Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Thyroid+papillary+carcinoma+patients+with+microcalcifications+expressed+significantly+higher+levels+of+Runx2+mRNA+in+serum+with+respect+to+patients+without+microcalcifications. assertion.
- assertion asSentence 30%25+of+acute+myeloid+leukemia+cases+express+a+Core+Binding+Factor+oncoprotein+or+harbor+point+mutations+in+one+or+both+AML1+%28RUNX1%29+genes. assertion.
- assertion asSentence AML-1+plays+a+role+in+driving+Mona+protein+expression+in+T+and+myelomonocytic+cells. assertion.
- assertion asSentence Transfected+human+Runx1+coordinates+the+proliferation+and+neuronal+differentiation+of+selected+populations+of+murine+neural+progenitors. assertion.
- assertion asSentence RUNX1+is+not+involved+in+most+cases+of+gastric+cancers. assertion.
- assertion asSentence TEL-AML1+fusion+in+transgenic+zebrafish+induces+a+B+cell+differentiation+arrest+and+demonstrates+leukemia+development+associated+with+loss+of+TEL+expression+and+elevated+Bcl2%2FBax+ratio. assertion.
- assertion asSentence Runx1+overexpression+inhibited+DNA-binding+and+transcriptional+activity+of+HIF-1alpha. assertion.
- assertion asSentence PRMT1-+dependent+methylation+of+RUNX1+at+arginine+residues+206+and+210+abrogates+its+association+with+SIN3A. assertion.
- assertion asSentence Survivin+gene+acts+as+a+critical+mediator+of+AML1%2FETO-induced+late+oncogeneic+events. assertion.
- assertion asSentence Transcription+factors+RUNX1+and+RUNX3+in+the+induction+and+suppressive+function+of+Foxp3%2B+inducible+regulatory+T+cells. assertion.
- assertion asSentence Stem+cell+exhaustion+due+to+Runx1+deficiency+is+prevented+by+Evi5+activation+in+leukemogenesis. assertion.
- assertion asSentence Genetic+variation+in+RUNX1+and+RUNX3+is+associated+with+rectal+cancer. assertion.
- assertion asSentence Alterations+of+the+RUNX1+gene+is+associated+with+myelodysplastic+syndromes+and+acute+myeloid+leukemia. assertion.
- assertion asSentence Runx1+involves+negative+auto-regulation+of+the+distal+Runx1+promoter+and+contributes+to+IL-2+production. assertion.
- assertion asSentence ETO+is+a+bona+fide+corepressor+that+links+the+transcriptional+pathogenesis+of+acute+leukemias+and+B-cell+lymphomas+and+offers+a+compelling+target+for+transcriptional+therapy+of+hematologic+malignancies. assertion.
- assertion asSentence Conditional+expression+of+AML1-ETO+by+the+ecdysone-inducible+system+dramatically+increases+the+expression+of+connexin+43+together+with+growth+arrest+at+G1+phase+in+leukemic+U937+cells. assertion.
- assertion asSentence AML1T1%2C+an+alternatively+spliced+isoform+of+the+t%288%3B21%29+transcript%2C+promotes+leukemogenesis. assertion.
- assertion asSentence The+interaction+between+SIN3B+and+ETO+required+an+intact+amino-terminus+of+ETO+and+the+NHR2+domain. assertion.
- assertion asSentence CBFbeta+is+essential+for+TEL-AML1%27s+ability+to+promote+self-renewal+of+B+cell+precursors+in+vitro. assertion.
- assertion asSentence CalpainB+is+required+for+AML1-ETO-induced+blood+cell+disorders+in+Drosophila. assertion.
- assertion asSentence N-Ras%28G12D%29+induces+features+of+stepwise+transformation+in+preleukemic+umbilical+cord+blood+cultures+expressing+the+AML1-ETO+fusion+gene. assertion.
- assertion asSentence RUNX3+regulates+RUNX1+expression+in+human+B+lymphoid+cell+lines. assertion.
- assertion asSentence There+is+a+strong+correlation+between+the+RH120480+fragment+of+RUNX3+gene+mutation+and+keloid. assertion.
- assertion asSentence A+role+for+RUNX3+as+a+tumour+suppressor+in+colorectal+cancer. assertion.
- assertion asSentence RUNX3+is+down-regulated+during+melanoma+progression. assertion.
- assertion asSentence Transgenic+expression+of+Runx3+in+mice+accelerated+CD4-positive+cells+to+a+T+helper+type+%28Th%291+cell-biased+population+or+down-modulated+Th2+cell+responses%2C+in+part+by+neutralizing+transcription+factor+GATA3. assertion.
- assertion asSentence Hypermethylation+downregulates+Runx3+gene+expression+and+its+restoration+suppresses+gastric+epithelial+cell+growth+by+inducing+p27+and+caspase3+in+human+gastric+cancer. assertion.
- assertion asSentence RUNX3+is+frequently+expressed+in+the+nuclei+of+ovarian+cancer+cell+lines+and+plays+an+oncogenic+role+in+ovarian+cancer. assertion.
- assertion asSentence RUNX3+binds+to+centrosomal+protein+rootletin. assertion.
- assertion asSentence Cbfb+enhances+osteogenic+differentiation+of+mesenchymal+stem+cells+by+stabilizing+Cbfa-1+proteins. assertion.
- assertion asSentence A+mechanism+for+the+effect+of+CBG+mutations+on+fatigue+is+not+readily+apparent+because+free+cortisol+levels+are+normal. assertion.
- assertion asSentence Allosteric+modulation+of+hormone+release+from+thyroxine+and+corticosteroid-binding+globulins. assertion.
- assertion asSentence Cbl-directed+monoubiquitination+of+CIN85+is+involved+in+regulation+of+ligand-induced+degradation+of+EGF+receptors. assertion.
- assertion asSentence C-Cbl-dependent+EphA2+protein+degradation+is+induced+by+ligand+binding. assertion.
- assertion asSentence Ron+tyrosine+kinase+receptor+desensitization+mediated+by+c-Cbl+and+its+binding+partner+Grb2. assertion.
- assertion asSentence Recruitment+of+CBL+to+lipid+rafts+mediates+signals+important+for+actin+reorganization+in+growing+neurites. assertion.
- assertion asSentence A+role+of+Cbl+dimerization+in+terminating+signaling+following+activation+of+receptor+tyroine+kinase. assertion.
- assertion asSentence Germline+CBL+mutations+cause+developmental+abnormalities+and+predispose+to+juvenile+myelomonocytic+leukemia. assertion.
- assertion asSentence Cbl+ubiquitin+ligase+plays+a+critical+role+in+the+maintenance+of+AJs+and+suppression+of+cell+migration+through+down-regulation+of+EGFR-Vav2+signaling. assertion.
- assertion asSentence The+C-terminal+region+of+c-Cbl+plays+a+crucial+role+in+the+temporal+and+spatial+control+of+5-HT%282A%29R+recycling. assertion.
- assertion asSentence Hsp47+recognizes+the+triple-helix+form+of+procollagen+in+vitro+and+in+vivo. assertion.
- assertion asSentence The+activation+domain+mutation+D444N+reduces+the+steady-state+levels+of+cystathionine+beta-synthase+4-fold+and+drastically+increases+the+activation+response+to+AdoMet+%28by+~100-fold%29+so+that+it+can+no+longer+be+activated+at+physiological+concentrations. assertion.
- assertion asSentence The+heme+of+cystathionine+beta-synthase+regulates+activity+through+changes+in+redox+state%2C+because+the+heme+prefers+to+be+in+the+ferric+state+at+physiological+pH. assertion.
- assertion asSentence No+association+between+and+the+cystathionine+beta-synthase+%28844ins68%29+insertion+polymorphism+and+cancer+of+the+upper+gastrointestinal+tract. assertion.
- assertion asSentence A+higher+risk+of+IMR+in+male+subjects+in+association+with+two+CBS+polymorphisms+and+mild+elevation+in+plHcy+concentration. assertion.
- assertion asSentence CH%283%29Hg-S-Cys+and+Cys-S-Hg-S-Cys+are+substrates+and+reversible+inhibitors+of+GTK. assertion.
- assertion asSentence CCK%27s+suppression+of+food+intake+is+enhanced+when+the+stomach+is+distended. assertion.
- assertion asSentence The+presence+of+CCK+receptors+in+human+ductal+pancreatic+tumor+samples+is+mainly+due+to+CCK2+expression+in+residual+pancreatic+islets+and+CCK1+in+pancreatic+nerves. assertion.
- assertion asSentence Krit1+and+integrin+cytoplasmic+domain-associated+protein-1+alpha+%28icap1alpha%29+act+concordantly+to+play+a+critical+role+in+beta+1-integrin-mediated+cell+proliferation. assertion.
- assertion asSentence CCM1+is+the+most+frequently+mutated+gene+in+cutaneous+vascular+malformations-familial+cerebral+cavernous+malformations+patients. assertion.
- assertion asSentence It+is+considered+that+tumorigenesis+with+UC-associated+dysplasia+is+of+the+bottom-up+type%2C+related+to+altered+expression+of+cyclin+A+and+p27%28Kip1%29. assertion.
- assertion asSentence Skp2-cyclin+A+interaction+serves+to+directly+protect+cyclin+A-cyclin-dependent+kinase+%28Cdk%292+from+inhibition+by+p27+through+competitive+binding. assertion.
- assertion asSentence Homocysteine-induced+differential+activation+of+Ras%2FERK+and+PI3K%2FAkt%2Fp70S6K+signaling+pathways+and+consequent+expression+of+cyclins+A+and+D1+are+dependent+on+beta1+integrin. assertion.
- assertion asSentence Cdc2%2Fcyclin+B1+interacts+with+and+modulates+inositol+1%2C4%2C5-trisphosphate+receptor+%28type+1%29+functions. assertion.
- assertion asSentence Inhibiting+Cdk7+in+G2+blocks+entry+to+mitosis+and+disrupts+Cdk1%2Fcyclin+B+complex+assembly. assertion.
- assertion asSentence Cyclin+B1+is+an+efficacy-predicting+biomarker+for+antineoplastic+Chk1+inhibitors. assertion.
- assertion asSentence Sustained+spindle-assembly+checkpoint+response+requires+de+novo+transcription+and+translation+of+cyclin+B1. assertion.
- assertion asSentence Tuberin+binding+to+cyclin+B1+regulates+mitotic+onset. assertion.
- assertion asSentence High+cyclin+D2+is+associated+with+higher+grade+%28III+and+IV%29+of+astrocytoma. assertion.
- assertion asSentence High+level+of+CCND2+expression+is+associated+with+nasopharyngeal+carcinoma. assertion.
- assertion asSentence High+expression+of+cyclin+D2+is+associated+with+mantle+cell+lymphoma. assertion.
- assertion asSentence Cyclin+D2+is+overexpressed+in+the+proliferation+centers+of+CLL%2FSLL+and+this+is+due%2C+in+part%2C+to+the+upregulation+of+NF-kappaB-related+pathways. assertion.
- assertion asSentence CCND3+is+the+primary+driver+of+the+cell+cycle%2C+in+cooperation+with+CCND1+that+integrates+extracellular+mitogenic+signaling. assertion.
- assertion asSentence Overexpressions+of+nuclear+cyclin+D3+is+associated+with+non-small+cell+lung+cancer. assertion.
- assertion asSentence Retinoic+acid-induced+cell+cycle+arrest+of+human+myeloid+cell+lines+is+associated+with+sequential+down-regulation+of+c-Myc+and+cyclin+E. assertion.
- assertion asSentence p220+is+an+essential+downstream+component+of+the+cyclin+E%2FCdk2+signaling+pathway+and+functions+to+coordinate+multiple+elements+of+the+G1%2FS+transition. assertion.
- assertion asSentence Overexpressed+in+breast+cancer+development. assertion.
- assertion asSentence The+overexpression+of+cyclin+E+positively+correlated+with+the+decreasing+degree+of+tumor+differentiation%2C+implicating+a+role+for+cyclin+E+in+the+promotion+of+tumorigenesis. assertion.
- assertion asSentence Aberrant+expression+of+cyclin+E+is+not+associated+with+low-risk+node+negative+breast+cancer. assertion.
- assertion asSentence CCNE1+is+upregulated+in+primary+gastric+cancer. assertion.
- assertion asSentence Intensive+immunoreactivity+of+cyclin+E+in+glandular+cells+is+typical+for+endometrial+hyperplasia. assertion.
- assertion asSentence CCNE1+silencing+with+siRNA+increases+multiple+myeloma+cell+sensitivity+to+seliciclib. assertion.
- assertion asSentence Does+not+increase+significantly+during+colorectal+carcinogenesis+and+during+later+metastasis+to+lymph+nodes. assertion.
- assertion asSentence HEXIM1+and+HEXIM2+maintain+the+balance+between+active+and+inactive+forms+of+P-TEFb%2C+a+heterodimeric+complex+composed+of+cyclin-dependent+kinase+9+and+cyclin+T. assertion.
- assertion asSentence CycT1-U7+mutant+inhibits+HIV+transcription+by+promoting+a+rapid+degradation+of+Tat. assertion.
- assertion asSentence A+direct+impact+of+CDK9-cyclin+T1+on+the+nuclear+localization+and+activity+of+the+viral+regulator+pUL69. assertion.
- assertion asSentence Cyclin+K+inhibits+HIV-1+gene+expression+and+replication+by+interfering+with+cyclin-dependent+kinase+9+%28CDK9%29-cyclin+T1+interaction+in+Nef-dependent+manner. assertion.
- assertion asSentence Accumulation+of+CD1a-positive+Langerhans+cells+and+mast+cells+in+actinic+cheilitis. assertion.
- assertion asSentence GM-CSF+independent+signaling+directed+toward+the+CD1a+genome+is+important+in+Langerhans+cell+biology. assertion.
- assertion asSentence Expression+of+DC-SIGN+and+CD1b+in+human+leprosy. assertion.
- assertion asSentence Group+1+CD1-restricted+T+cells+participate+in+adaptive+immune+responses+upon+mycobacterial+infection. assertion.
- assertion asSentence CD1b+has+a+mechanism+for+presenting+either+two+small+or+one+large+lipid%2C+allowing+presentation+of+antigens+with+an+unusually+broad+range+of+chain+lengths. assertion.
- assertion asSentence Expression+of+dendritic+cell+markers+CD11c%2FBDCA-1+and+CD123%2FBDCA-2+in+coronary+artery+disease+upon+activation+in+whole+blood. assertion.
- assertion asSentence Uncoupling+between+CD1d+upregulation+induced+by+retinoic+acid+and+conduritol-B-epoxide+and+iNKT+cell+responsiveness. assertion.
- assertion asSentence CD1d+is+downregulated+by+the+HPV16+E5+and+HPV6+E5+protein. assertion.
- assertion asSentence Binding+strength+and+dynamics+of+invariant+natural+killer+cell+T+cell+receptor%2FCD1d-glycosphingolipid+interaction+on+living+cells+by+single+molecule+force+spectroscopy. assertion.
- assertion asSentence CD2+mediates+activation+of+the+IFN-gamma+intronic+STAT+binding+region+in+mucosal+T+cells. assertion.
- assertion asSentence When+isolated+from+multiple+sclerosis+patients%2C+both+nonmature+and+effector+subsets+of+memory+CD127%28low%29+regulatory+T+cells+exhibit+kinetically+distinct+defects+in+suppression+that+are+evident+with+CD2+pathway+costimulation. assertion.
- assertion asSentence Stage-dependent+molecular+changes+in+Notch+signaling+that+are+critical+for+normal+human+T-cell+development. assertion.
- assertion asSentence A+combination+of+trastuzumab+antibody+and+phosphoantigen-stimulated+gammadelta+T-lymphocytes+increases+the+efficacy+of+trastuzumab+alone+against+HER-2-positive+breast+carcinoma+cell+lines+in+vivo+and+mammary+carcinoma+xenografts+in+mice. assertion.
- assertion asSentence The+CD3+epsilon+immune+recognition+receptor+cytoplasmic+domain+binds+to+acidic+and+mixed+phospholipid+vesicles+with+a+binding+strength+that+correlates+with+the+protein+net+charge+and+the+presence+of+clustered+basic+amino+acid+residues. assertion.
- assertion asSentence Notch-dependent+cytoplasmic+CD3+expression+can+only+be+achieved+during+the+early+phase+of+NK-cell+differentiation. assertion.
- assertion asSentence Several+amino+acids+are+essential+for+an+optimal+association+between+CD3gamma+and+CD3+and+the+assembly+of+a+cell-surface+expressed+TCR-CD3deltagammazeta2+complex. assertion.
- assertion asSentence The+CD3+gamma+immune+recognition+receptor+cytoplasmic+domain+binds+to+acidic+and+mixed+phospholipid+vesicles+with+a+binding+strength+that+correlates+with+the+protein+net+charge+and+the+presence+of+clustered+basic+amino+acid+residues. assertion.
- assertion asSentence HTLV-I+infection+initiates+a+process+leading+to+a+complete+loss+of+CD3+membrane+expression+by+an+epigenetic+mechanism+which+continues+along+time%2C+despite+an+early+silencing+of+the+viral+genome. assertion.
- assertion asSentence In+CD3gamma-deficient+patients+there+can+be+substitution+of+CD3gamma+by+the+CD3delta+chain+and+which+can+then+support+gammadelta+T+cell+development. assertion.
- assertion asSentence Stage-dependent+molecular+changes+in+Notch+signaling+that+are+critical+for+normal+human+T-cell+development. assertion.
- assertion asSentence Absence+or+reduction+of+TCR+zeta-chain+expression+in+inflammatory+skin+lymphocytic+infiltrates+not+consistent+with+pivotal+role+of+TCR+zeta-chain+in+process+of+immune+escape+of+tumour+cells. assertion.
- assertion asSentence Deficient+TCRzeta+%28CD247%29+phosphorylation+during+TCR+stimulation+seen+in+up+to+78%25+of+Systemic+lupus+erythematosus+patients%2C+independent+of+disease+activity%2C+race%2C+gender+and+age. assertion.
- assertion asSentence Altered+expression+of+the+TCR+signaling+related+genes+CD3+and+FcepsilonRIgamma+in+patients+with+aplastic+anemia. assertion.