Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Coronin+2A+and+cofilin+regulate+a+subset+of+focal-adhesion-turnover+events. assertion.
- assertion asSentence Cofilin-1+inactivation+leads+to+proteinuria. assertion.
- assertion asSentence Wild+type+CFTR+elevates+the+acid-gated+Na%28%2B%29+current+of+ASIC1a%2F2a+in+part+by+altering+the+kinetics+of+extracellular+Na%28%2B%29+interaction. assertion.
- assertion asSentence Role+for+functional+CFTR+in+regulation+of+lysozyme+secretion+in+human+airways. assertion.
- assertion asSentence Localisation+of+wild-type+and+DeltaF508-CFTR+in+nasal+epithelial+cells. assertion.
- assertion asSentence Aminoglycoside+antibiotics+suppress+a+premature+stop+mutation+in+a+Cftr+-%2F-+mouse+carrying+a+human+CFTR-G542X+transgene. assertion.
- assertion asSentence Overexpression+of+mutant+AMPK-alpha1+enhanced+forskolin-stimulated+I+short-circuit+currents%2C+consistent+with+dominant-negative+reduction+in+inhibition+of+CFTR+by+endogenous+AMPK. assertion.
- assertion asSentence A+genetic+marker+within+CFTR%2C+a+gene+adjacent+to+FOXP2%2C+has+a+strong+association+with+common+language+impairment. assertion.
- assertion asSentence CFTR+mutations+in+cytsic+fibrosis+patient+families+needs+genetic+counseling+to+prevent+the+disease+risk+in+subsequent+pregnacies. assertion.
- assertion asSentence A+frameshift+mutation+in+CFTR+is+not+rare. assertion.
- assertion asSentence Mutations+in+the+CFTR+gene+represent+the+major+cause+of+idiopathic+chronic+pancreatitis+in+Brazilian+patients. assertion.
- assertion asSentence Lipid+raft+localization+of+CFTR+is+required+for+signaling+in+response+to+Pseudomonas+aeruginosa+infection%2C+signaling+that+is+needed+for+the+coordination+of+innate+immunity+to+Pseudomonas+aeruginosa+lung+infection. assertion.
- assertion asSentence CFTR+is+regulated+through+a+MAP+kinase+signaling+cascade+dependently+or+not+on+an+activation+of+adrenergic+beta-3+receptor. assertion.
- assertion asSentence The+mutation+spectrum+of+CFTR+in+congenitl+bilateral+absence+of+vas+deferens+patients+does+not+overlap+with+the+Caucasian+CFTR+mutation+spectrum. assertion.
- assertion asSentence CFTR+mutations+appear+not+to+be+involved+in+female+infertility. assertion.
- assertion asSentence ATP+drives+tight+dimerization+of+CFTR%27s+cytoplasmic+nucleotide+binding+sites. assertion.
- assertion asSentence The+5T+variant+of+CFTR+has+a+milder+clinical+consequence+than+previously+estimated+in+females. assertion.
- assertion asSentence Mutations+and+variations+in+pancreatitis+patients. assertion.
- assertion asSentence CF+patients+homozygous+for+the+delta+F508+mutation+have+a+greater+incidence+of+hypoplastic+or+underdeveloped+sinuses. assertion.
- assertion asSentence CFTR+has+a+role+in+beta+adrenergic+receptor-dependent+alveolar+fluid+clearance. assertion.
- assertion asSentence Coat+protein+complex+I+plays+a+critical+role+in+CFTR+trafficking+to+the+cell+membrane+in+an+adenocarcinoma+cell+line. assertion.
- assertion asSentence A2A+receptors+open+Cl-+channels+in+pancreatic+ducts+cells+with+functional+cystic+fibrosis+transmembrane+regulator+%28CFTR%29. assertion.
- assertion asSentence Beta-oestradiol-dependent+up-regulation+of+NHERF1+significantly+increases+F508CFTR+functional+expression+in+CFBE41o%28-%29+cells. assertion.
- assertion asSentence Both+DNA+methylation+and+histone+deacetylation+contribute+to+CFTR+transcriptional+inhibition. assertion.
- assertion asSentence Functional+CFTR+Cl%28-%29+channel+activity+is+crucial+for+regulation+of+lung+proteasomal+degradation+and+NF-kappaB+activity+in+conditions+of+oxidative+stress. assertion.
- assertion asSentence Disruption+of+the+excessive+association+of+the+cochaperone%2C+Aha1%2C+with+DeltaF508+CFTR+is+associated+with+the+correction+of+its+maturation%2C+trafficking+and+regulated+anion+channel+activity+in+human+airway+epithelial+cells. assertion.
- assertion asSentence The+CFTR+gene+is+implicated+in+the+infertile+members+of+the+Cystic+fibrosis+families. assertion.
- assertion asSentence The+CFTR+N-terminus+has+an+important+role+in+avoiding+CFTR+turnover+and+in+rendering+effective+its+plasma+membrane+traffic. assertion.
- assertion asSentence CFTR+is+essential+for+human+sperm+fertilizing+capacity+and+the+impairment+of+CFTR+expression+in+spermatozoa+is+correlated+with+a+reduction+of+sperm+quality. assertion.
- assertion asSentence Structure+and+dynamics+of+NBD1+from+CFTR+. assertion.
- assertion asSentence Regulatory+insertion+removal+restores+maturation%2C+stability+and+function+of+DeltaF508+CFTR. assertion.
- assertion asSentence A+synonymous+single+nucleotide+polymorphism+in+DeltaF508+CFTR+alters+the+secondary+structure+of+the+mRNA+and+the+expression+of+the+mutant+protein. assertion.
- assertion asSentence Introducing+W401Y+or+W401F+mutations+into+G551D-CFTR+confers+better+ATP+responsiveness+for+cystic+fibrosis-associated+mutant+channel. assertion.
- assertion asSentence CFTR+expression+inversely+correlates+with+severity+of+emphysema+and+ceramide+accumulation+in+chronic+obstructive+pulmonary+disease+compared+with+control+subjects. assertion.
- assertion asSentence Gene+therapy+attempts+to+correct+CFTR+dysfunction+in+CF+by+transfection+of+airway+cells+with+the+wild-type+CFTR+gene+to+enable+cells+to+express+functional+CFTR. assertion.
- assertion asSentence Alternating+access+to+the+transmembrane+domain+of+the+ATP-binding+cassette+protein+cystic+fibrosis+transmembrane+conductance+regulator+%28ABCC7%29. assertion.
- assertion asSentence The+DeltaF508+mutation+alters+the+close+association+of+CFTR+and+ENaC. assertion.
- assertion asSentence CFTR+cytoplasmic+loop+3+is+readily+accessible+to+the+cytoplasm+and+support+the+involvement+of+this+region+in+the+control+of+channel+gating. assertion.
- assertion asSentence Human+chorionic+gonadotropin+does+not+induce+HOXA10+in+Ishikawa+cells. assertion.
- assertion asSentence Endometrial+IGF-I+and+-II+are+differentially+regulated+during+decidualization+and+by+human+chorionic+gonadotropin. assertion.
- assertion asSentence In+pertussis+toxin-treated+BeWo+cells%2C+6-chloromelatonin+stimulated+basal+hCG-beta+secretion+%28P+%3C+0.001%29. assertion.
- assertion asSentence Alpha-fetoprotein+and+human+chorionic+gonadotropin+beta+are+elevated+in+high-grade+neuroendocrine+tumors+with+a+rapidly+progressive+course+and+poorer+survival. assertion.
- assertion asSentence Pregnancy-associated+plasma+protein+A+and+free-beta-hCG+values+are+gestational+age+specific. assertion.
- assertion asSentence Increased+CA+19-9+level+is+associated+with+pancreatic+adenocarcinoma+and+cholangiocarcinoma. assertion.
- assertion asSentence The+highly+elevated+gene+expression+of+CEACAM6+and+CEACAM8+in+primary+myelofibrosis+can+serve+as+molecular+markers+of+myelofibrotic+transformation. assertion.
- assertion asSentence ChAT%2C+polymorphisms+do+not+constitute+a+major+genetic+risk+factor+for+susceptibility+to+Alzheimer%27s+disease+in+a+Sardinian+population. assertion.
- assertion asSentence Chk1+and+Chk2+control+the+induction+of+the+p53+related+transcription+factor+p73+in+response+to+DNA+damage. assertion.
- assertion asSentence Chk1-dependent+replication+checkpoint+which+slows+S+phase+progression+can+protect+tumour+cells+against+the+cytotoxic+effects+of+5FU. assertion.
- assertion asSentence The+Chk1+pathway+is+regulated+through+both+phosphorylation+of+Claspin+and+its+controlled+degradation. assertion.
- assertion asSentence Either+chk1+or+plk1-specific+antisense+oligodeoxynucleotides+enhanced+DNA+damaging+agent-induced+apoptosis. assertion.
- assertion asSentence Chk1-mediated+phosphorylation+of+FANCE+is+required+for+a+function+independent+of+FANCD2+monoubiquitination. assertion.
- assertion asSentence Inhibition+of+checkpoint+kinase+1+%28Chk1%29+by+RNA-mediated+interference+or+drug+treatment+suppressed+DNA-damage-induced+centrosome+amplification. assertion.
- assertion asSentence p53+is+activated+by+stimulation+of+mismatch+repair+in+response+to+the+misincorporation+of+deoxynucleotides+into+newly+synthesized+DNA%2C+long+before+the+lack+of+pyrimidine+nucleoside+triphosphates+causes+the+rate+of+DNA+synthesis+to+slow+appreciably. assertion.
- assertion asSentence Chk1+regulates+origin+firing+predominantly+by+controlling+Cdk2-Cdc25+function. assertion.
- assertion asSentence Critical+role+of+ATM%2FChk1+in+curcumin-mediated+G2%2FM+cell+cycle+arrest+and+apoptosis+in+pancreatic+cancer+cells. assertion.
- assertion asSentence Cdh1+reciprocally+regulates+the+Rb+pathway+through+competing+with+E2F1+to+bind+the+hypophosphorylated+form+of+Rb. assertion.
- assertion asSentence Cocrystal+structures+of+the+inhibitors+bound+to+CHK1+reveal+an+allosteric+site%2C+unique+to+CHK1%2C+located+in+the+C-terminal+domain+and+consisting+of+a+shallow+groove+linked+to+a+small+hydrophobic+pocket. assertion.
- assertion asSentence Chk1+signalling+causes+centrosome+amplification+after+ionizing+radiation+by+upregulating+Cdk2+activity+through+activating+phosphorylation. assertion.
- assertion asSentence In+the+absence+of+DNA+polymerase+eta%2C+Chk1+kinase+becomes+essential+for+replication+resumption+by+alternative+pathways%2C+via+fork+stabilization. assertion.
- assertion asSentence ATM+and+Chk1%2F2-mediated+phosphorylation+of+cdc25C+plays+a+major+role+in+cell+cycle+arrest+induced+by+pectenotoxin+2. assertion.
- assertion asSentence Tethering+DNA+damage+checkpoint+mediator+proteins+topoisomerase+IIbeta-binding+protein+1+%28TopBP1%29+and+Claspin+to+DNA+activates+ataxia-telangiectasia+mutated+and+RAD3-related+%28ATR%29+phosphorylation+of+checkpoint+kinase+1+%28Chk1%29. assertion.
- assertion asSentence Integrin+subunits+alpha5+and+alpha6+regulate+cell+cycle+by+modulating+the+chk1+and+Rb%2FE2F+pathways+to+affect+breast+cancer+metastasis. assertion.
- assertion asSentence Meninis+involved+in+the+activation+of+S-phase+arrest+in+multple+endocrein+neoplasia+by+interacting+with+CHES1. assertion.
- assertion asSentence Antiadrenergic+effect+of+vasostatin-1+is+mainly+due+to+a+phosphatidylinositol+3-kinase+dependent+nitric+oxide+release+by+cardiac+endothelial+cells. assertion.
- assertion asSentence Phaeochromocytomas+from+multiple+endocrine+neoplasia+type+2+patients+express+substantially+more+CGA+than+tumours+from+von+Hippel-Lindau+patients+at+both+the+mRNA+%283-fold+greater%29+and+protein+%2820-fold%29+level. assertion.
- assertion asSentence Semiquantitative+immunocytochemistry+for+chromogranin+A+in+amyotrophic+lateral+sclerosis. assertion.
- assertion asSentence Salivary+chromogranin+a+is+a+quantitative+marker+of+affective+state+of+patients+with+amyotrophic+lateral+sclerosis. assertion.
- assertion asSentence In+parathyroid+adenomas%2C+only+CgA+are+expressed. assertion.
- assertion asSentence Plasma+CgA+levels+are+increased+in+only+a+small+portion+of+patients+with+hereditary+head+and+neck+paragangliomas+and+have+limited+additional+value+to+the+combination+of+radiological+and+routine+biochemical+assessment+of+patients+with+HNPGL. assertion.
- assertion asSentence Increased+serum+chromogranin+A+is+associated+with+5-alpha+reductase+inhibitor+therapy+in+benign+prostatic+hyperplasia. assertion.
- assertion asSentence ChgA%2829-42%29+peptide+primed+splenocytes+proliferate+in+pancreatic+lymph+nodes+and+induce+diabetes+upon+adoptive+transfer+into+NOD+mice. assertion.
- assertion asSentence The+chitinase+3-like+protein+human+cartilage+glycoprotein+39+%28HC-gp39%29+stimulates+proliferation+of+human+connective-tissue+cells+and+activates+both+extracellular+signal-regulated+kinase-+and+protein+kinase+B-mediated+signalling+pathways. assertion.
- assertion asSentence A+functional+role+of+YKL-40+in+liver+fibrogenesis+and+should+be+taken+into+account+when+using+YKL-40+as+a+non-invasive+fibrosis+marker. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+CHI3L1+is+not+associated+with+type+2+diabetes+and+related+quantitative+traits. assertion.
- assertion asSentence YKL-40+expression+in+anal+carcinoma+predicts+shorter+overall+and+disease-free+survival. assertion.
- assertion asSentence Elevated+YKL-40+levels+in+congestive+heart+failure+patients+are+explained+by+the+presence+of+concomitant+diseases. assertion.
- assertion asSentence CHI3L1+single-nucleotide+polymorphism+rs4950928+%28131C%3EG%29+is+significantly+associated+with+asthma-related+hospital+admissions+in+children+and+young+adults+with+asthma. assertion.
- assertion asSentence YKL-40+levels+are+elevated+in+obese+youth+and+represent+a+marker+of+insulin+resistance+even+in+childhood. assertion.
- assertion asSentence In+patients+with+T2D+and+increasing+albuminuria+high+YKL-40+levels+predict+all-cause+mortality. assertion.
- assertion asSentence Human+chitotriosidase+is+expressed+in+the+eye+and+lacrimal+gland+and+has+an+antimicrobial+spectrum+different+from+lysozyme. assertion.
- assertion asSentence ASAH1+inhibition+synergistically+sensitizes+lung+cancer+cells+resistant+to+the+antiproliferative+effect+of+choline+kinase+alpha+inhibitors. assertion.
- assertion asSentence The+typical+mottled+irregularity+in+fundus+autofluorescence+is+a+valuable+diagnostic+criterion+that+facilitates+specific+genetic+testing. assertion.
- assertion asSentence Members+of+families+segregating+Duane+retraction+syndrome+%28DRS%29+as+an+autosomal+dominant+trait+should+be+screened+for+mutations+in+the+CHN1+gene%2C+enhancing+genetic+counseling+and+permitting+earlier+diagnosis. assertion.
- assertion asSentence Distribution+of+M1+receptors+in+human+colon. assertion.
- assertion asSentence There+is+a+higher+concentration+of+muscarinic-2+receptors+in+the+brain+of+aging+subjects+with+an+apolipoprotein+E-epsilon4+allele. assertion.
- assertion asSentence The+Chediak-Higashi+protein+interacts+with+SNARE+complex+and+signal+transduction+proteins. assertion.
- assertion asSentence The+muscarinic+acetylcholine+receptor+M3+is+a+mediator+of+bradycardia+and+bronchoconstriction+due+to+vagal+innervation. assertion.
- assertion asSentence Muscarinic+receptor+M3+expression+is+associated+with+invasive+migration+of+melanomas. assertion.
- assertion asSentence Structural+basis+of+M3+muscarinic+receptor+dimer%2Foligomer+formation. assertion.
- assertion asSentence Mutation+of+this+region+in+the+M3-MR+altered+receptor+coupling+to+G+protein. assertion.
- assertion asSentence Growth+factor-induced+HMVEC+migration%2C+a+key+angiogenesis+event%2C+requires+nAChR+activation--an+effect+mediated+in+part+by+nAChR-dependent+regulation+of+thioredoxin+activity. assertion.
- assertion asSentence The+detection+of+alpha3-AChR+autoantibody+aids+the+diagnosis+of+neurological+autoimmunity+and+cancer. assertion.
- assertion asSentence Loop+9+has+a+different+role+in+the+function+of+homomeric+and+heteromeric+receptors. assertion.
- assertion asSentence Single+Nucleotide+Polymorphisms+in+CHRNA3+is+associated+with+smoking+persistence+in+African+Americans. assertion.
- assertion asSentence Changes+in+nicotinic+acetylcholine+receptor+subunits+expression+in+brain+of+patients+with+Down+syndrome+and+Alzheimer%27s+disease. assertion.
- assertion asSentence CHRNA4+and+CHRNB2+do+not+play+a+major+role+in+Japanese+schizophrenia. assertion.
- assertion asSentence Missense+mutation+of+CHRNB4%2C+CHRNB3+and+CHRNA4+are+associated+with+sporadic+amyotrophic+lateral+sclerosis. assertion.
- assertion asSentence A+functional+polymorphism+on+the+nicotinic+receptor+alpha4+gene+CHRNA4+is+associated+with+working+memory+capacity+and+dopamine+receptor+2+polymorphisms. assertion.
- assertion asSentence A+de+novo+CHRNA4+gene+mutation+%28dbSNP%3Ars28931591%29+found+in+an+Italian+sporadic+patient+affected+by+nocturnal+frontal+lobe+epilepsy. assertion.
- assertion asSentence Smokers+who+carry+the+CHRNA3+and+CHRNA5+variants+are+expected+to+be+at+increased+risk+for+lung+cancer+compared+with+smokers+who+do+not+carry+these+alleles. assertion.