Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+PDE1A-PKCalpha+signaling+pathway+is+involved+in+the+upregulation+of+alpha-smooth+muscle+actin+by+TGF-beta1+in+adventitial+fibroblasts. assertion.
- assertion asSentence Simvastatin+can+decrease+the+expression+levels+of+CTGF+and+alpha-SMA+in+renal+tubulointerstitium+of+rats+with+diabetic+nephropathy. assertion.
- assertion asSentence Brain-specific+splicing+of+alpha-actinin+1+%28ACTN1%29+mRNA. assertion.
- assertion asSentence Desmin+and+alpha-actinin-2+content+in+rat+soleus+muscle+in+the+dynamics+of+gravitational+unloading+and+subsequent+reloading. assertion.
- assertion asSentence Transcription+factor+NF-kappa+B+is+necessary+for+up-regulation+of+type+1+angiotensin+II+receptor. assertion.
- assertion asSentence Nitric+oxide+synthase+mRNA+levels+correlate+with+gene+expression+of+angiotensin+II+type-1+receptorss+in+selected+brain+areas. assertion.
- assertion asSentence Exaggerated+natriuresis+after+selective+AT1+receptor+blockade+in+Dahl+salt-sensitive+rats. assertion.
- assertion asSentence AT2+receptor+promotes+ligand-independent%2C+constitutive+cardiomyocyte+hypertrophy+and+does+not+directly+antagonize+the+AT1+receptor+in+this+setting. assertion.
- assertion asSentence Lithium+administration+reduced+CREB+phosphorylation+and+at+the+same+time+down-regulated+CaMKIV+%28enzymatic+activity%2C+phospho-Thr196+and+protein+expression+level%29+in+cell+nuclei+from+the+hippocampus. assertion.
- assertion asSentence Cyclic+AMP+response-element+binding+protein+%28CREB%29+can+positively+regulate+COX-2+promoter+activity. assertion.
- assertion asSentence D-serine+modulates+gene+expression+in+Muller+glial+cells+from+the+retina+through+the+induction+of+transcription+factor+CREB+phosphorylation+and+the+expression+of+the+immediate-early+gene+c-fos. assertion.
- assertion asSentence The+A%28-656%29+allele+contributes+to+the+development+of+major+depressive+disorder+in+women+by+selectively+altering+the+activity+of+the+CREB1+promoter+in+glial+cells+exposed+to+17+beta-estradiol. assertion.
- assertion asSentence NMDA+receptor+activation+induces+postnatal+Muller+glia-derived+retinal+cell+progenitor+proliferation+and+transcription+factor+CREB+phosphorylation+both+in+culture+and+in+vivo. assertion.
- assertion asSentence TGFbeta+activates+ATF2+phosphorylation+and+Csrp2+gene+expression+via+a+CRE+promoter+element. assertion.
- assertion asSentence CRH+exerts+a+brain+region-specific+neuroprotective+effect+on+amyloid+beta+25-35+toxicity. assertion.
- assertion asSentence Both+age+and+experience+with+stress+interact+to+modulate+CRH+expression+in+the+paraventricular+nucleus+of+the+hypothalamus. assertion.
- assertion asSentence Increased+c-fos+mRNA+in+the+paraventricular+hypothalamic+nucleus+1+hr+after+acetic+acid+treatment+is+associated+with+no+changes+in+corticotrophin-releasing+factor+mRNA+expression. assertion.
- assertion asSentence The+presence+of+CRF+synapses+in+the+VTA+offers+a+mechanism+for+interactions+between+the+stress-associated+neuropeptide+CRF+and+the+mesocorticolimbic+DA+system. assertion.
- assertion asSentence Both+corticotropin+releasing+factor+and+nociceptin%2ForphaninFQ+exert+an+inhibitory+control+on+dorsal+raphe+nucleus+serotonergic+neurons. assertion.
- assertion asSentence CRF+is+expressed+in+both+proximal+and+distal+colon+and+more+prominently+in+enteric+neurons+of+the+submucosa+plus+muscle+layers+and+subject+to+upregulation+at+the+gene+and+protein+levels+by+LPS+through+corticosteroid+independent+pathways. assertion.
- assertion asSentence Animals+with+higher+levels+of+fear+have+higher+levels+of+Crh+in+basolateral+amygdala+and+medial+prefrontal+cortex. assertion.
- assertion asSentence During+acute+stress%2C+arginine+vasopressin+interacts+with+the+paraventricular+hypothalamic+nucleus+and+amygdala+to+change+their+rates+of+biosynthesis+and%2For+release+of+corticotrophin+releasing+factor+%28CRF%29. assertion.
- assertion asSentence Modulatory+influence+of+nitric+oxide+on+salivary+mucin+synthesis+is+closely+linked+to+ERK+and+p38+protein+kinase+activation%2C+in+conjunction+with+caspase-3+activation+and+apoptosis. assertion.
- assertion asSentence Intracellular+signaling+via+p38+MAPK+influences+the+hyperplastic+response+of+the+middle+ear+mucosa+during+Haemophilus+influenzae+otitis+media. assertion.
- assertion asSentence Rosiglitazone+treatment+impaired+TNF-alpha+activation+of+p38+and+p42%2Fo44+map+kinases. assertion.
- assertion asSentence Elevation+in+the+number+of+phosphorylated+erk-1+and+-2+neurons+in+various+brain+organs+significant+elevation+in+the+number+of+phosphorylated+extracellular+signal-regulated+kinase-1+and+-2-immunoreactive+neurons+in+brain+after+an+avoidance+test. assertion.
- assertion asSentence p38MAP+kinase+phosphorylation+decreased+in+liver+after+carbon+tetrachloride+intoxication. assertion.
- assertion asSentence Activation+of+p38MAPK+by+lead+acetate+paralled+impairment+of+glioma+cell+viability. assertion.
- assertion asSentence EGFR+activity+initiates+the+intrinsic+pathway+of+apoptosis+through+p38alpha-dependent+Bax+activation+in+intestinal+epithelial+cells. assertion.
- assertion asSentence In+the+rat+isolated+heart%2C+activation+of+p38-MAPK+is+neither+a+unique+feature+of+preconditioning+nor+a+prerequisite. assertion.
- assertion asSentence Physiological+dose+of+insulin+induced+rapid%2C+p38MAPK-dependent+phosphorylation+of+Hsp27+that+is+associated+with+improved+functional+recovery+after+ischemia-reperfusion+injury. assertion.
- assertion asSentence Basal+and+IGF-I-dependent+regulation+of+potassium+channels+by+p38MAPK+and+PI3-kinase+during+eccentric+cardiac+hypertrophy. assertion.
- assertion asSentence IL-1beta+stimulates+GDNF+release+through+the+pathways+of+IkappaB-nuclear+factor+kappa+B%2C+p38+MAP+kinase%2C+p44%2Fp42+MAP+kinase+and+JAK-STAT3. assertion.
- assertion asSentence SSeCKS+promoted+p38+and+JNK+activation+in+Schwann+cells+treated+by+TNF-alpha. assertion.
- assertion asSentence AMPK+regulates+glucocorticoid+actions+on+carbohydrate+metabolism+by+targeting+the+glucocorticoid+receptor+%28GR%29+and+modifying+transcription+of+glucocorticoid-responsive+genes+in+a+tissue-+and+promoter-specific+fashion. assertion.
- assertion asSentence Chronic+intermittent+hypoxia+can+activate+p38MAPK+in+cerebral+tissues+of+weanling+rats. assertion.
- assertion asSentence Silencing+of+p38+expression+inhibited+Nrf2+activation+and+NQO1+induction. assertion.
- assertion asSentence Acupuncture+decreases+the+proportion+of+activated+microglia+and+inhibits+both+p38MAPK+and+ERK+activation+in+microglia+at+lumbar4-5+level%2C+as+a+successful+intervention+for+relief+of+chronic+neuropathic+pain+after+spinal+cord+injury. assertion.
- assertion asSentence Casein+kinase+II+%28CK2%29+phosphorylates+the+serine+residue+%28Ser1480%29+within+the+C-terminal+PDZ+ligand+%28IESDV%29+of+the+NR2B+subunit+of+NMDAR+in+vitro+and+in+vivo. assertion.
- assertion asSentence Inhibition+of+protein+kinase+CK2+prevents+the+progression+of+glomerulonephritis. assertion.
- assertion asSentence NG2+is+expressed+by+a+distinct+cell+population+in+the+mature+central+nervous+system+with+the+homogeneous+antigenic+phenotype+of+oligodendrocyte+progenitors. assertion.
- assertion asSentence Drebrin+E+plays+a+role+in+axonal+growth+through+actin-myosin+interactions+in+the+transitional+zone+of+axonal+growth+cones+in+primary+hippocampal+neuronal+cultures. assertion.
- assertion asSentence Distinct+localization+of+GABA%28B%29+receptors+relative+to+synaptic+sites+in+the+rat+cerebellum+and+ventrobasal+thalamus. assertion.
- assertion asSentence Pre-+and+postsynaptic+inhibition+mediated+by+GABA%28B%29+receptors+in+rat+ventrolateral+periaqueductal+gray+neurons. assertion.
- assertion asSentence GABA%28B%29+receptors+exert+a+tight+control+over+spatial+learning+by+modulating+neuronal+excitability+in+the+entorhinal+cortex. assertion.
- assertion asSentence Pre-treatment+with+propofol+can+reduce+the+concentration+of+Gq%2F11+protein+in+kidney+tissue+during+acute+respiratory+distress+syndrome. assertion.
- assertion asSentence Inhibition+of+rat+granulosa+cell+differentiation+by+overexpression+of+Galphaq. assertion.
- assertion asSentence GnRH+receptor+can+be+expressed+by+gastric+smooth+muscle+cells+of+rats. assertion.
- assertion asSentence Competitive+interactions+of+Ca2%2B%2Fcalmodulin+and+MacMARCKS+with+mGluR7+control+the+tonic+inhibition+of+voltage-sensitive+Ca2%2B+channels. assertion.
- assertion asSentence MIF+proteins+play+an+important+role+in+the+development+of+acquired+drug+resistance+to+various+drugs+of+prostate+cancer+cells. assertion.
- assertion asSentence Baicalin%2C+a+Chinese+herbal+extract%2C+down-regulates+the+expression+of+macrophage+migration+inhibitory+factor. assertion.
- assertion asSentence nm23-beta+binds+to+YB-1+and+inhibits+MMP2+transcription. assertion.
- assertion asSentence Differential+involvement+of+MMP-2+and+VEGF+during+muscle+stretch-+versus+shear+stress-induced+angiogenesis. assertion.
- assertion asSentence MMP-2+produced+by+macrophages+participates+in+the+resorption+of+demineralized+bovine+bone. assertion.
- assertion asSentence Recombinaant+human+erythropoietin-activated+endothelial+cells+enhance+neural+progenitor+cell+migration+by+secreting+MMP2+and+MMP9. assertion.
- assertion asSentence Atioxidants+exertprotection+against+hydrogen+peroxide-mediateed+inactivation+and+downregulation+of+MMP-2+expression+during+onset+of+indomethacin-induced+ulceration. assertion.
- assertion asSentence Inhibition+of+MMP-2+protects+cardiac+myocytes+from+peroxynitrite-induced+contractile+dysfunction. assertion.
- assertion asSentence With+prolonged+hyperoxia%2C+the+balance+of+MMP-2%2FTIMP-2+can+not+be+maintained. assertion.
- assertion asSentence Gelatinolytic+activity+%28with+contribution+of+both+MMP-2+and+MMP-9%29+in+the+epithelium+and+at+the+epithelium-stroma+interface+are+in+part+responsible+for+the+tissue+remodeling+that+allows+epithelial+growth+and+its+projection+into+the+surrounding+stroma. assertion.
- assertion asSentence Cdc42+and+RhoA+have+opposing+roles+in+regulating+membrane+type+1-matrix+metalloproteinase+localization+and+matrix+metalloproteinase-2+activation. assertion.
- assertion asSentence Low+molecular-weight+fucoidan+increased+in+vitro+human+umbilical+cell+migration+and+decreased+vascular+smooth+muscle+cell+migration+in+rats. assertion.
- assertion asSentence Unbalanced+MMP%2FTIMP-1+expression+and+excessive+gelatinolytic+activity+contribute+to+paraquat-induced+pulmonary+fibrosis. assertion.
- assertion asSentence Matrix+metalloproteinase+2+induces+epithelial-mesenchymal+transition+in+prox-imal+tubules+from+the+luminal+side+and+progresses+fibrosis+in+mineralo-corticoid%2Fsalt-induced+hypertensive+rats. assertion.
- assertion asSentence MMP-9+plays+an+important+role+in+the+remodelling+of+extracellular+matrix+in+various+renal+diseases. assertion.
- assertion asSentence In+the+rat+hippocampus%2C+MMP-9+mRNA+is+associated+with+dendrites+and+dendritic+spines+bearing+asymmetric+%28excitatory%29+synapses. assertion.
- assertion asSentence The+expression+levels+of+MMP-9+and+TIMP-1+relate+closely+to+the+disruption+of+renal+tubular+epithelial-myofibroblast+transdifferentiation. assertion.
- assertion asSentence Alpha-1-antichymotrypsin+is+a+pathophysiologic+inhibitor+that+controls+MMP-9+activation+in+skin+tissue. assertion.
- assertion asSentence Normobaric+hyperoxia+treatment+reduces+MMP-9+expression+and+blood-brain+barrier+disruption+in+the+ischemic+brain. assertion.
- assertion asSentence MMP-9+is+a+key+molecular+effector%2C+downstream+of+HIF-1alpha+and+Wnt+activation%2C+responsible+for+increased+rates+of+NSC+proliferation+and+migration+in+1%25+O%282%29. assertion.
- assertion asSentence Jinqi+Jiangtang+Tablet+can+decrease+the+level+of+serum+MMP-9+and+down-regulate+the+MMP-9+expression+in+peripheral+blood+monocytes+in+rats+with+diabetes. assertion.
- assertion asSentence MMP+2+and+9+activation+is+essential+for+coronary+collateral+growth+%28CCG%29+and+is+mediated%2C+in+part%2C+by+p38+MAPK. assertion.
- assertion asSentence MMP-9+function+is+straightforwardly+attributable+to+nerve+and+synapse+degradation+following+cochlear+ablation. assertion.
- assertion asSentence Cross-talk+between+the+hemopexin+domain+of+MT1-MMP+and+adjacent+cell+surface+molecules+is+responsible+for+outside-in+signaling. assertion.
- assertion asSentence MT1-MMP+has+multiple+functions+and+is+implicated+in+multiple+steps+of+the+differentiation+process%2C+acting+to+regulate+homeostasis+of+the+osteogenic+differentiation. assertion.
- assertion asSentence Sympathetic+neurons+express+and+secrete+MMP-2+and+MT1-MMP+to+control+nerve+sprouting+via+pro-NGF+conversion. assertion.
- assertion asSentence MT1-MMP+plays+a+crucial+role+in+RAGE-activated+NADPH+oxidase-dependent+signaling+pathways. assertion.
- assertion asSentence High+MT1-MMP+is+associated+with+glomerulosclerosis+in+diabetic+nephropathy. assertion.
- assertion asSentence Estrogen+replacement+therapy+in+diabetic+ovariectomized+female+rats+potentiates+postischemic+leukocyte+adhesion+in+cerebral+venules+via+a+RAGE-related+process. assertion.
- assertion asSentence MT1-MMP+plays+a+crucial+role+in+RAGE-activated+NADPH+oxidase-dependent+signaling+pathways. assertion.
- assertion asSentence Arp2%2F3+and+cofilin+coordinate+a+dynamic+cycle+of+actin+branching+and+severing+at+the+cell+cortex%2C+essential+for+insulin-mediated+GLUT4+translocation+in+muscle+cells. assertion.
- assertion asSentence NF+kappa+B+pathway+is+involved+in+the+transcriptional+regulation+of+the+TNF-alpha+and+IL-6+overexpression+in+primary+Substance+P+-stimulated+mast+cells. assertion.
- assertion asSentence NF-kappaB+signaling+is+sufficient+to+suppress+ventricular+myocyte+death+during+hypoxia+through+a+mechanism+that+prevents+perturbations+to+the+mitochondrion+during+hypoxic+injury. assertion.
- assertion asSentence IL-6+plays+an+important+role+in+the+delayed+activation+of+STAT3+and+vascular+smooth+muscle+cell+proliferation+induced+by+heparin-binding+EGF-like+growth+factor. assertion.
- assertion asSentence Flavonoids+protected+against+IL-1beta%2FIFNgamma+induced+pancreatic+beta+cell+damage+by+inhibiting+activation+of+NFkappaB+p50%2Fp65+subunits. assertion.
- assertion asSentence Melatonin+possesses+protective+effect+on+lung+tissues+during+acute+lung+injury+by+scavenging+free+radicals+and+inhibiting+the+activation+of+NF-kappaB. assertion.
- assertion asSentence Activation+of+NF-kappaB+is+involved+in+the+GRO%2FKC-induced+enhancement+of+potassium+currents. assertion.
- assertion asSentence Stimulation+of+cardiomyocytes+with+TWEAK+promoted+nuclear+translocation+of+NF-kappaB+and+subsequent+induction+of+NF-kappaB+dependent+genes. assertion.
- assertion asSentence Curcumin+can+ameliorate+cerebral+pathological+changes+in+the+event+of+ischemia-reperfusion+injury+by+suppressing+the+expressions+of+NF-kappaB+and+ICAM-1. assertion.
- assertion asSentence Hyperglycemia+and+ovariectomy+severely+increased+NF-kappaB+activation+and+oxidant+levels+in+the+kidney+under+sepsis+conditions. assertion.
- assertion asSentence Liuwei+Dihuang+Pill+can+inhibit+the+expression+of+NF-kappaB+so+as+to+alleviate+the+renal+oxidative+lesion. assertion.
- assertion asSentence In+rats+with+monoarthritis%2C+expression+of+CX3CR1+and+NF-kappaB+mRNA+in+the+spinal+cord+decreased+significantly+after+treatment+with+pyrrolidine+dithiocarbamate. assertion.
- assertion asSentence Potassium+iodide+can+degrade+lead-induced+expression+of+nuclear+factor-kappaB+and+fibronectin+in+the+kidney. assertion.
- assertion asSentence Down-regulation+of+NF-kappaB%2FiNOS+is+a+key+event+in+the+molecular+mechanism+of+cerebral+ischemic+tolerance. assertion.
- assertion asSentence Taurine+can+decrease+the+levels+of+TNF-alpha+and+NF-kappaB+which+mitigates+liver+injury+after+limb+ischemia%2Freperfusion+injury+in+rats. assertion.
- assertion asSentence TLR4%2FNF-kappaB+participates+in+myocardial+injury+during+chronic+stress. assertion.
- assertion asSentence The+NF-kappaB+signal+pathway+plays+a+role+in+the+progression+of+aldosterone%2Fsalt-induced+renal+injury. assertion.
- assertion asSentence Biochemically%2C+the+XYS+decoction+also+reversed+CIS-induced+decreases+in+BDNF+and+increases+in+TrkB+and+NT-3+in+the+frontal+cortex+and+the+hippocampal+CA%281%29+subregion. assertion.
- assertion asSentence Endogenous+NT-3+has+a+distinctive+role+in+promoting+spiral+ganglion+axon+growth+in+the+organ+of+Corti+and+synaptogenesis+on+inner+hair+cells. assertion.
- assertion asSentence P2X3+receptor+localizes+into+lipid+rafts+in+neuronal+cells+of+rat+cerebellum. assertion.
- assertion asSentence P2X3+receptors+play+an+important+role+in+pressure+pain+and+mechanical+hyperalgesia+in+masseter+muscle+caused+by+excessive+muscular+contraction. assertion.