Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Among+all+three+PHD+proteins%2C+PHD2+is+uniquely+essential+during+mouse+embryogenesis. assertion.
- assertion asSentence TNF-alpha+inhibits+POEM+expression+through+the+NF-kappaB+signaling+pathway+and+down-regulation+of+POEM+influences+the+inhibition+of+osteoblast+differentiation+by+TNF-alpha. assertion.
- assertion asSentence Both+SPRED1+and+SPRED2+inhibit+the+ability+of+DYRK1A+to+phosphorylate+its+substrates. assertion.
- assertion asSentence Sp1+and+Sp3+compete+to+regulate+SK3+channel+expression+during+pregnancy+in+response+to+stimulation+by+estrogen. assertion.
- assertion asSentence Acquisition+of%2C+or+alterations+in%2C+commensal+bacteria+influences+intestinal+immune+homeostasis+via+direct+regulation+of+the+IL-25-IL-23-IL-17+axis. assertion.
- assertion asSentence Affixin+is+a+dysferlin+binding+protein+that+colocalizes+with+dysferlin+at+the+sarcolemma+of+normal+skeletal+muscle. assertion.
- assertion asSentence Puma+functions%2C+in+the+context+of+induced+overexpression+or+IL-3+deprivation%2C+primarily+by+binding+and+inactivating+anti-apoptotic+Bcl-2+family+members. assertion.
- assertion asSentence PGC-1beta+drives+the+formation+of+highly+oxidative+fibers+containing+type+IIX+myosin+heavy+chain. assertion.
- assertion asSentence The+Delphilin+protein+exhibits+diversity+at+its+N-terminus+by+variable+usage+of+the+first+several+exons. assertion.
- assertion asSentence TIM-1+signaling+in+B+cells+augments+antibody+production+by+enhancing+B+cell+proliferation+and+differentiation. assertion.
- assertion asSentence Progressive+retinal+degeneration+occurred+after+removal+of+Dicer+raises+the+possibility+that+miRNAs+are+involved+in+retinal+neurodegenerative+disorders. assertion.
- assertion asSentence The+expression+of+Sfmbt2+miRNAs+is+dependent+on+Dicer. assertion.
- assertion asSentence Reduced+functional+DNMT+activity+is+not+a+salient+feature+of+DICER1-deficient+embryonic+stem+cells. assertion.
- assertion asSentence Combined+NL1+and+SC1+overexpression+triggers+excitotoxic+neurodegeneration+through+SC1+signaling+at+synaptic+connections+initiated+by+NL1. assertion.
- assertion asSentence P2Y%282%29R%2FFLNa+interaction+selectively+regulates+spreading+and+migration+of+vascular+SMCs. assertion.
- assertion asSentence Local+epithelial+Rspo1+signalling+is+required+for+normal+development+of+the+mammary+gland. assertion.
- assertion asSentence TRPV1+channels+located+on+the+rectum+and+distal+colon+play+a+major+role+in+the+motor+function+in+the+large+intestine. assertion.
- assertion asSentence Conditioned+media+from+Lactobacillus+GG+induce+expression+of+heat+shock+protein+%28Hsp%2925+and+72+in+intestinal+epithelial+cells. assertion.
- assertion asSentence BPTF%2FFAC1+is+essential+in+the+extraembryonic+lineage+for+correct+development+of+the+ectoplacental+cone+and+fetomaternal+interactions. assertion.
- assertion asSentence p125%2FSec23-interacting+protein+plays+an+important+role+in+spermiogenesis. assertion.
- assertion asSentence BTLA+functions+to+regulate+T-cell+signaling+by+controlling+the+phosphorylated+form+of+TCRzeta+accumulation+in+the+lipid+raft. assertion.
- assertion asSentence The+ability+of+cells+to+rephosphorylate+4E-BP1%2C+resynthesise+eIF4GI+and+restore+the+rate+of+protein+synthesis+after+inactivation+of+p53+is+an+important+aspect+of+recovery+following+the+relief+of+physiological+stress. assertion.
- assertion asSentence MNK2+plays+a+unique+role%2C+not+shared+by+its+closest+paralog+MNK1%2C+in+limiting+protein+translation+through+its+negative+effect+on+eIF4G+Ser1108+phosphorylation+and+p70S6K+activation. assertion.
- assertion asSentence Cbl-b+controls+Runx2+expression+at+the+post-translational+level. assertion.
- assertion asSentence In+skeletal+muscle%2C+HDAC4+is+a+critical+modulator+of+MEF2-dependent+structural+and+contractile+gene+expression+in+response+to+neural+activity. assertion.
- assertion asSentence HDAC4+binds+and+promotes+the+deacetylation+and+activation+of+a+key+MAP3+kinase%2C+MEKK2. assertion.
- assertion asSentence This+TAF3+activity+is+critical+for+early+lineage+segregation+during+stem+cell+differentiation. assertion.
- assertion asSentence FABP3+stimulates+glucose+uptake+by+facilitating+AMPK-dependent+AS160+phosphorylation+in+skeletal+muscle. assertion.
- assertion asSentence NRG1+type+I+impacts+on+hippocampal+function+and+circuitry. assertion.
- assertion asSentence Mrgprd+influences+the+excitability+of+polymodal+nonpeptidergic+nociceptors+to+mechanical+and+thermal+stimuli. assertion.
- assertion asSentence LGI3+localizes+to+the+endocytic+pathway+and+its+accumulation+is+caused+by+endocytic+perturbation. assertion.
- assertion asSentence LGI3+is+a+neuritogenic+factor+whose+signaling+pathway+involves+Akt-mediated+FAK+activation. assertion.
- assertion asSentence M1+and+M5+muscarinic+cholinergic+receptors+are+not+involved+in+anti-viral+immunity. assertion.
- assertion asSentence The+minimal+90-amino+acid+AF9+fragment+in+MLL-AF9+retains+an+ability+to+form+higher+order+complexes+with+AF4%2AP-TEFb+and+with+DOT1. assertion.
- assertion asSentence Involves+VGLUT3. assertion.
- assertion asSentence The+majority+of+central+serotonin+is+generated+by+TPH2. assertion.
- assertion asSentence Jmjd3-mediated+H3K27+demethylation+is+crucial+for+regulating+M2+macrophage+development+leading+to+anti-helminth+host+responses. assertion.
- assertion asSentence The+sustained+inhibition+of+gastric+secretion+due+to+tumours+producing+PYY%2Fenteroglucagon+in+transgenic+mice+is+associated+with+an+increase+in+AQP4+expression+and+a+down-regulation+of+H%28%2B%29%2FK%28%2B%29-ATPase+in+parietal+cells. assertion.
- assertion asSentence Relative+deficiency+of+one+or+more+inositol+phosphates+accounts+for+neural+tube+defects+in+inositol+1%2C3%2C4-trisphosphate+5%2F6-kinase+knockout+mice. assertion.
- assertion asSentence Trif-related+adapter+molecule+%28TRAM%29+is+transiently+phosphorylated+by+PKCepsilon+on+serine-16+in+a+Toll-like+receptor+4-dependent+manner. assertion.
- assertion asSentence The+expression+of+HNF-6+and+OC-2+regulators+of+liver+and+pancreas+development+is+modulated+by+miR-495+and+miR-218. assertion.
- assertion asSentence Onecut-2%2FOnecut-3+double+knockout+is+a+perinatal+lethal. assertion.
- assertion asSentence %2864%29Cu-SarAr-SA-Aoc-bombesin%287-14%29+and+%2864%29Cu-SarAr-SA-Aoc-GSG-bombesin%287-14%29+bound+with+high+affinity+to+GRPR-expressing+cells. assertion.
- assertion asSentence Erk4+is+dispensable+for+mouse+embryonic+development+and+reveals+that+Erk3+and+Erk4+have+acquired+specialized+functions+through+evolutionary+diversification. assertion.
- assertion asSentence APH-1a+is+the+major+mammalian+APH-1+homolog+present+in+presenilin-dependent+gamma-secretase+complexes+during+embryogenesis. assertion.
- assertion asSentence NHE10+is+highly+expressed+in+OCs+in+response+to+receptor+activator+of+nuclear+factor-kappaB+ligand+signaling+and+is+required+for+OC+differentiation+and+survival. assertion.
- assertion asSentence Mpp4+organizes+a+presynaptic+protein+complex+and+has+a+role+in+modulating+Ca%282%2B%29+homeostasis+and+synaptic+transmission+in+rod+photoreceptors. assertion.
- assertion asSentence Diacylglycerol+kinase+delta+regulates+epidermal+growth+factor+receptors+by+modulating+protein+kinase+C+signaling. assertion.
- assertion asSentence DGKzeta+is+involved+in+IQGAP1%2FRac1-mediated+phagocytosis+upon+LPS+stimulation+in+macrophages. assertion.
- assertion asSentence GPR103b+and+QRFP+work+in+an+autocrine%2Fparacrine+manner+to+regulate+adipogenesis. assertion.
- assertion asSentence Sarcosin+%28Krp1%29+mRNA+is+expressed+in+the+myotome+part+of+the+mature+somites+in+mouse+embryos+from+embryonic+day+9.5+onwards. assertion.
- assertion asSentence CerkL+does+not+contribute+to+phosphorylation+of+Cer+and+has+no+impact+on+Cer+and+C16-C1P+levels+in+the+retina. assertion.
- assertion asSentence Expression+of+CA9+is+regulated+through+both+the+HIF-1+and+unfolded+protein+response+hypoxia+response+pathways+in+vitro+and+in+vivo. assertion.
- assertion asSentence The+dwarf+phenotype+of+the+cn%2Fcn+mouse+is+caused+by+a+loss-of-function+mutation+of+the+natriuretic+peptide+receptor+2+gene. assertion.
- assertion asSentence NPR-B+activity+represents+a+significant+portion+of+the+natriuretic+peptide-dependent+guanylyl+cyclase+activity+in+the+normal+heart+and+accounts+for+the+majority+of+the+natriuretic+peptide-dependent+activity+in+the+failed+heart. assertion.
- assertion asSentence The+CNP%2FGC-B+system+participates+in+regulation+of+adipogenesis%2C+particularly+at+an+early+stage+in+the+process. assertion.
- assertion asSentence Hypocretin+signaling+acting+on+Hcrtr-1+in+the+PVN+plays+a+crucial+role+in+the+expression+of+nicotine+withdrawal. assertion.
- assertion asSentence Prolactin+regulates+the+transcription+of+ZnT2+through+activation+of+the+Jak2%2FSTAT5+signaling+pathway+to+assist+in+providing+optimal+zinc+for+secretion+into+milk+during+lactation. assertion.
- assertion asSentence Gbx1+is+regionally+enriched+in+the+Basal+Nucleus+of+Meynert+of+mouse+brain. assertion.
- assertion asSentence P2X2+receptors+are+expressed+on+LHRH-containing+neurons. assertion.
- assertion asSentence Double+P2X2%2FP2X3+purinergic+receptor+knockout+mice+are+unable+to+respond+to+NaCl+or+the+artificial+sweetener+SC45647+as+taste+stimuli%2C+mirroring+the+lack+of+gustatory+nerve+responses+to+these+substances. assertion.
- assertion asSentence Clec9A+provides+targeted+recruitment+of+the+adaptive+immune+system+during+infection+and+can+also+be+utilized+to+enhance+immune+responses+generated+by+vaccines. assertion.
- assertion asSentence OSCAR+is+a+collagen+receptor+that+binds+to+specific+collagen+motifs+and+costimulates+osteoclastogenesis+in+DAP12-deficient+humans+and+mice. assertion.
- assertion asSentence These+two+siglec+proteins+have+evolved+distinct+endocytic+mechanisms+consistent+with+roles+in+cell+signaling+and+innate+immunity. assertion.
- assertion asSentence Amyotrophic+lateral+sclerosis-linked+mutations+can+variably+cause+loss+of+nuclear+functions+of+TLS+depending+on+the+degree+of+impairment+in+nuclear+localization. assertion.
- assertion asSentence Stomach+GOAT+mRNA+levels+correlate+with+circulating+acylated-ghrelin+levels+in+fasted+and+diet-induced+obese+mice. assertion.
- assertion asSentence CSGalNAcT1+is+required+for+normal+CS+production+in+developing+cartilage. assertion.
- assertion asSentence The+phospholipase+Cgamma2+signaling+pathway+plays+a+role+in+activation+of+light-chain+loci+and+contributes+to+receptor+editing. assertion.
- assertion asSentence Afg3l1+or+Afg3l2+are+required+for+maturation+of+newly+imported+paraplegin+subunits+after+their+cleavage+by+MPP. assertion.
- assertion asSentence Development+of+the+CD8%2B+ILLs+present+in+SH2+domain-containing+leukocyte+protein%2C+76-kDa+Y145F+mice+require+Eomes+and+PLZF. assertion.
- assertion asSentence Collybistin+deficiency+leads+to+significant+changes+of+GABAergic+inhibition%2C+network+excitability+and+synaptic+plasticity+in+vivo. assertion.
- assertion asSentence Diosgenin+stimulation+of+fecal+cholesterol+excretion+is+independent+of+NPC1L1-mediated+cholesterol+absorption. assertion.
- assertion asSentence Localization+and+function+of+Sidekick-2+require+its+incorporation+into+a+MAGI-containing+synaptic+scaffold. assertion.
- assertion asSentence The+majority+of+triglyceride+destined+for+secretion+by+liver+is+synthesized+by+DGAT2. assertion.
- assertion asSentence Activin+A+induces+IgA+isotype+switching+via+Smad3%2F4-mediated+germ+line+alpha+transcription. assertion.
- assertion asSentence Rspo2+is+critical+for+maintenance+of+the+AER+and+for+growth+and+patterning+in+limb+development. assertion.
- assertion asSentence The+IRAP+binding+protein%2C+vimentin%2C+plays+an+important+role+in+retention+of+GLUT4+storage+vesicles. assertion.
- assertion asSentence B7-H4+is+one+of+multiple+negative+cosignaling+molecules+that+collectively+provide+a+fine-tuning+mechanism+for+T-cell-mediated+immune+responses. assertion.
- assertion asSentence Murine+interferon-alpha12+is+a+protein+with+all+the+biological+traits+of+a+type+I+interferon. assertion.
- assertion asSentence EAAT5+acts+as+a+major+inhibitory+presynaptic+receptor+at+mammalian+rod+bipolar+cell+axon+terminals. assertion.
- assertion asSentence Plexin-A4+is+involved+in+the+precise+positioning+of+oligodendrocyte+precursor+cells+in+developing+cerebral+cortex. assertion.
- assertion asSentence Both+M2+mediate+the+muscarinic+autoinhibition+in+ACh+release+in+the+longitudinal+muscle+with+myenteric+plexus+preparation+of+the+mouse+ileum. assertion.
- assertion asSentence Cholinergic+modulation+through+M2+receptors+regulates+feedforward+inhibition+in+a+context-dependent+manner. assertion.
- assertion asSentence M1+and+M4+receptors+are+the+major+mAChR+subtypes+responsible+for+direct+cholinergic+modulation+of+the+excitatory+hippocampal+circuit. assertion.
- assertion asSentence Myocarditis+and+dilated+cardiomyopathy+associated+with+the+presence+of+autoantibodies+aginst+M2+muscarinic+acetylcholine+receptors+are+autoimmune+diseases. assertion.
- assertion asSentence Mutation+of+Chd2+dramatically+affects+mammalian+development+and+long-term+survival. assertion.
- assertion asSentence Nanos3+maintains+the+germ+cell+lineage+by+suppressing+both+Bax-dependent+and+Bax-independent+apoptotic+pathways. assertion.
- assertion asSentence The+CDK2%2Fcyclin+E%2Fp220%28NPAT%29%2FHINFP%2Fhistone+gene+signaling+pathway+at+the+G1%2FS+phase+transition+is+an+essential%2C+nonredundant+cell+cycle+regulatory+mechanism+that+is+established+early+in+embryogenesis. assertion.
- assertion asSentence The+Rab27a-Myrip-MyoVIIa+complex+regulates+tethering+of+melanosomes+onto+actin+filaments%2C+a+process+that+ensures+melanosome+movement+towards+the+cell+periphery. assertion.
- assertion asSentence STAT1-deficient+mice+produced+reduced+amounts+of+IL-27%2C+IL-10+and+SOCS1+and+developed+more+severe+uveitis. assertion.
- assertion asSentence The+silent+chemokine+receptor+CCX-CKR1%2C+regulates+homeostatic+leukocyte+migration+by+controlling+the+availability+of+chemokines+in+the+extracellular+space. assertion.
- assertion asSentence Compared+to+srGAP2+and+srGAP3%2C+the+onset+of+srGAP1+expression+is+later+in+most+CNS+tissues+in+mouse. assertion.
- assertion asSentence Loss+of+WRP+is+linked+to+impaired+learning+and+memory. assertion.
- assertion asSentence IRAK-4+kinase+activity+is+required+for+IRAK-4-dependent+signaling+in+innate+and+adaptive+immunity. assertion.
- assertion asSentence Through+regucalcin+and+L-gulonolactone+oxidase+expression%2C+beta-catenin+regulates+vitamin+C+biosynthesis+in+liver. assertion.
- assertion asSentence Cerebellofugal+axons+tend+to+stall+within+the+midline+region+in+Robo1%2F2+double+knockout+mice. assertion.
- assertion asSentence mGlu4+receptor+enhancers+are+promising+drugs+for+the+treatment+of+medulloblastomas. assertion.
- assertion asSentence mGlu4%2F5+receptor+subtypes+regulate+neuronal+differentiation+of+embryonic+stem+cells+in+a+context-dependent+manner. assertion.
- assertion asSentence Legionella+pneumophila-mediated+caspase-1+activation+involves+the+coordinate+activities+of+inflammasomes+differentially+regulated+by+Ipaf+and+Asc. assertion.
- assertion asSentence Neurofascin+optimizes+communication+between+mature+neurons+by+anchoring+the+key+elements+of+the+adult+axon+initial+segment+complex. assertion.