Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence One+way+in+which+inhibitory+signaling+can+control+NKG2D-mediated+activation+is+by+blocking+its+recruitment+to+GM1-rich+membrane+domains. assertion.
- assertion asSentence This+TLR+synergy+is+mediated%2C+at+least+in+part%2C+by+activation+of+the+transcription+factor+interferon+regulatory+factor+5+%28IRF5%29. assertion.
- assertion asSentence The+calcium+response+element+of+the+cocaine-+and+amphetamine-regulated+transcript+%28CART%29+proximal+promoter+is+involved+in+cyclic+AMP%2Fprotein+kinase+A%2FCREB+regulation+in+cells+having+a+neuronal+phenotype. assertion.
- assertion asSentence Pdk4+plays+an+important+role+in+bone+loss+at+unloading+by+promoting+osteoclastogenesis. assertion.
- assertion asSentence TWEAK%2FFn14+receptor+activation+exerts+different+effects+on+neural+progenitor+cells+and+their+progeny+depending+on+the+developmental+stage+of+the+cells. assertion.
- assertion asSentence CK1delta%2Fepsilon+binds+to+and+phosphorylates+the+N-terminal+domain+of+Dnmt1+and+regulates+Dnmt1+function+by+reducing+the+DNA-binding+activity. assertion.
- assertion asSentence Cicaprost+acts+by+regulating+the+expression+of+Skp2%2C+the+F-box+protein+that+targets+p27%28Kip1%29+for+ubiquitin-mediated+proteolysis. assertion.
- assertion asSentence Skp2+becomes+an+essential+survival+gene+when+susceptible+cells+incur+Rb1+deficiency. assertion.
- assertion asSentence ABCC6+localizes+to+the+mitochondria-associated+membrane+has+implications+for+its+mechanism+of+action+in+normal+and+diseased+states. assertion.
- assertion asSentence Oatp1a4+can+mediate+the+brain-to-blood+and+blood-to-brain+transport+of+its+substrate+drugs+across+the+blood-brain+barrier. assertion.
- assertion asSentence Signaling+from+TROY+regulates+neuronal+differentiation+at+least+in+part. assertion.
- assertion asSentence Melanopsin+in+retinal+ganglion+cells+is+involved+in+masking%2C+as+it+is+in+pupil+contraction+and+phase+shifts. assertion.
- assertion asSentence Even+if+melanopsin+functions+as+a+bistable+photopigment+with+photo-regenerative+activity+native+melanopsin+must+also+use+some+other+light-independent+retinoid+regeneration+mechanism+to+return+to+the+dark+state. assertion.
- assertion asSentence The+melanopsin-evoked+depolarization+in+retinal+ganglion+cells+is+not+mediated+by+either+TRPC3%2C+TRPC6+or+TRPC7+channel+subunits+alone. assertion.
- assertion asSentence Binding+of+phospho-Stat3+to+the+apelin+promoter+is+the+final+step+underlying+proinflammatory+cytokine-induced+enteric+apelin+expression+during+intestinal+inflammation. assertion.
- assertion asSentence SLIMMER+delayed+Siva-1-dependent+apoptosis+in+C2C12+myoblasts. assertion.
- assertion asSentence PI%283%29Kgamma+regulates+some+aspects+of+neutrophil+polarization+that+are+relevant+to+movement%2C+such+as+integrin-based+adhesion+and+the+accumulation+of+polymerized+%28F%29-actin+at+the+leading-edge. assertion.
- assertion asSentence In+vivo+network+of+alpha-tocopherol+%28AT%29%2C+AT-metabolites+and+ATTP+affects+the+transcription+of+genes+driven+by+AhR%2C+Nrf2+and+NF-kappaB%2C+transcription+factor+networks. assertion.
- assertion asSentence p150%28Sal2%29%2C+acting+in+part+as+a+p53-independent+regulator+of+p21+and+BAX%2C+can+function+in+some+cell+types+as+a+regulator+of+cell+growth+and+survival. assertion.
- assertion asSentence Host-derived+periostin+negatively+regulates+tumor+growth+by+promoting+capsule+formation+and+by+mediating+changes+in+the+deposition+and+organization+of+the+tumor+microenvironment+coordinated+by+periostin-producing+stromal+cells. assertion.
- assertion asSentence Periostin%2C+a+matricellular+protein%2C+promotes+incorporation+of+tenascin-C+into+the+extracellular+matrix+and+organizes+a+meshwork+architecture+of+the+extracellular+matrix. assertion.
- assertion asSentence The+majority+of+mutations+that+cause+type+3+hereditary+hemochromatosis+are+a+consequence+of+the+defective+localization+of+the+TFR2+protein. assertion.
- assertion asSentence HS6ST2+gene+influences+expression+of+genes+linked+to+aggrecan+metabolism+and+is+implicated+in+pathogenesis+of+osteoarthritis. assertion.
- assertion asSentence In+the+adrenal+gland%2C+PREB+regulates+the+transcription+of+the+CYP11B1+gene+via+cAMP. assertion.
- assertion asSentence IFN-gamma+stimulates+mC1rA+gene+expression+via+IRF-1+in+mouse+keratinocytes. assertion.
- assertion asSentence NG2%2B+polydendrocytes+in+the+embryonic+and+early+postnatal+brain+exhibit+developmental+fate+switch+from+oligodendrocytes+to+astrocytes+in+vivo+upon+removal+of+Olig2. assertion.
- assertion asSentence The+isolated+3.6-KB+promoter+fragment+alone+is+not+sufficient+for+the+complete+physiological+modulation+of+cyclin+C+RNA. assertion.
- assertion asSentence Tage4+represents+the+functional+orthologue+of+CD155+in+mouse. assertion.
- assertion asSentence Mammalian+nitrilase+2+is+omega-amidase. assertion.
- assertion asSentence Ncaph2+can+generate+three+different+N-termini%2C+all+encoded+by+exon+1%2C+one+of+which+is+translated+from+an+alternative+reading+frame. assertion.
- assertion asSentence Inhibition+of+ZNF238+%28RP58%29+expression+in+mouse+GNPs+decreases+the+expression+of+the+neuronal+differentiation+markers+MAP2+and+NeuN+and+downregulates+the+expression+of+the+cell+cycle+arrest+protein+p27%2C+a+regulator+of+GNP+differentiation. assertion.
- assertion asSentence The+Hap1-Ahi1+complex+in+the+brainstem+works+as+a+sensor+for+insulin+signals+in+feeding+control. assertion.
- assertion asSentence Caspr+serves+as+a+%22transmembrane+scaffold%22+that+stabilizes+the+Caspr%2Fcontactin+adhesion+complex+at+the+paranodal+junction+by+connecting+it+to+cytoskeletal+components+within+the+axon. assertion.
- assertion asSentence Retinoblastoma+protein+degradation+in+Lmna-%2F-+cells+occurs+by+gankyrin+and+MDM2-independent+mechanisms. assertion.
- assertion asSentence Spermatogenic+cells+lacking+Prx4+are+more+susceptible+to+cell+death+via+oxidative+damage+than+their+wild-type+counterparts. assertion.
- assertion asSentence Math5+is+not+sufficient+to+stimulate+retinal+ganglion+cell+%28RGC%29fate. assertion.
- assertion asSentence Msy2+represents+one+of+a+small+number+of+germ-cell-specific+genes+whose+deletion+leads+to+the+disruption+of+both+spermatogenesis+and+oogenesis. assertion.
- assertion asSentence Retinoid+X+receptor+%28RXR%29%2Fvitamin+D+receptor+and+RXR%2Fretinoic+acid+receptor-gamma+heterodimers+and+their+ligands+cell-autonomously+control+the+expression+of+thymic+stromal+lymphopoietin+in+mouse+epidermal+keratinocytes. assertion.
- assertion asSentence SNARE+proteins+are+necessary+for+the+increased+activity+of+KCC2+after+Zn%282%2B%29+stimulation+of+mZnR%2FGPR39. assertion.
- assertion asSentence OC-specific+NIK+lacking+its+TRAF3+binding+domain+%28NT3%29+transgenic+mice+have+an+exaggerated+osteolytic+response+to+arthritis. assertion.
- assertion asSentence NB-3+deficiency+affects+synapse+formation+during+postnatal+cerebellar+development. assertion.
- assertion asSentence Asc-1+is+the+only+high+affinity+D-serine+transporter+in+the+mouse+CNS+and+is+the+predominant+mechanism+for+D-serine+reuptake. assertion.
- assertion asSentence Modification+of+histones+bound+to+Cyp3a41+gene+contributes+to+sex+specificity+of+Cyp3a41+expression+by+controlling+access+of+HNF4+to+DNA. assertion.
- assertion asSentence RhoA-dependent+signaling+through+mDia1%2F2+and+the+MRTFs+is+important+for+SMC-specific+gene+expression+in+smooth+muscle+cells. assertion.
- assertion asSentence Cyclin-dependent+kinase-associated+proteins+Cks1+and+Cks2+are+essential+during+early+embryogenesis+and+for+cell+cycle+progression+in+somatic+cells. assertion.
- assertion asSentence IRF3+activation+is+a+master+switch+for+IL-27+synthesis. assertion.
- assertion asSentence Even+in+the+presence+of+exogenously+supplied+IFN%2C+IRF-3%28-%2F-%29+bone+marrow-derived+dendritic+cells+are+inherently+defective+in+the+control+of+HSV-1+replication. assertion.
- assertion asSentence IRF-3+serves+to+facilitate+virus+clearance+and+prevent+tissue+injury+in+response+to+reovirus+infection. assertion.
- assertion asSentence The+early+type+I+IFN+response+to+lymphocytic+choriomeningitis+virus+infection+in+the+central+nervous+system+is+controlled+by+a+concerted+action+of+IRF3+and+-7. assertion.
- assertion asSentence Variations+of+estrogen+alpha%2Fbeta+receptor+levels+are+associated+with+differences+in+social+interaction+through+the+OT+and+AVP+systems%2C+by+upregulating+gene+expression+for+those+peptides+and+the+oxytocin+and+vasopressin+1a+receptors. assertion.
- assertion asSentence T%28R%29+cells+and+the+ICOS-ICOS-ligand+signaling+pathway+are+critically+involved+in+respiratory+tolerance+and+in+downregulating+pulmonary+inflammation+in+asthma. assertion.
- assertion asSentence ICOS+on+activated+T+cells+contributes+to+neointimal+formation+through+the+regulation+of+smooth+muscle+cell+proliferation. assertion.
- assertion asSentence Expression+of+the+SVCT2+is+differentially+regulated+during+embryonic+development+and+in+adulthood. assertion.
- assertion asSentence GABA%28B%29R1+subunit+is+constitutively+expressed+by+adipocytes+to+primarily+regulate+leptin+expression+at+the+transcriptional+level. assertion.
- assertion asSentence The+Toll-like+receptor+7%2F9+response+to+nucleic+acids+in+dendritic+cells+is+biased+toward+DNA-sensing+by+Unc93B1. assertion.
- assertion asSentence A+specific+population+of+cortical+projection+neurons+can+be+directed+to+differentiate+outside+of+the+cortex+by+cell-autonomous+signaling. assertion.
- assertion asSentence Decreased+circulating+SO4+concentrations+modulate+5-HT+neurotransmitter+and+receptor+levels%2C+in+a+manner+consistent+with+the+behavioural+phenotypes+of+Nas1+mice. assertion.
- assertion asSentence IFT20+functions+in+the+delivery+of+ciliary+membrane+proteins+from+the+Golgi+complex+to+the+cilium. assertion.
- assertion asSentence Calbindin+D28k+acts+as+an+activity-dependent+sensor+that+targets+membrane%2Fcytoskeleton-bound+myo-inositol+monophosphatase+in+central+neurons. assertion.
- assertion asSentence Gene+expression+of+CXCL13%2C+a+chemokine+involved+in+B-cell+recruitment+into+lymphoid+follicles.the+presence+of+lymphoid+follicle-like+structures+containing+B+cells. assertion.
- assertion asSentence Mad2+and+BubR1+must+cooperate+to+inhibit+Cdc20+activity. assertion.
- assertion asSentence TRAF6-mediated+Lys%2863%29-linked+ubiquitination+of+Beclin-1+is+critical+for+TLR4-triggered+autophagy+in+macrophage. assertion.
- assertion asSentence HDAC7+nuclear+export+governs+a+self-sustaining+autoexcitatory+loop. assertion.
- assertion asSentence Cdh1+is+required+for+preventing+unscheduled+proliferation+of+specific+progenitor+cells+and+protecting+mammalian+cells+from+genomic+instability. assertion.
- assertion asSentence Show+that+this+regulation+of+editing+activity+cannot+be+explained+by+an+altered+expression+of+the+ADAR+proteins+but%2C+rather%2C+by+the+presence+of+a+regulatory+network+that+controls+the+editing+activity+during+development. assertion.
- assertion asSentence ADF%2Fn-cofilin-null+MKs+develop+significantly+fewer+proplatelets. assertion.
- assertion asSentence Mouse+Vps26b-Vps29-Vps35+retromer+complex+is+implicated+in+the+transport+of+sortilin+from+endosomes+to+the+trans-Golgi+network. assertion.
- assertion asSentence Haploinsufficiency+for+the+forkhead+transcription+factor+Foxo1+reverses+beta+cell+failure+in+Irs2%28-%2F-%29+mice+through+increased+expression+of+the+pancreatic+transcription+factor+pancreas%2Fduodenum+homeobox+gene-1+%28Pdx1%29. assertion.
- assertion asSentence FoxO1+modulates+energy+homeostasis+in+adipose+tissue+via+regulation+of+adipocyte+size+and+adipose+tissue-specific+gene+expression+in+response+to+excessive+calorie+intake. assertion.
- assertion asSentence Endothelial+cell+morphology+is+regulated+by+several+mechanisms+in+which+Foxo1+and+Foxo3+express+distinct+functional+properties+depending+on+differentiation+stages. assertion.
- assertion asSentence The+ERK5+signaling+pathway+promotes+cell+survival+by+downregulating+FasL+expression+via+a+mechanism+that+implicates+PKB-dependent+inhibition+of+Foxo3a+downstream+of+phosphoinositide+3+kinase. assertion.
- assertion asSentence FOXO3A+has+a+pivotal+role+in+dexamethasone+-induced+apoptosis. assertion.
- assertion asSentence Asna1+plays+a+crucial+role+during+early+embryonic+development. assertion.
- assertion asSentence MEF+promotes+cell+proliferation+and+functions+as+a+negative+regulator+of+osteogenic+differentiation+by+directly+interacting+with+Runx2+and+suppressing+its+transcriptional+activity. assertion.
- assertion asSentence Exhibited+specific+impairments+in+social+and+communication+behavior+displayed+specific+alterations+in+cortical+columnar+organization+in+the+somatosensory+cortex. assertion.
- assertion asSentence Inhibitor+of+apoptosis+proteins+are+required+during+development+to+limit+activity+of+receptor-interacting+protein+kinase+1+and+3+in+the+TNF+receptor+1+signalling+pathway. assertion.
- assertion asSentence The+promyogenic+effects+of+IGF-I+require+glycogen+synthase+kinase-3beta+%28GSK-3beta%29+inactivation+and+reveal+an+important+negative+regulatory+role+for+GSK-3beta+in+myogenesis. assertion.
- assertion asSentence GSK3beta+is+implicated+in+the+regulation+of+melanogenesis. assertion.
- assertion asSentence Cardioprotection+involves+both+a+pro-survival+mTOR+pathway+and+a+developmental+Wnt+pathway+targeting+GSK-3beta. assertion.
- assertion asSentence Integrin+outside-in+signaling+and+platelet+spreading+requires+Src+family+kinase-dependent+and+ADP+receptor-amplified+activation+of+the+PI3K-Akt-GSK-3beta+pathway. assertion.
- assertion asSentence Silencing+MR-1+protected+mice+myocardium+against+inflammatory+injury+induced+by+AngII+by+suppression+of+pro-inflammatory+transcription+factors+NF-kappaB+and+AP-1+signaling+pathway. assertion.
- assertion asSentence The+expansion+of+AKT-driven+prostate+epithelial+cells+requires+mTOR-dependent+survival+signaling+and+activation+of+hypoxia+inducible+factor+%28HIF%29-1+alpha. assertion.
- assertion asSentence PNC1+is+a+target+of+the+IGF-I%2FmTOR+pathway+that+is+essential+for+mitochondrial+activity+in+regulating+cell+growth+and+proliferation. assertion.
- assertion asSentence Dampening+the+TOR+pathway+leads+to+widespread+protection+from+an+array+of+age-related+diseases. assertion.
- assertion asSentence In+skeletal+muscle+cells+the+degradation+of+eIF3f+suppresses+S6K1+activation+by+mTOR+signaling. assertion.
- assertion asSentence mTOR+activation+in+hematopoietic+stem+cells+by+inflammatory+cytokines+underlies+defective+hematopoiesis+in+autoimmune+disease+and+inflammation. assertion.
- assertion asSentence Cardioprotection+involves+both+a+pro-survival+mTOR+pathway+and+a+developmental+Wnt+pathway+targeting+GSK-3beta. assertion.
- assertion asSentence Cxcl4+and+Cxcl7+play+a+role+in+the+development+of+neurobehavioral+alterations+that+are+triggered+by+in+utero+TCDD+exposure+and+later+surface+in+adults. assertion.
- assertion asSentence Brush+cells+of+the+mouse+trachea+express+the+receptors+Tas2R105+and+Tas2R108. assertion.
- assertion asSentence Brush+cells+of+the+mouse+trachea+express+the+receptors+Tas2R105+and+Tas2R108. assertion.
- assertion asSentence Basal+and+hormonal+stimulation+of+resistin+secretion+by+insulin+is+inhibited+by+ET-1. assertion.
- assertion asSentence Neuropeptie+Y+significantly+increased+resistin+mRNA+expression+in+white+adipose+tissue+compared+with+artificial+cerebrospinal+fluid+treated+controls. assertion.
- assertion asSentence DJ-1+regulates+expressions+of+genes+for+which+functions+are+thought+to+be+related+to+cell+death+or+neurodegeneration. assertion.
- assertion asSentence TACC2+is+not+required+for+mouse+development+and+normal+cell+proliferation+and+is+not+a+tumor+suppressor+protein. assertion.
- assertion asSentence Numerous+postmeiotic+genes+under+CREM+%28cAMP-responsive+element+modulator%29+control+require+the+coactivator+function+of+ACT+%28activator+of+CREM%29+in+testis. assertion.
- assertion asSentence The+proximal+promoter+of+IL-21+controls+its+Th-cell-subset-specific+expression+through+the+action+of+NFATc2+and+T-bet. assertion.
- assertion asSentence The+reduction+of+angptl4+mRNA+by+insulin+is+attenuated+in+insulin+resistance. assertion.
- assertion asSentence Transport+of+NH%284%29%28%2B%29+and+methyl+ammonium+%28%2B%29+by+Rhbg+is+pH+sensitive. assertion.
- assertion asSentence Cystatin+10+%28carminerin%29+contributes+to+chondrocyte+calcification+during+endochondral+ossification+under+physiological+and+pathological+conditions+through+the+transcriptional+inhibition+of+NPP1. assertion.
- assertion asSentence Ca%28v%293.2+T-channel-dependent+activation+of+extracellular+signal-regulated+kinase+in+paraventricular+thalamus+is+required+for+the+development+of+acid-induced+chronic+mechanical+hyperalgesia. assertion.