Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Germline+polymorphisms+in+adrenergic+beta-2+receptor+are+linked+to+the+antileukemic+effects+of+acute+lymphoblastic+leukemia+chemotherapy. assertion.
- assertion asSentence Beta-adrenergic+receptors+in+the+skeletal+muscles+play+an+important+physiological+role+in+the+regulation+of+protein+and+energy+balance. assertion.
- assertion asSentence beta3-adrenergic+receptors+play+a+role+in+proliferation+and+migration+of+cultured+human+retinal+endothelial+cells. assertion.
- assertion asSentence The+Trp64Arg+variation+in+the+beta-3+adrenergic+receptor+has+no+relationship+to+the+degree+or+incidence+of+childhood+obesity. assertion.
- assertion asSentence Polymorphisms+within+the+Beta-3+Adrenergic+Receptor+gene+are+associated+with+insulin+resistance+and+obesity. assertion.
- assertion asSentence Joint+association+of+allele+-75A+%28APOA1%29+and+allele+Arg64+%28ADRB3%29+increase+the+risk+of+DM2+in+a+population+from+southern+Spain. assertion.
- assertion asSentence Trp64Arg+polymorphism+of+%28beta3-adrenergic+receptor%29+ADRB3+is+related+to+obesity+in+postmenopausal+and+has+no+influence+on+oxidative+stress+intensification+after+standardized+physical+effort. assertion.
- assertion asSentence Polymorphism+of+the+beta-3+adrenergic+receptor+plays+a+role+in+the+genetic+predisposition+to+increased+small+dense+low-density+lipoprotein. assertion.
- assertion asSentence Upregulation+of+beta3-adrenergic+receptor+mRNA+is+associated+with+colon+cancer. assertion.
- assertion asSentence Beta%283%29-AR+gene+Trp64Arg+mutation+is+an+independent+risk+factor+for+the+incidence+of+metabolic+syndrome+in+males. assertion.
- assertion asSentence A+non-synonymous+ADRB3+rs4994+polymorphism+is+associated+with+Type-2+diabetes+and+Metabolic+Syndrome. assertion.
- assertion asSentence In+cells+overexpressing+G+protein-coupled+receptor+kinase+2+%28GRK2%29%2C+the+thyrotropin-releasing+hormone+receptor+is+not+phosphorylated. assertion.
- assertion asSentence Enhanced+GRK2+expression+and+desensitization+of+betaAR+vasodilatation+in+hypertensive+patients. assertion.
- assertion asSentence GRK3+is+a+negative+regulator+of+cell+growth+whose+expression+is+preferentially+reduced+in+glioblastoma+of+the+classical+subtype+as+a+consequence+of+activity+in+primary+gliomagenic+pathways. assertion.
- assertion asSentence The+mutation+of+lysine-297+and+arginine-340+on+the+alpha-adaptin+specifically+inhibits+the+ability+of+Nef+to+bind+AP-2+and+downregulate+CD4. assertion.
- assertion asSentence AP2+regulates+thrombin+receptor+constitutive+internalization+and+endothelial+cell+resensitization. assertion.
- assertion asSentence In+the+presence+of+NUP98-HOXA9%2C+AES+caused+an+increase+in+long-term+proliferation+of+primary+human+CD34%2B+cells+with+a+marked+increase+in+the+numbers+of+primitive+cells. assertion.
- assertion asSentence AFP+induces+dysfunction+and+apoptosis+of+APCs%2C+offering+a+mechanism+by+which+hepatocellular+carcinoma+escapes+immunological+control. assertion.
- assertion asSentence The+gene+expression+profile+of+hepatoblasts+throughout+life+consists+of+high+levels+of+expression+of+alpha-fetoprotein%28AFP%29. assertion.
- assertion asSentence The+presence+of+AFP+mRNA+in+preoperative+peripheral+blood+is+related+to+tumor+invasion+of+hepatocellular+carcinoma. assertion.
- assertion asSentence Alpha-fetoprotein+and+human+chorionic+gonadotropin+beta+are+elevated+in+high-grade+neuroendocrine+tumors+with+a+rapidly+progressive+course+and+poorer+survival. assertion.
- assertion asSentence In+Turkish+population%2C+short+repeated+alleles+of+the+aggrecan+gene+are+associated+with+increased+disc+degeneration+and+disc+herniation. assertion.
- assertion asSentence Allele+frequencies+and+genotype+distribution+combinations+of+four+polymorphisms+in+the+RAGE+gene+%286p21.3%2C+G82S%2C+1704G%2FT%2C+2184A%2FG+and+2245A%2FG%29+of+272+subjects+%28130+patients+with+plaque+psoriasis+and+142+healthy+control%29. assertion.
- assertion asSentence Thiazolidinedione+antidiabetics+modulate+vascular+endothelial+RAGE+expression. assertion.
- assertion asSentence The+RAGE2+haplotype+is+associated+with+diabetic+nephropathy+%28DN%29+in+type+2+diabetics+and+with+earlier+DN+onset+and+can+be+regarded+as+a+marker+for+DN. assertion.
- assertion asSentence AGER1+negatively+regulates+AGE-mediated+oxidant+stress-dependent+signaling+via+the+EGFR+and+Shc%2FGrb2%2FRas+pathway. assertion.
- assertion asSentence Serum+levels+are+significantly+higher+in+type+2+diabetic+patients+than+in+non-diabetics+and+are+positively+associated+with+the+presence+of+coronary+artery+disease. assertion.
- assertion asSentence The+RAGE+Ser82+allele+does+not+predispose+to+cardiovascular+events+in+rheumatoid+arthritis. assertion.
- assertion asSentence Plasma+soluble+RAGE+and+endogenous+secretory+RAGE+are+not+associated+with+measures+of+diabetic+neuropathy+in+type+2+diabetes+patients. assertion.
- assertion asSentence S100A8%2FA9-promoted+cell+growth+occurs+through+RAGE+signaling+and+activation+of+NF-kappaB. assertion.
- assertion asSentence Advanced+glycation+end+products+induce+calcification+of+vascular+smooth+muscle+cells+through+RAGE%2Fp38+MAPK. assertion.
- assertion asSentence The+phenotype+of+minor+allele+carriers+in+G82S+is+associated+with+reduced+levels+of+protective+sRAGE+in+healthy+infants. assertion.
- assertion asSentence Emphysema+and+chronic+cor+pulmonale+are+independent+predictors+of+reduced+sRAGE+in+chronic+obstructive+pulmonary+disease. assertion.
- assertion asSentence Upregulated+in+Papillomavirus-mediated+cervical+neoplasia+and+required+for+notch+activation. assertion.
- assertion asSentence Mammalian+target+of+rapamycin+regulates+murine+and+human+cell+differentiation+through+STAT3%2Fp63%2FJagged%2FNotch+cascade. assertion.
- assertion asSentence Jagged1+is+an+RBP-J+target+gene+that+is+activated+in+a+binary+manner+by+TLR+and+Notch+pathways. assertion.
- assertion asSentence The+Jagged-1+intracellular+domain+%28JICD%29+inhibits+Notch1+signaling+via+a+reduction+in+the+protein+stability+of+the+Notch1+intracellular+domain+%28Notch1-IC%29. assertion.
- assertion asSentence Polymorphism+in+essential+arterial+hypertension+in+childhood. assertion.
- assertion asSentence Locally+generated+Ang+II+amplifies+the+immunomediated+inflammatory+process+of+coronary+microvessels+occurring+in+unstable+angina. assertion.
- assertion asSentence Angiotensin+II+activates+mineralocorticoid-receptor-mediated+gene+transcription+via+the+AT1+receptor. assertion.
- assertion asSentence Dissection+of+DNA+cis+elements+that+are+demonstrably+indispensable+for+regulating+both+the+level+and+cell+type+specificity+of+hAGT+gene+transcription. assertion.
- assertion asSentence Angiotensin+II+mediates+the+inflammatory+gene+expression+effects+of+IL-18+by+inducing+the+expression+of+the+IL-18+receptor+alpha+subunit+in+vascular+smooth+muscle+cells+%28VSMCs%29+via+STAT-3+activation. assertion.
- assertion asSentence AGT+T174M+and+M235T+functional+polymorphisms+of+angiotensinogen%2Care+not+associated+with+recurrent+in-stent+restenosis. assertion.
- assertion asSentence The+AT1R+%5B1166A+%3E+C%5D+and+AGT+%5B-6G+%3E+A%5D+polymorphisms+do+not+influence+repolarization+parameters+in+this+Chinese+population+in+Taiwan. assertion.
- assertion asSentence Left-ventricular+hypertrophy+caused+by+exercise+training+is+exacerbated+in+homozygous+TT+individuals+with+angiotensinogen+polymorphism. assertion.
- assertion asSentence Cellular+expression+of+renal%2C+cardiac+and+pulmonary+inducible+nitric+oxide+synthase+in+double-transgenic+mice+expressing+human+renin+and+angiotensinogen+genes. assertion.
- assertion asSentence High+angiotensinogen+is+associated+with+IgA+nephropathy. assertion.
- assertion asSentence HMEEC+exposed+to+IL-1beta+and+TNF-alpha+demonstrated+significant+upregulation+of+mucin+secretion+in+a+dose-dependent+fashion. assertion.
- assertion asSentence Stimuli+acting+on+different+pathogen-sensing+receptors+converge+on+a+common+pathway+where+ATP+externalization+is+the+first+step+in+the+cascade+of+events+leading+to+inflammasome+activation+and+IL-1beta+and+IL-18+secretion. assertion.
- assertion asSentence Relation+of+atrophic+gastritis+with+Helicobacter+pylori-CagA%28%2B%29+and+Il-1RN+and+IL-1B+gene+polymorphisms. assertion.
- assertion asSentence IL-1B%28%2B3954%29+and+FcgammaRIIa+%28CD32%29+gene+polymorphisms+are+not+associated+with+an+increased+risk+of+Aggressive+and+chronic+periodontitis. assertion.
- assertion asSentence Nicotinamide+phosphoribosyltransferase+and+prostaglandin+H2+synthase+2+are+up-regulated+in+human+pancreatic+adenocarcinoma+cells+after+stimulation+with+interleukin-1. assertion.
- assertion asSentence PAMP-induced+ROS+trigger+an+antioxidant+response+involving+intracellular+redox+enzymes+and+release+of+cysteine%2C+ultimately+required+for+IL-1beta+processing+and+secretion. assertion.
- assertion asSentence Interleukin-1-beta+polymorphism+protects+the+development+of+GERD. assertion.
- assertion asSentence IL-1B+and+IL-1RN+polymorphisms+are+associated+with+the+development+of+gastric+cancer+and+H.+pylori+infection+markedly+increases+the+risk+of+GC+in+North+Indian+population. assertion.
- assertion asSentence Carriers+of+the+two+relatively+frequent+variants+of+the+IL-1b+gene+at+-31+and+-511+position%2C+i.e.+-31TT+and+-511CC%2C+are+at+a+higher+risk+of+developing+coronary+artery+disease+requiring+surgical+treatment+or+two-stage+percutaneous+angioplasty. assertion.
- assertion asSentence Rare+missense+variants+of+the+MEFV+gene+are%2C+collectively%2C+associated+with+risk+of+fibromyalgia+syndrome+along+with+high+levels+of+plasma+IL-1beta. assertion.
- assertion asSentence IL-1ss+and+IL-6+play+a+pivotal+role+as+a+triggering+factor+of+restenosis+after+percutaneous+transluminal+coronary+angioplasty. assertion.
- assertion asSentence No+associations+found+between+the+SNPs+of+IL-1alpha-889%2C+IL-1beta-511+and+risk+for+PD. assertion.
- assertion asSentence Tensile+strain+and+magnetic+particle+force+application+do+not+induce+MAP3K8+and+IL-1B+differential+gene+expression+in+a+similar+manner+to+fluid+shear+stress+in+human+mesenchymal+stem+cells. assertion.
- assertion asSentence Activated+CD4%2B+T+cells+can+be+stimulated+by+keratinocyte+derived+Il-1+beta+to+release+high+amounts+of+IL-17. assertion.
- assertion asSentence Varicella-zoster+virus+infection+triggers+formation+of+an+interleukin-1beta+%28IL-1beta%29-processing+inflammasome+complex. assertion.
- assertion asSentence Flap+surgery+has+a+significant+effect+on+decreasing+IL-1beta+concentration+in+the+gingival+crevicular+fluid+of+patients+with+moderate+to+severe+chronic+periodontitis. assertion.
- assertion asSentence %28IL%29-1beta+down-regulated+ADAMTS-13+mRNA+expression+in+cultured+human+astroglioma+cells+%26+microglial+cells. assertion.
- assertion asSentence Interleukin-1beta+induces+increased+transcriptional+activation+of+the+transforming+growth+factor-beta-activating+integrin+subunit+beta8+through+altering+chromatin+architecture. assertion.
- assertion asSentence p65-Dependent+production+of+interleukin-1beta+by+osteolytic+prostate+cancer+cells+causes+an+induction+of+chemokine+expression+in+osteoblasts. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+rs1143634+of+IL-1beta+and+rs8192284+of+IL-6+receptor+act+as+susceptibility+variations+in+Korean+non-Sjogren+dry+eye+patients. assertion.
- assertion asSentence IL-1beta+measurement+in+LPS-stimulated+WBC+is+useful+to+predict+responsiveness+to+anti-TNF+agents. assertion.
- assertion asSentence There+is+an+association+between+urolithiasis+and+polymorphism+in+the+IL-1Ra+gene. assertion.
- assertion asSentence Slight+association+of+mutations+with+hypertension. assertion.
- assertion asSentence Association+of+the+interleukin-1+gene+cluster+on+chromosome+2q13+with+knee+osteoarthritis. assertion.
- assertion asSentence No+correlation+of+polymorphisms+with+gastric+cancer. assertion.
- assertion asSentence Common+functional+polymorphisms+of+the+IL1RN+gene+are+associated+with+several+markers+of+systemic+inflammation. assertion.
- assertion asSentence Recombinant+human+interleukin-1+receptor+antagonist+attenuates+the+severity+of+spinal+cord+ischemic+injury+in+rabbits. assertion.
- assertion asSentence Detection+of+receptor+antagonist+tandem+repeat+polymorphisms+among+21+HLA+identical+renal+transplant+recipient+and+donor+pairs. assertion.
- assertion asSentence Relation+of+atrophic+gastritis+with+Helicobacter+pylori-CagA%28%2B%29+and+Il-1RN+and+IL-1B+gene+polymorphisms. assertion.
- assertion asSentence Systemic+lupus+erythematosus+patients+with+higher+IL-1+receptor+antagonist+are+at+lower+risk+for+developing+nephritis. assertion.
- assertion asSentence IFN-beta+triggers+an+atypical+MEK2%2FPI3Kdelta+signaling+cascade+to+regulate+sIL-1Ra+expression+in+monocytes. assertion.
- assertion asSentence This+meta-analysis+demonstrates+that+the+IL-1RN+VNTR+polymorphism+is+not+related+to+susceptibility+to+rheumatoid+arthritis. assertion.
- assertion asSentence Aberrant+interleukin-36Ra+structure+and+function+lead+to+unregulated+secretion+of+inflammatory+cytokines+and+generalized+pustular+psoriasis. assertion.
- assertion asSentence IL-2%28-%2F-%29+mucosa+exhibits+impaired+electroneutral+Na%28%2B%29-Cl%28-%29+absorption+and+electrogenic+Na%28%2B%29+transport+due+to+reduced+mRNA+and+protein+expression+of+NHE3+and+ENaC+beta-+and+gamma-subunit+mRNA. assertion.
- assertion asSentence IL-2+and+TGF-beta+trigger+a+cytokine-dependent+self-perpetuating+loop+to+sustain+specific+T+regulatory+cell+suppressive+activity. assertion.
- assertion asSentence Dendritic+cell-produced+IL-2+is+tightly+coregulated+with+the+expression+of+IL-15. assertion.
- assertion asSentence Endogenous+melatonin+is+an+essential+part+for+an+accurate+response+of+human+lymphocytes+through+the+modulation+of+IL-2%2FIL-2+receptor+system. assertion.
- assertion asSentence During+the+IL-2-induced+heart+graft+rejection+process%2C+infiltrated+T+cells+become+more+sensitive+to+apoptosis. assertion.
- assertion asSentence CD28+costimulation+activates+AKT+to+phosphorylate+NF90+at+Ser647+and+phosphorylation+triggers+NF90+to+relocate+to+the+cytoplasm+and+stabilize+IL-2+mRNA. assertion.
- assertion asSentence Inability+of+mixed+lymphocytes+to+respond+to+HPIV3+infected+antigen-presenting+cells+is+due+to+an+Il-2-dependent%2C+nonapoptotic+mechanism+involving+NK+cells+and+their+influence+is+exerted+in+contact+dependent+manner. assertion.
- assertion asSentence IL-2%2C+IL15+and+IL-15Ralpha-IgG1-Fc+complexes+significantly+enhanced+NK+and+CD8%28%2B%29+T+cells+proliferation+and+cytotoxicity. assertion.
- assertion asSentence miR-181c+serves+as+a+negative+regulator+that+modulates+the+activation+of+CD4%28%2B%29+T+cells. assertion.
- assertion asSentence A+quantitative+relationship+is+established+between+receptor+alpha+subunit+binding+affinity+and+mitogenic+activity+for+IL-2+and+IL-15. assertion.
- assertion asSentence IL-9Ralpha+and+IL-2Rbeta+homodimers+efficiently+mediate+constitutive+activation+of+ALL-associated+JAK1+mutants. assertion.
- assertion asSentence Reciprocal+modulation+of+circulating+CD4%2BCD25%2Bbright+T+cells+induced+by+extracorporeal+photochemotherapy+in+cutaneous+T-cell+lymphoma+and+chronic+graft-versus-host-disease+patients. assertion.
- assertion asSentence Differences+in+surface+expression+of+IL2RA+protein+are+restricted+to+particular+immune+cell+types+and+correlate+with+two+autoimmune+diseases%2C+type+1+diabetes+and+multiple+sclerosis. assertion.
- assertion asSentence A+CD25-positive+profile+of+T+regulatory+cells+%28Tregs%29+is+inhibited+by+a+hypocalcemic+vitamin+D+analog+TX527+which+has+immunoregulatory+properties. assertion.
- assertion asSentence There+is+no+significant+difference+in+IL-2R+rs2104286+polymorphism+between+idiopathic+demyelinating+optic+neuritis+patients+and+controls. assertion.
- assertion asSentence Absolute+of+CD4%28%2B%29CD25%28%2B%29FOXP3%28%2B%29+regulatory+T-cell+count+rather+than+its+ratio+in+peripheral+blood+is+related+to+long-term+survival+of+renal+allografts. assertion.
- assertion asSentence CD25+plays+an+important+role+in+regulating+monocyte-derived+CD40+expression+during+anti-porcine+cellular+responses. assertion.
- assertion asSentence Cultures+in+the+presence+of+peptide+epitopes+to+this+receptor+inhibited+T+cell+proliferation. assertion.
- assertion asSentence Human+IL-21+and+IL-4+bind+to+partially+overlapping+epitopes+of+common+gamma-chain. assertion.
- assertion asSentence The+IL-3%2FGM-CSF+locus+undergoes+progressive+stages+of+activation%2C+with+stepwise+increases+in+active+modifications+and+the+proportion+of+cytokine-expressing+cells%2C+throughout+the+course+of+T+cell+differentiation. assertion.