Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Chronic+intermittent+hypoxia+impairs+heart+rate+responses+to+AMPA+and+NMDA+and+induces+loss+of+GluR3+neurons+in+nucleus+ambiguous+of+F344+rats. assertion.
- assertion asSentence The+expression+of+3+beta-HSD%2C+a+converting+enzyme+of+progesterone%2C+is+increased+in+dorsal+root+ganglion+neurons+following+peripheral+nerve+injury. assertion.
- assertion asSentence Lycopene+protects+against+PCB-induced+changes+in+Leydig+cellular+StAR+protein%2C+cytochrome+P450+scc+expression+and+activity+of+3beta-HSD. assertion.
- assertion asSentence PP5+is+a+physiological+regulator+of+Raf-1+signalling+pathways. assertion.
- assertion asSentence Elevation+of+ADAM10+is+associated+with+thoracic+aortic+aneurysm. assertion.
- assertion asSentence Diurnal+rhythmicity+of+the+canonical+clock+genes+Per1%2C+Per2+and+Bmal1+in+the+rat+adrenal+gland+is+unaltered+after+hypophysectomy. assertion.
- assertion asSentence Pannexin-1+is+required+for+processing+of+caspase-1+and+release+of+mature+IL-1beta+induced+by+P2X%287%29+receptor+activation. assertion.
- assertion asSentence P2X7Rs+in+satellite+cells+play+a+crucial+role+in+maintaining+proper+P2X3R+expression+in+dorsal+root+ganglia. assertion.
- assertion asSentence Sustained+stimulation+of+vasopressin+and+oxytocin+release+by+ATP+and+phenylephrine+requires+recruitment+of+desensitization-resistant+P2X+purinergic+receptors. assertion.
- assertion asSentence Propofol+increases+the+activity+of+P2X7+receptors+in+activated+astrocytes. assertion.
- assertion asSentence The+ERK+pathway+mediates+P2X7+expression+and+cell+death+in+renal+interstitial+fibroblasts+exposed+to+necrotic+renal+epithelial+cells. assertion.
- assertion asSentence Selective+inhibition+of+the+P2X7+receptor+improves+both+the+functional+and+histopathological+consequences+of+a+contusive+spinal+cord+injury+in+rats. assertion.
- assertion asSentence The+decline+in+progesterone+formation+following+exposure+to+HPTE+in+cultured+ovarian+cells+is+associated+with+the+inhibition+of+catalytic+activity+of+P450scc+at+least+in+theca-interstitial+cells. assertion.
- assertion asSentence Stage-specific+expression+of+proprotein+form+of+hyaluronan+binding+protein+1+%28HABP1%29+during+spermatogenesis+in+rat. assertion.
- assertion asSentence Single-cell+PCR+of+dissociated+hippocampal+pyramidal+neurons+gave+detectable+signals+for+KCNQ2%2C+KCNQ3+and+KCNQ5. assertion.
- assertion asSentence Chronic+exposure+to+and+withdrawal+of+progesterone+induce+differential+effects+on+both+expression+of+the+delta+subunit+of+GABA%28A%29+receptors. assertion.
- assertion asSentence Transcriptional+activation+of+the+group+IIA+secretory+phospholipase+A2+gene+in+vascular+smooth+muscle. assertion.
- assertion asSentence The+regulation+of+sPLA2-IIA+gene+transcription+by+PPARalpha%2FRXR+and+PPARgamma%2FRXR+heterodimers+requires+an+interaction+with+a+PPAR+response+element+%28PPRE%29+of+the+sPLA2-IIA+promoter. assertion.
- assertion asSentence Chronic+beta2-adrenoceptor+stimulation+impairs+cardiac+relaxation+via+reduced+SERCA2a+protein+and+activity. assertion.
- assertion asSentence Chaiqinchengqi+decoction+can+up-regulate+the+expression+of+SERCA2+mRNA+of+pancreatic+tissues%2C+reduce+intracellular+calcium+overload+and+relieve+pancreatic+tissue+lesions. assertion.
- assertion asSentence Sarcolemmal+Ca2%2B-ATPase+ability+to+transport+Ca2%2B+gradually+diminishes+after+myocardial+infarction+in+the+rat. assertion.
- assertion asSentence Mitochondrial+transcription+factors+TFAM+and+TFB2M+regulate+Serca2+gene+transcription+in+cardiac+myocytes. assertion.
- assertion asSentence GABA%28C%29+receptors+are+specifically+involved+in+aspects+of+visual+image+motion+processing+in+the+rat+brain. assertion.
- assertion asSentence Activation+of+the+PERK%2FeIF2a+signaling+pathway+contributes+to+the+occurrence+and+development+of+hepatocyte+apoptosis+in+alcoholic+liver+injury. assertion.
- assertion asSentence Rat+brain+cholinergic%2C+dopaminergic%2C+noradrenergic+and+serotonergic+neurons+express+GABAA+receptors+derived+from+the+alpha3+subunit. assertion.
- assertion asSentence Polypeptide+levels+of+GABA-A-alpha+1+decrease+significantly+in+both+single+and+recurrent+seizure-treated+neonatal+rats+7+days+and+75+days+after+the+last+seizure%2C+compared+to+controls. assertion.
- assertion asSentence Protein+kinase+C+gamma+regulates+GABA%28A%29+alpha1+receptor+trafficking+after+ethanol+exposure. assertion.
- assertion asSentence GABA%28A%29Ralpha+and+GlyRalpha1+undergo+differential+changes+in+expression+during+the+development+of+the+cerebral+cortex. assertion.
- assertion asSentence The+GABA+A+receptor+alpha1-gamma2+subunit+interface+structure+undergoes+agonist-specific+conformational+changes. assertion.
- assertion asSentence The+gamma2+subunit+short+splice+variant+serves+dual+roles%2C+as+an+integral+subunit+of+the+GABA%28A%29+receptor+and+as+an+accessory+protein+acting+as+an+external+modulator+of+GABA%28A%29+receptor+function. assertion.
- assertion asSentence Ligand-+and+subunit-specific+conformational+changes+in+the+ligand-binding+domain+and+the+TM2-TM3+linker+of+%7Balpha%7D1+%7Bbeta%7D2+%7Bgamma%7D2+GABAA+receptors. assertion.
- assertion asSentence The+GABA+A+receptor+alpha1-gamma2+subunit+interface+structure+undergoes+agonist-specific+conformational+changes. assertion.
- assertion asSentence Deltamethrin+and+tefluthrin+%28but+not+S-bioallethrin%29+bind+to+Na%28v%291.6Q3+channels+in+the+open+state+and+imply+that+the+pyrethroid+receptor+of+resting+and+open+channels+occupies+different+conformations+that+exhibit+distinct+structure-activity+relationships. assertion.
- assertion asSentence Effects+of+Na%28%2B%29%2FCa%282%2B%29+exchanger+downregulation+on+contractility+and+%5BCa%282%2B%29%5D%28i%29+transients+in+adult+rat+myocytes. assertion.
- assertion asSentence The+reduced+efficiency+of+SNCX+to+regulate+%5BCa%282%2B%29%5D%28i%29+is+attributed%2C+in+part%2C+to+the+isoleucine-to-phenylalanine+mutation+at+amino+acid+218. assertion.
- assertion asSentence Acyl+CoAs+are+novel%2C+endogenous+activators+of+reverse-mode+NCX1+activity%2C+exhibiting+chain+length+and+saturation+dependence%2C+with+longer+chain+saturated+acyl+moieties+being+the+most+effective+NCX1+activators. assertion.
- assertion asSentence Phospholemman+regulates+cardiac+Na%2B%2FCa2%2B+exchanger+by+interacting+with+the+exchanger%27s+proximal+linker+domain. assertion.
- assertion asSentence Both+17-beta-estradiol+and+IGF-1+produced+an+increase+in+the+NCX-mediated+inward+current+and+a+decrease+in+the+NCX-mediated+outward+current. assertion.
- assertion asSentence The+TRPV1-NCX+coupling+plays+an+important+role+in+driving+cellular+functions+following+transduction+of+external+stimuli+to+odontoblasts. assertion.
- assertion asSentence In+adult+rats%2C+Kir4.1+expression+is+reduced+by+nearly+80%25+following+crush+spinal+cord+injury. assertion.
- assertion asSentence Astrocytes+in+the+CA1+region+of+the+hippocampus+are+progressively+depolarized+following+cerebral+ischemia+coinciding+with+decreased+potassium+channel+Kir4.1+protein+expression+in+glial+cells. assertion.
- assertion asSentence Reduced+folate+carrier%2FSlc19a1+is+the+major+%28if+not+the+only%29+folate+uptake+system+that+is+functional+in+intestinal+epithelial+cells. assertion.
- assertion asSentence The+activation+of+endothelial+S1P%28R1%29+is+responsible+for+the+protective+action+of+sphingosine-1-phosphate+on+microvessel+permeability. assertion.
- assertion asSentence Different+dietary+fatty+acids+have+dissimilar+effects+on+activity+and+gene+expression+of+Ctp. assertion.
- assertion asSentence Downregulation+of+BKCa+channel+beta1-subunit+in+the+type-2+diabetic+cerebral+artery+smooth+muscle+cells+contributes+to+cerebral+vascular+complication+in+type-2+diabetes+via+reducing+activity+of+BKCa+channels%2C+increasing+vascular+tone+and+blood+pressure. assertion.
- assertion asSentence Sema3A+regulates+the+earliest+step+of+neuronal+morphogenesis+by+polarizing+axon%2Fdendrite+formation. assertion.
- assertion asSentence Vacuolar+H%2B-ATPase+apical+accumulation+in+kidney+intercalated+cells+is+regulated+by+PKA+and+AMP-activated+protein+kinase. assertion.
- assertion asSentence In+the+presence+of+testosterone%2C+the+Cyp4A%2F20-HETE+system+plays+a+key+role+in+elevating+the+blood+pressure+secondary+to+insulin+resistance. assertion.
- assertion asSentence Schisandrin+B+can+reduce+pulmonary+fibrosis+induced+by+SiO2+through+inhibition+of+mRNA+expression+of+TGF-beta1+and+Smad4+in+the+lung+tissue. assertion.
- assertion asSentence Phosphorylation+of+PTEN+is+important+for+neuronal+survival+after+ischemia. assertion.
- assertion asSentence PTEN+is+a+potent+endogenously+produced+inhibitor+of+SMC+growth+and+increased+PTEN+activity+mediates+perlecan-induced+suppression+of+SMC+proliferation. assertion.
- assertion asSentence Captopril+can+up-regulate+PTEN+expression+in+cardiac+hypertrophy. assertion.
- assertion asSentence Physical+interaction+of+PTEN+with+a+region+in+the+third+intracellular+loop+%283L4F%29+of+the+serotonin+5-HT2C+receptor+%285-HT2cR%2C+formerly+5-HT1c+receptor%29+in+cell+cultures. assertion.
- assertion asSentence Sema4D%2FPlexin-B1+promotes+the+dephosphorylation+and+activation+of+PTEN+through+the+R-Ras+GAP+activity%2C+inducing+growth+cone+collapse. assertion.
- assertion asSentence Inhibition+of+PTEN+by+gene+knockdown+protects+neurons+from+p75+neutrotrophin+receptor+%28p75NTR%29+precursor-mediated+cell+death+in+brain. assertion.
- assertion asSentence Serum+response+factor+regulates+expression+of+phosphatase+and+tensin+homolog+through+a+microRNA+network+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence InsP6+suppresses+excitatory+neurotransmission+via+inhibition+of+the+presynaptic+synaptotagmin-1+C2B+domain-mediated+fusion+via+an+interaction+with+the+synaptotagmin+Ca2%2B-binding+sites. assertion.
- assertion asSentence Resp18+gene+expression+varies+with+activation+of+the+corpus+ghrelin-secreting+cells+and+the+antral+gastrin-secreting+cells. assertion.
- assertion asSentence The+total+amount+of+connexins+and+the+ratio+of+phosphorylated%2Fnon-phosphorylated+isoforms+gradually+increased+during+the+re-establishment+of+intercellular+communication+in+heart+myocytes. assertion.
- assertion asSentence The+presence+of+Cx36+in+ChAT-ir+neurons+is+consistent+with+electrical+coupling+between+sympathetic+preganglionic+motoneurons+and+between+somatic+motoneurons+through+gap+junctions+in+the+adult+spinal+cord. assertion.
- assertion asSentence Environmental+experience+does+not+affect+the+expression+of+GluR1+receptors+in+the+nucleus+accumbens+of+socially+isolated+rats+compared+to+environmentally+enriched+strains. assertion.
- assertion asSentence Preventing+GluR1+phosphorylation+with+mutant+GluR1+S845A+reduces+glutamate-evoked+currents+in+cultured+medium+spiny+neurons+and+blocks+the+locomotor+activity+produced+by+nucleus+accumbens+amphetamine. assertion.
- assertion asSentence This+RAB-dependent+GluA1+trafficking+requires+phosphorylation+and+activation+of+phosphoinositol-3-phosphate-5-kinase+%28PIKfyve%29+and+the+generation+of+PI%283%2C5%29P%282%29. assertion.
- assertion asSentence Phosphorylation+of+AMPA+receptor+subunit+GluA1+alters+neuronal+plasticity+and+temporal+coding. assertion.
- assertion asSentence The+surface+expression+of+neuronal+GIRK+channels+is+regulated+by+the+psychostimulant-sensitive+sorting+nexin+27+%28SNX27%29+protein+through+a+class+I+PDZ-binding+interaction. assertion.
- assertion asSentence Estradiol+regulates+dopamine-activataed+GIRK+channel+activity+in+pituitary+lactotrophs%2C+regulating+prolactin+release+during+the+estrous+cycle. assertion.
- assertion asSentence Proline-rich+tyrosine+kinase+2+%28Pyk2%29%2Fcell+adhesion+kinase+beta+%28CAKbeta%29%2C+a+Ca%282%2B%29-sensitive+non-receptor+tyrosine+kinase%2C+is+involved+in+ET-1-+and+PE-induced+cardiomyocyte+hypertrophy+medicated+through+Rac1+activation. assertion.
- assertion asSentence In+vascular+smooth+muscle+cells+shedding+of+membrane-bound+epidermal+growth+factor+%28EGF%29+receptor+ligands+and+activation+of+the+nonreceptor+tyrosine+kinases+Pyk2+and+Src+contributed+to+the+thrombin-induced+ERK1%2F2+phosphorylation. assertion.
- assertion asSentence Pyk2+acts+as+an+early+sensor+of+numerous+extracellular+signals+that+trigger+a+Ca%282%2B%29+flux+and%2For+reactive+oxygen+species+to+amplify+tyrosine+phosphorylation+signaling+events. assertion.
- assertion asSentence Induction+of+aconitate+hydratase+in+hepatocytes+of+starving+rats. assertion.
- assertion asSentence Activation+of+JNK2+by+lead+acetate+paralled+impairment+of+glioma+cell+viability. assertion.
- assertion asSentence An+abrupt+rise+in+oxidative+stress+activates+p38+MAPK+to+tilt+the+balance+in+a+competitive+AKT%2FJNK2+regulation+of+FOXO3+toward+its+activation%2C+eventually+leading+to+neuronal+death. assertion.
- assertion asSentence Downregulated+by+rosiglitazone. assertion.
- assertion asSentence Insulin+acutely+reduces+hepatic+FAS+activity+by+inducing+phosphorylation+of+the+carcinoembryonic+antigen-related+cell+adhesion+molecule+1+%28CEACAM1%29+and+its+interaction+with+FAS. assertion.
- assertion asSentence Normal+flux+through+Fasn+is+not+required+for+glucose-stimulated+insulin+secretion. assertion.
- assertion asSentence Dietary+soy+protein%2C+by+decreasing+circulating+insulin+levels+and+colon+FASN+expression%2C+attenuates+insulin-induced+DNA+damage+and+FASN-mediated+anti-apoptosis+during+carcinogenesis. assertion.
- assertion asSentence Coupling+between+ET%28B%29+receptor+stimulation+and+eNOS+activation+decreases+sinusoidal+constriction+and+plays+a+functionally+important+role+in+maintaining+microcirculation+and+tissue+oxygenation+in+the+normal+liver. assertion.
- assertion asSentence Endothelin-1-induced+vasodilatation+in+rat+breast+tumor+is+mediated+through+endothelin-B+receptors. assertion.
- assertion asSentence ETA+receptor+blockade+attenuates+hypertension+and+decreases+reactive+oxygen+species+in+ETB+receptor-deficient+rats. assertion.
- assertion asSentence ET%28B%29+receptor+activation+in+vivo+significantly+enhances+O2-+levels+in+sympathetic+ganglia%2C+due+to+both+pressor+effects+and+direct+stimulation+of+ET%28B%29+receptors+in+ganglion+cells. assertion.
- assertion asSentence Endothelin+b+receptor+play+a+role+in+the+disturbed+microvascular+autoregulation+and+in+the+sustained+reduction+of+blood+flow+following+trauma+to+the+brain. assertion.
- assertion asSentence The+intracellular+NF-kappaB+pathway+is+involved+in+the+process+of+induced+expression+of+vascular+SMC+ET%28B%29+receptors. assertion.
- assertion asSentence Minimally+modified+LDL+upregulates+ET%28B%29+receptors+of+cerebral+basilar+artery+via+the+PKC%2C+MAPK+and+NF-kappaB+signal+pathways. assertion.
- assertion asSentence C-SRC+and+ERK+play+a+role+in+acid-induced+activation+of+NHE-3+protein. assertion.
- assertion asSentence Decreased+ERK+activation+in+the+hippocampus+is+involved+in+sleep+deprivation-induced+spatial+memory+impairment. assertion.
- assertion asSentence Glucose-dependent+actions+of+ERK1%2F2+in+beta-cells+exerted+on+cytoplasmic+proteins%2C+includes+synapsin+I+and+participates+in+the+overall+glucose-induced+insulin+secretion. assertion.
- assertion asSentence Activated+ERK1%2F2+is+involved+in+an+efficient+cascade+for+synapse-to-nucleus+communication+regulating+gene+expression. assertion.
- assertion asSentence In+cultured+adult+rat+ventricular+myocytes%2C+sustained+intracellular+acidosis+activates+ERK1%2F2+through+proximal+activation+of+the+classical+Ras%2FRaf%2FMEK+pathway. assertion.
- assertion asSentence Adaptation+of+direct+pathway+neurons+after+neonatal+6-OHDA+lesions+involves+coupling+of+5-HT2+receptors+to+the+ERK1%2F2%2FMAP+Kinase+cascade%2C+a+pathway+not+typically+active+in+these+neurons. assertion.
- assertion asSentence Down-regulation+of+sst3R+mRNA+depends+on+acetaminophen-elicited%2C+5-HT1A+receptor-dependent+increase+in+neuronal+extracellular+signal-regulated+kinase+1%2F2+%28ERK1%2F2%29+activities+that+mediate+antinociception. assertion.
- assertion asSentence Stimulation+of+paraventricular+nucleus+prevents+gastric+ischemia+reperfusion+injury+by+activating+ERK1%2F2+to+inhibit+apoptosis+and+promote+cell+proliferation+in+the+gastric+mucosa. assertion.
- assertion asSentence PKA+and+VEGFR2+converge+at+the+MEK%2FERK1%2F2+pathway+to+protect+serum+starved+neuronal+cells+from+a+caspase-dependent+cell+death. assertion.
- assertion asSentence Increasing+cellular+cAMP+levels+inhibits+lacrimal+gland+p44%2Fp42+MAPK+activity. assertion.
- assertion asSentence Adenosine+A%281%29+receptor+agonists+and+oxidative+stress+differentially+modulate+subcellular+MAPKs. assertion.
- assertion asSentence Fas+Ag-FasL+coupling+leads+to+ERK1%2F2-mediated+proliferation+of+gastric+mucosal+cells. assertion.
- assertion asSentence Exogenous+CO+prevents+transplant-induced+hepatic+ischemia+reperfusion+injury+by+down-regulating+ERK1+activity. assertion.
- assertion asSentence Induction+and+activation+of+ErbB2+increases+the+expression+of+Akt+and+ERK1%2F2+kinases%2C+enhancing+the+responsiveness+of+hepatocytes+to+EGF+as+they+adapt+to+culture. assertion.
- assertion asSentence The+human+angiotensin+AT%281%29+receptor+supports+G+protein-independent+extracellular+signal-regulated+kinase+1%2F2+activation+and+cellular+proliferation. assertion.
- assertion asSentence Ether-linked+diglycerides+inhibit+vascular+smooth+muscle+cell+growth+via+decreased+ERK1%2F2+and+PI3K%2FAkt+signaling. assertion.
- assertion asSentence Transcriptional+down-regulation+of+thromboxane+A%282%29+receptor+expression+via+activation+of+MAPK+ERK1%2F2%2C+p38%2FNF-kappaB+pathways. assertion.