Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence A+high+cGMP+phosphodiesterase+activity+localizes+to+the+membrane+microdomain+raft+fraction+of+10-day-old+rat+cerebral+cortex. assertion.
- assertion asSentence Thrombin+activation+of+PI3K%2FPDK1%2FAkt+signaling+promotes+cyclin+D1+upregulation+and+retinal+pigment+epithelium+cell+proliferation. assertion.
- assertion asSentence NCS-1+protein+and+1-phosphatidylinositol+4-kinase+b+interact+in+neuronal+cells+and+are+translocated+to+membranes+during+nucleotide-evoked+exocytosis. assertion.
- assertion asSentence EP%282%29+and+EP%284%29+receptor+signaling+inhibits+ethanol-induced+gastric+mucosal+injury+through+cancellation+of+collecting+venule+constriction+by+reducing+LTC%284%29+production. assertion.
- assertion asSentence Zinc+regulation+demonstrates+the+metallopeptidase+property+of+AP-B. assertion.
- assertion asSentence Increased+RhoA%2FRho-kinase+signaling+is+a+major+factor+in+the+pathogenesis+of+age-associated+erectile+dysfunction+and+the+mechanism+involves+increased+penile+smooth+muscle+contractility+through+inhibition+of+myosin+light+chain+phosphatase. assertion.
- assertion asSentence Up-regulation+of+Rho%2FROCK+signaling+in+sarcoma+cells+drives+invasion+and+increased+generation+of+protrusive+forces. assertion.
- assertion asSentence RhoK-mediated+enhancement+of+myofilament+Ca%282%2B%29+sensitivity+is+coupled+with+the+alpha%281%29-adrenergic+vasoconstriction+in+penile+arteries+from+prediabetic+obese+Zucker+rats. assertion.
- assertion asSentence Npm1+is+essential+for+Rpl5+nuclear+export. assertion.
- assertion asSentence RSK1+%28ribosomal+S6+kinase+1%29%2C+a+downstream+target+of+MAPK+%28mitogen-activated+protein+kinase%29%2C+directly+phosphorylates+nNOS+%28neuronal+nitric+oxide+synthase%29+on+Ser847+in+response+to+mitogens. assertion.
- assertion asSentence Binding+domains+of+P11+interact+with+those+in+the+sodium+channel+Na%28V%291.8+intracellular+N-terminal+region. assertion.
- assertion asSentence Control+of+transplant+tolerance+and+intragraft+regulatory+T+cell+localization+by+myeloid-derived+suppressor+cells+and+CCL5. assertion.
- assertion asSentence Involved+in+basolateral+trafficking+pathways+in+most+renal+epithelial+cell+types. assertion.
- assertion asSentence Syntaxin-4+and+VAMP-1+and+VAMP-2+regulate+cardiac+myocyte+exocytosis+of+ANP. assertion.
- assertion asSentence Upregulation+of+thymosin+beta4+is+associated+with+lung+metastasis+in+chondrosarcoma. assertion.
- assertion asSentence An+unusual+negative+cross+talk+between+Ras+oncogene+and+the+cyclic+AMP+pathway+induces+inactivation+of+the+transcription+factor+Pax8. assertion.
- assertion asSentence Distal+regulation+by+Pax8+is+supported+by+the+interaction+with+chromatin+remodeling+factors+such+as+CTCF+and+Sp1. assertion.
- assertion asSentence Phosphate+uptake+via+Pit-1+is+required+for+osteochondrogenic+phenotypic+change+and+calcification+of+vascular+smooth+muscle+cells+in+vitro. assertion.
- assertion asSentence Dexamethasone+and+cyclic+AMP+regulate+sodium+phosphate+cotransporter+%28NaPi-IIb+and+Pit-1%29+mRNA+and+phosphate+uptake+in+rat+alveolar+type+II+epithelial+cells. assertion.
- assertion asSentence Incisor+enamel+formation+is+impaired+in+transgenic+rats+overexpressing+the+type+III+NaPi+transporter+Slc20a1. assertion.
- assertion asSentence The+CR1-mediated+self-association+of+the+PAR-3-containing+protein+complex+plays+a+role+during+the+formation+of+functional+tight+junctions. assertion.
- assertion asSentence RalA+and+the+exocyst+complex+influence+neuronal+polarity+through+PAR-3+and+aPKC. assertion.
- assertion asSentence SSeCKS+modulate+endothelial+cells+adhesion+and+spreading+by+reorganization+of+the+actin+cytoskeleton. assertion.
- assertion asSentence SSeCKS+modulate+Schwann+cells+adhesion%2C+spreading+and+migration+by+reorganization+of+the+actin+cytoskeleton. assertion.
- assertion asSentence RACK1+tethers+the+ERK+pathway+core+kinases+and+channels+signals+from+upstream+activation+by+integrins+to+downstream+targets+at+focal+adhesions. assertion.
- assertion asSentence PTZ-induced+seizures+of+the+rats+activate+glutamate+NMDA+receptors%2C+then+decrease+prolyl+oligopeptidase+enzyme+activity+in+hippocampal+neurons. assertion.
- assertion asSentence Involvement+of+Cyr61+and+CTGF+in+pericyte+detachment+and+anoikis%2C+implicating+these+proteins+in+the+pathogenesis+of+diabetic+retinopathy. assertion.
- assertion asSentence Levels+of+tight+junction+protein+occludin+are+decreased+in+blood-brain+barrier+cells+post-translationally+following+exposure+to+neurotoxicants. assertion.
- assertion asSentence In+female+rats%2C+increasing+age+and+17beta-estradiol+treatment+alters+the+expression+of+ERalpha+and+distinct+blood-brain+barrier+tight-junction+protein+isoforms+%28occludin+and+claudin-5%29+without+altering+functional+paracellular+permeability. assertion.
- assertion asSentence COX-2+derived+prostanoids+downregulate+OAT1+and+OAT3+during+lipopolysaccharide-induced+acute+renal+injury. assertion.
- assertion asSentence OAT3+and+OCT2+are+expressed+at+significant+levels+in+the+rat+olfactory+epithelia. assertion.
- assertion asSentence This+pathway+of+regulated+endocytosis+of+N-cadherin+via+protocadherin%2FTAO2beta%2FMEK3%2Fp38+provides+a+molecular+mechanism+for+transducing+neuronal+activity+into+changes+in+synaptic+morphologies. assertion.
- assertion asSentence Activity-regulated+loss+and+retention+of+synaptic+cadherin-2+contributes+to+flexibility+and+stability+in+synapse+structure+that+mediates+synaptic+remodeling+that+accompanies+long-lasting+plasticity. assertion.
- assertion asSentence Chronic+ethanol+ingestion+impairs+the+airway+epithelial+barrier+function+through+down-regulation+and+disruption+of+membrane+localization+of+occludin+and+E-cadherin. assertion.
- assertion asSentence The+retaining+of+E-cadherin+in+cell-cell+adhesion+junctions+affects+the+locomotor+activity+of+transformed+epithelial+cells+and+plays+an+important+role+in+their+collective+migration. assertion.
- assertion asSentence Renal+mRNA+and+protein+expression+of+Klotho+plays+important+an+role+in+progression+of+hypertensive+renal+damage+in+spontaneously+hypertensive+rats. assertion.
- assertion asSentence The+mRNA+levels+of+NET+in+the+LC+decreased+with+increasing+age+to+a+reduction+of+29%25%2C+30%25+and+43%25+in+3-%2C+8-+and+23-month-old+rats. assertion.
- assertion asSentence Peroxisome+proliferator-activated+receptor+%28PPAR%29+gamma+coactivator-1+recruitment+regulates+PPAR+subtype+specificity. assertion.
- assertion asSentence PGC-1+inhibits+insulin+and+BETA2%2FNeuroD+transcription+levels+and+attenuating+PGC-1+overexpression+protects+against+glucolipotoxicity-induced+beta-cell+dysfunction+both+in+vivo+and+in+vitro. assertion.
- assertion asSentence Omega-6+lipids+regulate+PPAR+turnover+via+reciprocal+switch+between+PGC-1+alpha+and+ubiquitination+to+have+dual+pro-+and+anti-atherogenic+effects. assertion.
- assertion asSentence The+mannose-binding+lectin+%28MBL%29-associated-serine+protease+%28MASP%29-2+binding+site+on+rat+ficolin-A+is+located+within+the+collagen-like+domain+and+encompasses+a+conserved+motif+that+is+present+in+both+MBLs+and+ficolins. assertion.
- assertion asSentence Rad+GTPase+inhibits+cardiac+fibrosis+through+connective+tissue+growth+factor+in+failing+hearts. assertion.
- assertion asSentence Glycogen+synthase+kinase+3+inhibition+slows+mitochondrial+adenine+nucleotide+transport+and+regulates+voltage-dependent+anion+channel+phosphorylation. assertion.
- assertion asSentence In+vivo+inhibition+of+caspases+and+poly%28ADP-ribose%29polymerase-1%2C+an+upstream+regulator+of+AIF+release+and+calpain%2C+proves+the+central+role+of+the+AIF-dependent+pathway+in+lipopolysasccharide-induced+nigral+dopaminergic+cell+death. assertion.
- assertion asSentence Activation+of+KATP+channels+in+slow-twitch+muscle+is+necessary+for+activation+of+the+NKCC+and+cell+volume+restoration+in+hyperosmotic+conditions. assertion.
- assertion asSentence ATP+activates+ATP-sensitive+potassium+channels+composed+of+mutant+sulfonylurea+receptor+1+and+Kir6.2+with+diminished+PIP2+sensitivity. assertion.
- assertion asSentence Smpd2+inhibition+participates+in+the+benefits+of+acetylcysteine+treatment+in+post-myocardial+infarction+in+failing+heart+rats. assertion.
- assertion asSentence Ontogenic+changes+in+bile+formation+are+mediated+in+part+by+the+regulation+of+expression+of+canalicular+membrane+transporter+Bsep. assertion.
- assertion asSentence Silibinin+prevents+bile+salt+secretory+failure+by+avoiding+redistribution+of+Bsep+by+a+mechanisms+involving+cyclic+AMP+and+calcium. assertion.
- assertion asSentence Cycin+kinase+inhibitor+p27+play+a+role+on+TNF-alpha+induced+mesangial+cell+proliferation. assertion.
- assertion asSentence Induction+of+p27kip+protein+is+almost+completely+abolished+following+depletion+of+JNK3+in+growth+arrested+glioma+cells. assertion.
- assertion asSentence Cypin+protein+acts+downstream+of+the+small+GTPase+RhoA+protein+to+regulate+dendrite+branching+in+hippocampal+neurons. assertion.
- assertion asSentence In+wild-type+PC12+transfected+with+REST+constructs%2C+expression+of+genes+encoding+proteins+of+dense-core+and+synaptic-like+vesicles+is+decreased. assertion.
- assertion asSentence Nrf2+regulates+rat+GCLC+promoter+by+modulating+the+expression+of+key+AP-1+and+NF-kappaB+family+members. assertion.
- assertion asSentence Nrf2+is+activated+in+the+anti-apoptotic+pathway+of+pancreatic+beta-cells+following+lithospermic+acid+B+treatment. assertion.
- assertion asSentence Ozonized+saline+can+strengthen+the+Nrf2+expression+in+liver+cells. assertion.
- assertion asSentence Nitric+oxide+donor+S-nitroso-N-acetylpenicillamine+activates+Nrf2+and+induces+Heme+oxygenase-1+expression+in+PC12+cells. assertion.
- assertion asSentence NKCC1%2C+a+transporter+abundant+in+the+immature+neocortex%2C+mediates+slow+chloride+ion+%28Cl-%29+uptake+at+a+rate+sufficient+to+maintain+the+high+intracellular+Cl-+concentration+required+to+render+GABA+responses+excitatory. assertion.
- assertion asSentence The+daily+rhythm+in+pineal+Pax4+expression+is+controlled+by+a+neural+system+which+acts+on+pinealocytes+through+an+adrenergic-cyclic+AMP+signalling+mechanism. assertion.
- assertion asSentence Rat+basophilic+leukaemia+RBL-2H3+cells+stably+transfected+with+the+chemoattractant+receptor+expressed+both+GIT1-p21-activated+kinase+and+GIT2-p21-activated+kinase+endogenous+complexes. assertion.
- assertion asSentence GIT1+colocalized+with+podosomes+and+GIT1+knockdown+using+short+interfering+RNA+significantly+reduced+podosome+formation. assertion.
- assertion asSentence Serum+inducible+kinase+acts+downstream+of+extracellular+signal-regulated+kinase+activation+in+immature+cortical+neurons+undergoing+morphogenesis+and+is+necessary+for+brain-derived+neurotrophic+factor+-promoted+dendrite+growth+and+branching. assertion.
- assertion asSentence Role+of+increased+expression+of+the+wolframin+gene+in+the+regulation+of+emotional+behavior. assertion.
- assertion asSentence A+role+for+WFS1+in+the+negative+regulation+of+ER+stress+signaling+and+in+the+pathogenesis+of+diseases+involving+chronic%2C+unresolvable+ER+stress%2C+such+as+pancreatic+beta+cell+death+in+diabetes. assertion.
- assertion asSentence Individual+pancreatic+acinar+cells+express+VAMP+8-specific+populations+of+zymogen+granules+that+orchestrate+the+constitutive+and+calcium%282%2B%29-regulated+secretory+pathways. assertion.
- assertion asSentence Nitric+oxide+enhances+Ca%282%2B%29-dependent+K%28%2B%29+channel+activity+in+rat+carotid+body+cells. assertion.
- assertion asSentence Slo1-caveolin-1+interaction+facilitates+the+tethering+of+the+Slo1+C-terminal+end+to+the+membrane. assertion.
- assertion asSentence Hypobaric+chronic+hypoxia+induces+increased+endothelial+BK%28Ca%29+channel+activity+that+contributes+to+reduced+myogenic+responsiveness+and+endothelial+cell+and+vascular+smooth+muscle+cell+hyperpolarization. assertion.
- assertion asSentence BKCa+and+KV+channels+limit+conducted+vasomotor+responses+in+rat+mesenteric+terminal+arterioles. assertion.
- assertion asSentence Preformed+reggie%2Fflotillin+caps+are+stable+priming+platforms+for+the+assembly+of+multiprotein+complexes+controlling+actin+reorganization+during+T+cell+activation. assertion.
- assertion asSentence During+development+from+postnatal+day+21+Nogo-A+is+expressed+in+association+with+tubulin+and+myelin+basic+protein+in+mature+oligodendrocytes+in+the+spinal+cord. assertion.
- assertion asSentence Galectin-3+promotes+K-Ras+signaling+to+both+Raf+and+PI3-K.+3. assertion.
- assertion asSentence Inhibition+of+galectin-3+using+RNAi+technique+can+suppress+proliferation+and+induce+apoptosis+in+hepatic+stellate+cells. assertion.
- assertion asSentence Differential+involvement+of+MMP-2+and+VEGF+during+muscle+stretch-+versus+shear+stress-induced+angiogenesis. assertion.
- assertion asSentence VEGF+promotes+SRF+expression+and+nuclear+translocation+and+increases+SRF+binding+activity+to+DNA+in+endothelial+cells+through+both+Rho-actin+and+MEK-ERK+dependent+signaling+pathways. assertion.
- assertion asSentence The+production+of+PGI%282%29+leads+to+an+increase+in+the+level+of+VEGF. assertion.
- assertion asSentence Decreased+dentate+neurogenesis+by+middle+age+is+linked+to+reduced+levels+of+VEGF+in+the+hippocampus%2C+as+it+influences+the+proliferation+of+stem%2Fprogenitor+cells+in+the+dentate+gyrus. assertion.
- assertion asSentence Tacrolimus-induced+nephrotoxicity+is+associated+with+increased+TGF-beta1+and+VEGF+and+decreased+BMP-7+expression. assertion.
- assertion asSentence Ischemia+reperfusion+leads+to+alterations+in+protein+tyrosine+phosphorylation+and+increased+expression+of+VEGF+in+rat+liver. assertion.
- assertion asSentence Red+wine+polyphenols+prevented+angiotensin+induced+expression+of+VEGF+in+rat+aorta. assertion.
- assertion asSentence A+direct+effect+of+testosterone+on+EG-VEGF+gene+expression+in+rat+pancreas+and+RINm5F+cells. assertion.
- assertion asSentence Inhibition+of+tumor-induced+edema+by+antisense+Vegf+is+mediated+by+suppressive+vesiculo-vacuolar+organelles. assertion.
- assertion asSentence Chronic+intermittent+fasting+improves+the+survival+following+large+myocardial+ischemia+by+activation+of+BDNF%2FVEGF%2FPI3K+signaling+pathway. assertion.
- assertion asSentence VEGF+regulates+levels+of+key+factors+involved+in+a+range+of+biological+processes+that+lead+to+cervical+remodeling. assertion.
- assertion asSentence Intravenously+administrated+bone+marrow-derived+mesenchymal+stem+cells+facilitate+neurological+function%2C+reduce+neuronal+apoptosis+and+promote+neuronal+proliferation+through+the+release+of+VEGF. assertion.
- assertion asSentence Estrogens+regulate+VEGF+expression+in+the+epiphyseal+growth+plate. assertion.
- assertion asSentence High+levels+of+VEGF-2+receptor+mRNA+in+hyper-aldosteronemic+animals+leads+to+impaired+function+and+downregulation+of+VEGF+and+VEGF-2+receptor+in+vivo. assertion.
- assertion asSentence VEGF+has+a+proliferative+and+cytoprotective+role+in+early+antral+follicles+and+in+granulosa+cells. assertion.
- assertion asSentence The+expression+of+VEGF+and+bFGF+is+significantly+increased+after+stromal+cell+transplantation+therapy+during+the+late+phase+of+acute+myocardial+infarction. assertion.
- assertion asSentence Thalidomide+can+inhibit+the+hepatic+VEGF+expression+and+arrest+the+development+of+rat+hepatoma. assertion.
- assertion asSentence Antenatal+dexamethasone+decreased+VEGF+expression%2C+betamethasone+tended+to+produce+the+induction+of+the+expression+of+VEGF. assertion.
- assertion asSentence Recombinant+sonic+hedgehog+treatment+can+enhance+the+expression+and+secretion+of+VEGF+and+bFGF+in+bone+marrow+mesenchymal+stem+cells. assertion.
- assertion asSentence Dynamic+temporal+changes+in+VEGF%2C+Ang-1+and+Ang-2+expression+stimulate+the+cerebral+angiogenesis+after+focal+cerebral+ischemia. assertion.
- assertion asSentence Intravitreal+injection+of+protamine+reduced+VEGF+expression+in+the+vitreous+body+of+rats+with+diabetes. assertion.
- assertion asSentence Ang+II+can+regulate+the+development+of+mesangial+matrix+expansion+in+the+early+phase+of+diabetic+nephropathy+through+Src+and+Smad1. assertion.
- assertion asSentence In+endothelial+cells%2C+G%28alphai%29+directly+interacts+with+SRC+and+this+interaction+leads+to+SRC+activation+and+phosphorylation+in+a+manner+that+is+regulated+by+beta%282%29AR+stimulation. assertion.
- assertion asSentence The+tyrosine+phosphorylation+of+HPK1+promotes+ischemic+brain+injury+by+activated+Src+via+N-methyl-d-aspartate+receptor+and%2C+ultimately%2C+the+activation+of+the+MLK3-MKK7-JNK3+pathway+after+cerebral+ischemia. assertion.
- assertion asSentence In+vascular+smooth+muscle+cells+shedding+of+membrane-bound+epidermal+growth+factor+%28EGF%29+receptor+ligands+and+activation+of+the+nonreceptor+tyrosine+kinases+Pyk2+and+Src+contributed+to+the+thrombin-induced+ERK1%2F2+phosphorylation. assertion.
- assertion asSentence In+the+mature+retina+caveolin-1+and+c-src+localized+mainly+to+the+cell+body+and+IS+of+photoreceptors%2C+with+only+very+weakly+labeled+OS. assertion.
- assertion asSentence Histamine+activates+TRPV1+after+stimulating+the+phospholipase+A2%2Flipoxygenase+pathway%2C+leading+to+the+excitation+of+sensory+neurons. assertion.