Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence ERalpha+is+placed+downstream+from+the+ErbB1-activated+Erk1%2F2+in+lactotrophs. assertion.
- assertion asSentence There+is+a+major+and+distinct+role+of+ERK1+in+the+regulation+of+hepatocyte+survival. assertion.
- assertion asSentence The+ability+of+human+granule+cells+to+respond+to+extracellular+acidification+by+generating+Ca%282%2B%29+signals+and+ERK+activation+is+state-dependent%2C+being+lost+upon+differentiation. assertion.
- assertion asSentence Activation+of+FGF+receptor+1+%28FGFR1%29%2C+largely+through+two+key+cytoplasmic+amino+acid+residues+that+are+linked+to+MAPK+and+PLC+activation%2C+suffices+to+promote+adult+neural+stem+cell+self-renewal. assertion.
- assertion asSentence Erk1%2F2+played+an+important+role+in+the+interplay+between+cell-extrinsic+cues+and+cell-intrinsic+genetic+mechanisms+in+neural+stem+cell+biology. assertion.
- assertion asSentence The+PKCalpha-ERK1%2F2+signaling+pathway+plays+a+negative+role+in+tamoxifen-induced+C6+cell+apoptosis. assertion.
- assertion asSentence 20-HETE+activates+the+Raf%2FMEK%2FERK+pathway+in+renal+epithelial+cells+through+an+EGFR-+and+c-Src-dependent+mechanism. assertion.
- assertion asSentence The+infection+of+rat+carotid+arteries+with+recombinant+adenovirus+encoding+SM22+alpha+inhibited+neointimal+hyperplasia+via+suppression+of+the+Raf-1-MEK1%2F2-extracellular+signal-regulated+kinase+1%2F2+signaling+pathway. assertion.
- assertion asSentence EV71-induced+COX-2+expression+associated+with+prostaglandin+E%282%29+production+is+mediated+through+activation+of+c-Src%2FPDGFR%2FPI3K%2FAkt%2Fp42%2Fp44+MAPK+to+initiate+the+expression+of+AP-1. assertion.
- assertion asSentence The+different+nucleocytoplasmic+shuttling+rate+of+ERK1+is+caused+by+its+N-terminal+region+encompassing+residues+1+to+39. assertion.
- assertion asSentence Capsaicin-induced+neural+potentiation+is+a+slowly+developing+Ca%282%2B%29-modulated+process+that+is+mediated+by+a+complex+intracellular+signaling+pathway+involving+activation+of+CaMKII+and+ERK1%2F2. assertion.
- assertion asSentence Chlorination+of+high-density+lipoprotein+induced+phosphorylation+of+p42%2F44+mitogen-activated+protein+kinase%2C+expression+of+transcription+factor+early+growth+response+1+and+enhanced+expression+of+heme+oxygenase-1+in+human+endothelial+cells. assertion.
- assertion asSentence Activation+of+the+Ras%2Fp38+MAPK%2FCREB+and+ERK1%2FERK2%2FTGFB1+pathways+is+required+for+AngII-induced+periostin+expression+in+cardiac+fibroblasts. assertion.
- assertion asSentence Role+of+ERK1%2F2+activation+in+microtubule+stabilization+and+glucose+transport+in+cardiomyocytes. assertion.
- assertion asSentence Along+with+MAPK%2C+AMPK+signaling+also+plays+a+crucial+role+in+the+progression+of+experi-mental+autoimmune+myocarditis. assertion.
- assertion asSentence Aldosterone+increases+the+phosphorylation+of+ERK1%2F2. assertion.
- assertion asSentence Noncompetitive+binding+of+alcohol+to+choline+carriers+from+immature+male+tissue. assertion.
- assertion asSentence Lipid+peroxidation+and+oxidative+stress+regulate+hepatic+Apob+degradation+and+VLDL+production. assertion.
- assertion asSentence The+initial+addition+of+phospholipids+to+apoB%3A1000+and+initiation+of+apoB-containing+lipoprotein+assembly+occur+independently+of+MTP+lipid+transfer+activity. assertion.
- assertion asSentence Doxycycline+induced+apoA-IV+expression+in+McA-RH7777+cells+alters+apoB+and+lipid+secretion. assertion.
- assertion asSentence The+stimulatory+effect+of+beta-amyloid+on+Ca%282%2B%29+influx+triggers+calpain-mediated+DNA+fragmentation+in+cultured+cortical+neurones. assertion.
- assertion asSentence Hydrocephalus+in+the+elderly+rat%2C+therefore%2C+can+induce+both+Abeta+and+pTau+accumulation. assertion.
- assertion asSentence An+enormous+and+rapid+production+and+extracellular+release+of+Abeta+and+the+soluble+APP+ectodomain. assertion.
- assertion asSentence T3+treatment+in+hypothyroid+animals+caused+beta-MHC+mRNA+to+decline+more+rapidly+than+beta-MHC+hnRNA%2C+demonstrating%2C+for+the+first+time%2C+a+posttranscriptional+mechanism%28s%29. assertion.
- assertion asSentence By+controlling+the+basal+threshold+of+Src+activity%2C+constitutes+an+important+negative+regulatory+mechanism+for+Src-mediated+signalling. assertion.
- assertion asSentence CREB+binding+protein+is+required+by+an+essential+GT+site+in+the+lamin+A+promoter+to+mediate+lamin+A+promoter+activation. assertion.
- assertion asSentence p300+is+essential+for+the+maintenance+of+mitochondrial+integrity+and+for+myocyte+survival+in+the+postnatal+left+ventricular+myocardium. assertion.
- assertion asSentence CBP+gene+silencing+significantly+inhibits+Ang+II-induced+vascular+smooth+muscle+cell+proliferation+through+down-regulation+NF-kB+transcriptional+activity%2C+rather+than+a+change+in+DNA+binding+or+nuclear+translocation. assertion.
- assertion asSentence Silencing+CBP+expression+also+suppressed+thrombin-induced+PDGF-B+expression+in+endothelial+cells. assertion.
- assertion asSentence Angiogenic+activity+of+rat+mast+cells+in+the+chick+embryo+chorioallantoic+membrane+is+down-regulated+by+treatment+with+recombinant+human+alpha-2a+interferon+and+partly+mediated+by+fibroblast+growth+factor-2. assertion.
- assertion asSentence Variations+in+the+nucleotide+sequence+of+the+promoter+and+coding+region+of+the+fibroblast+growth+factor+2+gene+do+not+play+a+role+in+the+cardiac+hypertrophy. assertion.
- assertion asSentence Overdose+fluoride+inhibits+the+expression+of+bFGF+and+affects+the+interaction+between+dental+epithelium+and+dental+mesenchyme. assertion.
- assertion asSentence Expression+of+FGF-2+in+neonatal+rat+cardiomyocytes+is+associated+with+Sp1+binding+to+the+FGF-2+promoter. assertion.
- assertion asSentence Schwann+cells+overexpressing+FGF-2+alone+or+combined+with+manual+stimulation+do+not+promote+functional+recovery+after+facial+nerve+injury. assertion.
- assertion asSentence The+expression+of+VEGF+and+bFGF+is+significantly+increased+after+stromal+cell+transplantation+therapy+during+the+late+phase+of+acute+myocardial+infarction. assertion.
- assertion asSentence The+VEGFR+response+mechanism+is+different+in+the+aging+ovary. assertion.
- assertion asSentence Reactive+oxygen+species+play+an+important+role+in+mediating+hypertension+in+response+to+chronic+sFlt-1+excess+during+pregnancy. assertion.
- assertion asSentence Hyperglycemia+can+cause+systolic+dysfunction+and+a+higher+expression+of+cTnI+in+cardiomyocytes+through+ROS%2C+enhancing+MEK%2FERK-induced+GATA-4+phosphorylation+and+accumulation+in+the+cell+nucleus. assertion.
- assertion asSentence Selective+upregulation+of+kainate+receptor+subunit+KA2+expression+contributes+to+inflammatory+hyperalgesia. assertion.
- assertion asSentence The+facilitatory+effects+of+kainate+on+mossy+fiber+synaptic+transmission+and+plasticity+are+mediated+by+GLU%28K6%29-containing+kainate+receptors. assertion.
- assertion asSentence Crystal+structure+and+binding+sites+of+subunits. assertion.
- assertion asSentence Inhibition+of+CXCR1+and+CXCR2+chemokine+receptors+improves+motor+and+autonomic+neurological+outcomes+after+spinal+cord+injury. assertion.
- assertion asSentence Small+conductance+Ca%282%2B%29-activated+K%28%2B%29+%28SK%29+channels+expressed+in+the+hypothalamic+paraventricular+nucleus+play+an+important+role+in+the+regulation+of+sympathetic+outflow+and+cardiovascular+function. assertion.
- assertion asSentence Immunocytochemical+localization+of+small-conductance%2C+calcium-dependent+potassium+channels+in+astrocytes+of+the+rat+supraoptic+nucleus. assertion.
- assertion asSentence Gene+is+developmentally+expressed+in+rat+skin. assertion.
- assertion asSentence PKG+I+inhibits+cardiac+myocyte+hypertrophy+by+targeting+the+calcineurin-NFAT+signaling+pathway+%28NFAT%29. assertion.
- assertion asSentence Activation+of+the+PERK%2FeIF2a+signaling+pathway+contributes+to+the+occurrence+and+development+of+hepatocyte+apoptosis+in+alcoholic+liver+injury. assertion.
- assertion asSentence Endogenous+RGS10+has+GTPase-activating+protein+%28GAP%29+activity+on+the+G-protein+species+that+mediates+activation+of+atrial+GIRK+channels. assertion.
- assertion asSentence Gi%2Fo+signaling+and+the+palmitoyltransferase+DHHC2+regulate+palmitate+cycling+and+shuttling+of+RGS7+family-binding+protein. assertion.
- assertion asSentence NCC+is+expressed+in+olfactory+epithelium+and+participates+in+generation+of+the+excitatory+receptor+current. assertion.
- assertion asSentence Cell+division+after+bilateral+adrenalectomy+occurs+in+a+specific+subpopulation+of+hormonally+null+cells+that+are+equally+sensitive+to+the+antiproliferative+effects+of+pasireotide+and+octreotide%2C+implicating+SSTR2+receptors+in+this+antimitotic+response. assertion.
- assertion asSentence Somatostatin+caused+rapid+rsst%282a%29+receptor+phosphorylation+and+desensitization+of+epithelial+antisecretory+responses%2C+neither+of+which+occurred+with+the+sst%282b%29+receptor. assertion.
- assertion asSentence Somatostatin+sst2A+receptor+participates+in+the+development+and+maturation+of+specific+neuronal+populations+during+rat+and+human+brain+ontogenesis. assertion.
- assertion asSentence Selective+activation+of+Sstr2+induces+a+feeding+response+in+the+light+phase+not+associated+with+changes+in+gastric+emptying. assertion.
- assertion asSentence Decreased+level+of+somatostatin+receptor+type+2+mRNA+and+protein+in+diabetic+rat+atria+leads+to+the+dicrease+of+atrial+natriuretic+peptide+%28ANP%29+secretion+due+to+an+attenuation+of+suppressive+effect+of+somatostatin+on+ANP+secretion. assertion.
- assertion asSentence Ucp2+and+Ucp3+function+in+concert+to+augment+tolerance+to+cardiac+ischemia. assertion.
- assertion asSentence Berberine+can+down-regulate+the+expression+levels+of+UCP2+mRNA+and+UCP2+proteins+of+hepatic+tissue+in+non-alcoholic+fatty+liver+disease+rats. assertion.
- assertion asSentence Activated+ERM+proteins+mediate+the+effects+of+acid-induced+NHE1+activation+in+left+ventricular+myocytes. assertion.
- assertion asSentence Ezrin+redistribute+apically+in+rat+uterine+epithelial+cells+at+the+time+of+implantation+and+in+response+to+cell+contact. assertion.
- assertion asSentence ErbB3+regulates+the+proper+timing+of+ezrin+clustering+in+the+Schwann+cell+processes+that+surround+the+nodes+of+Ranvier%2C+either+by+direct+regulation+of+ezrin+expression+or+by+indirect+alternative+splicing. assertion.
- assertion asSentence RTI%2840%29%2FMMC4%2FRTII%2870%29-+and+RTI%2840%29%2FMMC4-positive+cells+are+intermediates+in+the+ATII-to-ATI+cell+transformation. assertion.
- assertion asSentence Mating+behavior+induces+differential+Arc+expression+in+the+main+and+accessory+olfactory+bulbs+of+adult+rats. assertion.
- assertion asSentence Apoptotic+Ras+effector+molecules+RASSF1+and+NORE1+play+important+role+in+NGF+reduction+and+TNF-alpha-related+pancreatic+beta+cell+apoptosis+in+hyperglycemic+rats. assertion.
- assertion asSentence Sept3+is+a+neurone-specific+developmentally+regulated+protein+highly+enriched+in+nerve+terminals+which+supports+a+secretory+role+in+synaptic+vesicle+recycling. assertion.
- assertion asSentence p115+coordinates+sequential+tethering+and+docking+of+COPI+vesicles+by+first+using+long+tethers+%28Golgins%29+and+then+short+tethers+%28SNAREs%29. assertion.
- assertion asSentence Golgi+remodeling%2C+mediated+by+phosphorylation+of+GRASP65+by+ERK%2C+is+critical+for+the+establishment+of+cell+polarity+in+migrating+cells. assertion.
- assertion asSentence The+distinct+role+of+Hrs+in+promoting+recycling+of+internalized+TrkB-FL+receptors+is+independent+of+its+ubiquitin-interacting+motif. assertion.
- assertion asSentence Gal-1+promotes+H-Ras+signaling+to+Raf+. assertion.
- assertion asSentence The+capacity+for+an+augmented+anabolic+response+to+resistance+exercise+is+maintained+after+4+days+of+hindlimb+suspension+and+is+independent+of+mammalian+target+of+rapamycin+%28mTOR%29. assertion.
- assertion asSentence In+pancreatic+beta+cells%2C+expression+of+a+constitutively+active+form+of+Akt+increases+mTOR+activity+and+prevents+apoptosis+upon+AMP-activated+protein+kinase+activation. assertion.
- assertion asSentence mTOR+is+responsible+for+the+up-regulation+of+5%27+terminal+oligopyrimidine+mRNA+during+induction+of+long+term+potentiation. assertion.
- assertion asSentence There+is+a+dissociation+of+TSC2+and+mTOR+phosphorylation+in+vivo. assertion.
- assertion asSentence Rheb+itself+can+activate+both+protein+synthesis+and+cell+growth+in+ARVC+and+demonstrate+the+key+role+played+by+mTORC1+in+the+growth+of+cardiomyocytes. assertion.
- assertion asSentence H%282%29O%282%29+induces+autophagic+cell+death+in+C6+cells+via+the+BNIP3-mediated+suppression+of+the+mTOR+pathway. assertion.
- assertion asSentence Activation+of+mTORC1+overrides+the+absence+of+the+anchorage+and+stabilizes+Cdc6+at+least+partly+via+activating+Cdk4%2F6+that+induces+Emi1%2C+an+APC%2FC%28Cdh1%29+ubiquitin+ligase+inhibitor. assertion.
- assertion asSentence The+mTORC1+inhibition+during+energetic+stress+is+primarily+to+balance+metabolic+demand+with+supply. assertion.
- assertion asSentence mTORC1+within+the+nucleus+accumbens+is+a+contributor+to+molecular+mechanisms+underlying+alcohol-drinking+behaviors. assertion.
- assertion asSentence An+examination+of+parathyroid+hormone-related+peptide+%28PTHrP%29+receptor+mRNA+expression+in+6-week-old+parathyroidectomized+rats. assertion.
- assertion asSentence Silencing+suppresses+sodium+channel+messenger+RNA+%28mRNA%29+levels%2C+leaving+potassium+channel+mRNAs+unaltered. assertion.
- assertion asSentence Coexpression+of+CRLR+and+RAMP2+or+RAMP3+mediates+the+inhibitory+effect+of+adrenomedullin+on+cell+migration%2C+independent+of+cAMP-dependent+signaling+pathways. assertion.
- assertion asSentence ADAM17+is+one+of+the+elements+triggering+physiological+germ+cell+apoptosis+during+the+first+wave+of+spermaatogenesis. assertion.
- assertion asSentence Elevation+of+ADAM17+is+associated+with+thoracic+aortic+aneurysm. assertion.
- assertion asSentence ADAM17+activation+is+involved+in+epidermal+growth+factor+receptor+activation+and+subsequent+neointimal+hyperplasia+after+vascular+injury. assertion.
- assertion asSentence Endocannabinoid+system+modulates+glucose+homeostasis+through+the+coordinated+actions+of+cannabinoid+CB1+and+CB2+receptors. assertion.
- assertion asSentence The+mu-opioid+receptor+agonist+morphine+induces+peripheral+antinociception+mediated+by+cannabinoid+receptors. assertion.
- assertion asSentence Anandamide+have+an+important+implication+in+the+normal+function+of+placental+tissues. assertion.
- assertion asSentence Urotensin+II+receptor+expression+is+significantly+enhanced+in+the+myocardium+of+rats+with+diabetes+in+both+mRNA+and+protein+levels. assertion.
- assertion asSentence The+expression+of+U+II+and+Uts2R+in+right+ventricle+arteries+and+right+ventricle+myocytes+increases+significantly+during+the+formation+of+pulmonary+hypertension+and+right+ventricle+hypertrophy+in+rats+chronically+exposed+to+hypoxia-hypercapnia. assertion.
- assertion asSentence Actopaxin+is+phosphorylated+during+mitosis+and+is+a+substrate+for+cyclin+B1%2Fcdc2+kinase. assertion.
- assertion asSentence Apelin+acts+as+a+potent+diuretic+neuropeptide+counteracting+AVP+actions+through+inhibition+of+AVP+neuron+activity+and+AVP+release. assertion.
- assertion asSentence Broad+overlapping+distribution+in+neurons+and+glial+cells+reflects+the+functional+importance+of+ectonucleotidase+actions+in+the+nervous+system. assertion.
- assertion asSentence Cellular+distribution+of+p122RhoGAP%2C+a+GTPase-activating+protein+of+Rho+small+GTPase+and+an+activator+of+phospholipase+C-delta%281%29. assertion.
- assertion asSentence Grb14+is+a+normal+physiological+modulator+of+CNG+channel+function+in+vivo. assertion.
- assertion asSentence Differential+SUMOylation+of+LXRalpha+and+LXRbeta+mediates+transrepression+of+STAT1+inflammatory+signaling+in+IFN-gamma-stimulated+brain+astrocytes. assertion.
- assertion asSentence High+LXRalpha+is+associated+with+the+pathogenesis+of+non-alcoholic+steatohepatitis. assertion.
- assertion asSentence The+proliferative+action+of+Id1+on+the+organ+of+Corti+is+mediated+by+cyclin+D1+in+the+embryonic+cochlea. assertion.
- assertion asSentence Cyclin+D1+is+a+relevant+player+in+modulating+apoptosis+by+bile+acids%2C+in+part+through+a+p53-dependent+mechanism. assertion.
- assertion asSentence Early%2C+active+DNA+synthesis+and+mitosis+in+keratinocytes%2C+with+marked+proliferation+on+day+14%2C+that+depended+on+the+modulation+of+cyclin+D1-cyclin-dependent+kinase+4+and+histone+H1+kinase+activity+of+mitosis+phase+promoting+factor. assertion.
- assertion asSentence Oviductus+Ranae+treatment+can+lower+the+expressions+of+Cyclin+D1+and+CDK6+in+the+liver+to+enhance+the+liver+cell+proliferation+in+aged+male+rats. assertion.
- assertion asSentence CCN2+contributes+to+the+cigarette+smoke+extract+and+nicotine-induced+proliferation+of+pulmonary+artery+smooth+muscle+cells+at+least+in+part+by+upregulating+cyclin+D1+expression. assertion.