Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence MR+polyubiquitination+mediates+the+recruitment+of+p97+toward+the+endosomal+membrane%2C+proving+the+central+role+of+the+endocytic+receptor+and+its+ubiquitination+in+antigen+translocation. assertion.
- assertion asSentence NUP98-HOXA10HD%2C+a+novel%2C+canonical+NUP98-Hox+fusion%2C+significantly+enhances+the+self-renewal+capacity+of+hematopoietic+stem+cells. assertion.
- assertion asSentence Plasticity-related+gene-3+%28PRG-3%29+is+differentially+expressed+between+the+dorsal+and+lateral+cortex+at+P6. assertion.
- assertion asSentence Acetaldehyde+causes+nociception+via+TRPA1+activation. assertion.
- assertion asSentence TRPA1+is+involved+in+ET-1-induced+spontaneous+pain-like+behavior+in+mice. assertion.
- assertion asSentence HNF1alpha+is+a+more+potent+activator+of+AFM+promoter+than+is+HNF1beta. assertion.
- assertion asSentence Reduced+repair+of+a+DNA+topoisomerase+I-DNA+covalent+complex+because+of+truncated+CSB+proteins+is+involved+in+the+pathogenesis+of+CS-B. assertion.
- assertion asSentence The+absence+of+expression+of+the+three+isoenzymes+of+Itpk+does+not+prevent+the+formation+of+IP5+and+IP6%2C+at+least+in+mouse+embryonic+fibroblasts. assertion.
- assertion asSentence The+antiatherogenic+effects+of+PON2+are%2C+in+part%2C+mediated+by+the+role+of+PON2+in+mitochondrial+function. assertion.
- assertion asSentence MILI+and+MIWI2+play+essential+roles+in+establishing+de+novo+DNA+methylation+of+retrotransposons+in+fetal+male+germ+cells. assertion.
- assertion asSentence Expression+of+CD59b+is+essentially+restricted+to+adult+testis. assertion.
- assertion asSentence MafA+is+a+key+regulator+of+glucose-stimulated+insulin+secretion+in+vivo. assertion.
- assertion asSentence VGF+and%2For+VGF-derived+peptides+modulate+sympathetic+outflow+pathways+to+regulate+fat+storage+and+energy+expenditure. assertion.
- assertion asSentence Increased+activation+of+mTORC1+can+promote+carcinogenesis. assertion.
- assertion asSentence Insulin+receptor+substrate+2+is+crucially+involved+in+the+regulation+of+beta+cell+mass+and+leptin+sensitivity+in+beta+cells+and+the+hypothalamus. assertion.
- assertion asSentence Irs2%28-%2F-%29+mice+should+be+produced+by+embryo+transfer+using+Irs2%28-%2F-%29+mice+from+a+colony+consisting+of+female+Irs2%28-%2F%2B%29+x+male+Irs2%28-%2F-%29. assertion.
- assertion asSentence miR-9+suppresses+TLX+expression+to+negatively+regulate+neural+stem+cell+proliferation+and+accelerate+neural+differentiation. assertion.
- assertion asSentence Overexpression+of+miR-21+leads+to+a+pre-B+malignant+lymphoid-like+phenotype%2C+demonstrating+that+mir-21+is+a+genuine+oncogene. assertion.
- assertion asSentence MiR-150+controls+B+cell+differentiation+by+targeting+the+transcription+factor+c-Myb. assertion.
- assertion asSentence miR-182+functions+as+a+FoxO1+inhibitor+to+antagonize+osteoblast+proliferation+and+differentiation%2C+with+a+subsequent+negative+effect+on+osteogenesis. assertion.
- assertion asSentence The+regulation+of+the+transcription+of+the+miR-212%2F132+miRNA+cluster+and+the+miRNAs+derived+from+it+are+regulated+by+the+ERK1%2F2+pathway%2C+via+both+MSK-dependent+and+-independent+mechanisms. assertion.
- assertion asSentence Among+the+altered+aspects+of+intermediate+metabolism+detected+in+the+dwarf+mouse+liver--glutathione+metabolism%2C+the+urea+cycle+and+polyamine+biosynthesis--miRNA-27a+is+a+key+post-transcriptional+control. assertion.
- assertion asSentence miR-27a+promotes+myoblast+proliferation+through+targeting+myostatin. assertion.
- assertion asSentence miR-125b+buffers+and+fine-tunes+p53+network+activity+by+regulating+the+dose+of+both+proliferative+and+apoptotic+regulators. assertion.
- assertion asSentence hcrtr1+and+2+signaling+oppose+one+another+in+the+regulation+of+depression-like+behaviors. assertion.
- assertion asSentence Panx2+is+expressed+in+the+spiral+and+Scarpa%27s+ganglion+neurons. assertion.
- assertion asSentence SPAG8+acts+as+a+regulator+of+ACT+and+plays+an+important+role+in+CREM-ACT-mediated+gene+transcription+during+spermatogenesis. assertion.
- assertion asSentence Class+I+HDACs+increase+HNF4alpha+protein+expression+and+the+transcriptional+activity+of+FoxO1%2C+followed+by+the+induction+of+PEPCK+mRNA+expression+and+gluconeogenesis+in+liver. assertion.
- assertion asSentence Nlrc5+is+important+in+the+regulation+of+MHC-I+expression+by+reducing+H3K27me3+on+MHC-I+promoter+and+joins+CIITA+as+an+NLR+subfamily+that+controls+MHC+gene+transcription. assertion.
- assertion asSentence SAP-1+is+a+microvillus-specific+receptor-type+protein+tyrosine+phosphatase+that+regulates+intestinal+tumorigenesis. assertion.
- assertion asSentence Antigen+challenge+via+the+airway+activates+Gr-1%28%2B%29+cells+and+consequently+MMP+to+facilitate+the+recruitment+of+Th+cells+in+the+airway+inflammatory+response. assertion.
- assertion asSentence Parp-14+is+more+weakly+expressed%2C+mainly+in+the+thymus+during+development+and+in+adulthood. assertion.
- assertion asSentence GPx4+is+a+selenoenzyme+modulating+interneuron+function+and+parvalbumin+expression. assertion.
- assertion asSentence Sax2+is+required+for+the+coordinated+crosstalk+of+factors+involved+in+the+maintenance+of+energy+homeostasis. assertion.
- assertion asSentence miR-92a%2C+miR-150+and+miR-451+are+among+the+10+most+abundant+miRNA+in+plasma. assertion.
- assertion asSentence miR-92a%2C+miR-150+and+miR-451+are+among+the+10+most+abundant+miRNA+in+plasma. assertion.
- assertion asSentence Both+the+breeding+capacity+%28number+of+pups+produced%2Fbreeding+cage+during+a+5+months+period%29+and+the+mean+litter+size+are+significantly+increased+in+B10.Q.NFR%2FN-Fecq4+congenic+mice. assertion.
- assertion asSentence ISG15+plays+an+anti-dengue+virus+and+West+Nile+virus+function+via+protein+ISGylation. assertion.
- assertion asSentence Internalization+is+the+first+step+to+attenuation+of+Dectin-1-mediated+pro-inflammatory+responses. assertion.
- assertion asSentence Subcellular+region-specific+modifications+of+BC1+affect+the+binding+to+FMRP+and+the+interaction+with+its+mRNA+targets. assertion.
- assertion asSentence Transcriptional+activation+and+mRNA+stabilization+are+coordinately+regulated+by+calcium+and+cyclic+AMP+signals+for+the+cumulative+expression+of+pituitary+adenylate+cyclase+activating+polypeptide+mRNA+in+neurons. assertion.
- assertion asSentence PACAP+is+involved+in+DEX-induced+DA+biosynthesis+and+cell+proliferation+in+PC12+cells. assertion.
- assertion asSentence The+pY489-beta-adducin+immunoreactivity+is+located+in+the+hypothalamic+tanycytes+and+is+enhanced+after+fasting+for+36-48+h. assertion.
- assertion asSentence Activation+of+presynaptic+beta%282%29-adrenoceptors+facilitates+spontaneous+glutamate+release+to+VMH+neurons+via+cAMP%2FPKA+signal+transduction+pathway. assertion.
- assertion asSentence Muscle+fiber+type-dependent+effects+of+clenbuterol+on+expression+of+beta%282%29-AR+mRNA+are+closely+related+to+the+down-regulation+of+mRNA+expression. assertion.
- assertion asSentence Elevated+dietary+salt+enhances+the+sympathoexcitatory+actions+of+Ang+II+in+the+rostral+ventrolateral+medulla+%28RVLM%29+via+changes+in+the+intrinsic+properties+of+RVLM+neurons. assertion.
- assertion asSentence Glucose+induces+the+up-regulation+of+PRR+and+its+ligands+prorenin+and+renin%2C+leading+to+increased+IL-1beta+and+COX-2+production+via+the+angiotensin+II-dependent+pathway. assertion.
- assertion asSentence Angiotensin+I+%5Bas+Ang+%281-7%29%5D+is+involved+in+regulation+of+glucose+transport+in+jejunal+enterocytes. assertion.
- assertion asSentence Both+sex+and+hormonal+levels+can+selectively+affect+the+expression+and+subcellular+distribution+of+components+of+the+angiotensin+II+signaling+pathway+within+C1+RVLM+neurons. assertion.
- assertion asSentence Upregulation+of+AT%281%29R+and+iNOS+in+the+rostral+ventrolateral+medulla+is+important+in+the+maintenance+of+high+blood+pressure+and+renal+sympathetic+activation+in+2K-1C+hypertension. assertion.
- assertion asSentence AT2+within+both+RVLM+and+CVLM+plays+important+differential+roles+in+modulating+neurotransmission+and+cardiovascular+function+during+the+exercise+pressor+reflex. assertion.
- assertion asSentence AKT+signaling+pathway+plays+a+crucial+role+in+mediating+proliferating+and+secreted+signals+in+hepatic+sinusoidal+endothelial+cells. assertion.
- assertion asSentence AMPK+and+PI3-K%2FAkt+have+an+additive+effect+on+oxidative+stress-mediated+GLUT4+translocation. assertion.
- assertion asSentence In+neonatal+hypoxia-ischemia+autophagy+can+be+part+of+an+integrated+prosurvival+signaling+which+includes+the+PI3K-CREB-Akt-mammalian+target+of+rapamycin+%28mTOR%29+axis. assertion.
- assertion asSentence Hydrogen+sulfide+acts+via+cAMP-mediated+PI3K%2FAkt%2Fp70S6K+signal+pathways+to+inhibit+hippocampal+neuronal+apoptosis+and+protect+neurons+from+oxygen+glucose+deprivation%2Freoxygenation+injury. assertion.
- assertion asSentence APPL1+signaling+through+Akt+and+PAK+is+critical+for+spine+and+synaptic+development+and+point+to+a+role+for+APPL1+and+its+effectors+in+regulating+cognitive+function. assertion.
- assertion asSentence PKB+is+involved+in+the+inhibition+of+neurite+outgrowth+by+Nogo-A+in+PC12+cells. assertion.
- assertion asSentence Transcription+of+Alb+is+regulated+by+a+complicated+system+of+distant+enhancers. assertion.
- assertion asSentence AR+participates+in+estrogen%27s+deleterious+action+on+post-ischemic+neuropathology+in+diabetics+by+promoting+inflammation. assertion.
- assertion asSentence Na%2FK-ATPase+regulates+Caveolin-1+endocytic+trafficking+and+stabilizes+the+Cav1+plasma+membrane+pool. assertion.
- assertion asSentence PMCA+contributes+to+re-establish+resting+Ca%282%2B%29+levels+in+the+cilia+following+olfactory+responses. assertion.
- assertion asSentence CRH+and+AVP+regulate+mineralocorticoid+receptors+and+glucocorticoid+receptors+in+hippocampus+and+anterior+pituitary. assertion.
- assertion asSentence Only+AVP%2C+not+OXT+and+endogenous+opiate+peptides+in+PVH+involved+acupuncture+analgesia+in+the+rat. assertion.
- assertion asSentence Compulsive+treadmill+exercise+with+pre-familiarization+acutely+upregulates+rat+hippocampal+BDNF+gene+expression. assertion.
- assertion asSentence AMPK+mediates+kainic+acid+-induced+BDNF+expression+by+regulating+NF-kappaB+activation. assertion.
- assertion asSentence Neurotrophins+can+modulate+the+excitability+of+small+diameter+capsaicin-sensitive+sensory+neurons+through+the+activation+of+p75+neurotrophin+receptor+and+its+downstream+sphingomyelin+signalling+cascade. assertion.
- assertion asSentence BDNF+possesses+neuroprotective+properties+against+toxic+effects+of+Abeta+peptides. assertion.
- assertion asSentence Mesenchymal+stem+cells+can+be+differentiated+and+display+trophic+influences+as+those+of+Schwann+cells. assertion.
- assertion asSentence Bone+marrow+mesenchymal+stem+cells+promote+peripheral+nerve+regeneration+via+their+direct+release+of+BDNF. assertion.
- assertion asSentence The+protein+kinase+A+activation+and+BDNF+expression+in+the+dorsal+hippocampus+is+essential+for+the+improvement+of+two-way+active+avoidance+memory. assertion.
- assertion asSentence AKAP79%2F150+colocalizes+with+TRPV1+and+Ca%28V%29+1.2+in+the+soma+and+axon+initial+segment+in+a+subset+of+small+DRG+sensory+neurons. assertion.
- assertion asSentence The+calcium-sensing+receptor+%28CASR%29+gene+has+several+functional+kappaB+elements+that+mediate+its+upregulation+by+proinflammatory+cytokines. assertion.
- assertion asSentence Only+rLSEC-PEM-Hepatocyte+cultures+exhibited+increasing+CYP1A1%2F2+and+CYP3A+activity. assertion.
- assertion asSentence Enhanced+bradykinin+signaling+mediates+the+baroreflex-independent+sympathoexcitatory+effect+of+enalapril+in+diabetic+rats. assertion.
- assertion asSentence NQO1+can+contribute+to+inhibition+of+colon+carcinogenesis+at+the+post-initiation+stage. assertion.
- assertion asSentence Striatal+D1+receptors+are+critical+for+gene+induction+by+methylphenidate. assertion.
- assertion asSentence ERK5+signaling+regulates+glucose-induced+ET-1+expression+in+diabetes. assertion.
- assertion asSentence %5BF%5D-SB209670+binds+rapidly+and+primarily+to+endothelin-A+receptors+in+the+heart. assertion.
- assertion asSentence Bradykinin+at+reperfusion+triggers+its+cardioprotective+signalling+pathway+through+MMP-8-dependent+transactivation+of+the+EGFR. assertion.
- assertion asSentence Weak%2C+sustained+EGFR+phosphorylation%2C+rather+than+strong%2C+transient+phosphorylation%2C+strongly+induced+phosphorylation+of+the+ribosomal+protein+S6%2C+a+molecule+downstream+of+Akt. assertion.
- assertion asSentence Arterial+intimal+thickening+following+artery+ligation+is+critically-dependent+on+the+activation+of+Egr-1. assertion.
- assertion asSentence Lamotrigine+pretreatment+prevents+the+MK801-induced+upregulation+of+egr-1+expression%2Fneurodegeneration+in+a+region-selective+manner. assertion.
- assertion asSentence The+temporal+dynamics+of+arc+and+zif268+gene+expression+in+the+BLA+and+dHPC+encode+different+key+elements+of+drug+context-induced+cocaine-seeking. assertion.
- assertion asSentence Up-regulation+of+G6PD+in+pancreatic+beta-cells+would+induce+beta-cell+dysregulation+through+reactive+oxygen+species+accumulation+in+the+development+of+type+2+diabetes. assertion.
- assertion asSentence Expression+of+this+GABAergic+marker+is+highly+regulated+during+development%2C+with+greatest+levels+found+at+an+age+when+animals+are+transitioning+out+of+the+postnatal+period. assertion.
- assertion asSentence A+depalmitoylation-repalmitoylation+cycle+serves+to+cycle+GAD65+between+Golgi+and+post-Golgi+membranes+and+dynamically+control+levels+of+enzyme+directed+to+the+synapse. assertion.
- assertion asSentence Glucose-stimulated+insulin+release+is+decreased+by+chronic+exposure+to+tacrolimus+due+to+reduced+ATP+production+and+glycolysis+derived+from+reduced+glucokinase+activity. assertion.
- assertion asSentence DNA+hypermethylation+is+correlated+with+a+decline+in+hepatic+glucokinase+%28Gck%29+and+L-type+pyruvate+kinase+%28LPK%29+expression+in+high-fat+diet-induced+obese+rats+as+compared+with+the+control+diet+group. assertion.
- assertion asSentence Production+of+the+more+extensively+phosphorylated+species+of+connexin+43+in+cardiomyocytes+by+PMA+requires+activation+of+protein+kinase+C+epsilon. assertion.
- assertion asSentence The+phosphorylated+serine+990+and+phenylalanine+993+of+BACH1+anchor+the+binding+to+BRCA1+through+specific+interactions+with+a+surface+cleft+at+the+junction+of+the+two+BRCT+repeats. assertion.
- assertion asSentence RAD51D+polymorphism+is+not+associated+with+BRCA1+or+2+genes+in+breast+cancer. assertion.
- assertion asSentence The+occurrence+of+changes+in+BRCA1+gene+mutation+in+women+with+familial+ovarian+cancer+is+more+frequent+than+with+familial+breast+neoplasms. assertion.
- assertion asSentence Phosphorylated+BRCA1+is+predominantly+located+in+the+nucleus+and+mitochondria. assertion.
- assertion asSentence BRCA1%2F2+mutation+screening+should+be+considered+for+all+women+diagnosed+before+age+41. assertion.
- assertion asSentence The+frequency+of+the+hereditary+ovarian+carcinoma+is+attributed+to+BRCA1+gene+mutation. assertion.
- assertion asSentence The+whole+BRCA1+protein+interacts+with+ACCA+when+phosphorylated+on+Ser1263. assertion.
- assertion asSentence There+is+a+low+prevalence+of+BRCA1+exon+rearrangements+in+familial+and+young+sporadic+breast+cancer+patients. assertion.
- assertion asSentence The+G2%2FM+checkpoint-mediated+arrest+of+the+cell+cycle+is+critical+for+the+prevention+of+both+apoptosis+and+the+accumulation+of+cells+with+rereplicated+DNA%2C+because+the+loss+of+ATR%2C+BRCA1%2C+or+FANCA+promotes+apoptosis+and+suppresses+the+accumulation. assertion.
- assertion asSentence The+ubiquitin-proteasome+degradation+pathway+plays+a+significant+role+in+the+coordinated+protein+stability+of+BRCA1+and+its+partner+BARD1+in+ovarian+granulosa+cells. assertion.
- assertion asSentence Cyclin+D1%2Fcdk4-mediated+phosphorylation+of+BRCA1+inhibits+the+ability+of+BRCA1+to+be+recruited+to+particular+promoters+in+vivo. assertion.