Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Livers+with+peroxisome+proliferator-activated+receptor+alpha+activation+are+transcriptionally+geared+towards+fatty+acid+combustion. assertion.
- assertion asSentence WAT+remodeling+is+an+adaptive+response+to+excessive+fatty+acid+mobilization+whereby+Ppara+and+its+downstream+targets+elevate+fatty+acid+catabolism. assertion.
- assertion asSentence Chronic+activation+of+PPARalpha+is+detrimental+to+the+cardiac+recovery+during+reperfusion+after+ischemia. assertion.
- assertion asSentence Marimastat+reduces+liver+triglyceride+accumulation+by+increasing+fat+oxidation+and%2For+liver+clearance+of+triglycerides. assertion.
- assertion asSentence PPARalpha+is+involved+in+entrainment+of+the+circadian+clock+to+environmental+LD+conditions. assertion.
- assertion asSentence Bezafibrate-induced+circadian+FGF21+expression+is+due+to+circadian+variations+in+the+responsiveness+of+the+PPARalpha+system+in+the+liver. assertion.
- assertion asSentence Endogenous+PPAR-alpha+ligands+reduce+the+degree+of+tight+junction+permeability+in+the+ileum+tissues+associated+with+immobilization+stress. assertion.
- assertion asSentence The+hypotriglyceridemic+effect+of+GW501516+in+HFD-fed+mice+is+accompanied+by+an+increase+in+phospho-AMPK+levels+and+the+amplification+of+the+PGC-1alpha-lipin+1-PPARalpha+pathway. assertion.
- assertion asSentence PPARalpha+acts+as+a+key+component+of+brown+fat+thermogenesis+by+coordinately+regulating+lipid+catabolism+and+thermogenic+gene+expression+via+induction+of+PGC-1alpha+and+PRDM16. assertion.
- assertion asSentence Upregulation+of+gene+expression+by+PPARbeta%2Fdelta+is+sensitive+to+plasma+free+fatty+acid+levels. assertion.
- assertion asSentence That+the+agouti%2Fmelanocortin+signaling+pathway+regulates+levels+of+peroxisome+proliferator+activated+receptor+gamma+in+adipocytes. assertion.
- assertion asSentence Peroxisome+proliferator-activated+receptor+gamma+2+deficiency+impairs+the+development+of+adipose+tissue+and+insulin+sensitivity. assertion.
- assertion asSentence PPARgamma+has+a+significant+role+in+the+expression+of+behavioral+sensitization+to+METH+in+mice. assertion.
- assertion asSentence Wnt3a+conditioned+medium+suppresses+C%2FEBPbeta%2Fdelta-induced+adipogenesis+of+3T3-L1+cells+by+inhibiting+PPARgamma+induction. assertion.
- assertion asSentence DAA+is+a+valuable+medicinal+and+food+component+for+improving+inflammatory+changes+associated+with+obesity-related+diabetes. assertion.
- assertion asSentence Dietary+fat+has+a+significant+influence+on+bone+mineral+density+that+is+dependent+on+the+alleles+present+for+the+PPARG+gene. assertion.
- assertion asSentence Vitamin+E+up-regulates+adiponectin+expression+via+a+mechanism+that+implicates+PPARgamma+together+with+its+endogenous+ligand+15-deoxy-Delta12%2C14-prostaglandin+J2. assertion.
- assertion asSentence Conjugated+linoleic+acid+ameliorates+colitis+and+prevents+tumor+formation+in+part+through+a+PPARgamma-dependent+mechanism. assertion.
- assertion asSentence PPARgamma+regulates+cholesterol+metabolism+in+alveolar+macrophages. assertion.
- assertion asSentence PPARgamma-sparing+thiazolidinediones+%28TZDs%29+are+effective+for+treatment+of+type+2+diabetes+with+reduced+risk+of+PPARgamma-mediated+side+effects. assertion.
- assertion asSentence SirT1-dependent+Ppargamma+deacetylation+promotes+browning+of+subcutaneous+white+adipose+by+regulating+ligand-dependent+coactivator%2Fcorepressor+exchange+at+the+Ppargamma+transcriptional+complex. assertion.
- assertion asSentence TORCs+play+a+key+role+in+linking+these+external+signals+to+the+transcriptional+program+of+adaptive+mitochondrial+biogenesis+by+activating+PGC-1alpha+gene+transcription. assertion.
- assertion asSentence PPARgamma1-positive+precursor+cells+for+osteoblasts+and+adipocytes+expressed+RANKL+and+supported+osteoclastogenesis. assertion.
- assertion asSentence Downregulation+of+Pparalpha+and+its+coactivators%2CPgc1alpha+and+Pgc1beta%2C+is+responsible+for+the+reduced+utilization+of+fatty+acids+in+liver+and+skeletal+muscle+and+the+reduced+thermogenesis+occurring+in+the+lactating+animal. assertion.
- assertion asSentence PGC-1alpha+is+required+for+complete+skeletal+muscle+adaptations+induced+by+endurance+exercise+in+mice. assertion.
- assertion asSentence Beta%281%29-+and+alpha%282%29-adrenoceptors+regulate+DARPP-32+phosphorylation+in+neostriatal+neurons. assertion.
- assertion asSentence PI3Kgamma+inhibits+protein+phosphatase+2A+at+the+beta-adrenergic+receptor+complex%2C+altering+G+protein+coupling. assertion.
- assertion asSentence SKIP+regulates+insulin+signaling+in+skeletal+muscle. assertion.
- assertion asSentence Inpp5k+5-phosphatase+is+important+for+the+control+of+the+arginine+vasopressin%2Faquaporin-2+signalling+pathway+and+water+transport+in+kidney+collecting+ducts. assertion.
- assertion asSentence Mouse+R1beta+gene+produces+three+alternative+splice+variants+%28designated+as+mR1beta1%2C+mR1beta2+and+mR1beta3%29+that+have+different+N-terminal+protein+structures. assertion.
- assertion asSentence Chronic+elevation+of+cGMP%2C+as+seen+in+inflammatory+conditions%2C+triggers+ubiquitination+and+degradation+of+PKG-Ialpha+in+smooth+muscle. assertion.
- assertion asSentence JIP-2+and+-2+proteins+can+influence+insulin-stimulated+signal+transduction+mediated+by+insulin+receptor+substrate+proteins. assertion.
- assertion asSentence PKR+is+a+signaling+molecule+for+immune+responses+during+Respiratory+syncytial+virus+infections. assertion.
- assertion asSentence The+prion+protein+%28PrP%29+does+not+play+a+direct+role+in+copper+utilization+in+yeast. assertion.
- assertion asSentence The+simultaneous+presence+of+the+spectral+components+for+V160R1+is+strongly+correlated+with+the+coexistence+of+multiple+protein+conformations+in+local+structure+of+prion+protein+PrPC+over+a+varied+pH+range. assertion.
- assertion asSentence Prion+protein+expression+has+a+homeostatic+role+in+copper+metabolism. assertion.
- assertion asSentence PrP%28C%29+and+STI1+are+essential+to+astrocyte+development+and+act+through+distinct+signaling+pathways. assertion.
- assertion asSentence The+cellular+PrP%28Sc%29+content+decreases+upon+accumulation+of+cholesterol+in+late+endosomes%2C+as+induced+by+NPC-1+knock-down. assertion.
- assertion asSentence After+spinal+cord+injury+there+is+an+overall+improved+recovery+in+PrP-%2F-+mice+compared+with+their+PrP%2B%2F%2B+littermates. assertion.
- assertion asSentence Mutant+PrP+aggregation+and+intracellular+retention+are+closely+related+and+depend+critically+on+the+integrity+of+the+hydrophobic+core. assertion.
- assertion asSentence PrP%28C%29+is+abundant+in+the+nuclear+lamina+of+endocrine+and+neuronal+cells+and+interacts+with+histone+H1%280%29%2C+histone+H3+and+lamin+B1. assertion.
- assertion asSentence Activated+protein+C+generation+and+function+can+be+modulated+by+changes+in+phospholipid+occupancy+of+its+endothelial+cell+receptor. assertion.
- assertion asSentence Epithin+plays+an+important+role+in+the+compaction+processes+that+elicit+the+signal+for+the+differentiation+into+trophectoderm+and+inner+cell+mass. assertion.
- assertion asSentence Prosaposin+plays+an+important+role+in+the+neuronal+maturation+processes+of+the+vestibular+sensory+epithelium+and+the+maintenance+of+normal+vestibular+system+function. assertion.
- assertion asSentence CYTIP+and+cytoadhesin-1+are+upregulated+during+dendritic+cell+maturation. assertion.
- assertion asSentence PS+1+plays+an+important+role+in+growth+cone+structure+by+stabilizing+the+integrity+of+the+cytoskeleton. assertion.
- assertion asSentence Peripheral+immune+system+dysfunction+associated+with+an+delta-E9+mhPS1+allele+exacerbates+cerebral+amyloidosis+by+impacting+brain+A-beta+clearance. assertion.
- assertion asSentence A+prolonged%2C+substantially+elevated+level+of+Abeta+are+not+sufficient+to+cause+deficits+in+the+induction+or+expression+of+long-term+potentiation+in+the+CA1+hippocampal+region. assertion.
- assertion asSentence Erbb4+signaling+in+fetal+lung+type+II+cells+utilizes+the+pathway+of+the+PSEN-1-dependent+gamma-secretase+proteolysis%2C+followed+by+trafficking+with+YAP+to+the+nucleus. assertion.
- assertion asSentence Presenilins+1+and+2+are+highly+enriched+in+a+subcompartment+of+the+endoplasmic+reticulum+associated+with+mitochondria+that+forms+a+physical+bridge+between+the+two+organelles. assertion.
- assertion asSentence TNF-alpha+expression+is+primarily+dependent+on+both+the+chymotrypsin-and+the+trypsin-like+activities+of+X%2C+Y%2C+Z+subunits+%28PSMB5%2C+PSMB6%2C+PSMB7%29+of+the+proteasome. assertion.
- assertion asSentence PAFr+plays+an+important+role+in+hypersusceptibility+to+pneumococcal+infection+in+sickle+cell+disease. assertion.
- assertion asSentence The+patched1+and+the+pacrg-parkin-qkI+loci+genetically+interact+to+regulate+cilia+function+of+the+ependymal+cells. assertion.
- assertion asSentence PTEN+negatively+regulates+neural+stem+cell+proliferation. assertion.
- assertion asSentence PTEN+modulates+Mdm2+transcription+and+isoform+selection+by+negatively+regulating+its+P1+promoter. assertion.
- assertion asSentence C-Jun+contributes+to+the+promotion+of+cellular+survival+by+regulating+the+expression+of+PTEN. assertion.
- assertion asSentence Peroxynitrite-mediated+PTEN+upregulation+plays+an+important+role+in+cytokine-induced+pancreatic+beta-cell+apoptosis. assertion.
- assertion asSentence ROS-activated+PI3K+potentiates+age-related+macular+degeneration-related+retinal+pigment+epithelium+pathogenesis+through+phosphorylation%2Finactivation+of+PTEN. assertion.
- assertion asSentence PTF1+is+an+important+early+activator+of+Pdx1+in+acinar+and+endocrine+progenitor+cells+during+pancreas+development. assertion.
- assertion asSentence L-PGDS+is+beneficial+for+protecting+the+brain+against+transient+and+permanent+cerebral+ischemia. assertion.
- assertion asSentence The+backbone+conformation+of+the+bottom+region+of+mouse+lipocalin-type+prostaglandin+D+synthase+is+still+maintained+in+the+intermediate+state. assertion.
- assertion asSentence E+prostanoid+receptor+2+%28EP2%29-deficient+%28EP2%28-%2F-%29%29+macrophages+exhibited+enhanced+in+vitro+maturation+compared+with+wild-type+cells. assertion.
- assertion asSentence Genetic+background+significantly+modifies+the+blood+pressure+response+to+mPGES1+deficiency. assertion.
- assertion asSentence Both+cyclooxygenase-1+and+-2+isoforms+are+involved+in+the+negative+modulation+of+adipocyte+differentiation. assertion.
- assertion asSentence The+COX-2%2Fmicrosomal+prostaglandin+E+synthase-1+pathway+contributes+to+the+Helicobacter-associated+gastric+tumorigenesis. assertion.
- assertion asSentence COX-2+activity+confers+endothelium-dependent+vasodilatory+function+in+aged+DL+mice+in+the+face+of+a+pro-oxidative+environment. assertion.
- assertion asSentence Mycobacterial+pulmonary+inflammation+is+associated+with+suppressed+PGE%282%29+production+by+alveolar+macrophages. assertion.
- assertion asSentence The+cyclooxygenase+activity+of+COX-2+is+necessary+to+exacerbate+neuronal+hypoxia%2Fischemia+injury+rather+than+the+peroxidase+activity+of+the+enzyme. assertion.
- assertion asSentence COX-2+suppression+by+PGK-1+is+independent+of+its+catalytic+activity. assertion.
- assertion asSentence ADAMTS-7%2C+a+direct+target+of+PTHrP+signaling%2C+negatively+regulates+endochondral+bone+formation+by+associating+with+and+inactivating+GEP+chondrogenic+growth+factor. assertion.
- assertion asSentence Via+interaction+with+MyD88%2C+PYK2+is+involved+in+modulating+cytokine+stimulation+of+NF-kappaB+activity+and+signaling. assertion.
- assertion asSentence Influence+of+CNTF+family+of+cytokines+on+the+differentiation+of+late+retinal+progenitor+cell+population+is+partially+mediated+by+the+release+of+Ptn. assertion.
- assertion asSentence Protein-tyrosine+phosphatase+%28PTP%29-1B+is+an+essential+positive+regulator+of+the+initiation+of+outside-in+alphaIIbbeta3+integrin+signaling+in+platelets. assertion.
- assertion asSentence PLCgamma1+has+a+key+function+in+the+regulation+of+growth+hormone-mediated+signalling+by+negatively+regulating+Jak2+activation. assertion.
- assertion asSentence At+least+1+copy+of+tcptp+or+ptp1b+is+required+for+normal+embryonic+development. assertion.
- assertion asSentence Shp2+is+required+for+FGF4-evoked+activation+of+the+Src%2FRas%2FErk+pathway+that+culminates+in+phosphorylation+and+destabilization+of+the+proapoptotic+protein+Bim. assertion.
- assertion asSentence SHP2-mediated+tyrosine+dephosphorylation+is+an+important+step+in+Sema4D-induced+axon+repulsion. assertion.
- assertion asSentence Mkp1+KO+mice+displayed+delayed+differentiation+and+reduced+expressions+of+osteocalcin+%28OCN%29+and+Runx2+genes+associated+with+osteoblast+maturation+and+function. assertion.
- assertion asSentence ZFP36L1+and+ZFP36L2+bound+to+the+3%27+untranslated+region+%28UTR%29+of+MAPK+phosphatase-1+%28MKP-1%29+mRNA+and+downregulated+Mkp-1+3%27UTR-mediated+luciferase+activity. assertion.
- assertion asSentence Tyrosine+phosphorylation+of+SIRPalpha+is+an+immediate+response+of+neurons+in+the+brain+to+cold+stress. assertion.
- assertion asSentence RPTPalpha+is+required+for+rigidity-dependent+reinforcement+of+fibronectin+%28FN%29-cytoskeleton+bonds+and+the+rigidity+response+in+hippocampal+neuron+growth+cones. assertion.
- assertion asSentence RPTPsigma+limits+synapse+number+and+regulates+synapse+structure+and+function+in+the+mature+central+nervous+system. assertion.
- assertion asSentence PTX3+is+a+structural+constituent+of+the+cumulus+oophorus+extracellular+matrix+essential+for+female+fertility. assertion.
- assertion asSentence The+absence+of+the+parvalbumin+disrupts+the+regulation+of+Purkinje+cell+firing+rate+and+rhythmicity. assertion.
- assertion asSentence In+huntingtin-null+embryonic+stem+cells%2C+the+levels+of+Rab11+on+membranes+and+nucleotide+exchange+activity+on+Rab11+are+significantly+reduced+compared+with+normal+embryonic+stem+cells. assertion.
- assertion asSentence Rab3D+modulates+a+post-trans-Golgi+network+trafficking+step+that+is+required+for+osteoclastic+bone+resorption. assertion.
- assertion asSentence The+activation+of+Rac1+is+involved+in+the+enhancement+of+integrin-mediated+adhesion+induced+by+E-cadherin+expression. assertion.
- assertion asSentence Rad1%28K185%29+is+not+a+functional+counterpart+of+PCNA%28K164%29. assertion.
- assertion asSentence RAD52+cooperates+with+OGG1+to+repair+oxidative+DNA+damage+and+enhances+the+cellular+resistance+to+oxidative+stress. assertion.
- assertion asSentence Rad9+plays+dual+roles+in+generating+functional+antibodies+and+in+maintaining+the+integrity+of+the+whole+genome+in+B+cells. assertion.
- assertion asSentence Negative+regulatory+function+of+the+noncore+regions+of+RAG1%2F2+limits+the+RAG+endonuclease+activity+in+the+absence+of+an+activating+methylated+histone+tail+bound+to+the+complex. assertion.
- assertion asSentence Ras-GRF1+and+Ras-GRF2+couple+NMDA+glutamate+receptors+to+the+activation+of+the+Ras%2FErk+signaling+cascade+and+to+the+maintenance+of+CREB+transcription+factor+activity+in+cortical+neurons+of+adult+mice. assertion.
- assertion asSentence The+pRb-dependent+accumulation+of+cyclin+D3+is+functionally+relevant+to+the+process+of+skeletal+muscle+cell+differentiation. assertion.
- assertion asSentence Gadd45b+mediates+p38-induced+Rb+phosphorylation+by+enhancing+the+interaction+between+p38+and+Rb+during+Fas-induced+apoptosis+in+murine+hepatocytes. assertion.
- assertion asSentence The+gooseberry%2Fgooseberry-neuro+%28gsb%2Fgsb-n%29+transcription+factor+genes+act+to+specify+MP3+cell+fate. assertion.
- assertion asSentence p27+carries+out+overlapping+functions+with+p107+in+controlling+cell+cycle+exit+during+chondrocyte+maturation. assertion.
- assertion asSentence While+vitamin+A-replete+retinol+binding+protein+%28rbp%29-cryptochrome%28cry%29+1-+and+2-knockout+mice+are+light+responsive%2C+vitamin+A-depleted+knockout+mice+lose+most+behavioral+and+molecular+responses+to+light. assertion.
- assertion asSentence IRBP+is+essential+to+normal+cone+function+and+demonstrate+that+IRBP+has+a+cone-specific+visual+cycle+function. assertion.
- assertion asSentence Rbpj-mediated+canonical+Notch+signaling+inhibits+DRG+neuronal+differentiation. assertion.
- assertion asSentence While+CD43+binding+to+ezrin-radixin-moesin+proteins+is+crucial+for+S76+phosphorylation%2C+CD43+movement+and+regulation+of+T-cell+migration+can+occur+through+an+ERM-independent%2C+phosphorylation-dependent+mechanism. assertion.