Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence There+is+a+genetic+interaction+between+Cited2+and+Lmo4+in+control+of+thymus+development. assertion.
- assertion asSentence sik1+via+p57Kip2+plays+a+central+role+in+the+time+clock+mechanism+that+regulates+cardiac+cell+proliferation+and+differentiation. assertion.
- assertion asSentence In+the+early+stage+of+denervation%2C+the+levels+of+myostatin+mRNA+and+protein+in+the+denervated+gastrocnemius+muscle+increased+instantly%2C+reaching+a+peak+at+day+3+and+day+7+after+sciactic+neurectomy. assertion.
- assertion asSentence Myostatin+can+play+an+essential+role+in+the+adaptation+of+skeletal+muscle+to+hypoxic+environment. assertion.
- assertion asSentence Myostatin+is+involved+either+directly+in+the+control+of+neuromuscular+interrelationships+or+indirectly+through+its+effect+on+muscle+size. assertion.
- assertion asSentence Msx1+conjugation+to+SUMO-1+in+vivo+is+enhanced+by+an+E3+SUMO+ligase. assertion.
- assertion asSentence The+gene+Mtap1a+modifies+retinal+degeneration+in+Tub%28tub%2Ftub%29+and+Tulp1%28tm1Pjn%2Ftm1Pjn%29+mice. assertion.
- assertion asSentence DNA+fragmentation+and+caspase-3+activation+are+common+in+the+hippocampus+and+frontal+cortex+of+young+rTg4510+tauopathy+mice. assertion.
- assertion asSentence The+antidiabetic+drug+metformin+induces+PP2A+activity+and+reduces+tau+phosphorylation+at+PP2A-dependent+epitopes+in+vitro+and+in+vivo. assertion.
- assertion asSentence Increased+levels+of+tau+negatively+influence+secretagogin+expression+in+the+hippocampus+of+tau+tg+mice. assertion.
- assertion asSentence Methylenetetrahydrofolate+reductase+deficiency+impairs+endothelial+progenitor+cell+formation+and+increases+endothelial+progenitor+cell+senescence+by+endothelial+nitric+oxide+synthase+uncoupling+and+downregulation+of+SIRT1. assertion.
- assertion asSentence MiR-150+controls+B+cell+differentiation+by+targeting+the+transcription+factor+c-Myb. assertion.
- assertion asSentence Loss+of+only+the+p89-encoding+isoform+does+not+have+any+deleterious+effects+on+hematopoiesis+and+development. assertion.
- assertion asSentence Mammary+tumor+incidence+is+significantly+elevated+in+these+mixed+background+MMTV-c-myc+transgenic+mice+when+they+are+bred+continuously%2C+starting+at+7+weeks+of+age. assertion.
- assertion asSentence Myc-induced+chromatin+modifications+play+a+major+role+in+Myc-induced+exit+from+the+stem+cell+compartment. assertion.
- assertion asSentence Caspase-3+deletion+confers+protection+from+c-Myc-induced+apoptosis+and+diabetes+development+without+unwanted+tumorigenic+effects. assertion.
- assertion asSentence A+significant+decrease+in+c-Myc+transcript+and+protein+levels+can+be+achieved+after+a+short+trichostatin+A+treatment+applied+only+at+specific+circadian+times. assertion.
- assertion asSentence Both+TLR9+and+MyD88+are+essential+modulators+of+the+autoimmune+process+during+the+effector+phase+of+autoimmune+encephalomyelitis. assertion.
- assertion asSentence Necrotic+neurons+activate+in+microglia+a+MyD88-dependent+pathway+responsible+for+a+pro-inflammatory+response+that+also+leads+to+increased+neurotoxic+activity+through+induction+of+glutaminase. assertion.
- assertion asSentence LPS-induced+HSPC+expansion+involves+TLR4+inflammatory+signaling+through+MyD88+and+TRIF. assertion.
- assertion asSentence MyD88+signaling+is+essential+for+maintaining+neutrophil+migratory+function+and+chemokine+receptor+expression. assertion.
- assertion asSentence Peritoneal+catheter+elicited+IL-10-producing+macrophages+through+a+MyD88-dependent+pathway. assertion.
- assertion asSentence A+composite+homeo+and+paired+domain-binding+motif+within+the+-58%2F-56+enhancer+is+required+and+sufficient+for+activation+of+the+Myf5+gene+in+muscle+progenitor+cells+in+the+limb. assertion.
- assertion asSentence Myosin+Va+is+essential+for+terminal+climbing+fibers+extension+and+for+the+establishment+of+CF+synapses+within+the+proper+dendritic+territories+of+Purkinje+cells. assertion.
- assertion asSentence The+actin+D-loop+strongly+modulates+the+force+generation+by+myosin+II+and+the+processivity+of+myosin+V. assertion.
- assertion asSentence NCAM+mediates+the+anchoring+of+intracellular+organelles+in+nascent+synapses. assertion.
- assertion asSentence In+NCAM+deficient+mice+FGFR1-dependent+signaling+is+disrupted+and+it+can+be+restored+by+FGL+peptide. assertion.
- assertion asSentence Two+distinct+RNCAM+isoform-dependent+activities+influence+segregation+of+odorant+receptor-defined+axon+subclasses. assertion.
- assertion asSentence Increased+expression+of+interleukin-9+receptor+%28Il9R%29+is+associated+with+an+increased+binding+of+nucleolin. assertion.
- assertion asSentence The+floxed+SRC-3+mouse+lines+will+be+useful+for+investigating+the+cell+type-+and+developmental+stage-specific+functions+of+SRC-3. assertion.
- assertion asSentence NCOA1+and+NCOA3+cooperatively+regulate+placental+morphogenesis+and+embryo+survival. assertion.
- assertion asSentence Nedd4+is+involved+in+regulating+the+formation+and+function+of+the+neuromuscular+junctions+through+non-cell+autonomous+mechanisms. assertion.
- assertion asSentence Nek1+is+important+for+efficient+DNA+damage+checkpoint+control+and+for+proper+DNA+damage+repair. assertion.
- assertion asSentence Nestin+is+required+for+acetylcholine-induced%2C+Cdk5-dependent+dispersion+of+AChR+clusters+during+neuromuscular+junction+development. assertion.
- assertion asSentence Neurogenin+and+NeuroD+preferentially+recognize+neurogenesis-related+targets+through+an+enhancer+signature+of+clustered+consensus-binding+sites+and+regulate+neurogenesis+by+activating+a+core+set+of+transcription+factors. assertion.
- assertion asSentence Neurogenin+and+NeuroD+preferentially+recognize+neurogenesis-related+targets+through+an+enhancer+signature+of+clustered+consensus-binding+sites+and+regulate+neurogenesis+by+activating+a+core+set+of+transcription+factors. assertion.
- assertion asSentence Nf1+heterozygosity+of+bone+marrow-derived+cells+in+the+tumor+microenvironment+is+sufficient+to+allow+neurofibroma+progression+in+the+context+of+Schwann+cell+Nf1+deficiency. assertion.
- assertion asSentence Scleraxin+and+NFATc4+cooperate+to+activate+the+collagen+1a1+gene+specifically+in+tendon+fibroblasts. assertion.
- assertion asSentence NFATc1+is+essential+for+RANKL-induced+osteoclast+activation+via+up-regulation+of+osteoclast-activating+genes. assertion.
- assertion asSentence Orai1+plays+a+critical+role+in+the+differentiation+and+function+of+osteoclasts%2C+by+regulating+activation+of+the+transcription+factor+NFATc1. assertion.
- assertion asSentence NFAT1+mediates+PlGF-induced+myelomonocytic+cell+recruitment+via+the+induction+of+TNF-alpha. assertion.
- assertion asSentence The+mitochondrial+localization+of+RelB+and+NFATx+is+precisely+controlled+by+a+calcium+signal+sensitive+to+FK506+in+T+cells. assertion.
- assertion asSentence The+posttranslational+modifications+and+turnover+of+p45%2FNF-E2%2C+as+mediated+by+P-JNK%2C+contribute+to+the+control+of+its+homeostatic+concentration+and+consequently%2C+its+regulatory+functions. assertion.
- assertion asSentence Trsp%3ANrf2+double+deficiency+dramatically+exacerbates+the+anemia+and+increases+intracellular+hydrogen+peroxide+levels+in+erythroblasts. assertion.
- assertion asSentence Adaptive+activation+of+the+Nrf2%2Fantioxidant-response-element+pathway+confers+endothelial+protection+under+diabetic+hyperglycemia. assertion.
- assertion asSentence Clinically+established+fumarate+derivatives+activate+the+Nrf2+pathway+and+are+readily+testable+cytoprotective+agents. assertion.
- assertion asSentence Nrf3+has+a+crucial+role+in+smooth+muscle+cell+differentiation+from+embryonic+stem+cells. assertion.
- assertion asSentence Bis-BHA+possesses+anti-inflammatory+activity+against+chronic+periodontal+diseases. assertion.
- assertion asSentence Fucoidan+inhibited+IgE+production+by+preventing+the+NFkappaB+p52-mediated+pathways+activated+by+CD40. assertion.
- assertion asSentence Myofibrillogenesis+regulator-1+%28MR-1%29+plays+an+aggravative+role+in+the+development+of+cardiac+hypertrophy+via+activation+of+the+nuclear+factor+kappaB+signaling+pathway+%5BMR-1%5D. assertion.
- assertion asSentence TbetaRIII+acts+as+a+tumor+suppressor+in+nontumorigenic+mammary+epithelial+cells+at+least+in+part+by+inhibiting+NFkappaB-mediated+repression+of+E-cadherin. assertion.
- assertion asSentence NF-kappaB+subunit+p50+proteins+have+critical+in+vivo+functions+in+immunologically+mediated+renal+disease+by+downregulating+inflammation+during+the+resolution+period. assertion.
- assertion asSentence NF-kappaB+functions+downstream+of+Ras+to+promote+epigenetic+downregulation+of+FBP1. assertion.
- assertion asSentence Via+interaction+with+MyD88%2C+PYK2+is+involved+in+modulating+cytokine+stimulation+of+NF-kappaB+activity+and+signaling. assertion.
- assertion asSentence Monoacetylcurcumin+strongly+inhibited+IkappaB+phosphorylation%2C+nuclear+factor-kappaB+activation+and+tumor+necrosis+factor-alpha+production+induced+by+lipopolysaccharide. assertion.
- assertion asSentence The+inhibition+of+NF-kappaB+signaling+in+the+infected+lung+cells+of+IFNgammaR%28-%2F-%29+mice+reduces+virus+persistence+and+ameliorates+profibrotic+events. assertion.
- assertion asSentence The+JNK+MAPK+positively+regulate+peptidoglycan-induced+iNOS+and+nitric+oxide+expression+by+activating+NF-kappaB+and+AP-1+transcription+factors. assertion.
- assertion asSentence Fucoidan+inhibited+IgE+production+by+preventing+the+NFkappaB+p52-mediated+pathways+activated+by+CD40. assertion.
- assertion asSentence TNF+limits+RANKL-+and+TNF-induced+osteoclast+formation+in+vitro+and+in+vivo+by+increasing+NF-kappaB+p100+protein+accumulation+in+osteoclast+precursors. assertion.
- assertion asSentence IkappaB+kinase+beta+%28IKKbeta%29+can+be+activated+in+the+nucleus+by+Nkx3.2+in+the+absence+of+exogenous+IKK-activating+signals%2C+allowing+constitutive+nuclear+degradation+of+IkappaB-alpha. assertion.
- assertion asSentence Regulation+of+these+c-Rel-dependent+lymphoid+responses+is+a+non-redundant+function+of+IkappaBepsilon. assertion.
- assertion asSentence NF-Y+acts+upstream+of+E2F1+in+p53-mediated+apoptosis. assertion.
- assertion asSentence AMP-activated+protein+kinase+supports+the+NGF-induced+viability+of+human+HeLa+cells+to+glucose+starvation. assertion.
- assertion asSentence The+p75%28NTR%29+receptor+is+integral+to+neuronal+cell+survival+and+endogenous+reparative+mechanisms+after+compressive%2Fcontusive+SCI. assertion.
- assertion asSentence NGF+acts+through+its+low-affinity+receptor+p75%28NTR%29+in+a+developmentally+regulated+signaling+pathway+necessary+to+myogenic+differentiation+and+muscle+repair+in+vivo. assertion.
- assertion asSentence Generation+of+the+soluble+p75NTR+intracellular+domain+by+Trk-induced+cleavage+plays+a+fundamental+role+in+Trk-dependent+signaling+events. assertion.
- assertion asSentence NSCL-1+and+-2%2C+together+with+additional+cofactors%2C+directly+control+transcription+of+the+necdin+gene. assertion.
- assertion asSentence Shox2+plays+an+essential+role+in+the+sinoatrial+node+and+pacemaker+development+by+controlling+a+genetic+cascade+through+the+repression+of+Nkx2-5. assertion.
- assertion asSentence The+Nkx2.2+and+Nkx2.9+transcription+factors+contribute+crucially+to+the+formation+of+neuronal+networks+that+function+as+central+pattern+generators+for+locomotor+activity+in+the+spinal+cord. assertion.
- assertion asSentence Sustained+Nkx6.1+overexpression+in+vivo+does+not+stimulate+beta-cell+proliferation%2C+expand+beta-cell+mass%2C+or+improve+glucose+metabolism+in+either+normal+or+beta-cell-depleted+pancreata. assertion.
- assertion asSentence Heavy+metals+%28mercury%2C+lead+and+copper%29+regulate+the+expression+of+Noqo1+gene+through+a+transcriptonal+mechanism. assertion.
- assertion asSentence Nqo1+expression+and+activity+in+mouse+liver+are+induced+via+an+Nrf2-dependent+mechanism. assertion.
- assertion asSentence Cisplatin+markedly+increases+the+sensitivity+of+cancer+to+beta-lap+in+vitro+and+in+vivo+by+upregulating+NQO1. assertion.
- assertion asSentence Wnt+signaling+via+N-myc+is+crucial+for+the+control+of+neuron+number+in+the+developing+neocortex. assertion.
- assertion asSentence Cripto+binds+the+proprotein+convertases+Furin+and+PACE4+and+localizes+Nodal+processing+at+the+cell+surface. assertion.
- assertion asSentence Eyelid+opening+is+strongly+inhibited+in+transgenic+mice+overexpressing+the+bone+morphogenetic+protein+antagonist+noggin+from+the+keratin+5+promoter+in+the+epidermis. assertion.
- assertion asSentence nNOS+expression+in+LM-MP+varies+with+gender+during+early+stage+of+type+2+diabetes. assertion.
- assertion asSentence NOS1+redistribution+in+injured+myocardium+requires+the+formation+of+a+complex+with+the+PDZ+adaptor+protein+CAPON. assertion.
- assertion asSentence nNOS%2C+not+eNOS%2C+plays+the+dominant+role+in+modulating+Ca%282%2B%29+cycling+in+the+heart. assertion.
- assertion asSentence iNOS+activity+influences+MHC+I+expression+by+microglial+cells+one+and+two+weeks+after+axotomy. assertion.
- assertion asSentence hsp90+plays+a+primary+role+in+maturation+of+iNOS+protein+by+interacting+with+the+apoenzyme+in+cells+and+then+driving+heme+insertion+in+an+ATP-dependent+manner. assertion.
- assertion asSentence DUSP1+suppresses+iNOS+expression+by+limiting+p38+MAPK+activity+in+human+and+mouse+cells. assertion.
- assertion asSentence iNOS-induced+nuclear+CLIC4+is+an+essential+part+of+the+macrophage+deactivation+program. assertion.
- assertion asSentence The+down-regulation+of+MMP-9+by+agmatine+runs+parallel+to+the+up-regulation+of+eNOS+and+the+maintenance+of+functional+NO+release. assertion.
- assertion asSentence eNOS+and+nNOS+both+contribute+in+significant+ways+to+relaxation+in+mouse+thoracic+aorta. assertion.
- assertion asSentence Activation+of+the+PI3K%2FAkt%2FeNOS+pathway+in+spinal+cord+injury+is+a+protective+event%2C+triggered+in+order+to+protect+the+injured+tissue+through+a+fine+tuning+of+the+endothelial+nitric+oxide+pathway. assertion.
- assertion asSentence alphaNOS1+acts+in+concert+with+GluR1+to+produce+experience-dependent+plasticity+in+the+neocortex. assertion.
- assertion asSentence To+ensure+an+appropriate+outcome+in+the+thymus+in+response+to+a+lower+threshold+of+induced+Notch+signaling%2C+induction+of+the+additional+target+Hes5+is+required. assertion.
- assertion asSentence Notch+signaling+can+modulate+the+FOXP3+promoter+through+RBP-J-+and+Hes1-dependent+mechanisms. assertion.
- assertion asSentence Notch+acts+when+commitment+to+a+ciliated+or+non-ciliated+cell+fate+occurs+in+proximal+progenitors%2C+silencing+the+ciliated+program+in+the+cells+that+will+continue+to+expand+and+differentiate+into+secretory+cells. assertion.
- assertion asSentence Numb+inhibits+Notch1+activity+by+regulating+post-endocytic+sorting+events+that+lead+to+Notch1+degradation. assertion.
- assertion asSentence miR-19+is+sufficient+to+promote+leukaemogenesis+in+Notch1-induced+T-cell+acute+lymphoblastic+leukaemia+in+vivo. assertion.
- assertion asSentence Notch1+signaling+protects+cells+from+PARP-+and+NF-kappaB-induced+apoptosis+under+high+glucose+through+the+activation+of+Akt. assertion.
- assertion asSentence Notch1+positively+regulates+IL-6+expression+via+NF-kappaB+in+activated+macrophages. assertion.
- assertion asSentence Extracellular+YB-1+associates+with+outer+cell+membrane+components+and+interacts+with+extracellular+Notch-3+receptor+domains. assertion.
- assertion asSentence That+the+increased+Notch3-IC+degradation+correlates+with+higher+levels+of+c-Cbl+tyrosine+phosphorylation+in+Notch3-IC%2FpTalpha%28-%2F-%29+double-mutant+thymocytes. assertion.
- assertion asSentence The+cellular+PrP%28Sc%29+content+decreases+upon+accumulation+of+cholesterol+in+late+endosomes%2C+as+induced+by+NPC-1+knock-down. assertion.
- assertion asSentence At+least+in+the+somatosensory+neocortex+NPC1+protein+is+instrumental+in+synaptic+function. assertion.
- assertion asSentence Nociceptin%2Fnociceptin+receptor+signaling+plays+a+role+in+the+disease+pathogenesis+of+inflammatory+bowel+diseases. assertion.
- assertion asSentence NPRA+is+involved+in+tumor+angiogenesis. assertion.