Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence TRPV1+up-regulation+and+sensitization+is+a+specific+molecular+mechanism+contributing+to+hyperalgesia+in+chronic+pancreatitis. assertion.
- assertion asSentence The+TRPV1+receptor+plays+an+important+role+in+the+whole+brain%2C+not+confined+to+small+pial+venules. assertion.
- assertion asSentence TRPV1%2C+a+low-pressure+baroreceptor%2C+is+present+in+the+renal+pelvis+and+exclusively+regulates+neuropeptide+release+from+primary+renal+afferent+C-fibers+in+response+to+mechanostimulation. assertion.
- assertion asSentence Activation+of+native+or+recombinant+rat+TRPV1+leads+to+time-+and+agonist+concentration-dependent+increases+in+relative+permeability+to+large+cations+and+changes+in+Ca2%2B+permeability. assertion.
- assertion asSentence TRPV1+plays+a+crucial+role+in+contributing+to+the+capsaicin-sensitive+primary+afferent+fibers+mediating+the+glutamatergic+NMDA-dependent+cross-organ+sensitization+between+the+uterus+and+the+lower+urinary+tract+when+there+is+a+tissue+injury. assertion.
- assertion asSentence TRPV1+channels+in+primary+urothelial+cell+cultures+induce+ionic+currents+and+changes+in+intracellular+calcium. assertion.
- assertion asSentence The+principle+mechanisms+mediating+increase+in+%5BCa2%2B%5D+i+in+response+to+acidosis+are+a+brief+Ca2%2B+influx+through+TRPV1+followed+by+sustained+Ca2%2B+release+from+internal+stores. assertion.
- assertion asSentence C-terminus+of+TRPV1+is+a+signaling+intermediate+downstream+of+estrogen+and+PKCepsilon%2C+regulating+microtubule-stability+and+microtubule-dependent+pain+sensitization. assertion.
- assertion asSentence Histamine-induced+vasoconstriction+and+long-lasting+vasodilation+are+mediated+by+activation+of+TRPV1+on+capsaicin-sensitive+and+capsaicin-insensitive+nerves. assertion.
- assertion asSentence TRPV1-mediated+Ca%282%2B%29+entry+functionally+couples+with+CB1+receptor+activation+via+cAMP+signaling. assertion.
- assertion asSentence Lead+acetate+decreased+brain+AChE+activity+of+rats+in+dose%2Fage+dependent+manner. assertion.
- assertion asSentence Using+the+yeast+two-hybrid+system%2C+the+C-terminus+of+SYCP1+directly+interacts+with+SYCP2. assertion.
- assertion asSentence GIPC+acts+as+a+selective+scaffold+protein+to+assist+receptor+functions. assertion.
- assertion asSentence Upstream+stimulatory+factors+%28USF1+and+USF2%29+induce+Nr5a1+and+Shbg+gene+expression+during+the+onset+of+rat+Sertoli+cell+differentiation. assertion.
- assertion asSentence CDK-mediated+phosphorylation+regulates+the+activation+of+S6K1. assertion.
- assertion asSentence Atypical+protein+kinase+C+plays+a+critical+role+in+protein+transport+from+pre-Golgi+intermediates. assertion.
- assertion asSentence Caspr1+is+a+regulator+of+the+trafficking+of+AMPA+receptors+to+synapses. assertion.
- assertion asSentence EAAT4+is+expressed+by+astrocytes+within+the+rat+retina. assertion.
- assertion asSentence Ischemia-induced+association+of+the+stress+protein+alpha+B-crystallin+with+I-band+portion+of+cardiac+titin. assertion.
- assertion asSentence Glutamate+receptor+interacting+protein+is+localized+in+horizontal+cells%2C+dopaminergic+and+glycinergic+AII+amacrine+cells+and+large+ganglion+cells+of+the+retina. assertion.
- assertion asSentence The+growth+hormone+secretagogue+receptor+is+expressed+in+the+rat+adrenal+cortex. assertion.
- assertion asSentence Changes+in+ghrelin+and+ghrelin+receptor+expression+according+to+feeding+status. assertion.
- assertion asSentence Consumption+of+pistachio+as+20%25+of+daily+caloric+intake+increased+serum+PON1+activity+by+35%25. assertion.
- assertion asSentence There+are+at+least+two+distinct+pools+of+GSK-3beta+in+soleus+muscle%2C+one+phosphorylated+by+PKA+and+another+by+PKB. assertion.
- assertion asSentence Gsk3b+signaling+axis+regulates+opioid-induced+cardioprotection+via+the+K-ATP+channel. assertion.
- assertion asSentence Effect+of+ischemic+preconditioning+and+erythropoietin+on+interactions+between+GSK-3beta+and+subunits+of+the+mitochondrial+permeability+transition+pore. assertion.
- assertion asSentence Nonprimed+and+DYRK1A-primed+GSK3+beta-phosphorylation+sites+on+MAP1B+regulate+microtubule+dynamics+in+growing+axons. assertion.
- assertion asSentence Disruption+of+protective+signals+leading+to+GSK-3beta+phosphorylation+and+increase+in+mitochondrial+GSK-3beta+are+dual+mechanisms+by+which+increased+ER+stress+inhibits+EPO-induced+suppression+of+mPTP+opening+and+cardioprotection+in+diabetic+hearts. assertion.
- assertion asSentence GSK-3beta+inactivation+induces+the+increase+of+beta-cell+mass+in+diabetic+animals+based+on+the+sequential+stimulation+of+beta-cell+proliferation+and+neogenesis. assertion.
- assertion asSentence GSK3beta-mediated+Bax+activation+induces+apoptosis+and+tubular+damage+that+contribute+to+acute+ischemic+kidney+injury. assertion.
- assertion asSentence GSK-3beta+negatively+regulates+synaptic+vesicle+fusion+events+via+interfering+with+divalent+calcium+ion-dependent+SNARE+complex+formation. assertion.
- assertion asSentence Lack+of+isoflurane-induced+cardioprotective+effects%2C+seen+in+the+old+animals%2C+can+be+explained+by+age-related+differences+in+Akt%2FGSK-3beta+signaling+pathway+and+inability+to+reduce+mPTP+opening+after+ischemia%2Freperfusion+injury. assertion.
- assertion asSentence Inflammatory+factors+affect+tau+pathology+following+memory+deficits+in+splenectomized+animals+through+the+GSK-3beta+signaling+pathway. assertion.
- assertion asSentence Urocortin-induced+cardiomyocytes+hypertrophy+is+associated+with+regulation+of+GSK-3beta%2C+a+pivotal+kinase+involved+in+cardiac+hypertrophy%2C+in+a+PI3K-dependent+manner. assertion.
- assertion asSentence Glycogen+synthase+kinase+3+beta+positively+regulates+Notch+signaling+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence Following+neurotrauma%2C+autotaxin+is+strongly+up-regulated+in+reactive+astrocytes+adjacent+to+the+lesion. assertion.
- assertion asSentence Monoclonal+antibodies+are+immunosuppressive+in+pig+to+rat+islet+xenograft. assertion.
- assertion asSentence HO-1+mitigated+CD40L+transcription+in+the+xenograft+and+recipient+spleen. assertion.
- assertion asSentence Gestational+choline+deficiency+causes+global+and+Igf2+gene+DNA+hypermethylation+by+up-regulation+of+Dnmt1+expression. assertion.
- assertion asSentence Dominant+negative+IKK2-Treg+is+a+unique+population+of+CD4CD25+T+cells+expressing+high+levels+of+inducible+nitric+oxide+synthase. assertion.
- assertion asSentence Beta-catenin+upregulates+Bcl-2+promoter+activity+in+2-amino-1-methyl-6-phenylimidazo%284%2C5-b%29pyridine+%28PhIP%29-induced+colon+tumors+in+rat. assertion.
- assertion asSentence Beta-catenin+is+downstream+of+growth-factor-RTK+signalling+in+axon+differentiation. assertion.
- assertion asSentence Both+VEGF+and+histamine+increase+nuclear+beta-catenin+and+MMP-2+production%2C+the+role+of+beta-catenin+in+MMP-2+regulation+differs+between+the+two+stimuli. assertion.
- assertion asSentence Through+inhibition+of+GSK-3beta%2C+erythropoietin+maintains+beta-catenin+activity%2C+allowing+the+translocation+of+beta-catenin+from+the+endothelial+cell+cytoplasm+to+the+nucleus+through+a+Wnt1+pathway. assertion.
- assertion asSentence Ephrin+A2+expression+is+restricted+to+the+adult+thymic+medullary+epithelial+cells+and+some+perivascular+and+peritrabecular+areas. assertion.
- assertion asSentence A+PXR-mediated+negative+feedback+loop+attenuates+the+expression+of+CYP3A+in+response+to+the+PXR+agonist+pregnenalone-16alpha-carbonitrile. assertion.
- assertion asSentence Densely+clustered+at+synaptic+terminals+of+retinal+bipolar+cells+and+photoreceptors. assertion.
- assertion asSentence Overexpression+of+HCN1+channels+blunts+excitability+of+aortic+baroreceptor+neurons+and+baroreflex+sensitivity+in+diabetic+rats. assertion.
- assertion asSentence In+both+adult+and+neonataal+dentate+gyrus%2C+doublecortin-labeled+neuronal+perikarya+and+dendrites+contained+estrogen+receptor+beta. assertion.
- assertion asSentence DCX+has+a+distinct+role+in+cortical+interneuron+migration. assertion.
- assertion asSentence Dexamethasone+and+cyclic+AMP+regulate+sodium+phosphate+cotransporter+%28NaPi-IIb+and+Pit-1%29+mRNA+and+phosphate+uptake+in+rat+alveolar+type+II+epithelial+cells. assertion.
- assertion asSentence Ihh+signaling+pathway+plays+an+important+role+in+regulating+the+proliferation+and+apoptosis+of+precartilaginous+stem+cells. assertion.
- assertion asSentence Angiotensin+II+upregulated+KLF5+and+c-Jun+expression+and+inhibited+p21+expression+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence HDAC2+phosphorylation-dependent+Klf5+deacetylation+and+RARalpha+acetylation+induced+by+RAR+agonist+switch+the+transcription+regulatory+programs+of+p21+in+VSMCs. assertion.
- assertion asSentence Wnt4+is+expressed+in+the+adult+pituitary+gland+and+is+induced+by+estrogen. assertion.
- assertion asSentence EGF+also+activates+focal+adhesion+kinase+in+the+cytoplasm+to+rephosphorylate+Grb7%2C+releasing+KOR+mRNA+for+active+translation. assertion.
- assertion asSentence FKHR+acts+as+an+activator+of+the+G6Pase+gene. assertion.
- assertion asSentence Orexin-A+inhibits+glucagon+secretion+and+gene+expression+through+a+Foxo1-dependent+pathway. assertion.
- assertion asSentence FoxO1+induces+upregulation+of+CP+mRNA+levels+in+rat+liver+cells. assertion.
- assertion asSentence The+vesicular+glutamate+transporter+2+%28VGLUT2%29is+a+transmembrane+protein+responsible+for+loading+glutamate+into+synaptic+vesicles. assertion.
- assertion asSentence mRNA+expressed+expressed+in+thalamic+neurons+in+mapping+brain+circuits. assertion.
- assertion asSentence Neurosecretory+neurons+in+the+paraventricular%2C+periventricular%2C+supraoptic+nuclei+and+the+preoptic+area+secrete+glutamate+into+the+fenestrated+vessels+of+the+median+eminence+and+posterior+pituitary. assertion.
- assertion asSentence Coexpression+of+vesicular+glutamate+transporters+1+and+2%2C+glutamic+acid+decarboxylase+and+calretinin+in+rat+entorhinal+cortex. assertion.
- assertion asSentence Expressions+of+VGLUT2+mRNA+are+found+in+the+olfactory+epithelium%2C+migratory+cells+and+telencephalon+during+embryonic+development. assertion.
- assertion asSentence DGAT1+belongs+to+the+family+of+oligomeric+membrane+proteins+that+adopt+a+dual+membrane+topology. assertion.
- assertion asSentence The+RanGTPase+system+regulates+the+formation+of+retrograde+importin+signaling+complexes+in+the+axons+of+injured+peripheral+neurons. assertion.
- assertion asSentence Overexpression+of+SCG10+is+associated+with+Liver+Fibrosis. assertion.
- assertion asSentence CaMy1+via+SCG10+couples+Ca%282%2B%29+signals+with+the+dynamics+of+microtubules+during+neuronal+outgrowth+in+the+developing+brain. assertion.
- assertion asSentence Oatp1c1-dependent+substrate+transport+is+a+complex+process+involving+substrate+interaction+with+multiple+binding+sites+and+competition+binding+of+other+substrates. assertion.
- assertion asSentence RIM1-+or+Bassoon-binding+region+of+CAST+impairs+synaptic+transmission+in+cultured+superior+cervical+ganglion+neurons. assertion.
- assertion asSentence Elevated+levels+of+mRNA+expression+are+detected+for+histone+deacetylase+2+during+cell+differentiation+in+hippocampus+progenitor+cells. assertion.
- assertion asSentence YY1+activates+hBNP+transcription+through+interaction+with+histone+deacetylase+2+in+cardiac+myocytes. assertion.
- assertion asSentence Histone+deacetylase+2+expression+in+the+corpus+striatum+promotes+synaptic+plasticity+underlying+the+preference+for+nicotine. assertion.
- assertion asSentence HDAC2+phosphorylation-dependent+Klf5+deacetylation+and+RARalpha+acetylation+induced+by+RAR+agonist+switch+the+transcription+regulatory+programs+of+p21+in+VSMCs. assertion.
- assertion asSentence Maternal+high+fat+exposure+represses+p16+%28INK4a%29+gene+expression+in+the+mammary+gland+of+offspring+through+changes+of+histone+modifications+and+HDAC3+binding+activity+within+the+regulatory+regions+of+the+p16+%28INK4a%29+gene. assertion.
- assertion asSentence GluR2-NSF-betaSNAP-PICK1+complex+is+regulated+directly+by+Ca%282%2B%29%2C+allowing+for+the+transduction+of+Ca%282%2B%29+signals+into+concerted+alterations+in+protein-protein+interactions+to+bring+about+changes+in+AMPAR+trafficking+during+synaptic+plasticity. assertion.
- assertion asSentence Nucleobindin+1+is+a+calcium-regulated+guanine+nucleotide+dissociation+inhibitor+of+G%7Balpha%7Di1. assertion.
- assertion asSentence Phagocytosis+upregulates+hepcidin-gene+expression+and+downregulates+Hjv-+and+Fpn-1-gene+expression+within+the+liver. assertion.
- assertion asSentence Two+proteins+with+prominent+functions+in+endocytosis%2C+synaptojanin-1+and+dynamin%2C+bind+to+the+SH3+domain+of+human+Myo1E. assertion.
- assertion asSentence Peroxisomal-proliferator-activated+receptor+alpha+activates+transcription+of+the+hepatic+malonyl-CoA+decarboxylase+gene. assertion.
- assertion asSentence Increasing+myocardial+malonyl+CoA+levels+decreases+fatty+acid+oxidation+%26+accelerates+glucose+oxidation+in+ex+vivo+rat+hearts+This+switch+in+energy+substrate+preference+improves+cardiac+function+during+%26+after+ischemia. assertion.
- assertion asSentence Bile+acid+depletion+and+repletion+regulate+cholangiocyte+growth+and+secretion+by+a+phosphatidylinositol+3-kinase-dependent+pathway+in+rats. assertion.
- assertion asSentence The+maintenance+of+adrenergic+vascular+tone+by+the+MMP-EGFR+pathway+requires+PI3K+activation+and+ATP+synthesis. assertion.
- assertion asSentence In+macrophages+under+oxidative+stress+%28by+overloading+with+oxidized+LDL%29%2C+down-regulation+of+ABCG-1+and+ABCA-1+is+key+to+regulation+of+metabolism+of+7-ketocholesterol+and+other+sterols. assertion.
- assertion asSentence Processing+of+proprioceptive+information+at+the+level+of+the+mesencephalic+trigeminal+neurons+is+controlled+via+histamine+H1+and+H3+receptors+through+different+postsynaptic+mechanisms. assertion.
- assertion asSentence H3+receptor+density+in+cortical+tissue+of+SHR+animals+increases+with+age. assertion.
- assertion asSentence D%281%29-H%283%29+receptor+heteromers+work+as+processors+integrating+dopamine-+and+histamine-related+signals+involved+in+controlling+the+function+of+striatal+neurons+of+the+direct+striatal+pathway. assertion.
- assertion asSentence Tacrolimus-induced+nephrotoxicity+is+associated+with+increased+TGF-beta1+and+VEGF+and+decreased+BMP-7+expression. assertion.
- assertion asSentence BMP-7+failed+to+induce+the+mesenchymal-to-epithelial+transition+%28MET%29+in+NRK-49F+rat+renal+fibroblasts. assertion.
- assertion asSentence In+cultured+cerebellar+granule+cells+the+activation+of+the+Ca%282%2B%29%2Fcalcineurin+pathway+via+either+voltage-+or+ligand-+operated+Ca%282%2B%29+channels+regulates+MALS-1+and+MALS-2+expression+at+the+transcriptional+level+%28lin7%29. assertion.
- assertion asSentence The+target+site+for+Cu%282%2B%29+is+located+in+the+ADP%2FATP+carrier. assertion.
- assertion asSentence A+diurnal+variation+of+Ngb+mRNA+in+the+suprachiasmatic+nucleus%2C+having+a+peak+in+the+day+time+%28light-period%29+and+nadir+during+night+%28dark-period%29. assertion.
- assertion asSentence Neuroglobin+regulates+hypoxic+response+of+neuronal+cells+through+Hif-1alpha-+and+Nrf2-mediated+mechanism. assertion.
- assertion asSentence Down-regulation+of+ARC+%28apoptosis+repressor+with+caspase+recruitment+domain%29+contributes+to+vulnerability+of+hippocampal+neurons+to+ischemia%2Fhypoxia. assertion.
- assertion asSentence p66Shc+isoform+exerts+an+inhibitory+effect+on+the+mitogen-activated+protein+kinase+signaling+pathway+in+rodent+myoblasts. assertion.
- assertion asSentence Inhibition+of+p66ShcA+redox+activity+in+cardiac+muscle+cells+attenuates+hyperglycemia-induced+oxidative+stress+and+apoptosis. assertion.
- assertion asSentence Protein+kinase+C+theta+ensures+maximal+activation+of+myocyte+enhancer+factor+2+%28MEF2%29%2C+by+regulating+both+MEF2+transcriptional+complex+formation+and+histone+deacetylases+nuclear+export. assertion.
- assertion asSentence Elude+to+a+role+of+PKD+in+contraction-induced+GLUT4+translocation+which+does+not+involve+AMPK-alpha2. assertion.
- assertion asSentence PKD+facilitates+contraction+of+cardiomyocytes+by+increasing+Ca%282%2B%29+sensitivity+and+by+an+increased+calcium-activated+tension+of+contraction+through+phosphorylation+of+cMyBP-C. assertion.
- assertion asSentence Intracellular+reactive+oxygen+species+formation+partly+through+an+increasing+NOX4+activity+in+response+to+high+pacing+frequency+is+associated+with+an+increased+atrial+natriuretic+peptide+secretion. assertion.