Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Liposome-mediated+IFN-beta+gene+delivery+inhibits+glial+scar+formation+after+SCI+and+promotes+functional+recovery. assertion.
- assertion asSentence pDCs+and+type+I+IFNs+promote+inflammatory+responses+and+wound+healing+in+injured+skin. assertion.
- assertion asSentence Macrophages+infected+with+Legionella+pneumophila+produced+IFNbeta+in+a+STING-+and+IRF3-+dependent+manner. assertion.
- assertion asSentence IFN-gamma+promotes+the+severity+of+EC+during+the+effector+phase. assertion.
- assertion asSentence IFN-gamma+stimulates+mC1rA+gene+expression+via+IRF-1+in+mouse+keratinocytes. assertion.
- assertion asSentence The+interferon-gamma+produced+by+antigen-specific+CD4%28%2B%29+T+cells+plays+an+important+role+in+the+defense+against+Citrobacter+rodentium. assertion.
- assertion asSentence IL-18bp+acts+as+a+sensor+for+IFN-gamma+and+can+regulate+both+Th1+and+Th17+responses+in+the+CNS. assertion.
- assertion asSentence IFN-gamma+is+an+antiviral+effector+molecule+for+mouse+polyomavirus+infection. assertion.
- assertion asSentence Expression+of+the+ifng+gene+and+chromatin+remodeling+of+the+ifng+locus+are+under+the+control+of+a+Th2+LCR-mediated+Th2+differentiation+program. assertion.
- assertion asSentence IGF-1-induced+myoblast+differentiation+and+hypertrophy+are+driven%2C+at+least+in+part%2C+by+Neu2+upregulation+and+further+support+the+significant+role+of+cytosolic+sialidase+in+myoblasts. assertion.
- assertion asSentence PNC1+is+a+target+of+the+IGF-I%2FmTOR+pathway+that+is+essential+for+mitochondrial+activity+in+regulating+cell+growth+and+proliferation. assertion.
- assertion asSentence Loss+of+IGF-IEb+reduced+MyHC+isoform+mRNA+significantly. assertion.
- assertion asSentence The+myonuclear+organization+differs+between+hypertrophic+muscle+fibers+from+myostatin-knockout+%28Mstn-%2F-%29+and+IGF-1-overexpressing+%28mIgf1%2B%2F%2B%29+muscle+fibers. assertion.
- assertion asSentence Neither+insulin+nor+IGF-1+signaling+in+vascular+endothelial+cells+is+required+for+development+and+maintenance+of+BBB+or+BRB. assertion.
- assertion asSentence Infection+of+epithelial+cells+with+attenuated+Yersinia+enterocolitica+lacking+the+virulence+plasmid+pYV+leads+to+the+expression+of+CYR61+and+CTGF. assertion.
- assertion asSentence The+growth-promoting+role+of+IGFBP-2+in+prostate+cancer+is+inhibited+by+its+intracellular+interaction+with+PAPA-1. assertion.
- assertion asSentence Ihh+regulates+osteoblast+differentiation+of+mesenchymal+cells+through+up-regulation+of+the+expression+and+function+of+Runx2+by+Gli2. assertion.
- assertion asSentence IkappaB+kinase+beta+%28IKKbeta%29+can+be+activated+in+the+nucleus+by+Nkx3.2+in+the+absence+of+exogenous+IKK-activating+signals%2C+allowing+constitutive+nuclear+degradation+of+IkappaB-alpha. assertion.
- assertion asSentence RASSF2+regulates+osteoblast+and+osteoclast+differentiation+by+inhibiting+NF-kappaB+signalling+via+association+with+IkappaB+kinase+%28IKK%29+alpha+and+beta+forms+and+suppression+of+IKK+activity. assertion.
- assertion asSentence NEMO+forms+a+complex+with+IKKbeta+and+IkappaBalpha. assertion.
- assertion asSentence Th17+cells+convert+to+Th1+cells+through+IL-17+induction+of+mucosal+innate+IL-12+and+IL-23+production. assertion.
- assertion asSentence Neonates+acquire+the+ability+to+overcome+the+IL-12-regulated+Th2+bias+and+generate+Th1+responses+starting+6+d+after+birth. assertion.
- assertion asSentence Cholera+toxin+and+other+Gs-protein+agonists+can+affect+IL-12+production+and+dendritic+cell+differentiation+via+a+common+mechanism+involving+IRF8. assertion.
- assertion asSentence Both+plasmacytoid+dendritic+cells+and+splenic+conventional+dendritic+cells+mediate+in+vivo+the+innate+immune+response+to+Neospora+caninum+infection+through+the+production+of+IL-12. assertion.
- assertion asSentence IL-18+and+IL-12+generate+IL-13-producing+NK-like+cells+by+a+process+mediated+by+GM-CSF. assertion.
- assertion asSentence The+non-redundant+requirement+for+IL-7+and+IL-15+is+mediated+through+differential+activation+of+both+STAT5-dependent+and+STAT5-independent+pathways. assertion.
- assertion asSentence Acquisition+of%2C+or+alterations+in%2C+commensal+bacteria+influences+intestinal+immune+homeostasis+via+direct+regulation+of+the+IL-25-IL-23-IL-17+axis. assertion.
- assertion asSentence IL-17A+plays+a+pivotal+role+in+the+pathogenesis+of+dextran+sodium+sulfate-induced+colitis. assertion.
- assertion asSentence IL-12+inhabit+T+cell+differentiation+toward+Th17+cells. assertion.
- assertion asSentence Chronic+production+of+TNF-alpha+in+the+tumor+microenvironment+increases+myeloid+cell+recruitment+in+a+TNFR1+and+IL-17-dependent+manner+that+contributes+to+the+tumor-promoting+action+of+this+proinflammatory+cytokine. assertion.
- assertion asSentence Mainly+T%28h%2917+effector+mechanisms+are+of+critical+importance+to+H.+pylori+vaccine+protection. assertion.
- assertion asSentence The+destabilization+of+interferon-gamma+%28IFN-gamma%29+mRNA+induced+by+transforming+growth+factor+beta+leads+to+the+inhibition+of+antiviral+activity+and+IFN-gamma+production+in+interleukin-18-stimulated+LNK5E6+cells. assertion.
- assertion asSentence IL-18+suppresses+Fas-mediated+apoptosis+of+hepatocytes+by+up-regulation+of+NFkappaB+and+XIAP%2C+following+inhibition+of+caspase-3+activity. assertion.
- assertion asSentence IL-1alpha+is+the+major+mediator+of+the+IL-1RI-dependent+and+protective+innate+immune+responses+to+Mycobacterium+tuberculosis+in+mice. assertion.
- assertion asSentence IL-1beta+and+TNF-alpha+are+produced+by+largely+segregated+populations+of+microglia+and+macrophages+after+ischemic+stroke+in+mice. assertion.
- assertion asSentence Phagocytosis+and+lysozyme-based+cell+wall+degradation+of+S.+aureus+are+functionally+coupled+to+NLRP3+inflammasome+activation+and+IL-1beta+secretion. assertion.
- assertion asSentence Regulation+of+interleukin-1beta+by+interferon-gamma+is+different+in+humans+and+mice%2C+is+limited+by+suppressor+of+cytokine+signalling+1+and+influences+interleukin-17+production. assertion.
- assertion asSentence Xenon+enhances+LPS-induced+IL-1beta+expression+in+microglia+by+activation+of+ERK+1%2F2+signalling. assertion.
- assertion asSentence Caspase-1+plays+a+critical+role+in+the+cascade+of+events+involved+in+the+genesis+of+inflammatory+hypernociception+by+promoting+IL-1beta+maturation. assertion.
- assertion asSentence IL-1+beta+cytokine+systems+plays+a+role+in+sleep+regulation+and+in+the+alterations+in+sleep+that+follow+prolonged+wakefulness. assertion.
- assertion asSentence IL-1R+signaling+is+required+at+multiple+steps+during+the+course+of+sensitization+and+challenge+to+elicit+Contact+hypersensitivity. assertion.
- assertion asSentence IRAK-1+acts+as+the+essential+upstream+adaptor+that+recruits+BCL10+to+the+TLR4+signaling+complex+and+mediates+signaling+to+NF-kappaB+through+the+BCL10-MALT1-TRAF6-TAK1+cascade. assertion.
- assertion asSentence The+autoimmune+exocrinopathy+of+the+CD25KO+LG+is+composed+of+a+dynamic+Th-1+and+Th-17+response%2C+with+a+Th-17+phenotype+in+young+mice+shifting+to+a+Th-1-predominant+expression+at+later+time+points. assertion.
- assertion asSentence IL-4+functions+as+a+major+antiinflammatory+cytokine+in+proteoglycan-induced+arthritis+by+governing+the+activity+of+macrophages%2Fneutrophils+and+less+so+by+controlling+T+cell+activity+and+autoantibody+isotype+expression. assertion.
- assertion asSentence Transfer+of+IL-4Ralpha+%2B+macrophages+is+sufficient+to+enhance+TH2-driven%2C+allergic+inflammation. assertion.
- assertion asSentence TNF-alpha+plays+a+central+role+in+promoting+IL-17A%2FIL-5+from+CD4%28%2B%29+T+cells+and+collaborating+with+it+to+induce+airway+neutrophilia. assertion.
- assertion asSentence IL-6-gp130-STAT3-dependent+gene+expression+in+hepatocytes+mediates+IL-6-triggered+protection+in+immune-mediated+Con+A-induced+hepatitis. assertion.
- assertion asSentence IL-6+plays+an+important+role+in+CNS+repair+mechanisms+by+promoting+regrowth+and+axon+regeneration. assertion.
- assertion asSentence IL-6+plays+a+crucial+role+in+thyrotoxicosis-related+disturbances+of+bone+turnover+in+mice. assertion.
- assertion asSentence IL-6+does+not+play+an+important+role+in+bone+turnover+in+both+euthyroid+and+hypothyroid+mice. assertion.
- assertion asSentence IL-4+up-regulates+IL-6+expression+in+vascular+endothelium+through+NADPH+oxidase-mediated+reactive+oxygen+species+generation. assertion.
- assertion asSentence Foxp3%2BCD8%2BT+cells+increased+in+vivo+in+response+to+an+inflammatory+condition+via+enhanced+IL-6+signaling. assertion.
- assertion asSentence TNF-alpha+increased+IL-6+production+in+myoblasts+via+the+FAK%2FPI3K%2FAkt+and+NF-kappaB+signaling+pathway. assertion.
- assertion asSentence Melanocortins+regulate+Il6+gene+expression+and+production+in+3T3-L1+adipocytes+through+melanocortin+receptors+2+and+5. assertion.
- assertion asSentence Expression+of+PE_PGRS+62+protein+in+Mycobacterium+smegmatis+decrease+mRNA+expression+of+proinflammatory+cytokines+IL-1beta%2C+IL-6+in+macrophages. assertion.
- assertion asSentence VIP+synergistically+enhances+TNF-alpha-stimulated+IL-6+synthesis+via+up-regulating+p44%2Fp42+MAP+kinase+through+the+adenylyl+cyclase-cAMP+system+in+osteoblasts. assertion.
- assertion asSentence IL-6+plays+a+major+role+in+enterovirus+71-induced+immunopathogenesis. assertion.
- assertion asSentence Notch1+positively+regulates+IL-6+expression+via+NF-kappaB+in+activated+macrophages. assertion.
- assertion asSentence The+neuromedin+B-neuromedian+B+receptor+interaction+in+pregnant+myometrial+primary+cells+in+vitro+predominantly+influenced+uterine+activity+through+regulation+of+Il6+expression+via+the+Rela%2Fp65+pathway. assertion.
- assertion asSentence Muller+cell+activation+of+gp130+is+not+essential+for+photoreceptor+protection. assertion.
- assertion asSentence This+decrease+in+IL-7Ralpha+is+associated+with+defective+hematopoietic+development+in+Down+Syndrome. assertion.
- assertion asSentence Increased+expression+of+interleukin-9+receptor+%28Il9R%29+is+associated+with+an+increased+binding+of+nucleolin. assertion.
- assertion asSentence SHIP-1+acts+as+a+positive+regulator+in+Th2+cells+in+the+adaptive+immune+response+to+aeroallergen. assertion.
- assertion asSentence PCSK9-nullmice+carried+more+LDLR+and+less+insulin+in+their+pancreas. assertion.
- assertion asSentence TMED6+mRNA+is+highly+and+selectively+expressed+in+pancreas%2Cand+knockdown+of+TMED6+gene+expression+in+Min6+beta+cells+decreased+insulin+secretion. assertion.
- assertion asSentence Neither+insulin+nor+IGF-1+signaling+in+vascular+endothelial+cells+is+required+for+development+and+maintenance+of+BBB+or+BRB. assertion.
- assertion asSentence The+IGF-1R+is+more+active+in+signaling+than+the+IR+and+is+the+predominant+mediator+of+IGF+actions+in+virgin+MECs. assertion.
- assertion asSentence The+female+reproductive+functions+are+not+affected+when+Insr%2C+Igf1r+or+both+Insr%3BIgf1r+are+ablated+in+oocytes. assertion.
- assertion asSentence Inducible+nitric-oxide+synthase+reduces+insulin+receptor+substrate-1+expression+in+skeletal+muscle+via+proteasome-mediated+degradation. assertion.
- assertion asSentence ISL1+and+BRN3B+co-regulate+the+differentiation+of+murine+retinal+ganglion+cells+by+concurrently+bind+to+and+synergistically+regulate+the+expression+of+a+common+set+of+RGC-specific+genes. assertion.
- assertion asSentence Alpha+2+beta+1+integrin+provides+a+costimulatory+function+required+for+mast+cell+activation+and+cytokine+production+in+response+to+infection. assertion.
- assertion asSentence The+perturbed+orientation+of+talin+relative+to+the+membrane+in+the+F2+mutant+would+be+expected+to+in+turn+perturb+talin%2Fintegrin+interactions. assertion.
- assertion asSentence Tubular+epithelial+cells+are+induced+to+express+alpha%285%29-integrin+during+epithelial-mesenchymal+transition+and+tubular+epithelial+injury+in+vitro+and+in+vivo. assertion.
- assertion asSentence VASP+is+required+for+integrin+alpha5beta1-mediated+adhesion+which+stabilizes+endothelial+barrier+properties+at+least+in+part+by+facilitating+Rac+1+activation. assertion.
- assertion asSentence alpha5beta1+integrin+functions+in+the+regulation+of+neural+morphology+and+migration+during+cortical+development%2C+playing+a+role+in+cortical+lamination. assertion.
- assertion asSentence EGFR%2C+via+interaction+with+FcvarepsilonRI+and+integrin+alpha%285%29%2C+is+necessary+for+allergic+inflammation+associated+with+cellular+interaction. assertion.
- assertion asSentence A+lack+of+CD103+expression+does+not+affect+functional+impairment+of+effector+T-cell+responses+during+chronic+viral+infection. assertion.
- assertion asSentence Induction+of+alkaline+phosphatase%2C+type+I+collagen%2C+osteocalcin%2C+CD44%2C+CD47+and+CD51+by+mevinolin+is+responsible+for+the+osteoblastic+differentiation+of+D1+cells. assertion.
- assertion asSentence Lung+fibroblast+chemokine+secretion+directs+dendritic+cell+trafficking%2C+in+a+manner+that+is+critically+dependent+on+alphavbeta8-mediated+activation+of+TGF-beta+by+fibroblasts. assertion.
- assertion asSentence CD11c%28%2B%29+CD8alpha%28%2B%29+dendritic+cells+directly+or+indirectly+increase+the+amount+of+herpes+simplex+virus+1+latency+in+mouse+trigeminal+ganglia. assertion.
- assertion asSentence Engagement+of+leukocyte-associated+alpha%281%29beta%281%29+integrins+with+ECM+plays+a+pivotal+role+in+mediating+intestinal+inflammation+via+promotion+of+monocyte+movement+and%2For+activation+within+the+inflamed+interstitium. assertion.
- assertion asSentence Bone+marrow-derived+mesenchymal+stem+cells+use+a+different+pathway+from+hematopoietic+stem+cells+for+intramyocardial+trafficking+and+engraftment. assertion.
- assertion asSentence Expression+of+beta1+integrins+is+critically+important+for+the+expansion+of+epidermal+progenitor+cells+to+maintain+epidermal+homeostasis. assertion.
- assertion asSentence beta1+integrins+play+an+instructive+role+in+CNS+myelination+by+promoting+myelin+wrapping+in+a+process+that+depends+on+AKT. assertion.
- assertion asSentence Recognition+of+host-+and%2For+tumor-derived+fibronectin+via+alpha5beta1+is+important+for+tumor+growth+both+in+vitro+and+in+vivo. assertion.
- assertion asSentence The+preferential+pairing+of+beta1+integrin+with+alpha4+integrin+regulates+the+expression+of+alpha4beta7+on+T+cells. assertion.
- assertion asSentence The+induction+of+collagen+XIII+in+endothelial+cells+of+Alport+syndrome+kidneys+mediates+the+selective+recruitment+of+alpha1beta1+integrin-positive+monocytes. assertion.
- assertion asSentence LFA-1+plays+some+mechanisms+in+synaptic+contacts+and+synaptogenesis+of+hippocampal+neurons. assertion.
- assertion asSentence A+single+aromatic+residue+in+the+suppressor+domain+%28Tyr-167+in+IP%283%29R1+and+Trp-168+in+IP%283%29R3%29+plays+a+critical+role+in+the+coupling+between+ligand+binding+and+channel+gating. assertion.
- assertion asSentence KRAP+physically+associates+with+IP%283%29R+and+regulates+the+proper+localization+of+IP%283%29R+in+the+epithelial+cells+in+vivo+and+cultured+cells. assertion.
- assertion asSentence Expression+of+Notch+ligand+can+radically+increase+cell+strain+capacity+to+maintenance+of+in+vitro+hemopoiesis+in+the+co-culturing+system. assertion.
- assertion asSentence Jagged1+is+a+critical+positive+regulator+of+tip+cell+formation+and+sprouting+because+of+its+ability+to+modulate+Dll4-Notch+signaling+in+the+angiogenic+endothelium. assertion.
- assertion asSentence The+Jagged2-Notch+axis+plays+a+crucial+role+in+DC-mediated+natural+killer+cell+cytotoxicity. assertion.
- assertion asSentence PPARgamma+agonists+regulate+LIF+signaling+through+JAK-STAT+pathway+leading+to+growth+and+self-renewal+of+ES+cells. assertion.
- assertion asSentence JAK2+is+a+critical+regulator+of+IgE%2Fantigen-induced+production+of+LTC%284%29+in+mast+cells. assertion.
- assertion asSentence In+murine+microvascular+endothelial+cells%2C+Jun+siRNA+inhibits+Jun+mRNA+and+protein+expression%2C+matrix+metalloproteinase-2+expression%2C+blocks+cell+proliferation+and+suppresses+migration. assertion.
- assertion asSentence The+choline+kinase+alpha+promoter+has+a+distal+element+%28-875%2F-867%29+that+binds+c-jun+and+the+binding+of+c-jun+is+enhanced+by+treatment+with+CCl4. assertion.
- assertion asSentence Both+IKKalpha+and+IKKbeta+can+mediate+arsenite-induced+AP-1+transactivation+through+NF-kappaB+activity-independent+manner. assertion.
- assertion asSentence That+Frat+synergizes+with+Diversin+in+the+activation+of+JNK%2FAP-1+signaling. assertion.
- assertion asSentence A+unique+c-Fos+c-Jun+activator+protein-1+complex+in+gastric+macrophages+contributes+to+the+immune+escape+of+H.+pylori. assertion.