Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Tight+control+of+IkappaBbeta+protein+by+p65+is+necessary+for+the+maintenance+of+cellular+homeostasis. assertion.
- assertion asSentence TAK1+and+MKK6+constitute+the+p38+signalling+pathway+to+participate+to+Oc+differentiation+by+RANKL+through+p65+phosphorylation+and+NFATc1+induction. assertion.
- assertion asSentence NF-kappaB%2FRel+transcription+factors+act+as+pivotal+regulators+of+activity-dependent+inhibitory+and+excitatory+neuronal+function+regulating+synaptic+plasticity+and+memory. assertion.
- assertion asSentence Functional+cooperation+of+NFAT1+and+NF-kappaB+%28p65%29+synergistically+enhances+IL-9+transcription+in+CD4%28%2B%29+T+cells. assertion.
- assertion asSentence The+mitochondrial+localization+of+RelB+and+NFATx+is+precisely+controlled+by+a+calcium+signal+sensitive+to+FK506+in+T+cells. assertion.
- assertion asSentence Serum+response+factor+%28SRF%29+contributes+to+hippocampal+layer+and+nerve+fiber+organization+and+point+at+a+link+between+Srf+gene+transcription+and+reelin+signaling. assertion.
- assertion asSentence The+function+of+reelin+regulate+Purkinje+cells+in+the+developing+mouse+lateral+cerebellum+and+its+migration. assertion.
- assertion asSentence An+extensive%2C+pluripotency-specific+recruitment+profile+lends+REST+a+key+role+in+the+maintenance+of+the+ESC+phenotype. assertion.
- assertion asSentence The+loss+of+Rest+expression+by+itself+does+not+promote+the+development+of+colon+tumors+in+mice. assertion.
- assertion asSentence The+residue+cysteine+397+%28Cys397%29+plays+important+roles+in+the+global+folding+of+NRSF%2FREST+multiple+ZnFs+domain. assertion.
- assertion asSentence Genetic+interactions+involving+Ret+and+MafA+progressively+promote+the+differentiation+and+diversification+of+LTMs. assertion.
- assertion asSentence The+receptor+tyrosine+kinase+rearranged+during+transformation+%28Ret%29+binds+to+protocadherins+%28Pcdhs%29+in+differentiated+neuroblastoma+cells+and+is+required+for+stabilization+and+differentiation-induced+phosphorylation+of+Pcdh+proteins. assertion.
- assertion asSentence Rgs2-deficient+mice+revealed+enhanced+bronchoconstriction+to+spasmogens+and+an+absence+of+beta%282%29-adrenoceptor+agonist+%28LABA%29-induced+bronchoprotection. assertion.
- assertion asSentence Altering+RGS4+function+will+produce+a+complex+neuronal+phenotype+with+cell-+and+subdomain-specificity+in+the+cerebral+cortex. assertion.
- assertion asSentence The+receptor-interacting+protein+1+%28RIP1%29+regulates+p27%28Kip1%29+levels+and+cell-cycle+progression. assertion.
- assertion asSentence Inhibitor+of+apoptosis+proteins+are+required+during+development+to+limit+activity+of+receptor-interacting+protein+kinase+1+and+3+in+the+TNF+receptor+1+signalling+pathway. assertion.
- assertion asSentence Robo1+and+Robo2+mostly+cooperate+to+mediate+the+function+of+Slit+proteins+in+guiding+the+major+forebrain+projections. assertion.
- assertion asSentence Cerebellofugal+axons+tend+to+stall+within+the+midline+region+in+Robo1%2F2+double+knockout+mice. assertion.
- assertion asSentence Constitutive+activation+of+the+Rho-ROCK-LIM+kinase+pathway+by+extracellular+production+of+lysophosphatidic+acid+by+the+action+of+autotaxin+is+required+to+maintain+the+large+size+of+lysosomes+in+visceral+endoderm+cells. assertion.
- assertion asSentence Sphingosine+1-phosphate+%28S1P%29+is+capable+of+altering+pulmonary+vascular+tone+in+mouse+lung+through+S1P2+receptor-dependent+Rho-kinase+activation-mediated+vasoconstriction. assertion.
- assertion asSentence Rho-kinase+regulates+PGF%282alpha%29-stimulated+IL-6+synthesis+via+p38+MAP+kinase+activation+in+osteoblasts. assertion.
- assertion asSentence Constitutive+activation+of+the+Rho-ROCK-LIM+kinase+pathway+by+extracellular+production+of+lysophosphatidic+acid+by+the+action+of+autotaxin+is+required+to+maintain+the+large+size+of+lysosomes+in+visceral+endoderm+cells. assertion.
- assertion asSentence The+RhoA%2FRho-kinase+signaling+pathway+plays+an+essential+role+in+the+axon+patterning+of+cranial+somatic+motor+neurons+during+development. assertion.
- assertion asSentence Activation+of+RON+by+macrophage-stimulating+protein+inhibits+LPS-induced+macrophage+Cox-2+expression. assertion.
- assertion asSentence Ron+plays+a+critical+role+in+regulation+of+alveolar+macrophage+signaling+and+validates+this+receptor+as+a+target+in+TNFalpha-mediated+pulmonary+pathologies. assertion.
- assertion asSentence RON+signaling+mediates+cell+survival+and+in+vivo+resistance+to+gemcitabine+in+pancreatic+cancer. assertion.
- assertion asSentence Smad2+associated+with+retinoid+acid+receptor-related+orphan+receptor-gammat+%28RORgammat%29+and+enhanced+RORgammat-induced+Th17+cell+generation. assertion.
- assertion asSentence The+loss+of+rDNA+transcription+induced+nucleolar+structure+disorganization+and+apoptosis+in+preimplantation+embryos. assertion.
- assertion asSentence Both+the+ubiquitylation+and+proteasomal+degradation+of+the+largest+subunit+of+pol+II+%28Rpb1%29+following+UV-irradiation+are+significantly+suppressed+in+Elongin+A-deficient+cells. assertion.
- assertion asSentence RS1H+has+functional+significance+in+the+morphology+and+function+of+the+synapse+between+photoreceptors+and+second-order+neurons. assertion.
- assertion asSentence PPARgamma+is+the+predominant+heterodimerization+partner+for+RXR+during+late+stages+of+adipocyte+differentiation. assertion.
- assertion asSentence There+are+four+distinct+murine+FXR+isoforms+that+differentially+regulate+gene+expression+in+numerous+tissues+in+vivo. assertion.
- assertion asSentence The+bile+acid+sensor+FXR+regulates+the+activation+of+liver+NKT+cells. assertion.
- assertion asSentence FXR+increases+the+resistance+of+human+and+murine+gastric+epithelial+cells+to+inflammation-mediated+damage. assertion.
- assertion asSentence A+gain-of-function+mutation+in+RyR2+confers+an+increased+risk+of+cardiac+arrhythmias+and+sudden+death+in+young+mice. assertion.
- assertion asSentence S100A4+reduces+the+migratory+capacity+of+reactive+white+matter+astrocytes+in+the+injured+CNS+and+is+involved+in+glial+scar+formation+after+injury. assertion.
- assertion asSentence The+C-terminus+of+S100A9+protein+interferes+with+control+mechanisms+of+inflammatory+pain. assertion.
- assertion asSentence S100beta+is+important+for+brain+development+and+establishment+of+proper+brain+functions. assertion.
- assertion asSentence Nkx1-2+is+a+critical+component+of+the+gene+regulatory+network+that+operates+downstream+of+Wnt%2Fb-catenin+signaling+to+regulate+the+formation+of+mesendoderm. assertion.
- assertion asSentence The+increased+food+intake+and+increased+energy+expenditure+of+Scd1-%2F-+mice+are+independent+of+the+neuropeptide+melanin-concentrating+hormone. assertion.
- assertion asSentence Secretin+is+involved+in+synaptic+function+in+the+adult+brain. assertion.
- assertion asSentence SR-A+suppresses+the+macrophage+activation+by+inhibiting+the+binding+of+LPS+to+TLR4+in+a+competitive+manner+and+it+plays+a+pivotal+role+in+the+regulation+of+the+LPS-induced+inflammatory+response. assertion.
- assertion asSentence That+augmented+airway+eosinophilic+inflammation+and+hyperresponsiveness+in+RV-infected+mice+with+allergic+airways+disease+is+directed+in+part+by+eotaxin-1. assertion.
- assertion asSentence Pravastatin+prevents+CML+to+induce+MCP-1+expression+in+podocytes+via+modulation+of+the+intracellular+ERK%2FNF-kappaB+and+Sp1+signalling+pathway. assertion.
- assertion asSentence Blocking+PC-PLC+function+significantly+inhibited+lipopolysaccharide-induced+IL-8+and+MCP-1+production. assertion.
- assertion asSentence Ad36+infection+stimulated+an+inflammatory+state+by+increasing+the+level+of+MCP-1+through+the+activation+of+nuclear+factor+kappaB. assertion.
- assertion asSentence Pathogenesis+of+Sandhoff+disease+%28heritable+beta-hexosaminidase+deficiency%29+involves+an+increase+in+macrophage-inflammatory+protein+1alpha+that+induces+monocytes+to+infiltrate+the+CNS+and+trigger+neuronal+apoptosis. assertion.
- assertion asSentence Sepsis+leads+to+greatly+increased+expression+of+RANTES%2C+MIP-1alpha+and+their+cognate+receptors+in+the+diaphragm. assertion.
- assertion asSentence Functional+CCR5+and+RANTES%2FCCL5+are+required+for+the+persistence+of+chronic+fungal+asthma+in+mice. assertion.
- assertion asSentence RANTES+ablation+attenuates+immune-mediated+nephritis. assertion.
- assertion asSentence CCR7-mediated+cortex-to-medulla+migration+of+thymocytes+is+essential+for+establishing+central+tolerance+rather+than+for+supporting+the+maturation+or+export+of+thymocytes. assertion.
- assertion asSentence PPARgamma+activation+represses+FKN+signaling. assertion.
- assertion asSentence CX3CL1+has+neurotrophic+activity+on+hippocampal+neurons+through+its+activity+on+microglia. assertion.
- assertion asSentence SDF-1+and+MMP-9+function+independently+to+promote+the+trafficking+of+myeloid+cells+into+the+injured+cord. assertion.
- assertion asSentence Expression+of+both+Sfrp2+and+Sfrp5+during+development+of+the+Mullerian+duct+in+male+%28XY%29+and+female+%28XX%29+mouse+embryos+is+dynamic+and+sexually+dimorphic. assertion.
- assertion asSentence Early+establishment+of+influenza-specific+memory+within+the+CD8%28%2B%29CD62L%28hi%29+subset+preserves+clonal+diversity+and+prevents+%22overdominance%22+by+a+few+public%2C+or+shared%2C+clones. assertion.
- assertion asSentence CD62L+down-regulation+is+not+required+for+CD8+memory+cells+to+home+to+sites+of+infection. assertion.
- assertion asSentence L-selectin+and+ICAM-1+regulate+Th2+and+Th17+cell+accumulation+into+the+skin+and+lung%2C+leading+to+the+development+of+fibrosis. assertion.
- assertion asSentence Chimeras+of+P-selectin+and+immunoglobulin+%28P-sel-Ig%29+induced+formation+of+procoagulant+microparticles+in+human+blood+through+P-selectin+glycoprotein+ligand-1. assertion.
- assertion asSentence Chimeras+of+P-selectin+and+immunoglobulin+%28P-sel-Ig%29+induced+formation+of+procoagulant+microparticles+in+human+blood+through+P-selectin+glycoprotein+ligand-1. assertion.
- assertion asSentence SHP2-mediated+tyrosine+dephosphorylation+is+an+important+step+in+Sema4D-induced+axon+repulsion. assertion.
- assertion asSentence Sema6B%2C+another+class+6+transmembrane+semaphorin%2C+is+expressed+in+CA3+and+repels+mossy+fibers+in+a+PlxnA4-dependent+manner+in+vitro. assertion.
- assertion asSentence Hepatic+translation+of+Sepp1+mRNA+is+specifically+impaired+during+the+acute-phase+response. assertion.
- assertion asSentence The+PI3K%2FAkt%2FmTOR+signaling+network+regulates+Foxp3+expression. assertion.
- assertion asSentence Surface+LAP+expression+on+CD4+T+cells+is+controlled+by+Foxp3+and+TGF-beta. assertion.
- assertion asSentence The+ability+to+control+and+eliminate+P.+chabaudi+AS+infection+requires+a+tight+balance+between+CD4%2BFoxp3%2B+cells+and+effector+CD4%2B+Th1+cells%2C+a+balance+regulated+in+part+by+IL-2. assertion.
- assertion asSentence De+novo+Foxp3+expression+is+an+integral+component+of+establishing+and+maintaining+tolerance+among+naive+peripheral+CD4+T+cells. assertion.
- assertion asSentence CD8%28%2B%29+T+cell+tolerance+established+in+the+lung+depends+only+partially+on+the+function+of+CD4%2BCD25%2BFoxp3%2B+regulatory+T+cells. assertion.
- assertion asSentence Downregulation+of+PU.1+during+Pneumocystis+pneumonia+leads+to+decreased+expression+of+Dectin-1+in+alveolar+macrophages. assertion.
- assertion asSentence IRF8+binds+a+large+number+of+genes+by+targeting+two+distinct+motifs%2C+half+of+which+are+also+targeted+by+PU.1. assertion.
- assertion asSentence Maintenance+of+surfactant-associated+protein+B+expression+is+critical+to+survival+during+acute+lung+injury. assertion.
- assertion asSentence Hypoxia-induced+mitogenic+factor+induces+surfactant+protein+B+and+C+production+in+mouse+lungs+and+cell+lines+via+activation+of+phosphatidylinositol+3-kinase%2FAkt+and+ERK1%2F2+mitogen-activated+protein+kinases. assertion.
- assertion asSentence SP-D+has+a+significant+role+to+play+in+the+clearance+of+pneumococci+during+the+early+stages+of+infection+in+both+pulmonary+sites+and+blood. assertion.
- assertion asSentence SGK1+participates+in+the+stimulation+of+salt+appetite+during+pregnancy. assertion.
- assertion asSentence p66%28Shc%29+adaptor+protein+is+part+of+a+signal+transduction+pathway+relevant+to+hyperglycemia+vascular+damage. assertion.
- assertion asSentence Gli2+and+Gli3+act+together+with+Sonic+hedgehog+to+regulate+neuronal+patterning+by+controlling+progenitor+cell+segregation. assertion.
- assertion asSentence Genetic+loss+of+Shh+is+accompanied+by+an+up-regulation+of+Indian+Hedgehog+%28Ihh%29+and+maintenance+of+hedgehog+pathway+activity. assertion.
- assertion asSentence Shh+signaling%2C+acting+through+the+primary+cilia%2C+has+a+critical+role+in+the+expansion+and+establishment+of+postnatal+hippocampal+progenitors. assertion.
- assertion asSentence It+is+primarily+Hh-induced+VEGF-A+that+promotes+angiogenesis+in+vitro+and+augments+tumor-derived+VEGF+to+promote+angiogenesis+in+vivo. assertion.
- assertion asSentence The+timing+of+gene+expression+along+with+the+genetic+lineage+%28Shh+or+Gli1%29+within+the+neural+progenitors+segregate+mDA+neurons+into+distinct+spatial+domains. assertion.
- assertion asSentence In+the+absence+of+cooperating+mutations%2C+Hh+ligand+overexpression+in+the+mature+exocrine+pancreas+is+insufficient+to+induce+neoplasia. assertion.
- assertion asSentence Dab1+inhibits+the+activity+of+Siah-1A. assertion.
- assertion asSentence Synaptic+transmission+at+the+NMJ+is+not+crucially+dependent+on+the+particular+presence+of+most+ganglioside+family+members. assertion.
- assertion asSentence Destruction+of+glycolipid-enriched+microdomain+is+caused+by+ganglioside+deficiency+with+gradual+intensity+depending+on+the+degree+of+defects+of+their+compositions. assertion.
- assertion asSentence NKCC1+expressed+in+myenteric+ICC+is+involved+in+the+mechanism+of+slow+waves+in+the+murine+jejunum. assertion.
- assertion asSentence NKCC1+acting+in+concert+with+NCX+causes+a+perturbation+of+Ca%28m%29%282%2B%29+homeostasis+and+mitochondrial+dysfunction+and+cell+death+following+in+vitro+ischemia. assertion.
- assertion asSentence NKCC1+controls+GABAergic+signaling+and+neuroblast+migration+in+the+postnatal+forebrain. assertion.
- assertion asSentence EAAC1+of+EL+mice+at+10+weeks+of+age+decreased+more+than+those+of+DDY. assertion.
- assertion asSentence OCTN2+is+predominantly+responsible+for+the+uptake+of+carnitine+from+the+apical+surface+of+mouse+small+intestinal+epithelial+cells. assertion.
- assertion asSentence LPS-induced+increases+in+neutrophil+glucose+uptake+are+mediated+by+GLUT-1+translocation+to+the+cell+surface+in+response+to+sequential+activation+of+neutrophil+p38+and+HIF-1alpha+in+neutrophils. assertion.
- assertion asSentence A+portion+of+the+hypoglycemic+effects+of+berberine+can+be+attributed+to+its+acute+activation+of+the+transport+activity+of+GLUT1. assertion.
- assertion asSentence Glut3+haploinsufficiency+does+not+impair+brain+glucose+uptake+or+utilization. assertion.
- assertion asSentence Golgin-160+plays+an+important+role+in+directing+insulin-regulated+trafficking+proteins+toward+the+insulin-responsive+compartment+in+adipocytes. assertion.
- assertion asSentence Rab10+participates+in+GLUT4+translocation+in+3T3-L1+adipocytes. assertion.
- assertion asSentence Mammalian+erythroblast+enucleation+does+not+depend+on+the+membrane+integrity+generated+by+the+ankyrin-band+3+complex. assertion.
- assertion asSentence NHE1+activation+following+cerebral+ischemia+contributes+to+mitochondrial+damage+and+ischemic+apoptosis. assertion.
- assertion asSentence Slit1%2F2+-+Robo1%2F2+signaling+is+critical+during+the+initial+establishment+of+dopaminergic+pathways%2C+with+roles+in+the+dorsoventral+positioning+and+precise+pathfinding+of+these+ascending+longitudinal+axons. assertion.
- assertion asSentence The+normal+chromatin+remodeling+function+of+Brg1+is+necessary+for+the+G-CSF+dependent+differentiation+of+myeloid+cells+towards+the+granulocytic+lineage. assertion.
- assertion asSentence SMN+plays+a+protective+role+in+motor+neurons+by+its+chaperone+activity. assertion.
- assertion asSentence The+calcium+influx-triggered+phospholipase+D+and+acidic+sphingomyelinase+pathways+of+acidic+extracellular+pH+induced+matrix+metalloproteinase-9+expression%2C+at+least+in+part%2C+through+nuclear+factor-kappaB+activation. assertion.