Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Mammalian+target+of+rapamycin+complex+1+%28mTORC1%29+and+2+%28mTORC2%29+are+up-regulated+in+neoplastic+and+developing+immature+mast+cells+compared+with+their+terminally+differentiated+counterparts. assertion.
- assertion asSentence FSH+has+dose-dependent+anabolic+effects+on+bone+via+an+ovary-dependent+mechanism. assertion.
- assertion asSentence PGC-1+is+involved+in+progesterone+production+in+ovarian+granulosa+cells+by+potentiating+transcriptional+activities+of+SF1+proteins. assertion.
- assertion asSentence Si-RNA+induced+down-regulation+of+FUT1+and+FUT2+reduced+expression+of+fucosylated+nucleolin+glycoforms+and+their+exposure+at+the+cell+surface. assertion.
- assertion asSentence FUT6+plays+an+important+role+in+hepatocellular+carcinoma+growth+by+regulating+the+PI3K%2FAkt+signaling+pathway. assertion.
- assertion asSentence One+of+the+primary+mechanisms+by+which+P.+vivax+evades+host+immunity+is+through+DARC+indirectly+down-regulating+humoral+responses+against+erythrocytic+invasion+and+development. assertion.
- assertion asSentence The+Fyn+SH2+domain+forms+a+noisy+communication+channel+that+couples+residues+located+in+the+phosphopeptide+and+specificity+binding+sites+and+a+number+of+residues+at+the+other+side+of+the+domain. assertion.
- assertion asSentence SFK+trafficking+is+specified+by+the+palmitoylation+state+in+the+SH4+domain. assertion.
- assertion asSentence Phosphorylation+of+S21+within+the+pPKA+recognition+site+%28RxxS+motif%29+of+Fyn+regulates+its+tyrosine+kinase+activity+and+controls+focal+adhesion+targeting. assertion.
- assertion asSentence Ku70-Bax-clusterin+interactions+in+human+colon+cancer+are+modulated+by+IL-6+that+influences+Bax-dependent+cell+death+increasing+Ku70+binding+to+Bax+and+influencing+sCLU+production+that+promotes+tumor+cell+survival. assertion.
- assertion asSentence GABRA2+is+significant+reductions+in+parietal+cortex+in+subjects+with+autism. assertion.
- assertion asSentence The+collybistin-gephyrin+complex+has+an+intimate+role+in+the+clustering+of+GABA%28A%29Rs+containing+the+alpha2+subunit. assertion.
- assertion asSentence GABRB3+is+significantly+altered+in+cerebellum+and+significant+reductions+in+parietal+cortex+in+subjects+with+autism. assertion.
- assertion asSentence In+the+autistic+group+this+downregulation+of+both+benzodiazepine+sites+and+GABA%28A%29+receptors+in+the+ACC. assertion.
- assertion asSentence Reduced+catalytic+efficiency+and+increased+proteolytic+susceptibility+of+UDP-galactose+4-epimerase+are+causative+factors+in+type+III+galactosemia. assertion.
- assertion asSentence IL-4-treated+LS174T+cells+are+able+to+produce+mucins+with+a+higher+degree+of+O-glycosylation+than+untreated+counterparts. assertion.
- assertion asSentence The+sequences+and+O-glycosylation+patterns+direct+the+addition+of+the+first+and+second+sugar+residues+by+ppGalNAc-T+and+C1GalT+which+act+in+a+site+directed+fashion. assertion.
- assertion asSentence Biological+activity+%28catalytic+capacity+and+glycan-binding+ability%29+of+ppGalNAc-T2+is+regulated+by+acetylation. assertion.
- assertion asSentence There+is+no+strong+and+direct+interaction+between+POP+and+GAP43+at+physiological+conditions. assertion.
- assertion asSentence APT-2+is+the+protein+thioesterase+involved+in+the+acylation%2Fdeacylation+cycle+operating+in+GAP-43+subcellular+distribution. assertion.
- assertion asSentence gas6+signaling+through+the+Axl+receptor+and+the+PI3+kinase%2FAkt1+survival+pathway+protects+oligodendrocytes+from+growth+factor+withdrawal+and+TNFalpha-mediated+cell+death. assertion.
- assertion asSentence Axl+and+Gas6+expression+in+RCC+are+associated+with+tumor+advancement+and+patient+survival. assertion.
- assertion asSentence GATA-1+is+integral+to+successful+hematopoiesis. assertion.
- assertion asSentence GATA2+and+c-Jun%2Fc-Fos+act+additively+in+modulating+the+SIRT3-VNTR+enhancer+function. assertion.
- assertion asSentence Diminished+expression+of+GATA6+leads+to+a+compromised+nuclear+envelope+that+is+causal+for+polyploidy+and+aneuploidy+in+ovarian+tumorigenesis. assertion.
- assertion asSentence Nonsynonymous+GATA6+sequence+variants+are+infrequently+found+in+individuals+with+congenital+heart+defects. assertion.
- assertion asSentence GBA+variation+contribute+to+development+of+Parkinson+disease+in+French-Canadian. assertion.
- assertion asSentence Glucocerebrosidase+N370S+and+L444P+mutations+as+risk+factors+for+Parkinson%27s+disease+in+Brazilian+patients. assertion.
- assertion asSentence GBP-1+contributes+to+vascular+dysfunction+in+chronic+inflammatory+diseases+by+inhibiting+endothelial+progenitor+cell+%28EPC%29+angiogenic+activity+via+the+induction+of+premature+EPC+differentiation. assertion.
- assertion asSentence alpha12%2F13+represents+a+stable+subdomain+of+guanylate-binding+protein+1+%28hGBP1%29. assertion.
- assertion asSentence The+detection+of+GCH+I+mutations+is+helpful+in+early+diagnosis+of+non-typical+cases+of+dopa-responsive+dystonia. assertion.
- assertion asSentence T342P+GCK+missense+variant+is+not+a+pathogenic+mutation+causing+MODY. assertion.
- assertion asSentence The+reconstituted+membrane+system+in+cells+expressing+C2GnT-I+led+to+the+lipid+vesicles+exhibiting+an+enzyme+activity+11+times+higher+than+that+found+in+microsomal+membranes. assertion.
- assertion asSentence Myostatin+is+a+pro-fibrogenic+factor+that+enhances+cellular+proliferation+and+extracellular+matrix+synthesis+by+ACL+fibroblasts. assertion.
- assertion asSentence Withaferin+A+covalently+binds+soluble+recombinant+tetrameric+human+GFAP+at+cysteine+294. assertion.
- assertion asSentence Expression+of+PFAAP5+allows+neutrophil+elastase+to+potentiate+the+repression+of+Gfi1+target+genes. assertion.
- assertion asSentence Higher+serum+GGT+levels+are+associated+with+prehypertension+or+hypertension+in+the+general+male+population. assertion.
- assertion asSentence The+GHR+exon+10+SNPs%2C+not+d3%2Ffl-GHR%2C+contribute+to+changes+in+the+mandibular+ramus+height+of+Koreans. assertion.
- assertion asSentence Tyr%2FHis%281%29+and+Ile%2FThr%287%29+of+GIP%2FGLP-1+peptides+confer+differential+ligand+selectivity+toward+GIPR+and+GLP1R. assertion.
- assertion asSentence TGF-beta1+significantly+up-regulates+connexin+43+expression+and+intercellular+communication%2C+in+concert+with+increased+expression+of+alpha-actin%2C+calponin+and+SM1. assertion.
- assertion asSentence Cx43+contributes+to+RPE+differentiation+via+cAMP+signaling. assertion.
- assertion asSentence Asymmetric+dimethylarginine+inhibits+endothelial+gap+junction+function+via+downregulating+Cx43+expression. assertion.
- assertion asSentence Fusion+of+a+V5%2F6-His+tag+%28hexa+moiety+M+r+%3D+0.93+kDa%29+to+the+CT+segment+of+Cx40%2C+Cx43+and+Cx45+does+not+prevent+the+cells+from+forming+channels. assertion.
- assertion asSentence The+increase+in+Cx43+expression+induced+by+mechanical+strain+in+ossification+of+the+posterior+longitudinal+ligament+cells+plays+an+important+role+in+the+progression+of+Ossification+of+the+posterior+longitudinal+ligament. assertion.
- assertion asSentence Cx50+hemichannels+gating+control+can+be+cooperated+by+CaM+and+Ca2%2B. assertion.
- assertion asSentence GJB2+and+SLC26A4+mutations+together+make+up+a+major+cause+of+congenital+hearing+loss+in+the+Korean+population. assertion.
- assertion asSentence In+the+Moroccan+population+the+GJB2+gene+35delG+mutation+has+derived+from+a+single+origin+in+a+common+founder+process. assertion.
- assertion asSentence The+possibility+of+detecting+individuals+which+harbor+both+a+deafness-causing+mtDNA+mutation+and+a+mutation+in+the+GJB2+gene+is+rather+low. assertion.
- assertion asSentence Aberrant+expression+of+Cx26+in+cytoplasm+plays+a+tumor-suppressor+role+in+gastric+carcinoma+and+is+an+independent+biomarker+for+favorable+prognosis+in+intestinal-type+gastric+carcinoma. assertion.
- assertion asSentence Glypican+3+is+a+sensitive+and+specific+serum+marker+for+diagnosis+of+early+hepatocellular+carcinoma. assertion.
- assertion asSentence GPC3+is+expressed+in+a+subset+of+undifferentiated+embryonal+sarcoma+and+mesenchymal+hamartoma+of+the+liver. assertion.
- assertion asSentence Common+variants+in+glyoxalase+1+are+not+significant+susceptibility+factors+forautism+spectrum+disorders+in+the+Finnish+population. assertion.
- assertion asSentence The+GLP-1+receptor+is+restricted+to+the+pancreatic+beta+cells. assertion.
- assertion asSentence Glutaminase+is+an+important+factor+in+melanoma+cell+proliferation. assertion.
- assertion asSentence GAD2+and+GLUL+do+not+play+a+major+role+in+schizophrenia+pathogenesis+and+there+is+no+gene-gene+interaction+between+the+eight+genes+in+the+Japanese+population. assertion.
- assertion asSentence Oligomerization+of+the+mu-opioid+receptor+is+not+required+for+agonist+and+antagonist+binding+in+regard+to+allosteric+regulation+of+agonist+binding+by+Gi2. assertion.
- assertion asSentence Constitutive+XLalphas+activity+adds+to+the+molecular+pathogenesis+of+MAS+and+fibrous+dysplasia+of+bone. assertion.
- assertion asSentence Activation+of+PLCbeta%282%29+by+alpha%28q%29+and+beta1gamma2+differ+from+activation+by+Rac2+and+from+each+other. assertion.
- assertion asSentence EGF+is+an+upstream+regulator+of+the+autocrine+actions+of+GnRH-II+on+the+invasive+properties+of+ovarian+cancer+cells. assertion.
- assertion asSentence LRR2-4%2C+encompassing+a+pronounced+negative+charge+patch+on+human+glycoprotein+%28GP%29Ibalpha%2C+is+essential+for+GPIbalpha.von+Willebrand+factor-dependent+adhesion+as+hydrodynamic+shear+increases. assertion.
- assertion asSentence The+inherent+platelet+function+defect+is+due+to+a+gain-of-function+mutation+within+the+GP1BA+gene+coding+for+the+platelet+surface+glycoprotein+Ib+alpha+protein%2C+the+receptor+for+the+adhesive+protein+von+Willebrand+factor+%28VWF%29. assertion.
- assertion asSentence A+critical+component+of+Ras+signaling+is+the+activation+of+PLD. assertion.
- assertion asSentence M6a+modulates+mu-opioid+receptor+endocytosis+and+post-endocytotic+sorting+and+has+an+important+role+in+receptor+regulation. assertion.
- assertion asSentence The+intrahepatic+UII%2FUT+system+has+an+important+pathophysiological+role+in+cirrhosis+and+portal+hypertension. assertion.
- assertion asSentence GRK5+negatively+regulates+VEGF+signaling+in+human+coronary+artery+endothelial+cells. assertion.
- assertion asSentence Serum+alanine+aminotransferase+is+inadequate+for+diagnosing+lamivudine+resistance+and+has+implications+where+viral+resistance+testing+is+suboptimal+and+for+reimbursement+of+rescue+therapy. assertion.
- assertion asSentence GPx-1+inhibits+UVA-induced+AP-2alpha+expression+by+suppressing+the+accumulation+of+H%282%29O%282%29. assertion.
- assertion asSentence The+overexpressed+GRB7+and+GRB7v+are+associated+with+high-grade+tumors+and+exert+distinct+tumorigenic+functions+through+regulating+different+signaling+pathways+in+ovarian+cancer+cells. assertion.
- assertion asSentence Polymorphisms+in+the+GluR2+gene+%28GRIA2%29+are+not+a+major+contributory+factor+in+the+pathogenesis+of+ALS. assertion.
- assertion asSentence The+expression+of+GRIA2+among+the+differentially+expressed+genes+provides+better+prognosis+of+patients+with+advanced+serous+papillary+ovarian+adenocarcinoma. assertion.
- assertion asSentence The+interaction+between+PKCgamma+and+GluR4+is+specifically+required+to+assure+PKC-driven+phosphorylation+and+surface+membrane+expression+of+GluR4. assertion.
- assertion asSentence The+granulin%2Fepithelin+precursor+and+some+of+its+constituent+granulin+repeats+can+inhibit+HIV-1+transcription+via+Tat+without+directly+binding+to+cyclin+T1. assertion.
- assertion asSentence Homozygosity+of+the+single+nucleotide+polymorphism+rs5848+on+the+3%27UTR+of+progranulin+is+not+a+risk+factor+for+frontotemporal+lobar+degeneration. assertion.
- assertion asSentence ADAMTS-7%2C+a+direct+target+of+PTHrP+signaling%2C+negatively+regulates+endochondral+bone+formation+by+associating+with+and+inactivating+GEP+chondrogenic+growth+factor. assertion.
- assertion asSentence Intracellular+GEP+is+a+promoter-specific+transcriptional+repressor+that+modulates+the+function+of+cellular+and+viral+transcription+factors. assertion.
- assertion asSentence D1R-modulated+NR1a%2FNR2B+receptor+function+depends+on+PSD-95+and+is+subjected+to+the+regulation+of+PKA+and+PKC. assertion.
- assertion asSentence The+allelic+variant+%28C2664T%29+of+the+NR2b+confers+susceptibility+to+AD+. assertion.
- assertion asSentence DNA+methylation+decreases+GR+gene+expression+in+human+small+cell+lung+cancer+cells. assertion.
- assertion asSentence The+level+of+metabotropic+glutamate+receptor+2%2F3+is+elevated+in+the+prefrontal+cortex+in+patient+of+major+depression+disorder. assertion.
- assertion asSentence Overexpression+of+mGluR4+is+associated+with+poor+prognosis. assertion.
- assertion asSentence mGlu2+and+mGlu4+subunits+%28but+not+mGlu2+and+mGlu1%29+can+heteromerize. assertion.
- assertion asSentence CD1d+associates+in+the+ER+with+both+calnexin+and+calreticulin+and+with+the+thiol+oxidoreductase+ERp57+in+a+manner+dependent+on+glucose+trimming+of+its+N-linked+glycans. assertion.
- assertion asSentence Further+investigations+are+warranted+to+verify+the+involvement+of+ERp57+in+NAFLD+development. assertion.
- assertion asSentence The+turnover+of+Mcl-1+by+beta-TrCP+is+an+essential+mechanism+for+GSK-3beta-induced+apoptosis+and+contributes+to+GSK-3beta-mediated+tumor+suppression+and+chemosensitization. assertion.
- assertion asSentence Inhibition+of+the+GSK-3beta%2FeIF2Bepsilon+translational+control+pathway+contributes+to+airway+smooth+muscle+hypertrophy+in+vitro+and+in+vivo. assertion.
- assertion asSentence Leptin+regulates+tau+phosphorylation+through+a+pathway+involving+both+AMPK+and+GSK-3beta. assertion.
- assertion asSentence Overexpression+of+GSK-3beta+hindered+troglitazone-induced+cell+growth+inhibition+and+NFkappaB+inactivation. assertion.
- assertion asSentence Glycogen+synthase+kinase+3beta+%28GSK3beta%29+as+a+promising+target+for+leukemic+stem+cell+therapy+and+reveal+gender+differences+as+a+parameter+in+anti-leukemia+therapy. assertion.
- assertion asSentence The+neuronal+adenylate+kinase-1+%28AK1%29+is+induced+by+Abeta%2842%29+to+increase+abnormal+tau+phosphorylation+via+AMPK-GSK3beta+and+contributes+to+tau-mediated+neurodegeneration. assertion.
- assertion asSentence Higher+significant+risk+of+developing+erythema+in+patients+with+SNPS+in+XRCC1%2C+XRCC3+and+GSTA1. assertion.
- assertion asSentence GST+polymorphism+modifies+the+susceptibility+to+HNSCC+and+have+further+demonstrated+importance+of+gene-environment+interaction+in+modulating+the+risk+to+HNSCC. assertion.
- assertion asSentence Idua%28-%2F-%29+mice+present+deficits+in+long-term+memory+for+aversive+training+and+reduced+exploratory+behavior. assertion.
- assertion asSentence CXCR3+on+CD8%28%2B%29+T+cells+is+required+for+T+cell+recruitment+into+the+brain+and+the+development+of+murine+cerebral+malaria. assertion.
- assertion asSentence Dipyrithione+inhibits+IFN-gamma-induced+IP-10%2FCXCL10+expression+in+RAW264.7+cells+by+targeting+the+JAK1%2F2%2FSTAT1+signaling+pathways. assertion.
- assertion asSentence Gammadelta+T+cells+promote+the+resolution+of+fibrosis+through+the+production+of+CXCL10. assertion.
- assertion asSentence Mouse+hepatitis+virus+is+recognized+by+both+RIG-I+and+MDA5+and+induces+IFN-alpha%2Fbeta+through+the+activation+of+the+IRF-3+signaling+pathway. assertion.
- assertion asSentence Tyk2+tyrosine+kinase+is+essential+for+stable+cell+surface+expression+of+IFNAR1. assertion.
- assertion asSentence Adult+mice+deficient+in+type+I+IFN+receptor+%28IFNAR%28%28-%2F-%29%29%29+are+highly+susceptible+to+bluetongue+virus+BTV-4+and+BTV-8+infection+when+the+virus+is+administered+intravenously. assertion.
- assertion asSentence That+DC%2C+especially+the+CD8alpha%28%2B%29+subset%2C+from+type+I+IFN+receptor+knock+out+%28IFNAR+KO%29+mice%2C+display+a+reduced+turnover+rate+when+compared+with+DC+from+WT+mice. assertion.
- assertion asSentence That+DC%2C+especially+the+CD8alpha%28%2B%29+subset%2C+from+type+I+IFN+receptor+knock+out+%28IFNAR+KO%29+mice%2C+display+a+reduced+turnover+rate+when+compared+with+DC+from+WT+mice. assertion.