Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Cyclin+A+assembles+with+Cdk1+only+after+complex+formation+with+Cdk2+reaches+a+plateau+during+late+S+and+G2+phases. assertion.
- assertion asSentence Cdk2+is+required+for+cell+proliferation. assertion.
- assertion asSentence Epstein-Barr+virus+Rta-mediated+transactivation+of+p21+and+14-3-3sigma+arrests+cells+at+the+G1%2FS+transition+by+reducing+cyclin+E%2FCDK2+activity. assertion.
- assertion asSentence Sequential+extension+of+proliferative+lifespan+in+human+fibroblasts+is+induced+by+over-expression+of+CDK4+or+6+and+loss+of+p53+function. assertion.
- assertion asSentence Interferon+gamma+reduces+the+activity+of+Cdk4+and+Cdk2%2C+inhibiting+he+G1+cell+cycle+in+human+hepatocellular+carcinoma+cells. assertion.
- assertion asSentence Mantle+cell+lymphoma+should+be+very+sensitive+to+targeted+therapy+aimed+at+functional+inhibition+of+the+cyclin+D1%2FCDK4+complex. assertion.
- assertion asSentence The+expression+level+of+cyclin+D1+and+CDK4+protein+increased+in+human+embryonic+lung+fibroblasts+treated+with+quartz. assertion.
- assertion asSentence Cellular+production+of+IGFBP-3+leads+to+G1+cell+cycle+arrest+with+inhibition+of+CDK2+and+CDK4. assertion.
- assertion asSentence Abolishing+the+expression+of+cyclin+D1%2C+Cdk4+or+Nek2+in+MCF10A+human+mammary+epithelial+cells+expressing+H-Ras%28G12V%29+abrogated+Ras-induced+centrosome+amplification. assertion.
- assertion asSentence Germline+mutations+in+CDK4+gene+is+not+associated+with+suspected+genetic+predisposition+to+uveal+melanoma. assertion.
- assertion asSentence Immunohistochemical+expression+of+MDM2+and+CDK4+is+specific+and+provides+sensitive+markers+for+the+diagnosis+of+low-grade+osteosarcomas. assertion.
- assertion asSentence Mediates+exocytosis+and+decreases+beta-amyloid+peptide+formation+in+Alzheimer+disease. assertion.
- assertion asSentence The+Cdk5%2FDNA+damage+pathway+is+dysregulated+in+Huntington%27s+disease. assertion.
- assertion asSentence Phosphorylation+of+parkin+by+casein+kinase+I+and+cdk5+decreases+parkin+solubility%2C+leading+to+its+aggregation+and+inactivation. assertion.
- assertion asSentence HtrA2+and+Cdk5+interact+in+human+and+mouse+cell+lines+and+brain. assertion.
- assertion asSentence Phosphorylation+of+gephyrin+in+hippocampal+neurons+by+cyclin-dependent+kinase+CDK5+at+Ser-270+is+dependent+on+collybistin. assertion.
- assertion asSentence Epigenetic+regulation+of+the+hsa-miR-124a+microRNA+%28most+frequently+methylated+in+the+acute+lymphoblastic+leukemia+patients%29+mediates+the+increased+expression+of+CDK6+and+contributes+to+the+abnormal+proliferation+of+cells+both+in+vitro+and+in+vivo. assertion.
- assertion asSentence The+reduced+CDK7+kinase+activity+is+responsible+for+the+inactivation+of+CDC2%2Fp34+kinase+and+the+irreversible+G%282%29%2FM+phase+cell-cycle+arrest+of+a+human+gastric+carcinoma+cell+line. assertion.
- assertion asSentence CDK8+play+positive+roles+in+transcriptional+activation. assertion.
- assertion asSentence P-TEFb+containing+cyclin+K+and+Cdk9+can+activate+transcription+via+RNA. assertion.
- assertion asSentence HEXIM1+and+HEXIM2+maintain+the+balance+between+active+and+inactive+forms+of+P-TEFb%2C+a+heterodimeric+complex+composed+of+cyclin-dependent+kinase+9+and+cyclin+T. assertion.
- assertion asSentence HCMV+inter-regulation+with+CDK9%2Fcyclin+T1+is+at+least+partly+based+on+a+pUL69-cylin+T1+interaction. assertion.
- assertion asSentence Cyclin+K+inhibits+HIV-1+gene+expression+and+replication+by+interfering+with+cyclin-dependent+kinase+9+%28CDK9%29-cyclin+T1+interaction+in+Nef-dependent+manner. assertion.
- assertion asSentence The+inhibition+of+CDK9%2C+the+kinase+subunit+of+P-TEFb%2C+inhibited+AIRE-induced+pre-mRNA+splicing+of+these+genes. assertion.
- assertion asSentence CDK9+phosphorylates+UBE2A+and+regulates+UBE2A-mediated+monoubiquitination+of+both+H2B+and+PCNA. assertion.
- assertion asSentence Oxidized+low+density+lipoprotein+induces+the+cyclin-dependent+kinase+inhibitor+p21%28waf1%29+and+the+tumor+suppressor+Rb. assertion.
- assertion asSentence Cyclin+kinase+inhibitors+p21+are+associated+with+laryngeal+papillomas. assertion.
- assertion asSentence Downregulation+of+waf1+mediates+apoptosis+of+human+hepatocellular+carcinoma+cells+in+response+to+interferon-gamma. assertion.
- assertion asSentence p21+has+an+antiapoptotic+role+in+monocytic+leukemia. assertion.
- assertion asSentence Promoter+is+hypermethylated+in+various+lymphomas+and+carcinomas. assertion.
- assertion asSentence hRAD9+and+p53+co-regulate+p21+to+direct+cell+cycle+progression+by+similar+molecular+mechanisms. assertion.
- assertion asSentence Disruption+of+p53-p21%2FWAF1+cell+cycle+pathways+contributes+to+tumor+progression+and+worse+clinical+outcome+of+hepataocellular+hepatoma. assertion.
- assertion asSentence Quercetin+and+ellagic+acid+combined+increase+the+activation+of+p53+and+p21%28cip1%2Fwaf1. assertion.
- assertion asSentence Musashi+homolog+1+ability+to+regulate+progenitor+maintenance+is+through+the+translational+inhibition+of+the+cyclin-dependent+kinase+inhibitor+p21WAF-1. assertion.
- assertion asSentence APMCF1+participates+at+least+partially+in+cell+cycle+regulation+through+regulating+genes+such+as+p21+and+TIMP3. assertion.
- assertion asSentence Has+important+role+in+mediating+the+apoptotic+effect+of+histone+deacetylase+inhibitors. assertion.
- assertion asSentence p21%28WAF1%2FCIP1%29+%28p21%29%2C+a+negative+regulator+of+the+cell+division+cycle%2C+exhibits+proteasome-sensitive+turnover+and+ubiquitination+in+a+tumor+cell+line. assertion.
- assertion asSentence Spider+venom+activates+the+expression+of+p21+and+causes+selective+cell+cycle+arrest+at+G%282%29%2FM+phase%2C+leading+to+HepG2+cell+apoptosis. assertion.
- assertion asSentence Rhabdomyosarcoma+cells+overexpressing+MDM2+abrogated+ceramide-mediated+p21%28Cip1%2FWaf1%29+induction%2C+G%282%29+arrest+and+the+late+ensuing+apoptosis. assertion.
- assertion asSentence CARF+exerts+a+vital+control+on+the+p53-HDM2-p21WAF1+pathway+that+is+frequently+altered+in+cancer+cells. assertion.
- assertion asSentence Andrographolide+inhibits+human+colorectal+cancer+Lovo+cell+growth+by+G1-S+phase+arrest+and+inducing+the+expression+of+p53%2C+p21+and+p16. assertion.
- assertion asSentence The+p53-dependent+transcriptional+regulation+of+p21+in+response+to+DNA+damage+by+ultraviolet+radiation+and+ionizing+radiation+compared. assertion.
- assertion asSentence p21%28WAF1%2FCIP1%29+is+an+important+factor+in+the+sensitivity+of+cells+to+the+growth+inhibiting+and+apoptotic+effects+of+OSU03012. assertion.
- assertion asSentence Knockdown+of+endogenous+MBP-1+is+involved+in+cellular+senescence+of+HFF+through+p53-p21+pathway. assertion.
- assertion asSentence Monocytic+leukemia+zinc+finger+%28MOZ%29+interacts+with+p53+to+induce+p21+expression+and+cell-cycle+arrest. assertion.
- assertion asSentence Emi1+down-regulation+and+APC+activation+leads+to+stable+p21-dependent+G2+arrest+after+DNA+damage. assertion.
- assertion asSentence Nucleophosmin+as+a+positive+post-translational+regulator+of+p21. assertion.
- assertion asSentence CTIP2+is+a+constitutive+p21+gene+suppressor+that+cooperates+with+SUV39H1+and+histone+methylation+to+silence+the+p21+gene+transcription. assertion.
- assertion asSentence AP-2gamma+promotes+proliferation+in+breast+tumour+cells+by+direct+repression+of+the+CDKN1A+gene. assertion.
- assertion asSentence P21+Codon+31+with+AGA+%28Arg%29+allele+is+a+genetic+risk+factor+of+cervical+squamous+cell+carcinoma. assertion.
- assertion asSentence Stimulatory+effect+of+deltaEF1+on+cell+proliferation+through+p21+regulation+is+supported+by+an+inverse+correlation+of+deltaEF1+and+p21+expressions+in+breast+cancer+cell+proliferation. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+CIP1+gene+is+associated+with+esophageal+cancer. assertion.
- assertion asSentence NPAT+is+essential+for+histone+mRNA+3%27+end+processing+and+recruits+CDK9+to+replication-dependent+histone+genes. assertion.
- assertion asSentence HOXB13+is+associated+with+an+additive+growth+advantage+of+prostate+cancer+cells+in+the+absence+of+or+low+androgen+concentrations%2C+by+the+regulation+of+p21-mediated+E2F+signaling. assertion.
- assertion asSentence The+cyclin-dependent+kinase+inhibitor+p21WAF1%2FCIP1+is+able+to+influence+kinase+activities+both+in+a+negative+and+positive+manner. assertion.
- assertion asSentence Eupatilin+inhibits+the+growth+of+human+endometrial+cancer+cells+via+G2%2FM+phase+cell+cycle+arrest+through+the+upregulation+of+p21. assertion.
- assertion asSentence p21+regulates+adhesion+and+microtubule+dynamics+in+untransformed+human+mammary+epithelial+cells. assertion.
- assertion asSentence Homozygous+deletion+of+the+FHIT+gene%2C+p21WAF1+protein+expression+and+apoptosis+in+bilharzial+bladder+cancer. assertion.
- assertion asSentence Epstein-Barr+virus+Rta-mediated+transactivation+of+p21+and+14-3-3sigma+arrests+cells+at+the+G1%2FS+transition+by+reducing+cyclin+E%2FCDK2+activity. assertion.
- assertion asSentence IGFBP-rP1-induced+growth+arrest+is+associated+with+enhanced+expression+of+the+cyclin-dependent+kinase+inhibitor+p21. assertion.
- assertion asSentence The+COP9+signalosome+inhibits+p27%28kip1%29+degradation+and+impedes+G1-S+phase+progression+via+deneddylation+of+SCF+Cul1. assertion.
- assertion asSentence Akt+promotes+cell-cycle+progression+through+the+mechanisms+of+phosphorylation-dependent+14-3-3+binding+to+p27%28Kip1%29+and+cytoplasmic+localization. assertion.
- assertion asSentence Down-regulation+of+p27+is+associated+with+malignant+transformation+and+aggressive+phenotype+of+cervical+neoplasms. assertion.
- assertion asSentence Down-regulation+of+p27+is+associated+with+early+progression+of+head+%26+neck+squamous+cell+carcinoma. assertion.
- assertion asSentence The+classical+bipartite-type+basic+amino-acid+cluster+and+the+two+downstream+amino+acids+of+the+C-terminal+region+of+p27+function+as+a+nuclear+localization+signal+for+its+full+nuclear+import+activity. assertion.
- assertion asSentence FOXO4A3+also+can+regulate+p27+post-transcriptionally. assertion.
- assertion asSentence p27%28kip1%29+protein+downregulation+is+usually+achieved+by+proteasomal+degradation+and+is+often+correlated+to+a+worse+prognosis+in+several+types+of+human+cancers. assertion.
- assertion asSentence Modified+p27+expression%2C+mutated+at+threonine-187+or+deleted+at+the+p27-associated+protein+JAB1+binding+domain%2C+reduces+tumorigenicity+of+erbB-2+overexpressing+cells+in+nude+mice. assertion.
- assertion asSentence Expression+of+p27%28kip1%29+is+regulated+by+Jab1+in+lymphoma+cell+lines. assertion.
- assertion asSentence Antitumor+bioactivity+of+adenovirus-mediated+p27mt+in+colorectal+cancer+cell+line+SW480. assertion.
- assertion asSentence Low+p27%28Kip1%29+expression+is+associated+with+lymph+node+metastasis+in+intrahepatic+cholangiocarcinomas. assertion.
- assertion asSentence Elevated+intracellular+p27%28Kip1%29+level+in+leukemic+lymphocytes+of+early-+and+intermediate+stage+B-CLL+patients+contributes+to+rapid+progression+of+the+disease+and+mortality. assertion.
- assertion asSentence Nkx3.1+and+p27%28KIP1%29+cooperate+in+proliferation+inhibition+and+apoptosis+induction+in+human+androgen-independent+prostate+cancer+cells. assertion.
- assertion asSentence Heparin+inhibits+pulmonary+artery+smooth+muscle+cell+proliferation+through+GEF-H1%2FRhoA%2FROCK%2Fp27+signaling+pathway. assertion.
- assertion asSentence The+ER+stress-induced+apoptosis+is+enhanced+by+miR-221%2F222+mimics+and+attenuated+by+miR-221%2F222+inhibitors.+miR-221%2F222+promoted-apoptosis+under+ER+stress+is+associated+with+p27%28Kip1%29-+and+MEK%2FERK-mediated+cell+cycle+regulation. assertion.
- assertion asSentence p27Kip%281%29+expression+levels+are+critical+for+self-renewal+and+pluripotency+in+embryonic+stem+cells%2C+defining+a+role+for+p27Kip%281%29+in+controlling+an+epithelial+to+mesenchymal+transition. assertion.
- assertion asSentence Incomplete+folding+upon+binding+mediates+Cdk4%2Fcyclin+D+complex+activation+by+tyrosine+phosphorylation+of+inhibitor+p27+protein. assertion.
- assertion asSentence Involvement+of+JNKs+in+TM4SF5-mediated+p27%28Kip1%29+Ser10+phosphorylation+and+localization+during+epithelial-mesenchymal+transition. assertion.
- assertion asSentence Regulation+of+p27+by+Artemis+and+DDB2+is+important+for+cell+cycle+progression+in+normally+proliferating+cells. assertion.
- assertion asSentence Jab1%2FCSN5+negatively+regulates+p27+and+plays+a+role+in+the+pathogenesis+of+nasopharyngeal+carcinoma. assertion.
- assertion asSentence p27kip1+upregulated+by+hnRNPC1%2F2+antagonizes+CagA-mediated+pathogenesis. assertion.
- assertion asSentence An+epimutation+at+KvDMR1%2C+the+absence+of+maternal+methylation%2C+causes+the+aberrant+silencing+of+CDKN1C%2C+some+180+kb+away+on+the+maternal+chromosome. assertion.
- assertion asSentence Conservation+of+maternal+allele-specific+expression+of+CDKN1C+in+humans%2C+mice+and+swine+is+supported+by+expression+profiling+between+swine+parthenotes+and+biparental+control+fetuses. assertion.
- assertion asSentence The+degradation+of+cholesterol+didn%27t+affect+the+level+of+p57+in+cell+membrane. assertion.
- assertion asSentence Abnormal+expression+of+p16+gene+then+becomes+involved+in+the+development+and+metastasis+of+breast+cancer. assertion.
- assertion asSentence p16%2FINK4a+gene+inactivation+by+hypermethylation+is+associated+with+aggressive+variants+of+monoclonal+gammopathies. assertion.
- assertion asSentence p16%28INK4a%29+inactivation+is+not+required+to+immortalize+primary+human+mammary+epithelial+cells. assertion.
- assertion asSentence p16+Hypermethylation+in+the+early+stage+of+hepatitis+B+virus-associated+hepatocarcinogenesis. assertion.
- assertion asSentence Pathogenetic+and+biologic+significance+of+TP14ARF+alterations+in+nonsmall+cell+lung+carcinoma. assertion.
- assertion asSentence EBV+LMP1+blocks+p16INK4+pathway+by+promoting+nuclear+export+of+E2F-4+and+E2F-5. assertion.
- assertion asSentence Tumor+suppressor+genes+p15%28INK4b%29%2C+p14%28ARF%29+and+p16%28INK4a%29+are+located+at+the+9p21+locus+in+26+cryopreserved+neurofibromatosis+type+1-related+malignant+peripheral+nerve+sheath+tumors. assertion.
- assertion asSentence Upregulation+of+p14ARF+paralleled+with+MDM2+inhibition+contributes+to+p53+accumulation+in+the+nucleus+in+radiation-treated+breast+cancer+cells. assertion.
- assertion asSentence Methylation+of+the+p16+gene+CpG+island+ia+common+to+all+three+histological+patterns+associated+with+Cushing%27s+disease. assertion.
- assertion asSentence Accumulation+of+nevi+in+mutation+carriers+supports+a+nevogenic+role+for+this+CDKN2A+mutation. assertion.
- assertion asSentence MDM2-p73-P14ARF+pathway+is+involved+in+the+progression+of+bladder+cancer+to+a+more+malignant+and+aggressive+form. assertion.
- assertion asSentence p16%28INK4a%29+contributes+to+the+p53-independent+response+to+telomere+damage. assertion.
- assertion asSentence Point+mutations+in+CDKNA2+are+uncommon+event+in+the+atypical+nevi+of+persons+with+melanoma. assertion.
- assertion asSentence Signaling+events+required+for+G1+cell+cycle+arrest+and+apoptosis+induction+by+p14+ARF+dissociate+upstream+of+p53. assertion.
- assertion asSentence Effect+of+mutation+on+nevus+distribution. assertion.
- assertion asSentence Linkage+of+flat+mole+count+to+the+CDKN2A+gene+region+%289p21%29was+replicated+with+in+424+families+with+1024+twins+and+siblings%2C+plus+genotypes+for+690+parents. assertion.