Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Internalization+of+Dnf1p+from+the+plasma+membrane+uses+an+NPFXD+endocytosis+signal+and+its+recognition+by+Sla1p. assertion.
- assertion asSentence Pdr3p+activation+of+RSB1+transcription+is+an+important+feature+of+the+retrograde+response+allowing+normal+detoxification+of+an+endogenous+sphingolipid+precursor. assertion.
- assertion asSentence Investigation+of+kinetochore+assembly+in+the+absence+of+the+centromeric+histone+H3+variant+Cse4. assertion.
- assertion asSentence THe+copper+binding+site+is+co-translationally+formed+by+a+transient+interaction+between+Cox11p+and+this+nascent+cytochrome+C+oxidase+in+the+intermembrane+space. assertion.
- assertion asSentence Chs2%2C+as+the+chitin+synthase+that+produces+the+primary+septum%2C+couples+the+assembly+of+the+extracellular+matrix+with+the+dynamics+of+the+contractile+ring+during+cytokinesis. assertion.
- assertion asSentence eIF3+is+retained+on+ribosomes+throughout+uORF1+translation+and%2C+interacts+with+its+5%27+enhancer+at+the+mRNA+exit+channel+to+stabilize+mRNA+association+with+post-termination+40S+subunits+and+enable+resumption+of+scanning+for+reinitiation+downstream. assertion.
- assertion asSentence Hog1+prevents+Tec1+from+binding+to+filamentation+gene+promoters+in+a+kinase-dependent+manner. assertion.
- assertion asSentence PCNA+acts+as+a+scaffold+for+consecutive+protein-protein+interactions+that+allow+for+the+coordination+of+mismatch+repair+steps. assertion.
- assertion asSentence Diubiquitinated+Mcm10+interacts+with+PCNA+to+facilitate+an+essential+step+in+DNA+elongation. assertion.
- assertion asSentence NHP6B+is+required+for+transcription+of+a+subset+of+tRNA+genes+and+heterochromatin+barrier+function. assertion.
- assertion asSentence Vid24p+and+Sec28p+are+present+at+actin+patches+during+glucose+starvation. assertion.
- assertion asSentence Microautophagic+vacuole+invagination+requires+CMD1+in+a+Ca2%2B-independent+function. assertion.
- assertion asSentence Matalpha2+corepressors+Tup1+and+Ssn6+modify+the+in+vivo+degradation+rate+of+Matalpha2. assertion.
- assertion asSentence Anchoring+of+ASH1+mRNA+requires+molecular+remodeling+of+the+Myo4p-She3p-She2p+heterotrimeric+complex%2C+a+process+that+is+apparently+altered+when+mRNA+is+artificially+tethered+to+She2p. assertion.
- assertion asSentence Activation+of+the+checkpoint+kinase+Rad53+by+the+phosphatidyl+inositol+kinase-like+kinase+Mec1. assertion.
- assertion asSentence Mec1+has+a+role+in+the+localization+of+the+Polzeta-Rev1+complex+to+DNA+lesions. assertion.
- assertion asSentence A+chromatin+remodeling+complex+is+established+as+a+functional+component+in+the+Mec1%2FTel1+DNA+damage+signaling+pathway+that+modulates+checkpoint+responses. assertion.
- assertion asSentence Mec1+and+Tel1+inhibit+anaphase+in+response+to+DNA+damage+by+utilizing+spindle+assembly+checkpoint+proteins. assertion.
- assertion asSentence G1+phase+checkpoint+activation+of+Mec1+is+achieved+by+the+Ddc1+subunit+of+9-1-1. assertion.
- assertion asSentence Mec1+mutations+are+associated+with+increased+rates+of+spontaneous+loss+of+heterozygosity+leading+to+genome+instability. assertion.
- assertion asSentence The+role+of+translation+termination+factor+eRF1+in+the+regulation+of+pseudohyphal+growth+in+Saccharomyces+cerevisiae+cells. assertion.
- assertion asSentence Completion+of+S+phase+and+the+activity+of+the+CDK1+are+required+for+telomere+degradation. assertion.
- assertion asSentence Ime2-dependent+phosphorylation+of+a+subset+of+cell-cycle+proteins+limits+the+effects+of+Cdc14+in+meiosis. assertion.
- assertion asSentence Isc1p+as+an+upstream+regulator+of+Swe1p+levels+and+stability+and+Cdc28-Tyr-19+phosphorylation%2C+in+effect+signaling+recovery+from+the+effects+of+genotoxic+stress+and+allowing+G%282%29%2FM+progression. assertion.
- assertion asSentence Repression+of+NHEJ+at+G%282%29+is+achieved+by+efficient+end+resection+and+by+the+reduced+association+of+core+NHEJ+proteins+with+DNA+breaks%2C+both+of+which+depend+on+the+CDK1+activity. assertion.
- assertion asSentence Cdk1+kinase+counteracts+unscheduled+sumoylation+of+Srs2+and+targets+Srs2+to+dismantle+specific+DNA+structures. assertion.
- assertion asSentence Both+ARF-like+protein+Arl1p+and+Gcs1p+influence+the+distribution+of+Imh1p%2C+an+Arl1p+effector. assertion.
- assertion asSentence Ssz1+restores+endoplasmic+reticulum-associated+protein+degradation+in+cells+expressing+defective+cdc48-ufd1-npl4+complex+by+upregulating+cdc48. assertion.
- assertion asSentence Sec71p+facilitates+nuclear+outer-membrane+fusion. assertion.
- assertion asSentence Nbp2p+SH3+domain+made+contacts+with+the+Ste20+peptide+core+RXXPXXP+motif+and+the+Bem1p+SH3b+domain+made+stronger+contacts+with+residues+flanking+the+core+motif. assertion.
- assertion asSentence Origin+single-stranded+DNA+releases+Sld3+from+Mcm2-7%2C+allowing+GINS+to+bind+Mcm2-7. assertion.
- assertion asSentence Deletion+of+ISW1+and+CHD1+causes+widespread+intragenic+transcription. assertion.
- assertion asSentence Dut1+plays+a+central+role+in+the+prevention+of+the+formation+of+endogenous+DNA+damage. assertion.
- assertion asSentence Depletion+of+the+Ctr9+or+Paf1+component+of+the+Paf1+complex+delays+the+loss+of+histones+from+the+GAL1+gene+upon+induction. assertion.
- assertion asSentence Paf1+and+Ctr9+repress+SER3+by+maintaining+SRG1+transcription-dependent+nucleosome+occupancy. assertion.
- assertion asSentence By+promoting+histone+H2B+lysine+123+ubiquitylation%2C+Paf1+represses+the+ARG1+gene+by+negatively+affecting+Gcn4+occupancy+at+the+promoter. assertion.
- assertion asSentence The+present+investigations+examines+the+properties+of+the+Gln182Cys+single+mutant+and+the+Leu120Cys%2FGln182Ala+double+mutant+of+the+mitochondrial+citrate+transport+protein. assertion.
- assertion asSentence Kap114p%2C+responsible+for+the+nuclear+import+of+histones+H2A+and+H2B%2C+modulates+the+deposition+of+histones+H2A+and+H2B+by+the+histone+chaperone+Nap1p. assertion.
- assertion asSentence Overexpression+of+the+yeast+TMEM85+ortholog+YGL231c+leads+to+increased+resistance+to+oxidative+stress. assertion.
- assertion asSentence GMT+escapes+from+delivery+to+the+vacuole+by+recycling+to+the+endoplasmic+reticulum+and+retrieval+requires+the+lysine-rich+C-terminal+tail+that+can+bind+to+the+COPI+coat. assertion.
- assertion asSentence Chd1+and+SPT16+and+POB3+act+in+opposition+in+regulating+transcription. assertion.
- assertion asSentence IMPACT+bound+to+the+minimal+yeast+GCN1+segment+required+for+interaction+with+yeast+GCN2+and+YIH1+and+to+native+mouse+GCN1. assertion.
- assertion asSentence Two+histone+deacetylases%2C+RPD3+and+HOS2%2C+are+required+for+the+activation+of+DNA+damage-inducible+genes+RNR3+and+HUG1. assertion.
- assertion asSentence Synthetic+lethal+interaction+between+loss+of+CDC55+and+gene+deletions+lethal+with+rvs161%2C+all+of+which+function+in+endocytosis. assertion.
- assertion asSentence Atg17-Atg13+complex+formation+plays+an+important+role+in+normal+autophagosome+formation+via+binding+to+and+activating+the+Atg1+kinase. assertion.
- assertion asSentence An+Atg13+protein-mediated+self-association+of+the+Atg1+protein+kinase+is+important+for+the+induction+of+autophagy. assertion.
- assertion asSentence Degradation+of+several+hypomodified+mature+tRNA+species+in+Saccharomyces+cerevisiae+is+mediated+by+Met22+and+the+5%27-3%27+exonucleases+Rat1+and+Xrn1. assertion.
- assertion asSentence Deletion+of+SUA5+gene+led+to+the+loss+of+threonylcarbamoyladenosine. assertion.
- assertion asSentence Pex14p+is+required+in+only+catalytic+amounts+to+allow+initiation+of+the+selective+peroxisome+degradation+process. assertion.
- assertion asSentence Ies3p+subunit+of+the+Saccharomyces+cerevisiae+INO80+chromatin+remodeling+complex+interacts+with+a+conserved+tetratricopeptide+repeat+domain+of+the+telomerase+protein+Est1p. assertion.
- assertion asSentence These+two+related+chromatin+remodelers%2C+INO80+and+SWR1+have+distinct+roles+in+double-strand+break+repair+and+checkpoint+activation. assertion.
- assertion asSentence CDK+substrates+Sld3+and+Sld2+and+their+binding+partner+Dpb11%2C+together+with+the+DDK+subunit+Dbf4+control+S-phase+length+in+budding+yeast+Saccharomyces+cerevisiae+limiting+replication+initiationst+hrough+their+low+abundance. assertion.
- assertion asSentence Rmd9p+controls+the+processing%2Fstability+of+mitochondrial+mRNAs+and+its+overexpression+compensates+for+a+partial+deficiency+of+oxa1p+in+Saccharomyces+cerevisiae. assertion.
- assertion asSentence Myosin+light+chain+1+%28Mlc1p%29%2C+required+for+vesicle+delivery+at+the+mother-bud+neck+during+cytokinesis%2C+binds+to+the+Myo2p+GTD+in+a+region+overlapping+that+of+Ypt32p. assertion.
- assertion asSentence The+transcription+elongation+function+of+Rpb9+is+involved+in+transcription-coupled+DNA+repair. assertion.
- assertion asSentence In+response+to+ultraviolet+radiation%2C+Rpb9+also+functions+in+promoting+ubiquitylation+and+degradation+of+Rpb1%2C+the+largest+subunit+of+Pol+II. assertion.
- assertion asSentence Pkp2p+%28Ygl059wp%29+and+Ppp2p+%28Ycr079wp%29%2C+are+engaged+in+the+regulation+of+this+complex+by+affecting+the+phosphorylation+state+of+Pda1p. assertion.
- assertion asSentence The+non-proteolytic+requirement+for+the+proteasomal+Sug1+ATPase+includes+at+least+the+heat+and+oxidative+stress-responsive+genes. assertion.
- assertion asSentence Hap4%2C+Cat8+and+Mig1+activities+are+not+affected+by+different+glucose+concentrations+in+this+respirator+y+yeast+strain. assertion.
- assertion asSentence The+cooperation+of+endoplasmic+reticulum-associated+degradation+pathway+and+the+cytoplasm+to+vacuole+targeting+pathway+is+needed+for+an+efficient+degradation+of+misfolded+Pma1. assertion.
- assertion asSentence A+role+of+G%281%29+specific+APC%2FC%28Cdh1%29+activity+is+to+reset+substrate+levels+to+enables+appropriate+regulation+of+substrate+accumulation+in+the+subsequent+phases+of+the+cell+cycle. assertion.
- assertion asSentence Physical+interaction+between+Orm1+and+Orm2+and+serine+palmitoyltransferase%2C+responsible+for+the+first+committed+step+in+sphingolipid+synthesis%2C+further+supports+a+role+for+the+Orm+proteins+in+regulating+sphingolipid+synthesis. assertion.
- assertion asSentence Bud8p+and+Bud9p+carry+distinct+domains+for+delivery+of+the+proteins+to+the+cell+poles%2C+for+interaction+with+the+general+budding+machinery+and+for+association+with+other+cortical+tag+proteins. assertion.
- assertion asSentence BUD9+is+necessary+for+random+budding+in+each+deletion+mutant+of+EKC%2FKEOPS+components. assertion.
- assertion asSentence Pil1+and+Lsp1+self-assemble+into+higher-order+structures+and+bind+preferentially+to+phosphoinositide-containing+membranes. assertion.
- assertion asSentence Cdk1+phosphorylates+the+Mob1+protein+to+inhibit+the+activity+of+Dbf2-Mob1+kinase+that+regulates+Cdc14+phosphatase. assertion.
- assertion asSentence Esp1+localizes+to+the+mitotic+spindle+during+anaphase. assertion.
- assertion asSentence Tel2+can+specifically+and+differentially+regulate+the+function+of+individual+PIKKs. assertion.
- assertion asSentence Exchanging+the+conserved+tyrosine+%28Y%28344%29%29+with+aspartate+in+yeast+SHY1+uncouples+translational+regulation+of+Cox1+from+cytochrome+c+oxidase+assembly. assertion.
- assertion asSentence Both+rings+and+nonencircling+Dam1+oligomers+can+track+microtubule+ends+and+enable+processive+cargo+movement+in+vitro. assertion.
- assertion asSentence The+Dam1+complex+is+required+for+viability+because+its+function+as+a+processivity+factor+for+kinetochore-microtubule+binding+is+more+critical+when+chromosome+segregation+is+dependent+upon+a+single+kinetochore-microtubule. assertion.
- assertion asSentence The+positive-charge+cleft+of+the+C-terminal+domain+of+Utp8p+is+involved+in+tRNA-binding. assertion.
- assertion asSentence SKN1+is+involved+in+sphingolipid+biosynthesis+in+S.+cerevisiae. assertion.
- assertion asSentence The+RNA-binding+region+%28RNA1%29+in+the+N-terminal+domain+%28NTD%29+of+yeast+eIF4G1+can+functionally+substitute+for+the+PABP-binding+segment+to+rescue+the+function+of+an+eIF4G1-459+mutant+impaired+for+eIF4E+binding. assertion.
- assertion asSentence Cbp3p+and+Cbp4p+are+two+mitochondrial+proteins+which+are+postulated+to+act+as+chaperones+in+bc%281%29+complex+formation. assertion.
- assertion asSentence Under+normal+growth+conditions%2C+the+cell+assembles+stoichiometric+amounts+of+Y%28%2A%29+and+modulation+of+Y%28%2A%29+concentration+is+not+involved+in+the+regulation+of+RNR+activity. assertion.
- assertion asSentence TFIIF+stimulates+formation+of+the+first+two+phosphodiester+bonds+and+dramatically+stabilizes+a+short+RNA-DNA+hybrid+in+the+RNA+polymerase+II+%28RNAPII%29+active+center. assertion.
- assertion asSentence A+role+for+Ypp1+in+Stt4-dependent+events+at+the+plasma+membrane%2C+as+opposed+to+a+general+role+in+overall+metabolism+of+phosphatidylinositol+4-phosphate. assertion.
- assertion asSentence Ypp1+and+Efr3+are+required+for+the+formation+and+architecture+of+Stt4+PIK+patches+and+ultimately+plasma+membrane-based+PtdIns4P+signaling. assertion.
- assertion asSentence Human+wt+p53+expression+in+yeast+leads+to+gene+repression+of+thioredoxin+%28TRX1%2F2%29%2C+a+highly+conserved+multifunctional+antioxidative+and+antiapoptotic+protein+family. assertion.
- assertion asSentence Successful+cloning+of+CCH1+in+yeast+by+in+vivo+homologous+recombination+without+using+E.+coli. assertion.
- assertion asSentence Full-length+Pho81+is+required+to+control+trehalose+metabolism+and+the+PDS+targets+in+Saccharomyces. assertion.
- assertion asSentence Pfk1+underwent+a+large+conformational+change+upon+Mg-ATP+binding+arising+from+a+reorientation+of+the+alpha-+and+beta-subunits+in+the+dimers. assertion.
- assertion asSentence EKC%2FKEOPS+complex+is+specifically+involved+in+the+regulation+of+Bud9p+localization+downstream+of+Rax1p%2FRax2p. assertion.
- assertion asSentence Zuo1+efficiently+stimulates+the+ATPase+activity+of+Ssb+only+when+in+complex+with+another+Hsp70%2C+Ssz1. assertion.
- assertion asSentence Features+of+the+isomaltase+active+site+pocket+prevent+isomalto-oligosaccharides+from+binding+to+the+active+site+effectively. assertion.
- assertion asSentence The+ability+of+Swe1+to+inhibit+the+activity+of+different+B-type+cyclins+in+replication+initiation+correlates+with+the+normal+expression+timing+of+those+cyclins. assertion.
- assertion asSentence Swe1p+responds+to+cytoskeletal+perturbation%2C+not+bud+size%2C+in+S.+cerevisiae. assertion.
- assertion asSentence Swi3p+controls+SWI%2FSNF+assembly+and+ATP-dependent+H2A-H2B+displacement. assertion.
- assertion asSentence SGV1+is+required+for+the+normal+pattern+of+histone+methylation+by+SET2. assertion.
- assertion asSentence RNA+polymerase+II+carboxyl-terminal+domain+phosphorylation+regulates+protein+stability+of+the+Set2+methyltransferase+and+histone+H3+di-+and+trimethylation+at+lysine+36. assertion.
- assertion asSentence Full+transcriptional+activation+of+INO1+and+another+GRS-containing+gene+requires+GRS+I+%28gene+recruitment+sequences%29+mediated+targeting+of+the+promoter+to+the+nuclear+periphery. assertion.
- assertion asSentence Sna3p+sorting+depends+on+a+direct+interaction+between+a+PPAY+motif+within+its+C-terminal+cytosolic+tail+and+the+WW+domains+of+Rsp5p. assertion.
- assertion asSentence Spt10+and+Spt21+control+silencing+in+S.+cerevisiae+by+altering+chromatin+structure+through+roles+beyond+the+control+of+histone+gene+expression. assertion.
- assertion asSentence The+Lsm1p-7p-Pat1p+complex+protects+mRNAs+by+binding+at%2Fnear+the+3%27end+and+distinguishes+between+oligoadenyLated+and+polyadenylated+RNA. assertion.
- assertion asSentence ASF1+is+required+for+the+recruitment+of+the+SAS+histone+acetyltransferase+complex+to+the+HMLalpha+locus. assertion.
- assertion asSentence The+ectope+expression+of+Ime2+has+deterious+on+cell+cycle+regulation%2C+toxocity+and+the+response+of+the+DNA+damage+checkpoint. assertion.
- assertion asSentence Pam16%27s+J-like+domain+strongly+interacts+with+Pam18%27s+J+domain%2C+leading+to+a+productive+interaction+of+Pam18+with+mtHsp70+at+the+import+channel. assertion.
- assertion asSentence Two+negative+residues+in+TOK1%2C+Asp292+and+Asp426%2C+near+the+mouth+of+the+assembled+channel%2C+modulate+both+kinetics+and+conductance+of+the+channel. assertion.
- assertion asSentence Srs2+assoiates+with+Mre11+in+different+subcomplexes+following+checkpoint+activation+and+CDK1-mediated+Srs2+phosphorylation. assertion.