Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Loss+of+major+Shank3+species+produces+biochemical%2C+cellular+and+morphological+changes%2C+leading+to+behavioral+abnormalities+in+mice+that+bear+similarities+to+human+ASD+patients+with+SHANK3+mutations. assertion.
- assertion asSentence TRPM7+regulates+endocytic+compartmentalization+of+the+Fas+receptor+after+receptor+stimulation%2C+an+important+process+for+apoptotic+signaling. assertion.
- assertion asSentence UVR+activates+the+Bcl-2-regulated+apoptotic+pathway+predominantly+through+activation+of+Noxa+and%2C+depending+on+cellular+context%2C+Puma. assertion.
- assertion asSentence Expression+of+carbohydrate+response+element-binding+protein+%28ChREBP+or+Mlxipl%29%2C+an+important+transcriptional+regulator+of+carbohydrate+metabolism%2C+is+significantly+affected+in+compound+Foxa1%2Fa2+mutant+beta-cells. assertion.
- assertion asSentence Intraislet+ghrelin+does+not+play+a+major+role+in+the+regulation+of+insulin+secretion+in+vivo. assertion.
- assertion asSentence Gluconeogenesis+and+glycogenolysis+are+increased+and+insulin+sensitivity+is+improved+by+the+ablation+of+ghrelin+in+mice. assertion.
- assertion asSentence The+smpd3+promoter+is+activated+by+BMP2+and+is+directly+regulated+by+the+Runx2+transcription+factor. assertion.
- assertion asSentence CARM1+inhibits+pulmonary+cell+proliferation+and+is+required+for+proper+differentiation+of+alveolar+cells. assertion.
- assertion asSentence Evc+promotes+chondrocyte+proliferation%2C+chondrocyte+hypertrophy+and+the+differentiation+of+osteoblasts+in+the+perichondrium+and+reveal+that+Evc+is+essential+for+intrasphenoidal+synchondrosis+development. assertion.
- assertion asSentence ZFP191+is+required+for+the+myelinating+function+of+differentiated+oligodendrocytes. assertion.
- assertion asSentence Prdm8+is+an+obligate+partner+of+Bhlhb5%2C+forming+a+repressor+complex+that+directs+neural+circuit+assembly+in+part+through+the+precise+regulation+of+Cadherin-11. assertion.
- assertion asSentence PCBP3+can+function+as+a+repressor+dependent+on+binding+to+single-strand+and+double-stranded+poly%28C%29+sequences. assertion.
- assertion asSentence The+proximal+promoter+of+IL-21+controls+its+Th-cell-subset-specific+expression+through+the+action+of+NFATc2+and+T-bet. assertion.
- assertion asSentence C-Rel+plays+an+important+role+in+the+expression+of+IL-21+in+T+cells. assertion.
- assertion asSentence B7-H1+is+required+for+the+generation+of+multifunctional+Th1+responses+and+optimal+protective+immunity+to+primary+Salmonella+infection. assertion.
- assertion asSentence Inhibition+of+TRPA1+and+TRPV4+contribute+to+the+peripheral+analgesic+mechanisms+of+butamben. assertion.
- assertion asSentence Oocytes+lacking+Cables1+exhibit+lower+basal+levels+of+TAp63alpha+and+reduced+accumulation+of+phosphorylated+TAp63alpha+in+response+to+genotoxic+stress. assertion.
- assertion asSentence A+unified+change+in+nucleoside+transporter+%28NT%29+gene+expression+is+not+required+for+the+normal+development+and+functioning+of+the+ENT1+knockout+mice. assertion.
- assertion asSentence Ng+displays+a+strong+nuclear+localization+when+expressed+in+cell+lines+and+hippocampal+neurons. assertion.
- assertion asSentence SV2+performs+at+least+two+actions+at+the+synapse+that+contribute+to+neurotransmitter+release. assertion.
- assertion asSentence SMOC1%2FSmoc1+is+essential+for+ocular+and+limb+development+in+both+humans+and+mice. assertion.
- assertion asSentence Glycosylated+SV2A+and+SV2B+act+in+conjunction+with+gangliosides+to+mediate+the+entry+of+BoNT%2FE+into+neurons. assertion.
- assertion asSentence SV2+performs+at+least+two+actions+at+the+synapse+that+contribute+to+neurotransmitter+release. assertion.
- assertion asSentence The+Fe-heme+structure+in+solution+and+in+the+cryo-trapped+Ngb-carbonmonoxy+single+crystal+%28which+cracks+at+room+temperature%29+are+the+same. assertion.
- assertion asSentence Central+PGE2+synthesis+by+mPGES-1+is+a+general+and+critical+mechanism+for+fever+during+infectious+and+inflammatory+conditions. assertion.
- assertion asSentence The+TSC1%2FTSC2+complex+regulates+protein+translation+through+mainly+mTORC1-dependent+mechanisms+and+implicates+a+discrete+profile+of+deregulated+mRNA+translation+in+tuberous+sclerosis+pathology. assertion.
- assertion asSentence TSC2+phosphorylation+in+response+to+IGF-1+treatment+is+necessary+for+the+altered+distribution+of+the+TSC1%2FTSC2+complex+to+the+cytosol. assertion.
- assertion asSentence Calnuc+is+involved+in+LRP9+endosomal+sorting+to+prevent+the+delivery+of+LRP9+to+lysosomes. assertion.
- assertion asSentence Mixed+lineage+kinase-like+mitogen-activated+protein+triple+kinase+%28MLTK_-alpha+plays+a+key+role+in+the+UVB-+and+EGF-induced+phosphorylation+of+histone+H3+at+Ser28. assertion.
- assertion asSentence Junctate+over-expression+is+associated+with+an+increase+in+the+sarcoplasmic+reticulum+Ca2%2B+storage+capacity+and+releasable+Ca2%2B+content+and+support+a+physiological+role+for+junctate+in+intracellular+Ca2%2B+homeostasis. assertion.
- assertion asSentence Higher+plasma+apolipoprotein+AV+levels+reflect+an+increased+demand+for+plasma+triglyceride+hydrolysis+under+normal+physiological+conditions. assertion.
- assertion asSentence Cyclin-dependent+kinase-associated+proteins+Cks1+and+Cks2+are+essential+during+early+embryogenesis+and+for+cell+cycle+progression+in+somatic+cells. assertion.
- assertion asSentence Neudesin+plays+a+critical+role+in+the+early+stage+of+adipocyte+differentiation+in+which+C%2FEBPbeta+induces+PPARgamma+and+C%2FEBPalpha+expressions%2C+by+controlling+the+MAPK+pathway. assertion.
- assertion asSentence Bmi1+incorporates+Dmap1+in+polycomb+gene+silencing. assertion.
- assertion asSentence Anp32e%2FCpd1+mediates+synaptogenesis+process+by+modulating+Protein+Phosphatase+2A+activity. assertion.
- assertion asSentence PD-associated+LRRK2+mutations+display+disinhibited+kinase+activity+and+induce+a+progressive+reduction+in+neurite+length+and+branching+both+in+primary+neuronal+cultures+and+in+the+intact+rodent+CNS. assertion.
- assertion asSentence SIRT1+controls+ATGL+transcription+primarily+by+deacetylating+FoxO1. assertion.
- assertion asSentence Afg3l1+or+Afg3l2+are+required+for+maturation+of+newly+imported+paraplegin+subunits+after+their+cleavage+by+MPP. assertion.
- assertion asSentence Wwp2+influences+craniofacial+patterning+through+its+interactions+with+Goosecoid+%28Gsc%29. assertion.
- assertion asSentence N-acylethanolamine-hydrolyzing+acid+amidase+and+fatty+acid+amide+hydrolase+cooperatively+degrade+anandamide+and+other+N-acylethanolamines+in+macrophages. assertion.
- assertion asSentence Silencer+of+death+domains+protein+%28SODD%29+is+critical+for+the+regulation+of+tumor+necrosis+factor+signaling. assertion.
- assertion asSentence The+iron+storage+function+of+ferritin+plays+a+major+role+in+preventing+iron-mediated+cell+and+tissue+damage. assertion.
- assertion asSentence ALKBH8+is+a+tRNA+methyltransferase+required+for+the+final+step+in+the+biogenesis+of+mcm5U. assertion.
- assertion asSentence The+SCF%28atrogin-1%29+ubiquitin+ligase+complex+represses+calcineurin+by+targeting+it+for+ubiquitin-mediated+proteolysis%2C+leading+to+inhibition+of+cardiac+hypertrophy+in+response+to+pathologic+stimuli. assertion.
- assertion asSentence UFM1-UFBP1+participate+in+preventing+ER+stress-induced+apoptosis+in+protein+secretory+cells. assertion.
- assertion asSentence LPP3+participates+in+several+aspects+of+neuron-glia+communication+required+for+proper+cerebellum+development. assertion.
- assertion asSentence A+specific+isoform+of+beta-tubulin+is+required+for+mitosis. assertion.
- assertion asSentence PICT-1+plays+a+role+in+phosphatidylinositol+3%2C4%2C5-trisphosphate+signals+through+controlling+PTEN+protein+stability. assertion.
- assertion asSentence The+Gpr177-mediated+regulation+of+Wnt+is+crucial+for+organogenesis+in+health+and+disease. assertion.
- assertion asSentence The+interwoven+architecture+of+RNase+H2B+and+RNase+H2C+that+interface+with+RNase+H2A+in+a+complex+ideally+suited+for+nucleic+acid+binding+and+hydrolysis+coupled+to+protein-protein+interaction+motifs. assertion.
- assertion asSentence The+CFIm+subunits+NUDT21%2FCPSF5+and+CPSF6+are+highly+enriched+in+mouse+male+germ+cells+relative+to+somatic+cells. assertion.
- assertion asSentence That+DNA+repear+process+is+dictated+by+PARP1+through+its+interaction+with+the+chromosome-targeting+domain+of+the+hCAP-D2+subunit+of+condensin+I. assertion.
- assertion asSentence Neuritin+expression+is+well+correlated+to+the+maturation+of+hepatocytes+and+can+be+a+useful+tool+to+define+the+differentiation+stage+of+hepatocytes. assertion.
- assertion asSentence AdiR2+expression+is+regulated+by+palmitate+via+PPAR-alpha. assertion.
- assertion asSentence Nogo-A+becomes+phosphorylated+at+Tyr-694+in+the+N-terminal+region. assertion.
- assertion asSentence WASH+generates+an+actin+network+on+a+restricted+domain+of+sorting+and+recycling+endosomes. assertion.
- assertion asSentence DDAH1+is+required+for+metabolizing+asymmetrical+dimethylarginine+and+N%28omega%29-monomethyl-L-arginine. assertion.
- assertion asSentence Conformational+changes+in+the+switch+II+element+of+Nog1+have+a+critical+importance+for+the+dissociation+of+preribosome-bound+factors+during+intranucleolar+maturation. assertion.
- assertion asSentence The+deletion+of+Pacrg+%28PARKIN-coregulated+gene%29+is+the+cause+of+male+sterility+in+the+Quaking%28viable%29+%28qk%28v%29%29+mutant+mouse. assertion.
- assertion asSentence In+glycogen+synthase+kinase+%28GSK%293alpha%2FGSK3beta+homozygous+knockin+cells%2C+Wnt3a+induces+normal+inactivation+of+GSK3. assertion.
- assertion asSentence Tetherin+markedly+inhibits+the+replication+of+Moloney+murine+leukemia+virus+%28Mo-MLV%29+and+is+required+for+the+antiretroviral+activity+of+IFNalpha+to+be+fully+manifested+in+vitro. assertion.
- assertion asSentence A+tightly+controlled+expression+of+mKlhdc2+is+essential+for+a+faithful+execution+of+the+myogenic+differentiation+and+migration+program. assertion.
- assertion asSentence The+interwoven+architecture+of+RNase+H2B+and+RNase+H2C+that+interface+with+RNase+H2A+in+a+complex+ideally+suited+for+nucleic+acid+binding+and+hydrolysis+coupled+to+protein-protein+interaction+motifs. assertion.
- assertion asSentence Sema3F-dependent+inhibition+of+Rac1+by+the+Rac-GAP+beta2Chn+is+required+for+hippocampal+infrapyramidal+tract+pruning. assertion.
- assertion asSentence A+lack+of+neuronal+expression+of+CysLTR+in+the+murine+colonic+myenteric+plexus+attenuates+colitis+disease+progression. assertion.
- assertion asSentence Med23+serves+as+a+critical+link+transducing+insulin+signaling+to+the+transcriptional+cascade+during+adipocyte+differentiation. assertion.
- assertion asSentence One+major+function+of+AFAP-110+is+to+relay+signals+from+protein+kinase+C+alpha+that+direct+the+activation+of+c-Src+and+the+formation+of+podosomes. assertion.
- assertion asSentence The+functions+of+both+Inturned+and+Fuzzy+in+neural+tube+patterning+are+dependent+on+the+presence+of+cilia. assertion.
- assertion asSentence Activation+of+angiotensin+II+type+2+receptors+is+responsible+for+reduced+prorenin%2Frenin+receptor+expression+in+response+to+angiotensin+II+and+high+glucose+in+glomerular+mesangial+cells+and+renal+tissue+of+streptozocin-treated+rats. assertion.
- assertion asSentence PPARalpha+acts+as+a+key+component+of+brown+fat+thermogenesis+by+coordinately+regulating+lipid+catabolism+and+thermogenic+gene+expression+via+induction+of+PGC-1alpha+and+PRDM16. assertion.
- assertion asSentence GPR125+is+specifically+expressed+in+cells+of+the+choroid+plexus+and+is+upregulated+following+traumatic+brain+injury. assertion.
- assertion asSentence Edd+has+an+essential+role+in+extraembryonic+development. assertion.
- assertion asSentence Mrf-2+facilitates+the+induction+of+key+adipogenic+transcription+factors+C%2FEBPalpha+and+peroxisome+proliferator-activated+receptor-gamma. assertion.
- assertion asSentence FLRT3+plays+a+key+role+in+controlling+cell+adhesion+and+tissue+morphogenesis+in+the+developing+mouse+embryo. assertion.
- assertion asSentence Changes+in+MDA5+and+PTPN2+expression+modify+beta-cell+responses+to+dsRNA. assertion.
- assertion asSentence Viral+RNA+stimulates+glomerular+mesangial+cells+to+produce+large+amounts+of+type+I+IFN%2C+especially+when+being+delivered+into+the+intracellular+cytosol+where+it+can+interact+with+Mda5. assertion.
- assertion asSentence FLJ23560+%28BBS10%29+mutations+are+a+significant+cause+of+BBS. assertion.
- assertion asSentence The+two+different+PA+oligomers+are+equally+stabilized+by+ANTXR+interactions. assertion.
- assertion asSentence B55alpha-dependent+targeting+of+the+PP2A+holoenzyme+to+Akt+selectively+regulates+Akt+phosphorylation+at+Thr-308+to+regulate+cell+proliferation+and+survival. assertion.
- assertion asSentence Palladin+is+a+binding+partner+for+profilin%2C+interacting+with+profilin+via+a+poly+proline-containing+sequence+in+the+amino-terminal+half+of+palladin. assertion.
- assertion asSentence p70+S6+kinase+limits+the+TNF-alpha-stimulated+IL-6+synthesis+at+a+point+upstream+from+p44%2Fp42+MAP+kinase+and+Akt+in+osteoblast-like+cells. assertion.
- assertion asSentence In+skeletal+muscle+cells+the+degradation+of+eIF3f+suppresses+S6K1+activation+by+mTOR+signaling. assertion.
- assertion asSentence S6-kinases+1+and+2+are+dispensable+for+the+induction+of+SREBP+processing. assertion.
- assertion asSentence MNK2+plays+a+unique+role%2C+not+shared+by+its+closest+paralog+MNK1%2C+in+limiting+protein+translation+through+its+negative+effect+on+eIF4G+Ser1108+phosphorylation+and+p70S6K+activation. assertion.
- assertion asSentence A+repressive+nuclear+inhibitory+protein+element+is+involved+in+the+negative+regulation+of+AdipoR1+promoter+by+insulin. assertion.
- assertion asSentence AdipoR1+is+expressed+on+warm+sensitive+neurons+of+the+hypothalamic+preoptic+area+and+contribute+to+central+hyperthermic+effects+of+adiponectin. assertion.
- assertion asSentence The+UA%2FEC+region+is+a+functional+domain+of+LOTUS+serving+for+an+antagonistic+action+to+NgR1. assertion.
- assertion asSentence Afg3l1+or+Afg3l2+are+required+for+maturation+of+newly+imported+paraplegin+subunits+after+their+cleavage+by+MPP. assertion.
- assertion asSentence NFAT3%2Fcyclooxygenase-2+act+as+a+link+between+inflammation+and+carcinogenesis+by+being+involved+in+the+tumor+promotion+stage. assertion.
- assertion asSentence IRAK-M+selectively+attenuates+p38+activation+and+inhibits+innate+immunity+through+stabilizing+MKP-1. assertion.
- assertion asSentence Focal+adhesion+kinase+%28FAK%29+and+the+Arp2%2F3+complex+associate+and+colocalize+at+transient+structures+formed+early+after+cell+adhesion. assertion.
- assertion asSentence The+Arp2%2F3+complex+localizes+to+the+oocyte+cortical+cap+in+a+Ran-GTPase-dependent+manner+and+nucleates+actin+filaments+in+the+cortical+cap+and+a+cytoplasmic+actin+network. assertion.
- assertion asSentence Both+beta-TrCP-+and+Hrd1-dependent+degradation+mechanisms+regulate+the+transcriptional+activity+of+Nrf1+to+maintain+cellular+homeostasis. assertion.
- assertion asSentence Homocysteine-induced+ganglion+cell+loss+involves+the+dysregulation+of+mitochondrial+dynamics%2C+both+in+vivo+and+in+vitro. assertion.
- assertion asSentence Gtsf1%2FCue110+is+required+for+spermatogenesis+and+involved+in+retrotransposon+suppression+in+male+germ+cells. assertion.
- assertion asSentence RhoE+can+play+important+roles+in+the+postnatal+development+and+maturation+of+the+CNS%2C+especially+in+the+migratory+processes+affecting+the+neurones. assertion.
- assertion asSentence Debt91+is+an+immediate+early+gene+up-regulated+during+growth+factor-induced+branching+tubulogenesis. assertion.
- assertion asSentence Downregulation+of+Sost%2Fsclerostin+in+osteocytes+is+an+obligatory+step+in+the+mechanotransduction+cascade+that+activates+Wnt+signaling+and+directs+osteogenesis+to+where+bone+is+structurally+needed. assertion.
- assertion asSentence SPSB1+acts+through+a+negative-feedback+loop+that%2C+together+with+SPSB2%2C+controls+the+extent+of+iNOS+induction+and+nitric+oxide+production. assertion.
- assertion asSentence Loss+of+REDD1+induces+HIF-1+stabilization+and+tumorigenesis+through+a+reactive+oxygen+species-dependent+mechanism. assertion.