Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence p110beta+is+essential+for+the+ATP-+and+statin-induced+effects+and+support+a+role+of+nuclear+pAkt+in+cancer+development. assertion.
- assertion asSentence ATP13A2+regulates+mitochondrial+bioenergetics+through+macroautophagy. assertion.
- assertion asSentence SIRT4+inhibition+increases+fat+oxidative+capacity+in+liver+and+mitochondrial+function+in+muscle. assertion.
- assertion asSentence PCOLCE2+is+required+for+efficient+procollagen+processing+and+deposition+of+fibrillar+collagen+in+the+pressure-overloaded+myocardium. assertion.
- assertion asSentence Spinal+cord+injury+doesn%27t+significantly+change+the+expression+of+CatSpers+3. assertion.
- assertion asSentence IL-33+is+sufficient+and+required+for+severe+allergic+inflammation+in+the+lung+and+support+the+concept+of+IL-33+as+a+therapeutic+target+in+allergic+lung+inflammation. assertion.
- assertion asSentence An+inhibition+of+osteoclastogenesis+is+one+of+the+major+physiological+functions+of+IL-33%2C+at+least+in+mice. assertion.
- assertion asSentence ARMS%2FKidins220+is+important+for+the+growth+of+dendritic+arbors+and+spine+stability+during+an+activity-+and+BDNF-dependent+period+of+development. assertion.
- assertion asSentence CXCL13%2FCXCR5+facilitated+antigen+encounter+and+BCR+signaling+by+promoting+membrane+ruffling+and+LFA-1-supported+adhesion+require+a+functional+actin+cytoskeleton+and+the+activity+of+the+motor+protein+non-muscle+myosin+II+%28NM-II%29. assertion.
- assertion asSentence Prdm8+expression+is+tightly+regulated+in+a+spatio-temporal+manner+during+neural+development+and+mainly+restricted+to+postmitotic+neurons%2C+except+in+the+spinal+cord. assertion.
- assertion asSentence Prdm8+is+an+obligate+partner+of+Bhlhb5%2C+forming+a+repressor+complex+that+directs+neural+circuit+assembly+in+part+through+the+precise+regulation+of+Cadherin-11. assertion.
- assertion asSentence The+anorectic+actions+of+central+leptin+or+cerulenin+are+impaired+in+mice+with+brain+CPT-1c+deleted. assertion.
- assertion asSentence NT-4KO+mice+have+deficits+in+macronutrient+feedback+from+the+gastrointestinal+tract. assertion.
- assertion asSentence NT4+functions+at+early+embryonic+stages+and+is+derived+from+different+sources+than+Bdnf. assertion.
- assertion asSentence RACK1+functions+as+a+key+component+in+regulating+the+IRE1alpha+signaling+pathway+in+pancreatic+beta+cells. assertion.
- assertion asSentence %2857%29Arg+in+the+basic+region+of+DEC2+is+essential+for+its+activity+in+suppressing+CLOCK%2FBMAL2-mediated+transactivation. assertion.
- assertion asSentence Pumilio-2+is+expressed+most+abundantly+in+germ+cells+with+the+highest+expression+in+undifferentiated+gonocytes+and+spermatogonia. assertion.
- assertion asSentence The+absence+of+prestin%2C+not+hair-cell+loss%2C+is+the+primary+cause+of+high-frequency+hearing+threshold+elevation+in+prestin-%2F-+and+%2B%2F-+mice. assertion.
- assertion asSentence GPR50+can+enhance+TIP60-coactiavtion+of+glucocorticoid+receptor+%28GR%29+signalling. assertion.
- assertion asSentence The+TM+domain+of+TLR9+is+a+critical+regulatory+element+that+targets+TLR9+to+its+intracellular+location. assertion.
- assertion asSentence TLR4%2C+TLR9+and+MyD88+are+not+required+for+the+positive+selection+of+autoreactive+B+cells+in+the+primary+B+cell+repertoire. assertion.
- assertion asSentence Early+production+of+IFN+in+herpes+simplex+virus+infection+is+mediated+through+Toll-like+receptor+9+%28TLR9%29+and+plasmacytoid+dendritic+cells. assertion.
- assertion asSentence PLSCR1+is+a+TLR9-interacting+protein+that+plays+an+important+role+in+pDC%27s+type+1+IFN+responses+by+regulating+TLR9+trafficking+to+the+endosomal+compartment. assertion.
- assertion asSentence betaKlotho+and+FGFRs+form+the+cognate+FGF-21+receptor+complex%2C+mediating+FGF-21+cellular+specificity+and+physiological+effects. assertion.
- assertion asSentence Both+beta-Klotho+and+FGF-15%2F19+repress+the+apical+sodium-dependent+bile+acid+transporter+in+enterocytes+and+cholangiocytes. assertion.
- assertion asSentence tauCstF-64+mRNA+is+regulated+at+the+translational+or+post-translational+level. assertion.
- assertion asSentence IL-23+and+IL-17+form+a+functionally+relevant+%22immunological+axis%22+in+the+lungs+in+vivo. assertion.
- assertion asSentence IL-12+and+IL-23+signaling+are+dispensable+in+generating+a+protective+T-cell+response+following+CNS+infection+with+mouse+hepatitis+virus. assertion.
- assertion asSentence NXF2%2C+a+nucleo-cytoplasmic+mRNA+transporter%2C+plays+additional+roles+in+the+cytoplasmic+localization+of+mRNAs+through+interactions+with+cytoplasmic+motor+proteins. assertion.
- assertion asSentence Bicc1+functions+by+modulating+the+expression+of+polycystin+2+%28Pkd2+by+antagonizing+the+repressive+activity+of+the+miR-17+microRNA+family+on+the+3%27UTR+of+Pkd2+mRNA. assertion.
- assertion asSentence The+absence+of+Tas1R3+or+presence+of+the+non-taster+allele+in+mice+predetermines+rejection+of+alcohol. assertion.
- assertion asSentence TGF-beta1+promotes+epithelial-mesenchymal+transition+by+increasing+intracellular+ROS+levels+via+down-regulation+of+the+Grx1+gene+in+EpRas+cells. assertion.
- assertion asSentence Methylenetetrahydrofolate+reductase+deficiency+impairs+endothelial+progenitor+cell+formation+and+increases+endothelial+progenitor+cell+senescence+by+endothelial+nitric+oxide+synthase+uncoupling+and+downregulation+of+SIRT1. assertion.
- assertion asSentence Mir-9+and+Sirt1+protein+levels+are+actively+regulated+in+vivo+in+beta-islets+during+glucose-dependent+insulin+secretion. assertion.
- assertion asSentence miR-34a+is+required+for+proper+neuronal+differentiation%2C+in+part%2C+by+targeting+SIRT1+and+modulating+p53+activity. assertion.
- assertion asSentence Sirtuin+1+%28SIRT1%29-mediated+inhibition+of+hyperglycemia-induced+vascular+cell+senescence+is+mediated+at+least+partly+through+the+reduction+of+oxidative+stress. assertion.
- assertion asSentence Wnt7b+signals+through+Fzd1+and+-10+and+LRP5+and+implicate+these+Wnt+coreceptors+in+the+regulation+of+lung+airway+and+vascular+development. assertion.
- assertion asSentence P2X5+receptors+are+expressed+on+LHRH-containing+neurons. assertion.
- assertion asSentence TRIM11+plays+a+role+in+the+regulation+of+intracellular+humanin+level+through+ubiquitin-mediated+protein+degradation+pathways. assertion.
- assertion asSentence OAZ+participates+in+a+developmental+switch+regulating+the+transition+from+differentiation+to+maturation+in+ORNs. assertion.
- assertion asSentence Cognitive+impairment+related+to+OPHN1+loss+of+function+is+associated+with+both+presynaptic+and+postsynaptic+alterations. assertion.
- assertion asSentence PRG4+plays+a+significant+role+in+preserving+normal+joint+structure+and+function. assertion.
- assertion asSentence The+CDK2%2Fcyclin+E%2Fp220%28NPAT%29%2FHINFP%2Fhistone+gene+signaling+pathway+at+the+G1%2FS+phase+transition+is+an+essential%2C+nonredundant+cell+cycle+regulatory+mechanism+that+is+established+early+in+embryogenesis. assertion.
- assertion asSentence CUL4A+restricts+cellular+repair+capacity+by+regulating+nucleotide+excision+repair+and+the+G1%2FS+checkpoint+through+selective+degradation+of+the+DDB2+and+XPC+DNA+damage+sensors+and+the+p21%2FCIP1%2FWAF1+checkpoint+effector. assertion.
- assertion asSentence The+serine+protease+PCSK9+%28proprotein+convertase+subtilisin+kexin+type+9%29+contributes+to+the+disposal+of+non-acetylated+BACE1. assertion.
- assertion asSentence PCSK9-nullmice+carried+more+LDLR+and+less+insulin+in+their+pancreas. assertion.
- assertion asSentence Glucose-6-phosphate+dehydrogenase+%28G6PD%29+is+the+only+NADPH-producing+enzyme+activated+in+response+to+oxidative+stress. assertion.
- assertion asSentence The+extracellular+matrix+protein+mindin+modifies+the+airway+response+to+both+LPS+and+ozone. assertion.
- assertion asSentence All+mice+homozygous+for+a+null+allele+of+Tmem16a+died+within+one+month+of+birth+and+exhibited+severe+tracheomalacia+with+gaps+in+the+tracheal+cartilage+rings+along+the+entire+length+of+the+trachea. assertion.
- assertion asSentence The+CDK2%2Fcyclin+E%2Fp220%28NPAT%29%2FHINFP%2Fhistone+gene+signaling+pathway+at+the+G1%2FS+phase+transition+is+an+essential%2C+nonredundant+cell+cycle+regulatory+mechanism+that+is+established+early+in+embryogenesis. assertion.
- assertion asSentence Fig4+deficiency+affects+motor+neurons+differently+from+sensory+neurons+by+mechanisms+involving+excessive+retention+of+molecules+in+lysosomes+or+disruption+of+vacuolated+organelles. assertion.
- assertion asSentence ATP-citrate+lyase+%28ACLY%29+expression+and+activity+can+be+suppressed+by+exogenous+lipids+and+demonstrate+a+critical+role+for+ACLY+in+pancreatic+beta+cell+survival. assertion.
- assertion asSentence There+is+a+direct+correlation+between+ischemic+injury+and+extracellular+glycine+concentration+maintained+by+glycine+decarboxylase+and+the+glycine+cleavage+multienzyme+system. assertion.
- assertion asSentence CK1delta%2Fepsilon+binds+to+and+phosphorylates+the+N-terminal+domain+of+Dnmt1+and+regulates+Dnmt1+function+by+reducing+the+DNA-binding+activity. assertion.
- assertion asSentence Zizimin1+plays+an+important+role+in+dendrite+growth+in+hippocampal+neurons+through+activation+of+Cdc42. assertion.
- assertion asSentence Phr1+is+an+essential+regulator+of+retinal+ganglion+cell+projection+during+both+dLGN+and+SC+topographic+map+development. assertion.
- assertion asSentence GGEx18+improves+obesity+through+skeletal+muscle+AMPK+and+AMPK-stimulated+expression+of+PPARalpha+and+its+target+enzymes+for+fatty+acid+oxidation. assertion.
- assertion asSentence Lysophosphatidic+acid+stimulates+thymic+stromal+lymphopoietin+and+CCL20+expression+in+bronchial+epithelial+cells+via+CARMA3-mediated+NF-kappaB+activation. assertion.
- assertion asSentence DLK1+and+DLK2+act+as+inhibitory+non-canonical+protein+ligands+for+the+NOTCH1+receptor+that+modulate+NOTCH+signaling. assertion.
- assertion asSentence Galphai-TNFAIP8-mediated+rescue+of+pre-oncogenic+cells+enhances+progression+to+oncogenic+transformation%2C+providing+a+selective+target+to+inhibit+cellular+transformation. assertion.
- assertion asSentence UNC5A+promotes+neuronal+apoptosis+during+spinal+cord+development+independent+of+netrin-1. assertion.
- assertion asSentence Transcription+factor+ATF5+is+expressed+in+the+postnatal+brain. assertion.
- assertion asSentence Dio3+is+expressed+in+the+immature+cochlea+before+type+2+deiodinase+and+has+a+protective+role+in+hearing. assertion.
- assertion asSentence Osr2+is+involved+in+TGF-beta+regulating+cell+migration+and+cell+cycle+via+a+Smad3-ATF2+transcriptional+complex+mediating+pathway. assertion.
- assertion asSentence Dextromethorphan+inhibition+of+proton+currents+would+suppress+NADPH+oxidase+activity+and%2C+eventually%2C+microglial+activation. assertion.
- assertion asSentence A+second+cdk9+isoform%2C+termed+cdk9-55%2C+plays+a+fundamental+role+in+muscle+regeneration+and+differentiation+in+vivo. assertion.
- assertion asSentence CMF1+regulates+myocyte+differentiation+by+interaction+with+Rb+family+members+to+induce+expression+of+myogenic+regulatory+factors. assertion.
- assertion asSentence UT-B+deletion+causes+progressive+heart+block+in+mice. assertion.
- assertion asSentence CaMKIIdelta2+downregulates+insulin+gene+expression+by+Ser142+phosphorylation+of+CREB+and+reducing+binding+of+CREB+to+CBP. assertion.
- assertion asSentence mGluR1+and+mGluR5+play+different+and+non-overlapping+roles+in+the+regulation+of+the+excitability+of+bulbar+dopaminergic+neurons. assertion.
- assertion asSentence Activation+of+AMP-activated+protein+kinase+is+involved+in+vincristine-induced+cell+apoptosis+in+B16+melanoma+cells. assertion.
- assertion asSentence Mice+with+a+Carma1+point+mutation+lack+thymic+CD4%28%2B%29Foxp3%28%2B%29+T%28reg%29+cells+and+demonstrate+a+cell-intrinsic+requirement+for+CARMA1+in+thymic+Foxp3+induction. assertion.
- assertion asSentence Orai1+plays+a+critical+role+in+the+differentiation+and+function+of+osteoclasts%2C+by+regulating+activation+of+the+transcription+factor+NFATc1. assertion.
- assertion asSentence During+olfactory+neurogenesis%2C+NPY+acts+as+a+trophic+factor+for+the+maturation+and+survival+of+olfactory+receptor+neurons. assertion.
- assertion asSentence AAV-mediated+latexin+transduction+or+administration+of+a+small+molecule+carboxypeptidase+A+inhibitor+significantly+reduced+acetone-evoked+nociceptive+behavior+after+SNI. assertion.
- assertion asSentence The+abundance+of+GLO1+varies+between+different+murine+strains+and+within+different+sensory+neuron+populations. assertion.
- assertion asSentence PCL+induces+L929+cell+apoptosis+and+autophagy+via+blocking+Ras-Raf+and+PI3K-Akt+signaling+pathways. assertion.
- assertion asSentence AKP1C+type+is+controlled+by+Akp1c+allele+which+is+codominant+with+Akp1a+and+Akp1b+alleles. assertion.
- assertion asSentence ACh+reduced+alkaline+phosphatase+%28ALP%29+activity+in+osteoblasts. assertion.
- assertion asSentence A+keratinocyte+antigen-responsive+gamma+delta+T+cell+receptor+is+necessary+for+dendritic+epidermal+T+cells+%28DETC%29+to+become+activated+during+wound+repair+and+to+be+maintained+in+the+epidermis. assertion.
- assertion asSentence Gammadelta+T+cells+promote+the+resolution+of+fibrosis+through+the+production+of+CXCL10. assertion.
- assertion asSentence In+the+adrenal+gland%2C+PREB+regulates+the+transcription+of+the+CYP11B1+gene+via+cAMP. assertion.
- assertion asSentence PMI-null+cells+can+salvage+mannose+from+both+endogenous+and+external+glycoconjugates+via+lysosomal+and+nonlysosomal+degradation+pathways. assertion.
- assertion asSentence Euchromatic+Histone+H3+lysine+9+%28H3-K9%29+methylation+regulated+by+G9a+is+essential+for+early+embryogenesis+and+is+involved+in+the+transcriptional+repression+of+developmental+genes. assertion.
- assertion asSentence An+intramolecular+interaction+between+the+SH2+and+kinase+domains+in+Bcr-Abl+is+both+necessary+and+sufficient+for+high+catalytic+activity+of+the+enzyme. assertion.
- assertion asSentence Alpha-DB+plays+a+role+in+a+structure+or+regulation+mechanism+unique+to+MCH-expressing+neurons. assertion.
- assertion asSentence Rat+and+mouse+MCH+neurons+are+differentially+involved+in+anatomical+networks+that+control+feeding+and+the+sleep%2Fwake+cycle. assertion.
- assertion asSentence -1+ribosomal+frameshifting+contributes+to+the+toxicity+associated+with+%28exp%29CAG+repeats. assertion.
- assertion asSentence Ribosomal+S6+kinases+1+and+2+alone+are+not+essential+for+the+development+of+cardiac+hypertrophy. assertion.
- assertion asSentence Binding+of+ribosomal+S6+kinase+2+to+PDZ+domain+proteins+and+phosphorylation+of+these+proteins+or+their+binding+partners+regulates+excitatory+synaptic+transmission. assertion.
- assertion asSentence Mineralocorticoid+receptor+signaling+regulates+basal+monocyte%2Fmacrophage+function. assertion.
- assertion asSentence Macrophages+from+bbee+compared+to+single+knockout+mice+revealed+decreased+expression+of+essential+immune+response-related+genes+and+networks. assertion.
- assertion asSentence The+adapter+protein+PINCH1+critically+participates+in+the+regulation+of+the+cellular+radiosensitivity+of+normal+and+malignant+cells+similarly+under+adhesion+and+suspension+conditions. assertion.
- assertion asSentence The+electrostatic+switch+in+CBD1+and+the+associated+conformational+change+are+necessary+for+Na%2B%2FCa2%2B+exchanger+activation. assertion.
- assertion asSentence Glucocorticoid+treatment+blunts+LPS-induced+increase+in+%5BCa%282%2B%29%5D%28i%29+in+dendritic+cells+by+increasing+expression+and+activity+of+Na%28%2B%29%2FCa%282%2B%29+exchanger+NCX3. assertion.
- assertion asSentence Myocardial+expression+of+IL-1+is+sufficient+to+cause+LV+hypertrophy. assertion.
- assertion asSentence The+expression+of+interleukin-1+plays+an+important+role+in+lipopolysaccharide-induced+activation+of+microglia+and+the+associated+functional+deficits+in+learning+and+memory. assertion.
- assertion asSentence Deletion+of+DNaseI+hypersensitive+sites+does+not+have+an+obvious+impact+on+the+IgH+locus+or+B+cell+development. assertion.
- assertion asSentence hs5-7%2C+a+high-density+CTCF-binding+region+at+the+3%27+end+of+the+Igh+locus%2C+impacts+usage+of+V%28H%29+regions+as+far+as+500+kb+away. assertion.
- assertion asSentence Poly%28A%29+tail+elongation+and+shortening+is+a+mechanism+in+regulating+the+decay+of+casein+mRNA. assertion.