Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence BRCA1+splice+variant+BRCA1a%2Fp110+can+induce+apoptosis+of+human+breast%2C+ovarian+and+prostatic+cancer+cells. assertion.
- assertion asSentence BRCA1+C-terminal+domain+is+implicated+in+recombination+control. assertion.
- assertion asSentence A+mutation+in+the+5%27+UTR+of+the+BRCA1+gene+downregulates+translational+efficiency+of+the+protein+in+breast+cancer. assertion.
- assertion asSentence Self-image+and+self-disclosure+concerning+prophylactic+mastectomy+%28PM%29+for+women+with+a+BRCA1%2F2+mutation. assertion.
- assertion asSentence The+site+of+first+distant+metastasis+is+different+between+BRCA1-+and+BRCA2-associated+and+sporadic+breast+cancer+patients. assertion.
- assertion asSentence High+frequency+of+BRCA1%2F2+and+p53+somatic+inactivation+in+sporadic+ovarian+cancer. assertion.
- assertion asSentence Brca1+regulates+Activation-induced+cytidine+deaminase-dependent+DNA+lesion+repair+and+is+required+to+recruit+ubiquitinated+FancD2+to+DNA+damage. assertion.
- assertion asSentence Silent-RNA-mediated+downregulation+of+BRCA1+in+primary+human+breast+cancer+gland+tumor+cells+triggers+upregulation+of+endogenous+intracellular+IGF-I+in+vitro. assertion.
- assertion asSentence Tumors+grow+quickly+in+women+with+BRCA1+mutations+and+in+young+women. assertion.
- assertion asSentence A+modified+natural+IVF+cycle+is+an+effective+and+safe+solution+for+BRCA1+or+BRCA2+mutation+gene+carrier+women+with+couple+infertility. assertion.
- assertion asSentence The+proximal+BRCA1+promoter+segment+comprises+cis-acting+elements+that+are+targeted+by+Sp-binding+and+CRE-binding+proteins+that+contribute+to+regulation+of+BRCA1+transcription. assertion.
- assertion asSentence Mutation+of+the+PP1-binding+motif+affects+BRCA1+redistribution+in+response+to+DNA+damage. assertion.
- assertion asSentence NFBD1%2C+53BP1+and+BRCA1+have+both+unique+and+redundant+functions+in+radiation-induced+phosphorylation+and+localization+events+in+the+ATM-Chk2+pathway. assertion.
- assertion asSentence Absence+of+germline+BRCA1+mutations+in+familial+pancreatic+cancer+patients. assertion.
- assertion asSentence BRCA1+knockdown+in+mammary+epithelial+cells+causes+telomere+dysfunction. assertion.
- assertion asSentence Genetic+variants+in+the+BRCA1+gene+is+associated+with+breast+cancer. assertion.
- assertion asSentence Histopathological+criteria+and+selection+algorithms+for+BRCA1+genetic+testing. assertion.
- assertion asSentence MDM2SNP309G%2FG+main+effect+on+BRCA1%2F2+positive+mutation+carriers+is+linked+to+its+effect+on+patients+survival. assertion.
- assertion asSentence Women+with+early-onset+triple-negative+breast+cancer+are+candidates+for+genetic+testing+for+BRCA1%2C+even+in+the+absence+of+a+family+history+of+breast+or+ovarian+cancer. assertion.
- assertion asSentence Promoter+methylation+is+a+not+a+frequent+%22second-hit%22+in+tumors+from+BRCA1+or+BRCA2+carriers. assertion.
- assertion asSentence Primary+breast+cancer+with+an+unmethylated+BRCA1+gene+is+prone+to+achieve+a+pathological+complete+response+to+anthracycline-based+neoadjuvant+chemotherapy+than+those+with+a+methylated+BRCA1+gene. assertion.
- assertion asSentence An+aberrant+luminal+progenitor+population+is+a+target+for+transformation+in+BRCA1-associated+basal+tumors+. assertion.
- assertion asSentence BRCA1%2F2+mutation+is+associated+with+ipsilateral-breast+tumor+recurrence+after+breast-conserving+surgery. assertion.
- assertion asSentence BRCA1+associated+cancers+are+predominantly+high+grade+%28G3%29%2C+triple+negative%2C+highly+proliferative+%28median+Ki-67+55%25%29+and+only+exceptionally+accompanied+by+lobular+intraepithelial+neoplasia. assertion.
- assertion asSentence BRCA1+mutation+testing+is+associated+with+ovarian+cancer+prevention. assertion.
- assertion asSentence BRCA1+expression+is+downregulated+in+uterine+leiomyosarcoma. assertion.
- assertion asSentence In+human+cells+BRCA1+binding+to+FANCJ+is+critical+to+regulate+DNA+repair+choice+and+promote+genomic+stability. assertion.
- assertion asSentence BRCA1+mutation+is+associated+with+increases+in+breast+cancer+worry+in+African+American+women. assertion.
- assertion asSentence The+risks+of+subsequent+contralateral+breast+cancer+are+substantial+for+women+who+carry+a+BRCA1%2FBRCA2+mutation. assertion.
- assertion asSentence Approximately+30%25+of+women+with+fallopian+tube+cancer+have+a+mutation+in+BRCA1+or+BRCA2. assertion.
- assertion asSentence BRCA1+genes+mutations+are+responsible+for+a+significant+proportion+of+breast+cancer. assertion.
- assertion asSentence BRCA1+mutation+is+associated+with+menopausal+status+modifying+the+association+between+body+weight+and+breast+cancer+and+disease+progression. assertion.
- assertion asSentence BRCA1+mutations+are+associated+with+breast+carcinoma+In+Situ. assertion.
- assertion asSentence BRCA1+germline+mutations+are+associated+with+uterine+serous+carcinoma. assertion.
- assertion asSentence 7-fold+increase+in+Endometrial+Cancer+risk+with+tamoxifen+exposure+is+asscoiated+with+female+family+members+from+BRCA1+mutation. assertion.
- assertion asSentence Zinc+finger+of+P53+and+Ring+finger+of+BRCA1+are+similar+domains+having+mostly+binding+activity. assertion.
- assertion asSentence The+BRCA1+methylation+is+significantly+decreased+in+ovarian+cancer+by+comparison+with+the+control+group. assertion.
- assertion asSentence More+than+50%25+of+the+Ashkenazi+Jewish+chromosomes+with+the+BRCA1+185delAG+mutation+share+an+identical+2.1+Mb+haplotype+and+nearly+16%25+of+Ashkenazi+Jewish+chromosomes+carrying+the+BRCA2+6174delT+mutation+share+a+1.4+Mb+haplotype. assertion.
- assertion asSentence The+Tunisian+population+has+a+spectrum+of+prevalent+BRCA1+mutations%2C+some+of+which+appear+as+recurrent+and+founding+mutations%2C+as+is+the+c.798_799delTT+mutation. assertion.
- assertion asSentence Risk-reducing+salpingo-oophorectomy+%28RRSO%29+in+BRCA+mutation+carriers. assertion.
- assertion asSentence Mutations+in+the+BRCA1+gene+is+associated+with+osteopenia+and+osteoporosis+after+risk-reducing+salpingo-oophorectomy+in+breast+cancer+patients. assertion.
- assertion asSentence Absent%2Flow+BRCA1+protein+expression+is+a+favourable+prognostic+marker+in+ovarian+cancer. assertion.
- assertion asSentence Promoter+hypermethylation+patterns+of+of+BRCA1+germ+line+mutation+carriers+are+associated+with+fallopian+tube+neoplasms. assertion.
- assertion asSentence The+C-terminal+proteolytic+fragment+of+the+breast+cancer+susceptibility+type+1+protein+%28BRCA1%29+is+degraded+by+the+N-end+rule+pathway. assertion.
- assertion asSentence There+is+a+high+prevalence+of+germ-line+BRCA1+mutations+in+high-risk+Taiwanese+patients+as+in+Caucasians. assertion.
- assertion asSentence Increased+risk+of+Prostate+cancer+%28PrCa%29+in+men+who+harbour+germline+mutations+in+BRCA1. assertion.
- assertion asSentence High+BRCA1+expression+is+associated+witth+high+insulin-like+growth+factor+I+receptor+gene+expression+and+uterine+serous+carcinoma. assertion.
- assertion asSentence Mucinous+ovarian+cancers+without+a+KRAS+mutation+have+not+sustained+alternative+activation+of+this+signaling+pathway+through+mutation+of+the+BRAF+oncogene. assertion.
- assertion asSentence Uceal+melanomas+arise+independent+of+oncogenic+BRAF+and+NRAS+mutations. assertion.
- assertion asSentence Mutations+of+the+BRAF+gene+are+partly+involved+in+the+malignant+transformation+of+the+endometrium. assertion.
- assertion asSentence In+patients+with+papillary+thyroid+cancer%2C+BRAF+mutation+is+associated+with+poorer+clinicopathological+outcomes+and+independently+predicts+recurrence. assertion.
- assertion asSentence Melanoma+cells+require+either+B-RAF+or+phosphoinositide-3+kinase+activation+for+protection+from+anoikis. assertion.
- assertion asSentence Single+nucleotide+polymorphism+found+exclusively+in+papillary+thyroid+carcinoma. assertion.
- assertion asSentence BRAF+T1976A+mutation+is+present+at+high+frequency+in+benign+naevi+such+as+Spitz+and+Reed. assertion.
- assertion asSentence Blood+values+increased+in+untreated+Parkinson+disease+patientes. assertion.
- assertion asSentence Resveratrol+significantly+enhanced+cigarette+smoke-stimulated+caspase+3+and+caspase+9+activity+in+human+bronchial+epithelial+cells. assertion.
- assertion asSentence Single+Nucleotide+Polymorphisms+in+CASP9+is+asspciated+with+lung+cancer. assertion.
- assertion asSentence cIAP1+cooperatively+interacts+with+oligomerized+processed+caspase-9+in+the+apoptosome+and+blocks+procaspase-3+activation. assertion.
- assertion asSentence The+CASP-9+-1263A%2FG+polymorphism+is+associated+with+a+high+risk+of+discogenic+low+back+pain. assertion.
- assertion asSentence p53+mediates+DNA+damaging+doxorubicin-induced+apoptosis+in+neurobblastoma+IMR32+cells+through+the+caspase-9+pathway. assertion.
- assertion asSentence Facilitated+maturation+of+Ca2%2B+handling+properties+of+human+embryonic+stem+cell-derived+cardiomyocytes+by+calsequestrin+expression. assertion.
- assertion asSentence The+human+CASQ2+mutation+K206N+is+associated+with+hyperglycosylation+and+altered+cellular+calcium+handling. assertion.
- assertion asSentence Aspartate+to+histidine+casq2+mutation+causes+arrhythmia+in+cardiomyocytes+generated+from+catecholaminergic+polymorphic+ventricular+tachycardia+patients. assertion.
- assertion asSentence Three+adjacent+serines+in+the+extracellular+domains+of+the+CaR+are+required+for+L-amino+acid-mediated+potentiation+of+receptor+function. assertion.
- assertion asSentence R990G+polymorphism+of+CASR+does+produce+a+gain-of-function+and+predispose+to+primary+hypercalciuria. assertion.
- assertion asSentence Endocytosis+and+trafficking+of+CaR+modulate+PTHrP+secretion. assertion.
- assertion asSentence CaSR+is+present+on+basal+cells+of+the+human+esophagus+and+is+present+in+a+functional+manner+on+the+esophageal+epithelial+cell+line%2C+HET-1A. assertion.
- assertion asSentence The+risk+of+chronic+pancreatitis+with+CASR+R990G+is+increased+in+subjects+with+moderate+to+heavy+alcohol+consumption. assertion.
- assertion asSentence CASR+has+a+role+in+Alzheimer+disease+susceptibility. assertion.
- assertion asSentence One+function+of+Gcm2+is+to+maintain+high+levels+of+CaR+expression+in+parathyroid+cells. assertion.
- assertion asSentence Single-nucleotide+polymorphisms+and+CATTCA+haplotype+of+the+CaSR+gene+first+block+is+associated+with+kidney+stones+in+normocitraturic+patients. assertion.
- assertion asSentence Gamma-glutamyl+peptides+and+L-amino+acids+activate+the+CaR+via+a+common+mechanism. assertion.
- assertion asSentence The+extracellular+calcium-induced+increase+in+cytosolic+Ca%282%2B%29+due+to+upregulated+CaSR%2C+contributes+to+the+augmented+Ca%282%2B%29+influx+and+excessive+pulmonary+artery+smooth+muscle+cell+proliferation+in+pulmonary+arterial+hypertension. assertion.
- assertion asSentence Catalase+overexpression+has+a+protective+role+against+Ultraviolet+B+irradiation+by+preventing+DNA+damage+mediated+by+the+late+reactive+oxygen+species+increase. assertion.
- assertion asSentence Increased+catalase+expression+is+associated+with+multiple+sclerosis+lesions. assertion.
- assertion asSentence Overexpression+of+catalase%2FSOD1+in+ApoE-deficient+mice+suppresses+benzo%28a%29pyrene-accelerated+atherosclerosis. assertion.
- assertion asSentence Chronic+arsenic+exposure+causes+higher+serum+catalase+activity+that+correlates+with+induction+of+genetic+damage. assertion.
- assertion asSentence Histone+H4+deacetylation+down-regulates+catalase+gene+expression+in+doxorubicin-resistant+AML+subline. assertion.
- assertion asSentence Up-regulated+caveolin-1+accentuates+the+metastasis+capability+of+lung+adenocarcinoma+by+inducing+filopodia+formation. assertion.
- assertion asSentence Caveolae+plays+a+role+in+signal-transducing+function+of+cardiac+Na%2B%2FK%2B-ATPase. assertion.
- assertion asSentence Caveolin-1+plays+an+important+role+in+senescence-associated+morphological+changes+by+regulating+focal+adhesion+kinase+activity+and+actin+stress+fiber+formation+in+the+senescent+cells. assertion.
- assertion asSentence The+downregulation+of+caveolin-1+in+HCT+116+cells+inhibited+degradation+of+the+extracellular+matrix+protein+collagen+IV+and+the+invasion+of+these+cells+through+Matrigel. assertion.
- assertion asSentence Interacts+with+rotavirus+NSP4+and+contributes+to+NSP4+intracellular+trafficking+from+the+endoplasmic+reticulum+to+the+cell+surface. assertion.
- assertion asSentence Homocysteine+induced+impairment+of+nitric+oxide+production+through+through+a+modulation+of+Caveolin-1+expression. assertion.
- assertion asSentence Prolonged+stimulation+of+isolated+human+thyrocytes+by+TSH%2FcAMP%2FcAMP-dependent+protein+kinase+inhibits+caveolin-1+expression. assertion.
- assertion asSentence PAR1+localization+in+the+caveolin-enriched+membrane+microdomain%2C+bound+to+caveolin-1%2C+represents+a+crucial+requirement+for+TF+induction+in+endothelial+cells. assertion.
- assertion asSentence COX-2+is+localized+within+caveolae+compartment+and+colocalized+with+CAV-1+protein+in+lobular+intraepithelial+neoplasia+of+the+breast. assertion.
- assertion asSentence Immunostaining+of+Cav-1+can+be+used+as+a+first+step+to+stratify+human+breast+cancer+patients+and+to+predict+the+presence+of+Cav-1+mutations. assertion.
- assertion asSentence Cav-1+functions+as+a+tumor+suppressor+in+the+stromal+microenvironment. assertion.
- assertion asSentence RNAi+knockdown+of+Cav-1+increased+COX-2+protein+level+and+decreased+ubiquitinated+COX-2+accumulation. assertion.
- assertion asSentence Interaction+of+caveolin-1+functionally+regulates+the+activity+of+the+vascular+subtype+of+K%28ATP%29+potassium+channel+Kir6.1+in+rat+aortic+smooth+muscle+cells. assertion.
- assertion asSentence Cav-1+polymorphisms+are+associated+with+oral+cancer. assertion.
- assertion asSentence Caveolin-1+plays+an+important+role+in+airway+inflammation+by+modulating+the+effect+of+specific+cytokines+on+intracellular+calcium%5BCa%282%2B%29%5D. assertion.
- assertion asSentence Caveolin1+acts+upon+EGF+endosomes+internalized+via+the+Clathrin-pathway+and+functions+at+the+transition+from+early+to+late+endosomes. assertion.
- assertion asSentence P28L+mutation+in+the+CAV-3+gene+and+the+consequent+caveolin-3+deficiency+is+associated+with+elevated+serum+kreatine+kinase+levels. assertion.
- assertion asSentence Cbfa1+is+required+in+mediating+the+bone+anabolic+effects+of+parathyroid+hormone. assertion.
- assertion asSentence Fidelity+of+Runx2+intranuclear+organization+is+necessary+for+expression+of+target+genes+that+mediate+the+osteolytic+activity+of+metastatic+breast+cancer+cells. assertion.
- assertion asSentence RUNX2+influences+joint+formation+by+affecting+the+differentiation+pathways+of+chondrocytes+and+osteoblasts. assertion.
- assertion asSentence TFII-I+plays+an+inhibitory+role+in+regulating+genes+that+are+essential+in+osteogenesis+and+intersects+with+the+bone-specific+transcription+factor+Runx2+and+the+retinoblastoma+protein%2C+pRb. assertion.
- assertion asSentence Runx2+stabilizes+HIF-1alpha+by+binding+to+ODDD+to+block+the+interaction+between+von+Hippel-Lindau+protein+and+HIF-1alpha. assertion.