Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Paxillin+and+Hic-5+associate+with+GIT1+with+different+binding+modes. assertion.
- assertion asSentence TGF-beta2+influences+synaptic+function%2C+rather+than+synaptogenesis%2C+specifically+at+central+synapses. assertion.
- assertion asSentence TGF-beta2+expression+by+murine+melanoma+cells+is+necessary+for+the+establishment+and+growth+of+metastases+in+the+brain+parenchyma. assertion.
- assertion asSentence TNF-alpha+induces+the+formation+of+fibrotic+foci+by+cultured+retinal+pigment+epithelial+cells+through+activation+of+transforming+growth+factor-TGF-beta+signaling+in+a+manner+dependent+on+hyaluronan-CD44-moesin+interaction. assertion.
- assertion asSentence TbetaRIII+acts+as+a+tumor+suppressor+in+nontumorigenic+mammary+epithelial+cells+at+least+in+part+by+inhibiting+NFkappaB-mediated+repression+of+E-cadherin. assertion.
- assertion asSentence Endocrine+effects+of+inhibin+as+a+negative+feedback+controller+of+follicle+stimulating+hormone+production+in+gonadotropes+are+dependent+on+betaglycan+expression. assertion.
- assertion asSentence Impaired+adipogenesis+by+mutant+thyroid+hormone+receptors+is+isoform+dependent. assertion.
- assertion asSentence Thyroid+hormone+receptor+beta+is+involved+in+suppression+of+the+central+component+of+the+hypothalamic-pituitary-thyroid+axis+in+acute+illness. assertion.
- assertion asSentence Thy-1+down-regulates+TNF-alpha-activated+gene+expression+via+interfering+with+SFK-+and+NF-kappaB-mediated+transactivation. assertion.
- assertion asSentence The+NR2C+and+Tiam1+maturation+genes+are+synergistically+controlled+by+the+activity-dependent+induction+of+Etv1. assertion.
- assertion asSentence KAP-1+is+a+critical+heterochromatic+factor+that+undergoes+specific+modifications+to+promote+DSB+repair+and+mitotic+progression+in+a+manner+that+allows+localized+and+transient+chromatin+relaxation. assertion.
- assertion asSentence TRIM28+is+differentially+required+by+ZFP568+and+other+factors+during+the+early+stages+of+mouse+embryogenesis. assertion.
- assertion asSentence The+MT2-MMP+catalytic+domain+has+a+higher+propensity+than+that+of+MT1-MMP+to+initiate+cleavage+of+the+MMP-2+prodomain+in+the+absence+of+TIMP-2. assertion.
- assertion asSentence ISF%2FShIF+confers+stromal+cells+with+enhanced+supporting+activities+for+HSCs+by+modulating+Wnt-activity+and+the+extracellular+matrix. assertion.
- assertion asSentence Shigella+infection+of+macrophages+can+induce+cell+death+independent+of+caspase-1+or+toll-like+receptor+4+activity. assertion.
- assertion asSentence Toll-like+receptor+4+contributes+to+the+initiation+of+central+nervous+system+neuroimmune+activation+after+L5+nerve+transection. assertion.
- assertion asSentence Endotoxemia+promotes+platelet+thrombus+formation+independent+of+neutrophils+and+without+enhancement+of+platelet+aggregation%2C+via+a+TLR4-dependent+mechanism. assertion.
- assertion asSentence IRAK-1+acts+as+the+essential+upstream+adaptor+that+recruits+BCL10+to+the+TLR4+signaling+complex+and+mediates+signaling+to+NF-kappaB+through+the+BCL10-MALT1-TRAF6-TAK1+cascade. assertion.
- assertion asSentence Innate+immune+recognition+by+TLR4+is+involved+in+protective+mechanisms+against+peroral+infection+with+Toxoplasma+gondii+ME49. assertion.
- assertion asSentence H.+pylori+activates+TLR2+and+TLR4%2C+leading+to+the+secretion+of+distinct+cytokines+by+bone+marrow+derived+macrophages. assertion.
- assertion asSentence While+TRAF6+is+absolutely+essential+for+TLR7+activation+of+ERK%2C+JNK+and+NF+kappa+B+pathways%2C+TLR4-induced+ERK%2C+JNK+pathways+and+IKK-mediated+phosphorylation+of+I+kappa+B+family+members. assertion.
- assertion asSentence Vasoactive+Intestinal+Peptide+promotes+endotoxin+tolerance+by+downregulating+TLR4+expression+via+Akt1. assertion.
- assertion asSentence TLR2%2C+TLR4+and+MyD88+are+critical+for+Mtb-induced+macrophage+death. assertion.
- assertion asSentence TLR4+signals+are+important+for+the+recognition+of+Candida+albicans+by+macrophages+and+their+absence+allows+persistence+of+the+infection. assertion.
- assertion asSentence TRAF6-mediated+Lys%2863%29-linked+ubiquitination+of+Beclin-1+is+critical+for+TLR4-triggered+autophagy+in+macrophage. assertion.
- assertion asSentence LPS-induced+circadian+responses+are+mediated+by+TLR4+in+mice. assertion.
- assertion asSentence TLR6+associates+with+TLR2+to+induce+tolerogenic+DC+and+regulatory+type-1+T+cells+selectively+secreting+IL-10. assertion.
- assertion asSentence TLX+plays+an+important+role+in+neural+development+by+regulating+cell+cycle+progression+and+exit+of+neural+stem+cells+in+the+developing+brain. assertion.
- assertion asSentence miR-9+suppresses+TLX+expression+to+negatively+regulate+neural+stem+cell+proliferation+and+accelerate+neural+differentiation. assertion.
- assertion asSentence Periostin%2C+a+matricellular+protein%2C+promotes+incorporation+of+tenascin-C+into+the+extracellular+matrix+and+organizes+a+meshwork+architecture+of+the+extracellular+matrix. assertion.
- assertion asSentence TNF+abrogates+insulin-induced+stimulation+of+protein+synthesis+in+myotubes+through+a+decrease+in+eIF4F+complex+assembly+independently+of+S6K1+and+4E-BP1+signaling+and+dependently+on+a+MEK1-sensitive+signaling+pathway. assertion.
- assertion asSentence Parenchymal+hippocampal+and+striatal+injury+persist+in+B6%2F129+TNF%28-%2F-%29+mice+following+theiler%27s+murine+encephalomyelitis+virus+infection. assertion.
- assertion asSentence TNF-alpha+and+activation+of+Vgamma1%2B+gammadelta+T+cells+are+required+for+the+development+of+airway+hyperresponsiveness+after+Ozone+exposure. assertion.
- assertion asSentence IL-1beta+and+TNF-alpha+are+produced+by+largely+segregated+populations+of+microglia+and+macrophages+after+ischemic+stroke+in+mice. assertion.
- assertion asSentence TNF-alpha+and+IL-6+signals+are+necessary+for+liver+regeneration+and+NF-kappaB+and+STAT3+binding+are+activated+via+TNF-alpha+and+IL-6+signal+pathways. assertion.
- assertion asSentence Chronic+production+of+TNF-alpha+in+the+tumor+microenvironment+increases+myeloid+cell+recruitment+in+a+TNFR1+and+IL-17-dependent+manner+that+contributes+to+the+tumor-promoting+action+of+this+proinflammatory+cytokine. assertion.
- assertion asSentence Protein+kinase+A-mediated+phosphorylation+of+CREB+promotes+TNFalpha+suppression+and+IL-10+induction. assertion.
- assertion asSentence Scorpion+venom+induces+insulin+resistance+by+mechanisms+involving+TNF-alpha-dependent+Map4k4+kinase+activation+in+the+adipose+tissue. assertion.
- assertion asSentence TNFalpha+is+induced+by+RANKL+in+pOCs+and+serves+as+an+autocrine+factor+promoting+osteoclastogenesis+through+c-Fos+and+NFATc1+activation. assertion.
- assertion asSentence SR-A+promotes+osteoclastogenesis+via+augmentation+of+the+expression+level+of+RANK+and+its+related+molecules. assertion.
- assertion asSentence Murine+gammadelta-T-cell+effector+functions+and+expansion+upon+activation+are+very+effectively+inhibited+by+alphabeta+Treg+through+a+contact-dependent+mechanism+that+can+be+partially+abrogated+by+manipulating+GITR+signals. assertion.
- assertion asSentence TNFR1+mediates+sickness+behavior+and+dysregulation+of+clock+genes+in+autoimmune+diseases. assertion.
- assertion asSentence TNFR2+has+a+protective+role+in+TNF-alpha-induced+bone+resorption. assertion.
- assertion asSentence TNFR2+mediates+striatal+healing+following+theiler%27s+murine+encephalomyelitis+virus+infection. assertion.
- assertion asSentence The+CD40-CD154+receptor-ligand+pair+is+highly+concentrated+into+a+central+region+of+the+immunological+synapse+on+mouse+lymphocytes+only+following+formation+of+the+T+cell+receptor%2FCD3+central+supramolecular-activating+cluster. assertion.
- assertion asSentence CD40+helps+limit+progressive+cryptococcal+growth+in+the+lung+and+protects+against+lethal+central+nervous+system+dissemination. assertion.
- assertion asSentence CD30L%2FCD30+signaling+executed+by+the+T-T+cell+interaction+plays+a+critical+role+in+Th17+cell+differentiation. assertion.
- assertion asSentence CD11c%2BCD8%2B+T-cells+play+a+role+in+the+anti-tumor+immunity+induced+by+anti-4-1BB+mAb. assertion.
- assertion asSentence Tumor+necrosis+factor+receptor-1+integrity+is+required+for+optimal+RANK%2FRANK+ligand-mediated+osteoclastogenesis. assertion.
- assertion asSentence NFATc1+is+essential+for+RANKL-induced+osteoclast+activation+via+up-regulation+of+osteoclast-activating+genes. assertion.
- assertion asSentence TIEG+directly+binds+to+and+inhibits+OPG+promoter+activity+in+osteoblasts%28OBs%29%2C+partially+explaining+the+inability+of+TIEG+KO+OBs+to+fully+support+osteoclast+differentiation. assertion.
- assertion asSentence TWEAK+suppresses+production+of+IFN-gamma+and+IL-12%2C+curtailing+the+innate+response+and+its+transition+to+adaptive+TH1+immunity. assertion.
- assertion asSentence TWEAK%2FFn14+receptor+activation+exerts+different+effects+on+neural+progenitor+cells+and+their+progeny+depending+on+the+developmental+stage+of+the+cells. assertion.
- assertion asSentence Short-term+ex+vivo+exposure+of+primary+naive+CD4%28%2B%29+T-cells+to+Staphylococcus+enterotoxin+A+%28SEA%29induces+differential+expression+of+the+T+cell+surface+receptor+CD154+in+a+time-+and+dose-dependent+manner. assertion.
- assertion asSentence Sterile+chronic+immune+activation+driven+by+enhanced+expression+of+CD70+is+in+fact+highly+protective+against+atherosclerosis. assertion.
- assertion asSentence 4-1BB+and+4-1BBL+do+not+play+a+strong+or+dominant+role+in+driving+the+generation+of+high+frequencies+of+vaccinia+virus+-specific+CD8+T+cells. assertion.
- assertion asSentence GSK3+contributes+to+mitotic+tankyrase+phosphorylation. assertion.
- assertion asSentence Cardiac+expression+of+slow+skeletal+troponin+T+%28Tnnt1%29+strictly+depends+on+the+physical+interaction+between+GATA4-FOG2+in+the+myocardium+of+both+atria+and+ventricles. assertion.
- assertion asSentence TNR+restricts+functional+recovery+by+limiting+posttraumatic+remodeling+of+synapses+around+motoneuronal+cell+bodies+where+TNR+is+normally+expressed+in+perineuronal+nets. assertion.
- assertion asSentence While+TPPII+contributes+to+the+trimming+of+peptides+with+very+long+N-terminal+extensions%2C+TPPII+is+not+essential+for+generating+most+MHC+class+I-presented+peptides+or+for+stimulating+CTL+responses+to+several+Ags+in+vivo. assertion.
- assertion asSentence The+major+effect+of+GRP94+on+muscle+differentiation+is+mediated+by+its+regulation+of+IGF+production. assertion.
- assertion asSentence IRAK-1+acts+as+the+essential+upstream+adaptor+that+recruits+BCL10+to+the+TLR4+signaling+complex+and+mediates+signaling+to+NF-kappaB+through+the+BCL10-MALT1-TRAF6-TAK1+cascade. assertion.
- assertion asSentence TRAF6+negatively+regulates+TNFalpha-induced+NF-kappaB+activation+through+its+ubiquitin+ligase+activity. assertion.
- assertion asSentence TRAF6-mediated+Lys%2863%29-linked+ubiquitination+of+Beclin-1+is+critical+for+TLR4-triggered+autophagy+in+macrophage. assertion.
- assertion asSentence TRAIL+is+not+a+critical+factor+for+thymocyte+negative+selection. assertion.
- assertion asSentence The+TRAIL%2FDR5+pathway+is+one+of+the+mechanisms+used+by+T+regulatory+cells+to+regulate+immune+responses+both+in+vitro+and+in+vivo. assertion.
- assertion asSentence Osteoblasts+containing+intracellular+S.+aureus+induce+TRAIL+expression+in+uninfected+osteoblasts+present+in+infected+cultures. assertion.
- assertion asSentence The+distribution+of+hypophysiotropic+TRH+neurons+in+mice+is+vastly+different+from+the+pattern+in+rats%2C+with+a+dominant+occurrence+of+these+neurosecretory+cells+in+the+compact+part+and+adjacent+regions+at+the+mid-level+of+the+PVN. assertion.
- assertion asSentence Both+initiation+and+maintenance+of+senescence+is+p53-dependent. assertion.
- assertion asSentence 5-lipoxygenase+activity+increases+during+senescence-like+growth+arrest+via+a+p53%2Fp21-dependent+pathway+in+both+human+and+mouse+embryo+fibroblasts. assertion.
- assertion asSentence p53+acts+through+distinct%2C+stimulus-specific+pathways+to+induce+apoptosis. assertion.
- assertion asSentence Caspase-2+activation+mediated+by+p53+is+an+important+pathway+involved+in+the+mitochondrial+release+of+apoptosis-inducing+factor+in+response+to+cisplatin+injury. assertion.
- assertion asSentence Ultraviolet-C+light+activates+in+mouse+embryonic+fibroblasts+both+the+Fas+%28CD95%2C+Apo-1%29+receptor+and+the+mitochondrial+damage+pathways. assertion.
- assertion asSentence Acetylation+at+lysine+317+negatively+regulates+p53+apoptotic+activities+after+DNA+damage. assertion.
- assertion asSentence p14ARF+regulates+E2F-1+ubiquitination+and+degradation+via+a+p53-dependent+mechanism. assertion.
- assertion asSentence P1+promoter+is+the+main+driving+force+for+transcribing+the+bcl-2+gene+and+P1+activity+is+modulated+by+M+and+P2+in+a+p53-dependent+and+-independent+manner. assertion.
- assertion asSentence Acetylation+of+Lys-317+modulates+the+functions+of+p53+and+influences+the+cross-talk+between+the+DNA+damage+response+and+other+signaling+pathways. assertion.
- assertion asSentence The+DN+effects+of+mutant+p53+are+evident+in+the+stem-cell+context%2C+in+which+its+expression+is+relatively+high+compared+with+terminally+differentiated+cells. assertion.
- assertion asSentence Tumorigenicity+mediated+by+p53+loss+does+not+require+either+Cdk2+or+Cdk4. assertion.
- assertion asSentence By+keeping+B-cell+populations+in+check%2C+p53-dependent+apoptosis+prevents+irregular+B+cells+from+eventuating+in+lymphomas. assertion.
- assertion asSentence Local+Sca-1low+dermal+mesenchymal+stem%2Fprogenitor+cells+are+preferential+targets+for+malignant+transformation+associated+with+deficiencies+in+both+p53+and+Rb. assertion.
- assertion asSentence p53+functions+as+a+negative+regulator+in+mast+cells. assertion.
- assertion asSentence p53+retards+growth+and+suppresses+etoposide-induced+apoptosis+in+pin1%28-%2F-%29+mouse+embryonic+fibroblasts. assertion.
- assertion asSentence TAp63+isoforms+are+robust+mediators+of+senescence+that+inhibit+tumorigenesis+in+vivo. assertion.
- assertion asSentence p73+is+essential+for+suppressing+polyploidy+and+aneuploidy+when+p53+is+inactivated. assertion.
- assertion asSentence Both+diacylglycerol+and+its+metabolite%2C+arachidonic+acid%2C+mediate+excitatory+odor+responses+in+the+vomeronasal+organ%2C+by+activating+two+types+of+channels%2C+a+TRPC2+and+a+separate+Ca%282%2B%29-permeable+channel. assertion.
- assertion asSentence The+melanopsin-evoked+depolarization+in+retinal+ganglion+cells+is+not+mediated+by+either+TRPC3%2C+TRPC6+or+TRPC7+channel+subunits+alone. assertion.
- assertion asSentence Intracellular+calcium+has+dual+and+opposite+effects+on+the+activation+of+TRPC5. assertion.
- assertion asSentence The+melanopsin-evoked+depolarization+in+retinal+ganglion+cells+is+not+mediated+by+either+TRPC3%2C+TRPC6+or+TRPC7+channel+subunits+alone. assertion.
- assertion asSentence The+TRPC6-dependency+of+acute+hypoxic+pulmonary+vasoconstriction+is+induced+via+diacylglycerol. assertion.
- assertion asSentence Ubiquitin+recognition+by+TSG101+is+required+for+cSMAC+formation%2C+T+cell+receptor+%28TCR%29+microcluster+signal+termination%2C+TCR+downregulation. assertion.
- assertion asSentence A+junction+element+between+Tsix+and+Xist+binds+Ctcf+and+contributes+to+the+initiation+of+X-chromosome+inactivation. assertion.
- assertion asSentence Regulated+Twist1+expression+contributes+to+growth+plate+organization+and+endochondral+ossification+to+modulate+postnatal+longitudinal+bone+growth. assertion.
- assertion asSentence Blocking+the+OX-40%2FOX40L+interaction+reduced+atherogenesis+by+inhibition+of+IL-4+mediated+Th2+induced+isotype+switching+and+subsequent+increased+levels+of+anti-oxLDL+IgM. assertion.
- assertion asSentence Accumulation+of+tyrosinase+in+the+endoplasmic+reticulum+of+melanocytes+leads+to+ER+stress+and+activation+of+the+unfolded+protein+response. assertion.
- assertion asSentence Most%2C+if+not+all%2C+SUMO-1+functions+are+compensated+for+in+vivo+by+SUMO-2+and+SUMO-3. assertion.
- assertion asSentence A+component+of+the+neuronal+ubiquitin%2Fproteasomal+pathway%2C+ubiquitin+C-terminal+hydrolase+L1+%28Uch-L1%29%2C+is+required+for+normal+synaptic+and+cognitive+function. assertion.
- assertion asSentence UCH-L1-mediated+maintenance+of+the+temporal+integrity+and+persistence+of+CREB+phosphorylation+underlies+these+impairments. assertion.
- assertion asSentence Adipocytes+respond+to+long-term+mitochondrial+uncoupling+by+minimizing+ATP+utilization. assertion.
- assertion asSentence UCP2+can+regulate+mast+cell+activation. assertion.