Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Knock-in+mutations+of+the+nuclear+co-repressor+SMRT+in+C57BL%2F6+mice+produces+a+previously+unidentified+respiratory+distress+syndrome+caused+by+prematurity+of+the+type+I+pneumocyte. assertion.
- assertion asSentence Bcl6-SMRT%2FNCoR+complexes+constrain+immune+responses+and+contribute+to+the+prevention+of+atherosclerosis. assertion.
- assertion asSentence Wt1+is+an+activator+of+Snai1+and+a+repressor+of+Cdh1+in+epicardial+cells. assertion.
- assertion asSentence The+expression+of+Notch+target+genes+Snail+and+Bmp2+are+impaired+in+Adam10-deficient+cardiac+tissues. assertion.
- assertion asSentence Snail1+controls+Zeb1+expression+at+multiple+levels+and+acts+cooperatively+with+Twist+in+the+ZEB1+gene+transcription+induction. assertion.
- assertion asSentence VILIP-1+is+involved+in+epithelial-mesenchymal+transition+%28EMT%29+of+squamous+cell+carcinoma+%28SCC%29+cells+by+regulating+the+transcription+factor+Snail1+in+a+cAMP-dependent+manner. assertion.
- assertion asSentence Alpha-synuclein+plays+a+major+role+in+actin+cytoskeletal+dynamics+and+various+aspects+of+microfilament+function. assertion.
- assertion asSentence A-synuclein+aggregation+is+a+key+feature+associated+with+reductions+of+axonal+transport+motor+proteins+in+Parkinson%27s+disease. assertion.
- assertion asSentence G93A+superoxide+dismutase+%28SOD%29%2C+like+wild-type+SOD%2C+protects+calcineurin+against+inactivation. assertion.
- assertion asSentence Concerted+changes+in+the+hepatic+expression+of+iron-+and+haem-related+genes+in+response+to+haemolytic+anaemia+in+Sod1-%2F-+mice+act+to+reduce+toxic+iron+accumulation+in+the+liver+and+respond+to+the+needs+of+erythropoiesis. assertion.
- assertion asSentence In+the+context+of+aging%2C+CuZnSOD+has+an+essential+role+to+protect+against+excessive+oxidative+stress+in+ischemic+tissues+and+preserve+the+function+of+EPCs. assertion.
- assertion asSentence Mitochondrial+oxidative+stress+and+dysfunction+play+a+mechanistic+role+in+epilepsy+occurring+in+Sod2-%2F-+mice+and+treatment+with+a+lipophilic+metalloporphyrin. assertion.
- assertion asSentence SOD3+attenuates+emphysema+and+reduces+oxidative+fragmentation+of+ECM+in+lung. assertion.
- assertion asSentence The+survival+of+neural+and+mesenchymal+progenitor+cells+critically+relies+on+the+redundantly+acting+SoxC+transcription+factors+Sox4%2C+Sox11+and+Sox12. assertion.
- assertion asSentence Sox17+functions+cell-autonomously+to+specify+gallbladder%2Fbile-duct+in+the+mouse+embryo. assertion.
- assertion asSentence Blocking+acetylation+at+a+key+lysine+residue+retains+Sox2+in+the+nucleus+and+sustains+expression+of+its+target+genes+under+hyperacetylation+or+differentiation+conditions. assertion.
- assertion asSentence Klf4+interacts+directly+with+Oct4+and+Sox2+when+expressed+at+levels+sufficient+to+induce+induced+pluripotent+stem+cells. assertion.
- assertion asSentence Sox2%2C+along+with+Neurog1+and+NeuroD1%2C+are+sufficient+to+induce+a+neuronal+fate+in+nonsensory+regions+of+the+cochlea. assertion.
- assertion asSentence SOX6+is+a+central+regulator+of+both+progenitor+and+cortical+interneuron+diversity+during+neocortical+development. assertion.
- assertion asSentence Stat3+is+required+for+Sox6+expression+during+neuronal+differentiation. assertion.
- assertion asSentence Sox8+reinforces+Sox9+function+in+testis+differentiation+of+mice. assertion.
- assertion asSentence MiR-140+is+co-expressed+with+Wwp2-C+and+is+activated+by+Sox9+to+target+Sp1+in+maintaining+chondrocyte+proliferation. assertion.
- assertion asSentence Organ+fate+commitment+and+progenitor+cell+expansion+are+coordinately+controlled+by+the+activity+of+a+Sox9%2FFgf10%2FFgfr2b+feed-forward+loop+in+the+pancreatic+niche. assertion.
- assertion asSentence Increased+Sp1+binding+to+the+AhR+promoter+region+is+an+underlying+mechanism+for+upregulation+of+AhR+expression+in+mouse+aortic+endothelial+cells+that+overexpress+Cu%2FZn-SOD+and%2For+catalase. assertion.
- assertion asSentence PDGF-BB-induced+TRAIL+transcriptional+activity+requires+the+cooperation+of+Sp1%2C+ac-H3+and+p300%2C+mediating+increased+expression+of+TRAIL+which+is+important+for+VSMC+proliferation+and+migration. assertion.
- assertion asSentence Sp3+and+YY1+recruit+general+transcription+factors+and+facilitate+the+assembly+of+a+preinitiation+complex. assertion.
- assertion asSentence Increased+tumor+burden+in+the+absence+of+host+SPARC+is+a+consequence+of+reduced+collagen+deposition%2C+a+disrupted+vascular+basement+membrane%2C+enhanced+vascular+function+and+an+immune-tolerant%2C+pro-metastatic+microenvironment. assertion.
- assertion asSentence SPHK1+activation+by+TGF-beta1+leads+to+Rho-associated+myofibroblasts+differentiation+mediated+by+transactivated+S1P+receptors+in+the+lung+fibrogenic+process. assertion.
- assertion asSentence SphK%2FS1P+receptor+signaling+plays+an+important+role+in+excitatory+synaptic+transmission+in+the+CA3+region+of+hippocampus+and+has+profound+effects+on+hippocampal+function+such+as+spatial+learning. assertion.
- assertion asSentence Maspin+is+a+tumour+suppressor+in+malignant+melanoma. assertion.
- assertion asSentence OPN+plays+an+important+role+in+tumor+growth+through+the+enhancement+of+angiogenesis+in+vivo. assertion.
- assertion asSentence In+response+to+allergen%2C+osteopontin+induces+the+switching+of+lung+fibroblasts+to+a+pro-fibrogenic+myofibroblast+phenotype. assertion.
- assertion asSentence Functional+interactions+of+OPN+with+integrins+and+the+other+binding+partners+can+be+modulated+by+the+intramolecular+interactions. assertion.
- assertion asSentence OPN+expression+by+TECs+is+an+important+factor+in+initial+inflammatory+responses+that+involves+NK+cells+activity+in+kidney+IRI. assertion.
- assertion asSentence Sustained+production+of+osteopontin+impairs+host+defense+during+established+septic+melioidosis. assertion.
- assertion asSentence Osteopontin+%28OPN%29+is+up-regulated+by+bronchiolar+epithelial+cells+after+chrysotile+asbestos+exposures. assertion.
- assertion asSentence SR-BI+homo-oligomerization+occurs+even+when+the+receptor+is+non-functional. assertion.
- assertion asSentence SR-BI%2C+a+scavenger+receptor+primarily+involved+in+high-density+lipoprotein+cholesterol+transport%2C+plays+an+essential+role+in+Alzheimer%27s+disease+and+cerebral+amyloid+angiopathy. assertion.
- assertion asSentence Distinct+modes+of+spatial+activation+and+membrane+delivery%2C+under+the+control+of+specific+acylation+attachment+sequences+and+endosome+sub-type+requirements%2C+define+distinct+properties+of+the+three+SFKs+%28Src+family+kinases%29. assertion.
- assertion asSentence TrkC+induces+the+PI3K-Akt+cascade+through+the+activation+of+c-Src. assertion.
- assertion asSentence The+phosphoprotein+associated+with+glycosphigolipid-enriched+microdomains+%28PAG%29%2FCsk+binding+protein+%28Cbp%29+modulates+SFK+activity+in+the+brain. assertion.
- assertion asSentence Saturated+fatty+acids+activate+JNK+and+inhibit+insulin+signaling+through+c-Src+activation. assertion.
- assertion asSentence Physiological+doses+of+fish+oil+feeding+effectively+decrease+expression+of+liver+lipogenic+enzymes+by+inhibiting+the+sterol+regulatory+element+binding+protein-1+proteolytic+cascade. assertion.
- assertion asSentence Elovl-6+is+regulated+directly+and+primarily+by+SREBP-1c. assertion.
- assertion asSentence Orotic+acid+induces+hepatic+lipogenesis%2C+mediated+predominantly+by+the+AMPK%2FSREBP-1+pathway+in+rat+hepatocytes+and+human+hepatoma+cell+lines. assertion.
- assertion asSentence Curcumin+inhibits+srebp-2+expression+in+cultured+HSCs+by+activating+PPARgamma+and+reducing+the+SP-1+activity. assertion.
- assertion asSentence Serum+response+factor+plays+an+important+role+in+sprouting+angiogenesis+and+small+vessel+integrity+in+the+mouse+embryo. assertion.
- assertion asSentence Srf+is+required+for+normal+megakaryocyte+maturation+and+platelet+production+partly+because+of+regulation+of+cytoskeletal+genes. assertion.
- assertion asSentence CHD8+plays+a+dual+role+in+smooth+muscle+cells+modulating+SRF+activity+toward+differentiation+genes+and+promoting+cell+survival+through+interactions+with+both+SRF+and+CTCF+to+regulate+expression+of+Birc5+and+CARD10. assertion.
- assertion asSentence Distinct+roles+for+SRF+during+neuronal+development. assertion.
- assertion asSentence Dipyrithione+inhibits+IFN-gamma-induced+IP-10%2FCXCL10+expression+in+RAW264.7+cells+by+targeting+the+JAK1%2F2%2FSTAT1+signaling+pathways. assertion.
- assertion asSentence The+capacity+of+the+rabies+virus+P+protein+to+inhibit+STAT1+nuclear+translocation+and+interferon+signaling+correlates+with+the+viral+pathogenicity. assertion.
- assertion asSentence IL-6-gp130-STAT3-dependent+gene+expression+in+hepatocytes+mediates+IL-6-triggered+protection+in+immune-mediated+Con+A-induced+hepatitis. assertion.
- assertion asSentence Phosphorylated+STAT3+immunoreactivity+is+not+found+in+the+arcuate+nucleus+of+db%2Fdb+pups+from+P5+onwards%3B%2C+these+animals+do+not+respond+to+leptin+treatment+with+an+increased+expression+of+hypothalamic+P-STAT3-IR. assertion.
- assertion asSentence The+gp130%2FStat3+axis+represents+an+essential+effector+of+activated+Rac1+for+the+regulation+of+key+cellular+functions. assertion.
- assertion asSentence Stat3+impairs+invasiveness+of+intestinal+tumors+in+APC%28Min%29+mice. assertion.
- assertion asSentence The+dephosphorylation+of+phospho-STAT3+corresponds+to+the+activation+of+ERKs+pathway+from+the+time-courses+of+the+phosphorylation+levels+in+detail. assertion.
- assertion asSentence Both%2C+Stat3+and+Stat5+are+necessary+for+initial+neoplastic+cell+transformation. assertion.
- assertion asSentence The+immune+modulatory+effects+of+STAT3+blockade+can+enhance+the+therapeutic+efficacy+of+IFN-alpha+immunotherapy+by+enhancing+both+innate+and+adaptive+cytotoxic+T-cell+activities. assertion.
- assertion asSentence STAT3+is+not+a+central+regulator+of+acute+liver+injury+induced+by+ischemia+reperfusion. assertion.
- assertion asSentence STAT3+is+necessary+for+efficient+repair+of+damaged+DNA%2C+partly+by+modulating+the+ATM-Chk2+and+ATR-Chk1+pathways. assertion.
- assertion asSentence The+mammary+glands+are+indeed+targeted+by+STC%2C+even+in+the+virgin+state. assertion.
- assertion asSentence ALK-SMAD3-Dec1+signalling+provides+an+input+pathway+in+the+mammalian+molecular+clock. assertion.
- assertion asSentence Spt5%2C+a+factor+normally+associated+with+stalled+or+paused+Pol+II%2C+is+required+for+class+switch+recombination. assertion.
- assertion asSentence Spt4+and+Spt5+have+essential+functions+in+the+DNA+repair+phase+of+immunoglobulin+class+switch+recombination. assertion.
- assertion asSentence K%28ATP%29%2FSUR1+channels+facilitate+the+cardiac+response+to+stress+by+regulating+PGC-1alpha+and+its+target+genes%2C+at+least+partially+through+the+FOXO1+pathway. assertion.
- assertion asSentence The+clathrin-mediated+endocytosis+of+the+SNARE+VAMP7+is+directly+mediated+by+Hrb%2C+a+clathrin+adaptor+and+ArfGAP. assertion.
- assertion asSentence Site-specific+synapsin+I+phosphorylation+participates+in+the+expression+of+post-tetanic+potentiation+and+its+enhancement+by+BDNF. assertion.
- assertion asSentence Wildtype-syndecan-1%28WT-sdc1%29+and+unshedding-syndecan-1%28uS-sdc1%29+are+successfully+constructed. assertion.
- assertion asSentence SP-induced+chemokine+synthesis+in+mouse+pancreatic+acinar+cells+is+NF-kappaB+dependent. assertion.
- assertion asSentence The+de+novo+expression+of+SM22alpha+in+glomerular+epithelial+cells+affects+the+course+of+crescentic+glomerulonephritis. assertion.
- assertion asSentence GATA-2%2C+Fli-1+and+Elf-1+are+key+components+of+an+enhanceosome+responsible+for+activating+SCL+transcription+and+establishing+the+transcriptional+programme+required+for+HSC+formation. assertion.
- assertion asSentence PSF1+is+tightly+regulated+at+the+transcriptional+level+in+stem+cells. assertion.
- assertion asSentence Myogenic+induction+of+the+taurine+transporter+prevents+dexamethasone-induced+muscle+atrophy. assertion.
- assertion asSentence Ngn2%2C+neuroD+and+Tbr+transcription+factors+are+involved+in+postnatal+neurogenesis+in+the+olfactory+bulb. assertion.
- assertion asSentence The+expression+of+Tbr1+in+neural+stem+and+progenitor+cells+prevents+them+from+following+an+astrocyte+fate+during+olfactory+bulb+development. assertion.
- assertion asSentence Homozygous+mutation+of+the+mouse+homolog+Tbx1+is+associated+with+severe+inner+ear+defects+that+prevent+the+formation+of+the+cochlea+and+of+the+vestibulum. assertion.
- assertion asSentence Deficits+in+prepulse+inhibition%2C+a+behavioral+abnormality+and+schizophrenia+endophenotype%2C+in+Df1%2F%2B+mice+are+caused+by+haploinsufficiency+of+two+genes%2C+Tbx1+and+Gnb1l. assertion.
- assertion asSentence Pharyngeal+arch+artery+%28PAA%29+formation+requires+the+pharyngeal+surface+ectoderm+as+a+signalling+centre+from+which+Gbx2%2C+in+response+to+Tbx1%2C+triggers+directional+cues+to+the+adjacent+cardiac+neural+crest+cells+en+route+to+the+caudal+PAAs. assertion.
- assertion asSentence Isoprostanes+inhibit+angiogenesis+via+activation+of+the+TBXA2R. assertion.
- assertion asSentence Hepatocyte+nuclear+factors+%28HNF%29+4alpha+and+HNF1alpha+regulate+proline+metabolism+in+adult+liver. assertion.
- assertion asSentence The+intra-cytoplasmic+%28IC%29+domain+of+CD3epsilon+plays+a+critical+role+in+regulating+TCR+expression+on+DP+thymocytes. assertion.
- assertion asSentence Cripto+binds+the+proprotein+convertases+Furin+and+PACE4+and+localizes+Nodal+processing+at+the+cell+surface. assertion.
- assertion asSentence Prx+II+help+maintain+hippocampal+synaptic+plasticity+against+age-related+oxidative+damage. assertion.
- assertion asSentence Prx+II+plays+a+key+antioxidation+role+in+the+maturation+of+oocytes+and+development+of+early+embryos. assertion.
- assertion asSentence Disturbed+angiopoietin%2FTie-2+signaling+contributes+to+the+hyperglycemic+exacerbation+of+myocardial+infarction+and+impaired+angiogenesis. assertion.
- assertion asSentence IP6+represses+telomerase+activity+in+prostate+cancer+cells+by+posttranslational+modification+of+TERT+via+the+deactivation+of+Akt+and+PKCalpha. assertion.
- assertion asSentence TFAM+alone+is+sufficient+to+organize+mitochondrial+chromatin+and+provide+a+mechanism+for+nucleoid+formation. assertion.
- assertion asSentence Allergen+exposure+leads+to+the+trans-differentiation+of+Clara+cells+toward+a+TFF1-expressing+mucous+phenotype. assertion.
- assertion asSentence TFF1-knockout+mice+demonstrate+amplification+and+invasiveness+of+gastric+stem%2Fprogenitor+cells. assertion.
- assertion asSentence A+PI3K-ERK+signaling+pathway+via+the+PS-receptor+is+intimately+involved+in+the+production+of+TGF-beta1+which+regulates+macrophage+functions. assertion.
- assertion asSentence Unilateral+nephrectomy+leads+to+up-regulation+of+syndecan-2-+and+TGF-beta-mediated+glomerulosclerosis+in+syndecan-4+deficient+male+mice. assertion.
- assertion asSentence MafA-dependent+transcriptional+activation+is+negatively+regulated+by+TGF-beta+signaling. assertion.
- assertion asSentence TGF-beta1+is+involved+in+cardiomyocyte+differentiation+by+regulating+cell+cycle+progression+and+cardiac+gene+expression+in+an+autocrine+or+paracrine+manner. assertion.
- assertion asSentence TGF-beta1+augments+overall+protein+expression+levels+of+select+pro-inflammatory+genes+in+astrocytes+in+a+promiscuous+manner+by+reducing+the+magnitude+of+noise+in+the+cellular+population. assertion.
- assertion asSentence TGF-beta+inhibits+G1+arrest+and+maintains+TWIST2+expression+in+C2C12+cells. assertion.
- assertion asSentence Autocrine+TGF-beta+signaling+is+necessary+for+the+survival+of+GDNF%2FCNTF-differentiated+tsAM5D+cells+upon+the+temperature+shift. assertion.
- assertion asSentence Three+different+branches+of+TGF-beta+signaling+function+in+concert+as+complementary+effectors%2C+allowing+TGF-beta+to+fine+tune+the+iNKT+cell+differentiation+program. assertion.
- assertion asSentence Breast+cancer-derived+factors+induce+osteoclastogenesis+through+the+activation+of+calcium%2Fprotein+kinase+Calpha+and+TGFbeta-dependent+ERK1%2F2+and+p38+signaling+pathways. assertion.
- assertion asSentence Transforming+growth+factor-beta%28TGF-beta%29+directly+influences+mitochondrial+energy+metabolism+by+regulating+UCP3+expression. assertion.