Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+C742T+mutation+of+the+alpha1%2C+3+N-acetyl-D-galactosaminyl-transferase+gene+can+lead+to+A2+phenotype+and+with+anti-A1+antibody+in+serum. assertion.
- assertion asSentence The+interaction+between+BRCA1+and+acetyl-CoA-carboxylase+is+regulated+during+cell+cycle+progression. assertion.
- assertion asSentence Human+cytomegalovirus+infection+induces+an+increase+in+ACC1+mRNA+and+protein+expression. assertion.
- assertion asSentence Human+adipose+tissue%2C+unlike+rodent+adipose%2C+expresses+more+ACC2+mRNA+relative+to+the+oxidative+tissues+muscle+and+heart. assertion.
- assertion asSentence ACACB+overexpression+in+renal+proximal+tubular+epithelial+cell+increased+proinflammatory+cytokine+expression%2C+such+as+IL-6%2C+at+least+partly+by+increasing+mRNA+stability+through+a+p38+MAPK-dependent+pathway. assertion.
- assertion asSentence Structure-guided+inhibitor+design+for+human+acetyl-coenzyme+A+carboxylase+by+interspecies+active+site+conversion. assertion.
- assertion asSentence Protein+misfolding+of+MCAD+protein+is+the+molecular+basis+in+medium-chain+acyl-CoA+dehydrogenase+deficiency. assertion.
- assertion asSentence RNA+secondary+structures+located+in+the+vicinity+of+the+GGC%281274-1276%29+codon+are+required+for+production+of+the+56-kDa+isoform. assertion.
- assertion asSentence High+ACAT1+expression+is+associated+with+estrogen+receptor+negative+basal-like+breast+cancer. assertion.
- assertion asSentence Modified+AChE+gene+expression+and+properties+are+causally+involved+in+thymic+function+and+development. assertion.
- assertion asSentence Combination+of+obidoxime+and+HI6+reactivated+AChE+inhibited+by+a+range+of+cholinesterase+inhibitors. assertion.
- assertion asSentence Overexpression+of+mutant+hyperphosphorylated+tau+%28P-tau%29+leads+to+an+increase+in+activity+of+AChE+in+the+brain+of+transgenic+mice. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+ACO1+gene+is+associated+with+cutaneous+malignant+melanoma. assertion.
- assertion asSentence DNA+immunization+against+proacrosin+impairs+fertility+in+male+mice. assertion.
- assertion asSentence In+overweight+women+%28BMI+%3E+25%29%2C+the+proportion+of+low+activity+ACP1+phenotypes+is+much+lower+in+type+1+diabetes+than+in+gestational+diabetes+and+in+healthy+females. assertion.
- assertion asSentence TRACP+5b+activity+and+its+interval+change+after+treatment+bore+a+prognostic+role+in+breast+cancer+patients+with+bone+metastasis+and+a+high+baseline+serum+TRACP+5b+activity. assertion.
- assertion asSentence Missense+mutations+of+ACTA1+cause+an+autosomal+dominant+congenital+myopathy+with+cores. assertion.
- assertion asSentence Over-expression+of+Nkx2.5+and%2For+cardiac+alpha-actin+inhibit+the+contraction+ability+of+adipose+tissue-derived+stromal+cells-derived+cardiomyocytes. assertion.
- assertion asSentence Actin+accumulates+throughout+the+activated+immunological+synapse. assertion.
- assertion asSentence Platelets+gal-1+forms+an+intracellular+complex+with+monomeric+actin. assertion.
- assertion asSentence Alpha-SMA+metabolism+in+basal+cell+carcinoma+is+associated+with+a+more+aggressive+behaviour+of+this+tumor. assertion.
- assertion asSentence Beta-actin+localizes+to+an+active+U6+promoter+in+RNA+polymerase+III+%28pol+III%29+and+is+essential+for+basal+pol+III+transcription. assertion.
- assertion asSentence Variations+in+ACTC1+is+associated+with+refractive+errors+and+myopia. assertion.
- assertion asSentence Alpha-actinin-4+is+important+for+the+NF-kappaB+nuclear+translocation+and+its+functions+inside+the+nucleus. assertion.
- assertion asSentence Heterozygous+mutations+in+the+promoters+of+the+ACTN4+and+SYNPO+genes+are+found+in+patients+with+idiopathic+focal+segmental+glomerulosclerosis. assertion.
- assertion asSentence Epothilone+B+antagonizes+glioma+cell+motility+associated+with+reorganization+of+the+actin-binding+protein+alpha-actinin+4. assertion.
- assertion asSentence ACTN3+R577X+polymorphism+is+associated+with+preferred+racing+distance+in+speed+skaters+and+muscle+fibre+type+composition. assertion.
- assertion asSentence Inhibin+alpha-subunit+N+terminus+interacts+with+activin+type+IB+receptor+to+disrupt+activin+signaling. assertion.
- assertion asSentence Mutation+in+activin+type+II+receptor+is+associated+with+colorectal+cancer. assertion.
- assertion asSentence Inhibition+of+negative+regulators+of+skeletal+muscle+by+a+soluble+form+of+activin+type+IIB+receptor+%28ACE-031%29+increases+muscle+mass+independent+of+fiber-type+expression. assertion.
- assertion asSentence Mutation+found+in+40%25+of+hereditary+hemorrhagic+telangiectasia+patients. assertion.
- assertion asSentence Genetic+and+pharmacological+targeting+of+activin+receptor-like+kinase+1+impairs+tumor+growth+and+angiogenesis. assertion.
- assertion asSentence Genetic+deficiency+of+ACY1+leads+to+functional+ACY1+deficiency+and+excretion+of+N-acetylated+amino+acids. assertion.
- assertion asSentence The+measurement+of+adenosine+deaminase+activity+in+ascites+represents+a+diagnostic+advance+in+tuberculous+peritonitis+among+end-stage+renal+failure+patients. assertion.
- assertion asSentence ADA+is+a+relevant+modulator+of+CD4%2B+T+cell+differentiation%2C+even+in+cells+from+immunologically+compromised+individuals. assertion.
- assertion asSentence ADAM8+and+EGFR+are+overexpressed+in+non-small+cell+lung+cancer. assertion.
- assertion asSentence APH-1+plays+a+GXXXG-dependent+scaffolding+role+in+both+the+initial+assembly+and+subsequent+maturation+and+maintenance+of+the+active+gamma-secretase+complex. assertion.
- assertion asSentence ADAM10+is+the+protease+responsible+for+constitutive+and+regulated+Pcdh+gamma+shedding+events+that+modulate+the+cell+adhesion+role+of+Pcdh+gamma. assertion.
- assertion asSentence Translational+repression+of+the+disintegrin+and+metalloprotease+ADAM10+by+a+stable+G-quadruplex+secondary+structure+in+its+5%27-untranslated+region. assertion.
- assertion asSentence ADAR1+mRNA+is+expressed+broadly+in+larynx+carcinoma. assertion.
- assertion asSentence Distinct+mechanisms+of+regulation+by+Ca2%2B%2Fcalmodulin+of+type+1+and+8+adenylyl+cyclases+support+their+different+physiological+roles. assertion.
- assertion asSentence Adenylyl+cyclase+V+and+adenylyl+cyclase+VI+interacts+with+A-kinase+anchoring+protein+79+%28AKAP79%29+in+a+complex+that+associates+with+protein+kinase+A+forming+a+negative+feedback+loop+that+termporally+regulates+cAMP+production. assertion.
- assertion asSentence Expression+of+a+novel%2C+relatively+common+variant+of+ADCY6+parallels+an+increase+in+adenylyl+cyclase+activity+and+adenylyl+cyclase-mediated+function+in+humans. assertion.
- assertion asSentence AC6+localizes+in+lipid+raft+fractions+of+bronchial+airway+smooth+muscle+where+it+is+stimulated+by+beta2+adrenergic-+and+prostacyclin+receptors+and+inhibited+by+divalent+calcium+ions. assertion.
- assertion asSentence The+PACAP%2C+through+PAC1%2C+is+a+potent+mediator+of+adult+neural+stem+cell+proliferation. assertion.
- assertion asSentence PACAP+receptor+type+1+mRNA+is+expressed+in+the+trigeminal%2C+otic+and+superior+cervical+ganglia+%28prejunctional%29+and+cerebral+arteries+%28postjunctional%29. assertion.
- assertion asSentence VPAC2+and%2For+PAC1+receptor+activation+is+involved+in+cutaneous+active+vasodilation+in+humans. assertion.
- assertion asSentence The+Gly460Trp+polymorphism+of+ADD-1+is+associated+with+low+renin+hypertension. assertion.
- assertion asSentence Alpha-adducin+Gly460Trp+polymorphism%2C+in+combination+with+systolic+blood+pressure%2C+is+a+strong+predictor+of+cardiovascular+mortality+and+morbidity. assertion.
- assertion asSentence Physiological+interaction+between+the+ADD1+and+WNK1-NEDD4L+pathways+influences+the+effects+of+variants+in+these+genes+on+sodium-related+BP+regulation. assertion.
- assertion asSentence Genetic+variration+in+alpha+adducion+alter+renal+function+and%2For+vasoreactivity+are+logical+candidates+to+explain+some+of+the+individual+variability+in+the+blood+pressure+response+to+exercise. assertion.
- assertion asSentence Phosphorylation+of+beta-adducin+by+GSK3+promotes+efficient+neurite+outgrowth+in+neurons. assertion.
- assertion asSentence Left+ventricular+diastolic+relaxation+is+modulated+by+genetic+variation+in+ADD3. assertion.
- assertion asSentence There+is+no+significant+interaction+between+alcohol+consumption+and+ADH2+genotype. assertion.
- assertion asSentence Single+Nucleotide+Polymorphism+in+ADH1B+gene+is+associated+with+upper+aerodigestive+cancer. assertion.
- assertion asSentence Genetic+polymorphism+of+the+gene+is+substantially+involving+in+individual+variation+of+susceptibility+to+alcohol+dependence. assertion.
- assertion asSentence ADH1B+polymorphisms+are+associated+with+alcohol+and+tobacco+consumption+for+younger+aged+esophageal+squamous+cell+carcinoma. assertion.
- assertion asSentence rs1229984+in+ADH1B+is+associated+with+prenatal+reduced+alcohol+consumption+over+the+life-course. assertion.
- assertion asSentence Japanese+males+bearing+alcoholism-susceptible+homozygotes+at+both+inactive+ADH1B+Arg%2FArg+and+active+ALDH2+Glu%2FGlu+genotypes+have+a+10+times+greater+risk+for+suicide+compared+with+the+males+bearing+alcoholism-protective+homozygotes+at+both+loci. assertion.
- assertion asSentence There+is+no+significant+interaction+between+alcohol+consumption+and+ADH3+genotype. assertion.
- assertion asSentence ADH1C%2A2+allele%2C+related+to+slower+oxidation+rate%2C+attenuates+the+lower+diabetes+risk+among+moderate+to+heavy+drinkers. assertion.
- assertion asSentence Subjects+with+ADH1C%2A1%2F%2A1+and+CYP2E1%2Ac1%2F%2Ac2+genotypes+become+alcohol+dependent+at+a+considerably+younger+age+than+the+subjects+with+ADH1C%2A1%2F%2A2%2C+ADH1C%2A2%2F%2A2+and+CYP2E1%2Ac1%2F%2Ac1+genotypes. assertion.
- assertion asSentence POZ+domain+of+FBI1+represses+transcription+of+ADH5. assertion.
- assertion asSentence The+catalytic+properties%2C+gene+expression+and+protein+levels+of+certain+proteins+involved+in+mitochondrial+ATP+synthesis%2C+such+as+F1F0-ATPase%2C+ANT+and+AK%2C+in+human+skin+fibroblasts+with+trisomic+karyotype%2C+compared+them+with+euploid+fibroblasts. assertion.
- assertion asSentence Existence+of+the+19-repeat+allele+is+associated+with+genetic+predispositions+to+develop+essential+hypertension+and+diabetic+nephropathy. assertion.
- assertion asSentence Adrenomedullin+production+is+decreased+in+preeclampsia. assertion.
- assertion asSentence Both+luteinized+granulosa+cells+and+macrophages+actively+secrete+VEGF+and+adrenomedullin+into+follicular+fluid+in+the+human+ovary. assertion.
- assertion asSentence AM+plays+role+in+controlling+lymphatic+endothelial+permeability+and+lymphatic+flow+through+reorganization+of+junctional+proteins. assertion.
- assertion asSentence Human+adrenomedullin+up-regulates+interleukin-13+receptor+alpha2+chain+in+prostate+cancer+in+vitro+and+in+vivo. assertion.
- assertion asSentence Structure+of+micelle-bound+adrenomedullin. assertion.
- assertion asSentence PARP+immunoreactivity+is+increased+3-fold+in+spinal+cord+tissues+of+sporadic+amyotrophic+lateral+sclerosis+%28sALS%29+patients+compared+with+non-neurological+disease+controls%2C+demonstrating+a+role+of+glial+alterations+in+sALS+pathogenesis. assertion.
- assertion asSentence Upregulated+by+cetrorelix+in+cultured+leiomyoma+cells. assertion.
- assertion asSentence PARP-1+functions+both+as+a+structural+component+of+chromatin+and+a+modulator+of+chromatin+structure+through+its+intrinsic+enzymatic+activity. assertion.
- assertion asSentence The+specific+inhibition+of+Aurora-B+kinase+activity+by+PARP-1+contributes+to+the+physiological+response+to+DNA+damage. assertion.
- assertion asSentence Upon+heat+shock%2C+the+Hsp70.1+promoter-bound+PARP-1+is+released+to+activate+transcription+through+ADP-ribosylation+of+other+Hsp70.1+promoter-bound+proteins. assertion.
- assertion asSentence During+conditions+of+oxidative+stress+in+lymphocytes%2C+TRPM2+acts+as+a+downstream+effector+of+the+PARP%2Fpoly%28ADP-ribose%29+glycohydrolase+pathway+through+PARP-dependent+formation+of+ADP-ribose. assertion.
- assertion asSentence Low+concentration+of+arsenite+exacerbates+UVR-induced+DNA+strand+breaks+by+inhibiting+PARP-1+activity. assertion.
- assertion asSentence This+variant+can+interact+with+ADPRT-762Ala+variant+to+further+substantially+increase+susceptibility+to+the+disease+and+regional+LN+metastasis. assertion.
- assertion asSentence Poly%28ADP-ribose%29+polymerase-1+positively+regulates+micro+opioid+receptor+%28MOR%29+gene+transcription+via+G-172+T. assertion.
- assertion asSentence The+N-terminal+GzmA+cleavage+fragment+of+PARP-1+acts+as+a+PARP-1+dominant+negative%2C+binding+to+DNA+and+blocking+DNA+repair. assertion.
- assertion asSentence PARP1+differentially+influences+DNA+synthesis+in+SP-+and+LP+BER+pathways. assertion.
- assertion asSentence PARP1+and+telomeric+repeat+binding+factor+%28TRF%291+are+overexpressed+in+muscle+from+Duchenne+muscular+dystrophy+patients. assertion.
- assertion asSentence The+difference+between+a+long-lived+and+a+short-lived+species+tested%2C+man+and+rat%2C+is+directly+mirrored+by+the+enzymatic+parameters+of+recombinant+PARP-1. assertion.
- assertion asSentence The+PARP-1+BRCT+domain+has+a+specialized+role+in+assembling+mutagenic+DNA+repair+complexes+involved+in+antibody+diversification. assertion.
- assertion asSentence The+rate-limiting+factor+in+poly%28ADP-ribose%29-mediated+proteasomal+activation+in+oxidative+stress+is+PARP-1+and+not+the+nuclear+proteasome+itself. assertion.
- assertion asSentence Both+chemical+inhibition+of+PARP1+and+PARP1+depletion+using+small+hairpin+RNA+enhance+integration+of+the+Adeno-associated+virus+type+2+genome+in+HeLa+cells. assertion.
- assertion asSentence PARP-1+suppressed+MMP9+expression+in+undifferentiated%2C+non-apoptotic+keratinocytes. assertion.
- assertion asSentence OGG1+binding+to+PARP-1+plays+a+functional+role+in+the+repair+of+oxidative+DNA+damage. assertion.
- assertion asSentence PARP-1+Val762Ala+polymorphism+is+associated+with+risk+of+cervical+carcinoma. assertion.
- assertion asSentence Administration+of+an+alpha-1A-specific+blocker+reduced+analgesic+dosage+and+colic+episodes+after+shock+wave+lithotripsy+of+lower+ureteral+stones. assertion.
- assertion asSentence Presence+of+the+Arg347+allele+in+the+ADRA1A+gene+is+a+risk+factor+for+occurrence+of+more+severe+metabolic+abnormalities+in+patients+with+schizophrenia. assertion.
- assertion asSentence Middle-aged+white+men+carrying+the+DD+genotype+of+the+alpha%282B%29-AR+have+a+significantly+increased+risk+for+sudden+cardiac+death+and+myocardial+infarction%2C+especially+before+the+age+of+55+years. assertion.
- assertion asSentence Homozygote+for+insertion+%5BI%5D%2Fdeletion+allele+of+alpha%282B%29-AR+gene+polymorphism+is+associated+with+silent+myocardial+ischemia+in+type+2+diabetes+mellitus+patients+with+coronary+artery+disease. assertion.
- assertion asSentence In+cardiomyocytes+derived+from+embryonic+stem+cells%2C+beta%281%29-+and+beta%282%29-adrenoceptors+contributed+to+contractile+responses. assertion.
- assertion asSentence Significant+correlation+between+beta1-AR+and+G-protein-coupled+receptor+kinases+expression+in+heart+failure+heart+transplantation+patients. assertion.
- assertion asSentence Insulin+and+beta-adrenergic+agonists+stimulate+a+rapid+phosphorylation+and+sequestration+of+the+beta2-adrenergic+receptors+%28beta2ARs%29. assertion.
- assertion asSentence Dual+regulation+on+hbeta2AR+trafficking+and+signaling+by+NSF+through+direct+binding+to+cargo+receptor+and+its+ATPase+activity. assertion.
- assertion asSentence Association+between+polymorphisms+in+the+beta2-adrenergic+receptor+gene+with+myocardial+infarction+and+ischaemic+stroke+in+women. assertion.
- assertion asSentence ADRB2+Gln27Glu+polymorphism+has+a+modulating+effect+on+diet-induced+changes+on+body+weight+and+body+composition. assertion.
- assertion asSentence The+haplotypes+of+ADRB2+consisting+of+the+SNP%2C+46A%2FG+and+79C%2FG%2C+have+a+greater+power+for+predicting+high-altitude+pulmonary+oedema. assertion.