Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Under+nutrient+sufficiency%2C+high+mTOR+activity+prevents+Ulk1+activation+by+phosphorylating+Ulk1+Ser+757+and+disrupting+the+interaction+between+Ulk1+and+AMPK. assertion.
- assertion asSentence Liver+X+receptors+play+a+role+in+adipocyte+differentiation+by+regulation+of+lipogenesis+and+expression+of+adipocyte-specific+genes%2C+such+as+peroxisome+proliferator-activated+receptor-gamma. assertion.
- assertion asSentence Transgenic+overexpression+of+LXR-alpha+in+macrophages+has+significant+antiatherogenic+properties+in+LDL-receptor+deficient+mice. assertion.
- assertion asSentence Reduction+in+the+level+of+ApoER2+is+the+reason+for+the+retarded+migration+of+eurons+in+LXRbeta%28-%2F-%29+mice. assertion.
- assertion asSentence 4-%28methylnitrosamino%29-1-%283-pyridyl%29-1-butanone+exposure+of+Clara+cell+10-kDa+protein+knock-out+mice+causes+a+significantly+higher+incidence+of+airway+epithelial+hyperplasia+and+lung+adenomas+compared+with+wild+type+littermates. assertion.
- assertion asSentence The+synaptic+expression+of+utrophin+is+also+driven+by+calcineurin-NFAT+signaling+and+occurs+in+conjunction+with+signaling+events+that+involve+GA+binding+protein+and+PGC-1alpha. assertion.
- assertion asSentence Cardiac+contractile+dysfunction+of+mdx+mice+is+generally+worsened+in+mice+also+lacking+utrophin. assertion.
- assertion asSentence VAMP8+is+one+of+the+v-SNARE+that+regulate+the+lytic+ability+of+CTL+by+influencing+the+ability+of+the+lytic+granules+to+fuse+with+the+plasma+membrane+and+release+its+contents. assertion.
- assertion asSentence Regulate+primary+granule+fusion. assertion.
- assertion asSentence Vav2+plays+crucial+roles+in+the+maintenance+of+cardiovascular+homeostasis+in+mice. assertion.
- assertion asSentence Vav2%2F3+guanine+nucleotide+exchange+factors+play+a+critical+role+in+host-mediated+tumor+progression+and+angiogenesis%2C+particularly+in+tumor+endothelium. assertion.
- assertion asSentence A+non-functioning+VDR+is+associated+with+a+latent+defect+in+the+regulation+of+myeloid+cell+differentiation+and+proliferation. assertion.
- assertion asSentence Hypoxia-inducible+factor+1+alpha+%28Hif1a%29+and+vascular+endothelial+growth+factor+A+are+components+of+a+key+pathway+to+support+chondrocyte+survival+during+embryonic+bone+development. assertion.
- assertion asSentence Leptin+signaling+promotes+the+growth+of+mammary+tumors+and+increases+the+expression+of+vascular+endothelial+growth+factor+and+its+receptor+type+two+%28VEGF-R2%29. assertion.
- assertion asSentence The+tumor+biological+marker+CD147+functionally+mediates+MMP-11%2C+VEGF-A+expression+and+tumor+lymphatic+metastasis. assertion.
- assertion asSentence Immobilization+of+VEGF+is+a+useful+strategy+to+promote+the+invasion+and+proliferation+of+endothelial+cells+into+a+scaffold. assertion.
- assertion asSentence Tumor+cells+promote+their+growth+by+exploiting+A%282B%29+adenosine+receptor-dependent+regulation+of+VEGF+in+host+immune+cells. assertion.
- assertion asSentence The+RPE-derived+VEGF+plays+a+critical+role+in+choroidal+vascular+development+during+organogenesis+before+E15. assertion.
- assertion asSentence VEGF-B%2C+instead+of+acting+as+an+angiogenic+factor%2C+exerts+direct+neuroprotective+effects+through+FLT1. assertion.
- assertion asSentence That+OUBC+induces+profound+lymphangiogenesis+in+the+tumor+and+SLN+and+substantial+lymphatic+metastasis+to+SLN+through+VEGF-C%2FD-VEGFR-3+signaling+pathway. assertion.
- assertion asSentence VHL+loss+leads+to+senescence+under+atmospheric+conditions+%2821%25+O%282%29%29. assertion.
- assertion asSentence Neurons+express+vimentin+as+part+of+an+evolutionarily+conserved%2C+damage-response+mechanism+which+recapitulates+a+developmental+program+used+by+differentiating+neurons+to+establish+dendrites+and+synaptic+connections. assertion.
- assertion asSentence The+PACAP+and+VIP+have+evolved+to+possess+distinct+biological+activities+and+intimate+that+the+respective+knockout+phenotypes+represent+deficits+unmitigated+by+the+actions+of+the+complementary+related+peptide. assertion.
- assertion asSentence Both+VPAC1+and+VPAC2+receptors+are+dynamically+regulated+by+Ikaros%2C+a+master+transcriptional+regulator+for+thymocyte+differentiation%2C+during+early+thymic+development. assertion.
- assertion asSentence Both+VPAC1+and+VPAC2+receptors+are+dynamically+regulated+by+Ikaros%2C+a+master+transcriptional+regulator+for+thymocyte+differentiation%2C+during+early+thymic+development. assertion.
- assertion asSentence N-acetylcysteine+reduced+soluble+plasma-type+von+Willebrand+factor+%28vWF%29+multimers+in+a+concentration-dependent+manner+and+rapidly+degraded+ultra-large+vWF+multimer+strings+extruded+from+activated+endothelial+cells. assertion.
- assertion asSentence The+EVH1+domain+intrabodies+inhibit+only+the+function+that+regulates+IL-2+synthesis+without+affecting+the+overall+domain+structure+of+WASP. assertion.
- assertion asSentence WASp+expression+in+dendritic+cells+regulates+both+the+ability+to+traffic+to+secondary+lymphoid+organs+and+to+activate+naive+T+cells+in+lymph+nodes. assertion.
- assertion asSentence C-myc-tagged+murine+Wnt-1+produced+in+Escherichia+coli+is+appropriate+for+inducing+intracellular+signaling+of+the+canonical+Wnt+pathway+in+eukaryotic+cells+via+stabilization+of+cytosolic+beta-catenin. assertion.
- assertion asSentence Wnt-10b+is+unique+and+plays+an+important+role+in+differentiation+of+epithelial+cells+in+the+hair+follicle. assertion.
- assertion asSentence Wnt9b%2C+produced+by+the+kidney+collecting+ducts%2C+nonautonomously+regulates+morphogenesis+of+the+developing+kidney+tubules. assertion.
- assertion asSentence Wnt5a+and+Wnt5b+control+the+pace+of+transitions+between+different+chondrocyte+zones. assertion.
- assertion asSentence Wnt5a+regulates+chondrogenesis+and+chondrocyte+hypertrophy+in+a+stage-dependent+manner+through+differential+utilization+of+NFAT-+and+NF-kappaB-dependent+signal+transduction. assertion.
- assertion asSentence Wnt7b+is+a+key+regulator+of+the+tissue+architecture+that+establishes+a+functional+physiologically+active+mammalian+kidney. assertion.
- assertion asSentence WT1+expression+is+a+common+marker+of+both+hepatocyte+and+endothelial+progenitors. assertion.
- assertion asSentence Neuroglobin+contributes+to+neuronal+defensive+machinery+against+oxidative+injuries+by+regulating+14-3-3gamma+expression. assertion.
- assertion asSentence Ikaros+possesses+the+properties+of+a+bona+fide+tumor+suppressor+gene+for+the+T-cell+lineage. assertion.
- assertion asSentence Ik-1+and+Ik-2+proteins+through+their+DNA+binding+act+as+positive+regulators+of+ENK+gene+expression+in+the+developing+striatum+and+participate+in+regulating+enkephalinergic+differentiation. assertion.
- assertion asSentence Ikaros+acts+as+a+negative+regulator+on+iNOS+expression. assertion.
- assertion asSentence ZnT3+protein+is+involved+in+the+Abeta+aggregation+in+the+cerebellum+of+the+AbetaPP%2FPS1+mouse. assertion.
- assertion asSentence Endogenous+apelin-APJ+signaling+plays+a+modest+role+in+maintaining+basal+cardiac+function+in+adult+mice+with+a+more+substantive+role+during+conditions+of+stress. assertion.
- assertion asSentence Integrin+outside-in+signaling+and+platelet+spreading+requires+Src+family+kinase-dependent+and+ADP+receptor-amplified+activation+of+the+PI3K-Akt-GSK-3beta+pathway. assertion.
- assertion asSentence The+contribution+of+PS2+on+gamma-secretase+activity+is+of+less+importance%2C+explaining+the+mild+phenotype+of+PS2-deficient+mice. assertion.
- assertion asSentence BACE1+gene+expression+is+regulated+by+DNA+methylation+of+at+least+two+CpG+sites+at+positions+%2B298+and+%2B351+in+the+5%27-UTR+in+BV-2+microglial+cells. assertion.
- assertion asSentence The+presence+or+absence+of+associated+SKAP55+defines+functionally+distinct+pools+of+ADAP. assertion.
- assertion asSentence MIC-1+is+secreted+from+melanoma+cells+together+with+VEGF+to+promote+vascular+development+mediated+by+%28V600E%29B-Raf+signaling. assertion.
- assertion asSentence ERK5+regulates+Nur77+function+through+its+phosphorylation. assertion.
- assertion asSentence IGF-1-induced+myoblast+differentiation+and+hypertrophy+are+driven%2C+at+least+in+part%2C+by+Neu2+upregulation+and+further+support+the+significant+role+of+cytosolic+sialidase+in+myoblasts. assertion.
- assertion asSentence TCAP+acts%2C+in+part%2C+as+a+functional+region+of+the+teneurins+to+regulate+neurite+and+axonal+growth+of+neurons. assertion.
- assertion asSentence Osr1+and+Osr2+function+redundantly+to+control+synovial+joint+formation. assertion.
- assertion asSentence Slc26a4+is+upregulated+with+NaCl+restriction+and+is+critical+in+the+maintenance+of+acid-base+balance+and+in+the+renal+conservation+of+Cl-+and+water+during+NaCl+restriction. assertion.
- assertion asSentence The+subcellular+localization+of+RGS7+in+neurons+and+found+that+a+significant+fraction+is+present+in+cytoplasmic+puncta. assertion.
- assertion asSentence The+primary+role+of+double-stranded+RNA+binding+by+the+NS1A+protein+in+virus-infected+cells+is+to+sequester+dsRNA+away+from+RNAse+L. assertion.
- assertion asSentence The+severe+cardiac+dysfunction+in+Scgd%28-%2F-%29+mice+at+8+months. assertion.
- assertion asSentence SPRY1+is+an+endogenous+angiogenesis+inhibitor. assertion.
- assertion asSentence Antagonism+of+fibroblast+growth+factor+signaling+by+Sprouty2+is+essential+for+establishing+the+cytoarchitecture+of+the+organ+of+Corti+and+for+hearing. assertion.
- assertion asSentence H.+pylori+activates+TLR2+and+TLR4%2C+leading+to+the+secretion+of+distinct+cytokines+by+bone+marrow+derived+macrophages. assertion.
- assertion asSentence Formation+of+the+TLR1-TLR2+heterodimer+brings+the+intracellular+TIR+domains+close+to+each+other+to+promote+dimerization+and+initiate+signaling. assertion.
- assertion asSentence Macrophage-dependent+TLR2+signaling+is+crucial+for+TNF--dependent%2FRANKL-independent+osteoclastogenesis+in+response+to+Porphyromonas+gingivalis+infection. assertion.
- assertion asSentence Ara-LAM+confers+protection+against+leishmanial+pathogenesis+via+TLR2+signaling-mediated+induction+of+the+proinflammatory+response. assertion.
- assertion asSentence M.+tuberculosis+restricts+proinflammatory+responses+by+masking+cell+surface+interactions+between+TLR2+agonists+on+M.+tuberculosis+and+TLR2+on+macrophages+via+the+Hip1+protein. assertion.
- assertion asSentence CD36+modulates+the+cytokine-inducing+activity+of+Plasmodium+falciparum+glycosylphosphatidylinositols+by+collaborating+with+TLR2+in+dendritic+cells. assertion.
- assertion asSentence B+cell+activation+factor+%28BAFF%29+production+by+radiation-resistant+stromal+cells+is+completely+sufficient+to+provide+a+necessary+signal+for+B+cell+survival%2Fmaturation. assertion.
- assertion asSentence Interaction+of+ANG2%2C+a+proangiogenic+factor%2C+with+its+receptor+Tie2+promotes+neural+progenitor+cell+differentiation+into+neuronal+lineage+cells. assertion.
- assertion asSentence Fto+plays+an+essential+role+in+postnatal+growth. assertion.
- assertion asSentence The+phosphorylation+of+Ser%28338%29+and+Tyr%28341%29+on+Raf-1+exerts+an+important+effect+on+reconfiguring+the+two+MEK1-binding+sites. assertion.
- assertion asSentence HSP70+expression+is+up-regulated+by+SEK1+and+down-regulated+by+MKK7+through+distinct+MAPK+isoforms+in+mouse+embryonic+stem+cells+treated+with+cadmium+chloride. assertion.
- assertion asSentence DLK+plays+a+significant+role+in+the+coordinated+regulation+of+radial+migration+and+axon+projection+by+modulating+JNK+activity. assertion.
- assertion asSentence DLK+enhances+regeneration+by+promoting+a+retrograde+injury+signal+that+is+required+for+the+activation+of+the+neuronal+proregenerative+program. assertion.
- assertion asSentence HDAC4+binds+and+promotes+the+deacetylation+and+activation+of+a+key+MAP3+kinase%2C+MEKK2. assertion.
- assertion asSentence TAK1+is+a+critical+regulator+of+both+MAPK+and+BMP+signaling+and+is+necessary+for+proper+cartilage+and+joint+development. assertion.
- assertion asSentence PARP1+phosphorylation+by+ERK1%2F2+is+required+for+maximal+PARP-1+activation+after+DNA+damage. assertion.
- assertion asSentence ERK1%2F2+regulates+angiotensin+II-dependent+cell+proliferation+via+cytoplasmic+activation+of+RSK2+and+nuclear+activation+of+elk1. assertion.
- assertion asSentence While+TRAF6+is+absolutely+essential+for+TLR7+activation+of+ERK%2C+JNK+and+NF+kappa+B+pathways%2C+TLR4-induced+ERK%2C+JNK+pathways+and+IKK-mediated+phosphorylation+of+I+kappa+B+family+members. assertion.
- assertion asSentence Lipid+raft-enriched+insulin+receptor+substrate-1+contributes+substantially+to+growth+hormone-induced+ERK+activation+in+lipid+rafts+in+3T3-F442A+fibroblasts. assertion.
- assertion asSentence ERK1+and+ERK2+coordinate+endothelial+cell+proliferation+and+migration+during+angiogenesis. assertion.
- assertion asSentence Thiazolidinediones+%28TZDs%29+rapidly+activated+Erk1%2F2+and+p38+through+Ras+proteins+and+GPR40%2C+a+receptor+expressed+on+the+surface+of+osteocytes. assertion.
- assertion asSentence Cholesterol+depletion+induces+apoptosis+through+a+RhoA-+and+p38+MAPK-dependent+mechanism. assertion.
- assertion asSentence p38+MAPK+is+not+a+downstream+component+of+AMPK-mediated+signaling+in+skeletal+muscle. assertion.
- assertion asSentence Breast+cancer-derived+factors+induce+osteoclastogenesis+through+the+activation+of+calcium%2Fprotein+kinase+Calpha+and+TGFbeta-dependent+ERK1%2F2+and+p38+signaling+pathways. assertion.
- assertion asSentence IL-1beta+increases+the+excitability+of+hippocampal+CA1+neurons+in+the+p38-dependent+inhibition+of+I%28NMDA-OUT%29. assertion.
- assertion asSentence Over-expression+of+caveolin-1+aggravates+the+AT-1+injury+induced+by+LPS%2C+involving+in+modulation+of+the+cPLA2+mediated+by+the+cPLA2%2Fp38+MAPK+pathway. assertion.
- assertion asSentence Early+expression+of+p-p38+MAPK+in+the+microglia+and+late+induction+of+p-NF-kappaB+in+astrocyte+play+an+important+role+in+trigeminal+neuropathic+pain. assertion.
- assertion asSentence p38gamma+is+selectively+activated+in+slow+skeletal+muscle+and+is+involved+in+the+normal+growth+and+development+of+a+subset+of+skeletal+muscle. assertion.
- assertion asSentence Mechanical+stress+regulates+Runx2+activation+and+favors+osteoblast+differentiation+through+the+activation+of+MAPK+signal+transduction+pathways+and+Ras%2FRaf-dependent+ERK1%2F2+activation%2C+independent+of+p38+MAPK+signaling. assertion.
- assertion asSentence The+hepatocyte+growth+factor-dependent+phosphorylation+of+ERK1%2F2+is+the+endogenous+signal+that+sequesters+CAR+in+the+cytoplasm+of+mouse+primary+hepatocytes. assertion.
- assertion asSentence MEK1%2F2-ERK1%2F2+signaling+is+involved+in+the+adiponectin-induced+secretion+of+G-CSF. assertion.
- assertion asSentence Berberine+inhibited+Th17+differentiation+by+activating+ERK1%2F2+and+inhibited+Th1+differentiation+by+inhibiting+p38+MAPK+and+JNK+activation. assertion.
- assertion asSentence Thiazolidinediones+%28TZDs%29+rapidly+activated+Erk1%2F2+and+p38+through+G+protein-coupled+receptor+40+%28GPR40%29%2C+a+receptor+expressed+on+the+surface+of+osteocytes. assertion.
- assertion asSentence MKK4+is+an+essential+activator+of+JNK+required+for+the+normal+development+of+the+brain. assertion.
- assertion asSentence JSAP1+antagonizes+the+mitogenic+effect+of+Sonic+hedgehog+on+cerebellar+granule+cell+precursors+and+promotes+their+exit+from+the+cell+cycle+and+differentiation%2C+by+modulating+JNK+activity. assertion.
- assertion asSentence The+JNK+MAPK+positively+regulate+peptidoglycan-induced+iNOS+and+nitric+oxide+expression+by+activating+NF-kappaB+and+AP-1+transcription+factors. assertion.
- assertion asSentence Deletion+of+Nbea+leads+to+reduced+numbers+of+spinous+synapses+in+cultured+neurons+from+complete+knockouts+and+in+cortical+tissue+from+heterozygous+mice%2C+accompanied+by+altered+miniature+postsynaptic+currents. assertion.
- assertion asSentence LRH-1+and+Nanog+cooperate+to+regulate+Dax1+expression+in+mouse+embryonic+stem+cells. assertion.
- assertion asSentence Paxillin-kinase-linker+is+an+integral+component+of+growth+factor+and+cell+adhesion+cross-talk+signaling%2C+controlling+the+development+of+front-rear+cell+polarity+and+directional+cell+migration. assertion.
- assertion asSentence The+constitutive+degradation+pathway+for+cyclin+E+that+is+regulated+by+the+Cullin3-based+E3+ligase+is+essential+to+maintain+quiescence+in+mammalian+cells. assertion.
- assertion asSentence Wnt5a-Ror-Dishevelled+signaling+constitutes+a+core+noncanonical+Wnt+pathway+that+is+conserved+through+evolution+and+is+crucial+during+embryonic+development. assertion.
- assertion asSentence Affixin+is+a+dysferlin+binding+protein+that+colocalizes+with+dysferlin+at+the+sarcolemma+of+normal+skeletal+muscle. assertion.
- assertion asSentence Bid-mediated+mitochondrial+release+of+apoptosis-inducing+factor+followed+by+rapid+nuclear+translocation+is+a+major+mechanism+of+glutamate-induced+neuronal+death. assertion.
- assertion asSentence VILIP-1+led+to+reduced+migration+of+aggressive+SCC+cells+depending+on+cAMP+levels. assertion.