function+cooperatively+with+NFATc1+to+transactivate+the+V-ATPase+d2+promoter+during+RANKL-induced+osteoclastogenesis. assertion.
- assertion asSentence Deficient+mice+develop+a+lethal+form+of+skeletal+dysplasia+with+severe+shortening+of+limbs+and+facial+structures. assertion.
- assertion asSentence Sp1+site+is+crucial+for+Cldn19+gene+expression+in+kidney+cells. assertion.
- assertion asSentence WAVE2+deficiency+reveals+distinct+roles+in+embryogenesis+and+Rac-mediated+actin-based+motility. assertion.
- assertion asSentence The+WAVE2%2FAbi1+complex+differentially+regulates+megakaryocyte+development+and+spreading. assertion.
- assertion asSentence Inactivation+of+N-acyl+phosphatidylethanolamine+phospholipase+D+reveals+multiple+mechanisms+for+the+biosynthesis+of+endocannabinoids. assertion.
- assertion asSentence Splicing+inhibition%2C+nonsense-mediated+decay+and+nonsense-altered+splicing+each+has+an+individual+partial+effect+that+together+associate+into+an+efficient+surveillance+machinery%2C+downregulating+nonfunctional+immunoglobulin+kappa+mRNA. assertion.
- assertion asSentence GRIP1+and+2+regulate+activity-dependent+AMPA+receptor+recycling+via+exocyst+complex+interactions. assertion.
- assertion asSentence During+gating%2C+the+alpha-helix+of+the+delta+subunit+M2+segment+bends+or+swivels+about+its+central+amino+acid+residues%2C+with+the+conformational+change+of+the+extracellular+half+preceding+the+movement+of+the+intracellular+half+upon+opening. assertion.
- assertion asSentence Muscarinic+analgesia+is+exclusively+mediated+by+a+combination+of+M%282%29+and+M%284%29+mAChRs+at+both+spinal+and+supraspinal+sites. assertion.
- assertion asSentence Presynaptic+M%282%29-muscarinic+receptors+play+a+major+role+in+the+control+of+the+time+course+of+evoked+acetylcholine+release+under+physiological+conditions. assertion.
- assertion asSentence M2+receptors+play+a+key+role+in+regulating+pharmacologically+%26+physiologically+evoked+hippocampal+acetylcholine+release+required+for+the+development+and+expression+mnemonic+%26+cognitive+events. assertion.
- assertion asSentence The+increased+pituitary-adrenal+sensitivity+to+these+challenges+noted+in+M%282%29+knockout+mice+is+consistent+with+M%282%29+being+primarily+a+presynaptic+autoreceptor. assertion.
- assertion asSentence ZFP568+controls+the+production+of+secreted+factors+required+to+promote+morphogenesis+of+extraembryonic+tissues. assertion.
- assertion asSentence IkappaBNS+significantly+impacts+the+development+and+functions+of+B+cells+and+plasma+cells. assertion.
- assertion asSentence ZFP536+promotes+the+late+phase+of+oligodendrocyte+differentiation. assertion.
- assertion asSentence Siglec-G-deficient+B1a+lymphocytes+survive+longer+in+vitro+and+become+the+dominant+population+when+injected+in+competition+with+wild-type+B1a+cells+into+Rag1-deficient+mice. assertion.
- assertion asSentence Serum+interleukin+%28IL%29-1beta+and+TNF-alpha+after+lipopolysaccharide+injection+are+decreased+in+PYNOD-transgenic+and+apoptosis-associated+speck-like+protein+containing+a+caspase+recruitment+domain+knockout+mice+compared+with+those+of+wild-type+mice. assertion.
- assertion asSentence Neuropoietin+induced+activation+of+STAT3+tyrosine+phosphorylation+in+adipocytes+is+independent+of+LIFR+phosphorylation+and+degradation. assertion.
- assertion asSentence MCPH1+is+essential+for+mitotic+and+meiotic+recombination+DNA+repair+and+maintaining+genomic+stability. assertion.
- assertion asSentence Inactivation+of+mouse+ortholog+Rpgrip1l+%28Ftm%29+recapitulates+the+cerebral%2C+renal+and+hepatic+defects+of+cerebello-oculo-renal+syndrome+and+Meckel+syndrome. assertion.
- assertion asSentence Efficient+induction+of+apoptosis+by+oncogene+activation+depends+on+coordinated+action+of+ARF+and+ATM%2FATR+pathways+in+the+regulation+of+p53. assertion.
- assertion asSentence Removal+of+Pot1a+and+Pot1b+from+telomeres+initiates+an+ATR-dependent+DNA+damage+response. assertion.
- assertion asSentence hMSH2+recruits+ATR+to+DNA+damage+sites+for+activation+during+DNA+damage-induced+apoptosis. assertion.
- assertion asSentence Tethering+DNA+damage+checkpoint+mediator+proteins+topoisomerase+IIbeta-binding+protein+1+%28TopBP1%29+and+Claspin+to+DNA+activates+ataxia-telangiectasia+mutated+and+RAD3-related+%28ATR%29+phosphorylation+of+checkpoint+kinase+1+%28Chk1%29. assertion.
- assertion asSentence Atr+loss+impacted+neurogenesis+relatively+late+during+neural+development+involving+only+certain+progenitor+populations. assertion.
- assertion asSentence CIBZ+binds+to+a+Myog+promoter-proximal+region+and+inhibits+Myog+transcription+in+a+methylation-dependent+manner. assertion.
- assertion asSentence Severely+reduced+levels+of+mutant+Vps54+and%2C+consequently%2C+of+the+whole+GARP+complex+underlie+the+phenotype+of+the+wobbler+mouse. assertion.
- assertion asSentence KCNE2+influences+blood-CSF+anion+flux+by+regulating+KCNQ1+and+KCNA3+in+the+choroid+plexus+epithelium. assertion.
- assertion asSentence Assembly+with+NETO1+and+NETO2+differentially+modifies+homomeric+glutamate+K1+%28GluK1%29+kainate+receptor+gating. assertion.
- assertion asSentence Mouse+hepatitis+virus+Ns2+cleaves+2%27%2C5%27-oligoadenylate%2C+the+product+of+2%27%2C5%27-oligoadenylate+synthetase%2C+to+prevent+activation+of+the+cellular+endoribonuclease+RNase+L+and+consequently+block+viral+RNA+degradation. assertion.
- assertion asSentence DIgR2+is+a+functionally+inhibitory+receptor+and+can+mediate+negative+signaling+to+regulate+DC-initiated+antigen-specific+T-cell+responses. assertion.
- assertion asSentence IL-27+directly+acts+on+naive+CD8%2B+T+cells+in+T-bet+transcription+factor-dependent+and+-independent+manners+and+augments+generation+of+cytotoxic+T+lymphocytes+with+enhanced+granzyme+B+expression. assertion.
- assertion asSentence Role+for+IL-27-IL-27R+interaction+in+controlling+the+homeostasis+of+the+intestinal+T+cell+pool+and+in+limiting+intestinal+inflammation+through+regulation+of+innate+and+adaptive+immune+cell+function. assertion.
- assertion asSentence Liver+dendritic+cells+respond+distinctly+to+lipopolysaccharides+stimulation+by+secreting+IL-27+which+synergizes+with+silencing+of+bioactive+IL-12+activity+leading+to+profound+T+cell+inhibition. assertion.
- assertion asSentence IL-27+suppresses+granulocyte+macrophage-colony+stimulating+factor+%28GM-CSF%29+expression+in+activated+murine+T+cells. assertion.
- assertion asSentence TRPV3+and+TRPV4+are+ion+channels+activated+by+modest+increases+in+ambient+temperature. assertion.
- assertion asSentence Nod2+plays+a+distinct+role+in+the+regulation+of+muramyl+dipeptide-induced+caspase-1+activation+and+IL-1+beta+secretion+in+macrophages. assertion.
- assertion asSentence Cross-tolerization+between+Nod1+and+Nod2+leads+to+increased+recognition+of+both+pathogenic+and+commensal+bacteria+in+Nod2-deficient+macrophages+pre-exposed+to+microbial+ligands. assertion.
- assertion asSentence NOD2+contributes+to+cutaneous+defense+against+Staphylococcus+aureus+through+alpha-toxin-dependent+innate+immune+activation. assertion.
- assertion asSentence Demonstrate+a+T+cell-intrinsic+role+for+Nod2+signaling+that+is+critical+for+host+defense+against+Toxoplasma+gondii. assertion.
- assertion asSentence Synergism+of+NOD2+and+NLRP3+activators+promotes+a+unique+transcriptional+profile+in+murine+dendritic+cells. assertion.
- assertion asSentence Mutated+major+histocompatibility+complex+class+II+transactivator+up-regulates+interleukin-33-dependent+differentiation+of+Th2+subset+through+Nod2+binding+for+NLR+%28NOD-like+receptor%29+signaling+initiation. assertion.
- assertion asSentence The+receptive+range+of+MOR32-11+is+unique+to+its+odorant+space+region. assertion.
- assertion asSentence The+receptive+range+of+MOR40-4+is+unique+to+its+odorant+space+region. assertion.
- assertion asSentence Increased+anxiety-like+behavior+in+neuropsin+%28kallikrein-related+peptidase+8%29+gene-deficient+mice. assertion.
- assertion asSentence Expression+of+Robo%2FSlit+and+Semaphorin%2FPlexin%2FNeuropilin+family+members+in+the+developing+hypothalamic+paraventricular+and+supraoptic+nuclei. assertion.
- assertion asSentence Regulation+of+transcription+and+pre-mRNA+processing+of+Rnf35+in+eggs+and+in+pre-implantation+embryos. assertion.
- assertion asSentence MyD88s+acts+as+a+negative+regulator+of+IL-1R%2FTLR%2FMyD88-triggered+signals%2C+leading+to+a+transcriptionally+controlled+negative+regulation+of+innate+immune+responses. assertion.
- assertion asSentence Absence+of+IRAK4+kinase+activity+leads+to+delayed+onset+of+autoimmune+encephalomyelitis+with+reduced+mononuclear+cell+infiltration+of+the+spinal+cord+and+a+lack+of+CD4-positive+T+helper+%28Th%29+cell-mediated+interleukin+%28IL%29-17+production. assertion.
- assertion asSentence The+PDZ-binding+domain+of+5-HT2A+receptor+is+a+necessary+signal+for+the+preferential+targeting+of+the+5-HT2A+receptor+to+the+dendritic+compartment+of+cultured+cortical+pyramidal+neurons. assertion.
- assertion asSentence Chronic+treatment+with+ACTH+increases+5-HT%282A%29-receptor+synthesis%2Fgene+transcription+in+the+prefrontal+cortex. assertion.
- assertion asSentence The+5-HT2A+receptor+plays+a+complex+role+in+the+amygdaloid+complex%2C+since+it+can+regulate+amygdaloid+activity+by+acting+on+different+neuronal+populations. assertion.
- assertion asSentence The+mRNA+and+protein+expressions+of+5-HT2A+receptor+increased+in+excessive+fatigue+rats+and+restraint+stress+rats. assertion.
- assertion asSentence P2Y2+and+P2Y4+receptors+in+granulosa+cells+modulate+Cl-+permeability+by+regulating+Ca2%2B-release. assertion.
- assertion asSentence A+synthetic+peptide+from+transforming+growth+factor-beta1+type+III+receptor+prevents+myocardial+fibrosis+in+spontaneously+hypertensive+rats. assertion.
- assertion asSentence Tyrosine+kinase+C+receptors+are+localized+in+both+enkephalin-positive+and+enkephalin-negative+neurons+in+neostriatum+and+nucleus+accumbens. assertion.
- assertion asSentence After+nerve+injury%2C+tyrosine+kinase+C+expression+is+increased+in+small+dorsal+root+ganglionic+cells+of+allodynic+animals+and+the+medium-+and+large-size+nonallodynic+animals%27+cells. assertion.
- assertion asSentence PC3%2FTis21%2FBTG2+promotes+differentiation+of+neural+cells+and+protects+neurons+from+apoptosis. assertion.
- assertion asSentence GluR2+is+a+key+subunit+that+controls+recycling+and+degradation+of+AMPA+receptors+after+internalization. assertion.
- assertion asSentence The+distributions+of+NMDA%2FNR1+and+AMPA%2FGluR2+in+the+hippocampal+formation+are+basically+same. assertion.
- assertion asSentence Intracerebroventricular+treatment+with+vascular+endothelial+growth+factor+%28VEGF%29A+induces+GluR2+expression+in+the+ventral+spinal+cord+of+rats%2C+a+mechanism+that+contributes+to+the+protective+effect+of+VEGF+on+motor+neurons. assertion.
- assertion asSentence Long-term+exposure+to+endogenous+levels+of+tributyltin+decreases+GluR2+expression+and+increases+neuronal+vulnerability+to+glutamate. assertion.
- assertion asSentence Crystal+structure+of+the+alpha-amino-3-hydroxy-5-methyl-4-isoxazole+propionic+acid+%28AMPA%29-sensitive%2C+homotetrameric%2C+rat+GluA2+receptor+at+3.6+A+resolution+in+complex+with+a+competitive+antagonist. assertion.
- assertion asSentence GluR3+is+targeted+to+lysosomes+regardless+of+NMDA+receptor+activation. assertion.
- assertion asSentence Similar+to+clozapine%2C+JL+13+does+not+alter+levels+of+NMDA+and+AMPA+receptors+in+hippocampus+and+entorhinal+cortex. assertion.