Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Npr1+gene+transcription%2C+an+important+regulator+in+the+control+of+hypertension+and+cardiovascular+events%2C+is+critically+controlled+by+histone+acetyltransferase+p300+and+Ets-1. assertion.
- assertion asSentence Binding+of+NF-Y+to+this+CCAAT-box+domain+is+responsible+for+the+basal+regulation+of+1B+isoforms+of+DMT1+mRNA. assertion.
- assertion asSentence Divalent+metal+transporter+1+%28DMT1%29+participates+in+inflammatory+lung+injury+after+bleomycin+with+DMT1+knockout+mice+having+increased+inflammation+and+damage+following+exposure. assertion.
- assertion asSentence Chronic+NRAP+overexpression+in+the+mouse+leads+to+right+ventricular+cardiomyopathy+by+10+months+of+age. assertion.
- assertion asSentence Both+beta-TrCP-+and+Hrd1-dependent+degradation+mechanisms+regulate+the+transcriptional+activity+of+Nrf1+to+maintain+cellular+homeostasis. assertion.
- assertion asSentence Brn-3c+is+capable+of+activating+both+BDNF+and+NT-3+promoters+in+inner+ear+sensory+epithelial+cell+lines. assertion.
- assertion asSentence Overexpression+of+nerve+growth+factor+%28NGF%29+in+brown+adipose+tissue+%28BAT%29+of+NGF-transgenic+mice+elevates+both+mRNA+and+protein+levels+of+vascular+endothelial+growth+factor+%28VEGF%29+and+VEGF-receptors. assertion.
- assertion asSentence A+reduction+in+NT-3+availability+during+development+impairs+motor+nerve+terminal+maturation+and+synaptic+vesicle+recycling+and+leads+to+a+reduction+in+muscle+fiber+diameter. assertion.
- assertion asSentence Neurotrophin-3+%28NT-3%29+regulates+the+development+of+physiological+properties+of+ON-OFF+center+RGCs. assertion.
- assertion asSentence The+absence+of+the+ligand+Netrin-1+leads+to+a+decrease+by+half+of+the+inferior+olivary+neuron+number+and+control+the+cell+migration. assertion.
- assertion asSentence Down-regulation+of+TrkA+also+occurs+in+the+cerebellum+of+SCA17+transgenic+mice+prior+to+Purkinje+cell+degeneration. assertion.
- assertion asSentence Neurotrophin+activation+of+Trk+stimulates+an+increase+in+VEGF+transcription+that+is+mediated+by+induction+of+HIF-1alpha. assertion.
- assertion asSentence Numb+and+Numblike+have+evolved+to+acquire+at+least+partially+distinct+functions. assertion.
- assertion asSentence The+mitochondria+are+the+major+site+for+OGG1+repair+activity+under+conditions+of+oxidative+stress. assertion.
- assertion asSentence Heparin+enhances+osteoclastic+bone+resorption+by+inhibiting+osteoprotegerin+activity. assertion.
- assertion asSentence The+NMDAR%2FnNOS+cascade%2C+activated+via+MORs%2C+provide+the+free+zinc+ions+required+for+inactive+PKCgamma+to+bind+to+HINT1%2FRGSZ+complex+at+the+C+terminus+of+the+receptor. assertion.
- assertion asSentence Otx2+is+an+essential+regulator+of+the+identity%2C+extent+and+fate+of+neuronal+progenitor+domains+in+the+ventral+midbrain. assertion.
- assertion asSentence Otx2+plays+a+functional+role+in+the+maturation+of+retinal+photoreceptor+and+bipolar+cells. assertion.
- assertion asSentence The+P2X1+receptor+contributes+to+the+formation+of+platelet+thrombi%2C+particularly+in+arteries+in+which+shear+forces+are+high. assertion.
- assertion asSentence ATP+release+and+autocrine%2C+positive+feedback+through+P2X%287%29+receptors+is+required+for+the+effective+activation+of+T+cells. assertion.
- assertion asSentence Purinergic+signaling+in+microglia+triggered+by+neuronal+ATP+modulates+excitotoxic+cortical+lesion+by+regulating+COX-1+dependent+prostanoid+production. assertion.
- assertion asSentence TLR4+priming+and+subsequent+stimulation+of+P2X7+led+to+synergistic+release+ofdocosahexaenoic+acid+%28DHA%29. assertion.
- assertion asSentence Both+endothelial+and+platelet+beta3+integrins+contribute+to+extracellular+PDI+binding+at+the+vascular+injury+site. assertion.
- assertion asSentence The+LCS+contributes+pyramidal+neurons+to+ventral+forebrain+structures+and+reveals+that+DCX+and+LIS1+have+important+functions+in+this+major+migratory+pathway+in+the+developing+forebrain. assertion.
- assertion asSentence Lis1+is+essential+for+precise+control+of+mitotic+spindle+orientation+in+both+neuroepithelial+stem+cells+and+radial+glial+progenitor+cells. assertion.
- assertion asSentence Pax3+is+required+for+cardiac+outflow+tract+septation+because+it+blocks+p53-dependent+processes+during+cardiac+neural+crest+migration. assertion.
- assertion asSentence PAX5+regulates+Csf1r+in+B+cells+by+reducing+the+frequency+of+binding+of+the+basal+transcription+machinery+to+the+promoter. assertion.
- assertion asSentence Pax6+regulates+the+timing+of+retinal+neurogenesis+and+couples+it+with+specific+neuron+differentiation+programs. assertion.
- assertion asSentence Photoreceptor+injury+induces+migration+of+PAX6-positive+Muller+cell+nuclei+toward+the+outer+part+of+the+INL+and+into+the+inner+part+of+the+outer+nuclear+layer.+and+express+cell+cycle+markers. assertion.
- assertion asSentence During+limb+development%2C+Pbx1+nuclear+expression+correlates+with+the+Meis+expression+domain. assertion.
- assertion asSentence PCAF+histone+acetylase+is+involved+lifelong+in+the+chromatin+remodeling+necessary+for+memory+formation+and+response+to+stress. assertion.
- assertion asSentence Gamma-linoleic+acid+positively+modulates+TR4+activity+to+promote+the+expression+of+downstream+genes+apolipoprotein+E+%28ApoE%29+and+phosphoenolpyruvate+carboxykinase. assertion.
- assertion asSentence The+Pcp2%28L7%29+protein+acts+as+a+sensorimotor+damper+that+modulates+time-+and+sense-dependent+changes+in+motor+responses. assertion.
- assertion asSentence CD4%28%2B%29PD-1%28high%29+T+cells+are+dysregulated+IFN-gamma-producing%2C+proinflammatory+cells+in+NZB%2FW+F1+mice. assertion.
- assertion asSentence PDE4D+and+PDE4B+have+specialized+functions+in+mouse+embryonic+fibroblasts+with+PDE4B+controlling+cAMP+in+a+discrete+subdomain+near+the+plasma+membrane. assertion.
- assertion asSentence In+high-fat-fed+apolipoprotein+E%28-%2F-%29+mice%2C+inhibition+of+PDGFRbeta+tyrosine+kinase+activity+leads+to+inhibition+of+GAG+synthesis+on+vascular+PGs+and+aortic+lipid+area. assertion.
- assertion asSentence Induced+expression+of+Pdx1+transcription+factor+in+combination+with+low+serum%2Fserum+replacement+concentrations+increases+endocrine+cell+differentiation+from+murine+embryonic+stem+cells. assertion.
- assertion asSentence JNK+activation+is+involved+in+PGE%282%29-induced+beta-cell+dysfunction+through+dephosphorylation+of+Akt+and+FOXO1%2C+leads+to+nuclear+accumulation+of+FOXO1+and+nucleocytoplasmic+shuttling+of+PDX1. assertion.
- assertion asSentence Phosphatidylethanolamine+N+-methyltransferase+%28PEMT%29+knockout+mice+do+not+display+normal+concentrations+of+choline+metabolites+even+with+a+supplemental+source+of+dietary+choline. assertion.
- assertion asSentence Lipopolysaccharide+exerts+a+time-dependent+inhibitory+effect+on+Per1+and+Per2+gene+expression+in+the+heart+and+liver. assertion.
- assertion asSentence mPER2+is+expressed+in+proliferating+neural+stem%2Fprogenitor+cells+%28NPCs%29+and+persists+in+early+post-mitotic+and+mature+newborn+neurons+from+the+adult+DG. assertion.
- assertion asSentence In+mice+lacking+middle-wavelength+cones%2C+induction+of+mPer1+and+mPer2+mRNAs+in+the+SCN+are+attenuated+in+response+to+light+exposures+of+mid+to+long+wavelengths. assertion.
- assertion asSentence NFAT1+mediates+PlGF-induced+myelomonocytic+cell+recruitment+via+the+induction+of+TNF-alpha. assertion.
- assertion asSentence Binding+of+PBX4%2C+plus+its+coactivator+PREP1%2C+is+a+rate-limiting+step+leading+to+the+initiation+of+tissue-specific+transcription+of+the+Pgk2+gene. assertion.
- assertion asSentence A+functional+link+between+SUMO-1+and+PR+is+of+physiological+importance+for+the+local+modulation+of+PR-mediated+events+in+the+ovary. assertion.
- assertion asSentence Mdr1a%2Fb+plays+a+role+in+irinotecan+and+SN-38+elimination. assertion.
- assertion asSentence Phosphorylation+of+GluR2+S880+and+NSF+and+PICK1+binding+to+GluR2+dynamically+regulate+GluR2+recycling. assertion.
- assertion asSentence Receptor+reappearance+is+time+and+dose+dependent%2C+being+more+delayed+in+cells+treated+with+50+ng%2Fml+%2848+h%29+compared+with+10+ng%2Fml+%2824+h%29. assertion.
- assertion asSentence PDGFRalpha+downstream+effectors%2C+especially+PI3K%2C+are+essential+for+cell+migration+of+a+somite-derived+dorsal+mesenchyme+and+disruption+of+receptor+signaling+in+these+cells+leads+to+spina+bifida. assertion.
- assertion asSentence The+activation+of+NF-kappaB+through+the+PI3K-PKC-reactive+oxygen+species+and+PI3K-Akt+pathways+is+required+for+the+Hb-induced+IDO+expression+in+bone+marrow+dendritic+cells. assertion.
- assertion asSentence TLR2-MyD88-dependent+signaling+enhances+the+basal+level+of+phagocytosis+of+Listeria+monocytogenes+by+macrophages+through+activation+of+PI3K+and+Rac1. assertion.
- assertion asSentence The+PI3K%2FAkt+signal+transduction+pathway+is+involved+in+the+regulation+and+release+of+pro-inflammatory+cytokines+such+as+TNF-alpha+and+plays+an+important+role+in+the+development+and+progression+of+ulcerative+colitis. assertion.
- assertion asSentence Activation+of+the+PI3K%2FAkt%2FeNOS+pathway+in+spinal+cord+injury+is+a+protective+event%2C+triggered+in+order+to+protect+the+injured+tissue+through+a+fine+tuning+of+the+endothelial+nitric+oxide+pathway. assertion.
- assertion asSentence PITX2+and+PITX1+have+overlapping+roles+in+thyrotroph+function+and+response+to+hypothyroidism. assertion.
- assertion asSentence Pitx2+functions+to+regulate+the+early+stages+of+vascular+smooth+muscle+cell+differentiation. assertion.
- assertion asSentence PITX2+and+PITX1+have+overlapping+roles+in+thyrotroph+function+and+response+to+hypothyroidism. assertion.
- assertion asSentence M2+pyruvate+kinase+is+a+metabolic+sensor+which+regulates+cell+proliferation%2C+cell+growth+and+apoptotic+cell+death+in+a+glucose+supply-dependent+manner. assertion.
- assertion asSentence PKA+phosphorylation+of+Kv4.2+plays+an+important+role+in+the+trafficking+of+Kv4.2+through+its+specific+interaction+with+KChIP4a. assertion.
- assertion asSentence IP6+represses+telomerase+activity+in+prostate+cancer+cells+by+posttranslational+modification+of+TERT+via+the+deactivation+of+Akt+and+PKCalpha. assertion.
- assertion asSentence Induction+of+the+endoplasmic+reticulum+stress+response+through+PKC+signaling+is+an+important+component+for+the+preparation+of+a+T+cell+response+to+antigen. assertion.
- assertion asSentence Flow+stimulates+net+O%282%29%28-%29+production+in+thick+ascending+limbs+via+PKC-alpha-mediated+activation+of+NADPH+oxidase. assertion.
- assertion asSentence Control+of+PKCalpha-induced+oxidative+burst+by+Leishmania+mexicana+lipophosphoglycan+relates+with+its+success+to+infect+murine+macrophages. assertion.
- assertion asSentence PKC-alpha+protects+against+ANG+II-induced+decreases+in+urine+concentrating+ability+by+maintaining+AQP2+levels+through+CREB+phosphorylation. assertion.
- assertion asSentence Protein+kinase+C+beta+is+a+key+mediator+of+insulin-mediated+activation+of+hepatic+SREBP-1c+and+its+target+lipogenic+genes. assertion.
- assertion asSentence At+least+delta+isoform+of+PKC+is+involved+in+MAPKs+activation+by+estrogen+in+C2C12+cells. assertion.
- assertion asSentence Protein+kinase+C+epsilon-mediated+phosphorylation+of+vimentin+is+a+key+process+in+integrin+traffic+through+the+cell. assertion.
- assertion asSentence In+Prkce%28-%2F-%29+mice%2C+conditioned+place+preference+and+self-administer+behaviors+are+associated+with+reduced+levels+of+alpha%286%29+and+beta%283%29+nicotinic+receptor+subunit+mRNA+in+the+ventral+midbrain+and+striatum. assertion.
- assertion asSentence Activation+of+PKCeta+by+PDK1+is+driven+by+atypical+PKClambda. assertion.
- assertion asSentence Vav1+and+PI3K+regulation+of+PLCgamma+contributes+to+the+activation+of+PKD+in+response+to+BCR+and+or+CD19+cross-linking. assertion.
- assertion asSentence PKC+zeta+participates+in+early+transcription+activation+in+1-cell+stage+fertilized+eggs. assertion.
- assertion asSentence Atypical+PKCzeta%2Fiota+isotypes+serve+as+direct+downstream+targets+of+PKCtheta+in+the+signalling+pathway+leading+to+NF-kappaB+activation+in+T+lymphocytes. assertion.
- assertion asSentence Membrane-bound+polycystin+1+has+a+central+role+in+regulating+morphogenic+protein+signaling+at+cell-matrix+interfaces+in+non-confluent+cells. assertion.
- assertion asSentence PC1+regulates+osteoblast+function+through+intracellular+calcium-dependent+control+of+Runx2-II+expression. assertion.
- assertion asSentence Polycystin-2+plays+a+role+in+centrosome+duplication. assertion.
- assertion asSentence PC-2+regulates+FSS-induced+MAP+kinase+trafficking+into+the+nucleus+of+CD+cells. assertion.
- assertion asSentence Nodal+flow+is+sensed+in+a+manner+dependent+on+Pkd2+by+the+cilia+of+crown+cells+located+at+the+edge+of+the+node. assertion.
- assertion asSentence Prep1+is+an+essential+gene+that+acts+upstream+of+and+within+a+Pbx-Meis+network+that+regulates+multiple+aspects+of+embryonic+development. assertion.
- assertion asSentence Over-expression+of+caveolin-1+aggravates+the+AT-1+injury+induced+by+LPS%2C+involving+in+modulation+of+the+cPLA2+mediated+by+the+cPLA2%2Fp38+MAPK+pathway. assertion.
- assertion asSentence SHP+inhibits+PAI-1+expression+in+VSMCs+through+the+suppression+of+TGF-beta%2FSmad3+and+AP-1+activity. assertion.
- assertion asSentence An+inhibitory+effect+toward+glycosylated+PAI-1+is+a+prerequisite+for+efficient+PAI-1+inhibition+in+mice. assertion.
- assertion asSentence An+additional+plasminogen+activator+provides+sufficient+plasmin+activity+to+sustain+the+healing+process+albeit+at+decreased+speed+in+the+absence+of+uPA%2C+tPA+and+galardin-sensitive+matrix+metalloproteinase+%28MMPs%29. assertion.
- assertion asSentence The+neuroprotective+effect+of+neuroserpin+is+due+to+inhibition+of+plasmin-mediated+excitotoxin-induced+cell+death+and+is+independent+of+neuroserpin%27s+ability+to+inhibit+tissue+plasminogen+activator+activity. assertion.
- assertion asSentence Phospholipase+C+delta%281%29+is+required+for+skin+stem+cell+lineage+commitment. assertion.
- assertion asSentence Receptor-triggered+phospholipase+C+activity+is+enhanced+by+positive+feedback+from+Ca2%2B+entering+the+cytoplasm+from+intracellular+stores+and+via+store-operated+channels+in+the+plasma+membrane. assertion.
- assertion asSentence Rapid+activation+of+the+TrkB+neurotrophin+receptor+and+PLCgamma1+signaling+is+a+common+mechanism+for+all+antidepressant+drugs. assertion.
- assertion asSentence The+Phospholipase+D2+%28PLD2%29-GTPase+Rac2+protein-protein+interaction+is+sufficient+for+the+guanine+nucleotide+exchange+factor+%28GEF%29+function. assertion.
- assertion asSentence alpha2-antiplasmin+is+a+critical+regulator+for+vascular+remodeling+by+inhibiting+p53%2Fp21+pathway. assertion.
- assertion asSentence Overexpression+of+the+C-terminal+domain+of+Plk+is+more+effective+than+wild-type+or+kinase-defective+Plk+in+causing+mitotic+delay+or+arrest. assertion.
- assertion asSentence Caffeine-induced+CaMKII+activation+and+phospholamban+phosphorylation+play+a+role+in+the+relaxation+of+gastric+fundus+smooth+muscles. assertion.
- assertion asSentence OSP%2Fclaudin-11+and+PLP+have+essential+structural+functions+in+maintaining+normal+compact+myelin+and+there+is+redundancy+in+their+functions. assertion.
- assertion asSentence PLTP+is+essential+in+mediating+the+association+of+triacyl+lipid+A+with+lipoproteins%2C+leading+to+extension+of+its+residence+time+and+to+magnification+of+its+proinflammatory+and+anticancer+properties. assertion.
- assertion asSentence PML+%28promyelocytic+leukemia%29interacts+with+Chk2+and+activates+Chk2+by+mediating+its+autophosphorylation+step. assertion.
- assertion asSentence RBMS3%2C+by+binding+Prx1+mRNA+in+a+sequence-specific+manner%2C+controls+Prx1+expression+and+indirectly+collagen+synthesis. assertion.
- assertion asSentence Astrocytes+are+unique+among+cell+types+of+neuroblast+origin+in+terms+of+expression+Pinin+protein. assertion.
- assertion asSentence Septin+5+is+a+core+molecular+substrate+that+differentiates+distinct+release+modalities+at+the+central+synapse. assertion.
- assertion asSentence Sept14+is+involved+in+neuronal+migration+in+cerebral+cortex+via+interaction+with+Sept4. assertion.
- assertion asSentence A+let-7+miRNA-loaded+RNA-induced+silencing+complex+interacts+with+the+poly%28A%29-binding+protein+and+the+CAF1+and+CCR4+deadenylases+for+miRNA+mediated+deadenylation. assertion.
- assertion asSentence OCA-B+is+required+for+pre-BCR+and+BCR+signaling+at+multiple+stages+of+B+cell+development+through+its+nontranscriptional+regulation+of+SYK. assertion.
- assertion asSentence Oct-6+normally+represses+Wnt1+expression+in+the+early+diencephalon+and+replacement+by+Brn-1+as+a+weaker+inhibitor+is+no+longer+sufficient+to+maintain+the+necessary+level+of+repression+in+the+mouse+mutant. assertion.
- assertion asSentence Pou4f1+is+regionally+enriched+in+the+Brainstem+%28Pons+and+Medulla%29+of+mouse+brain. assertion.