Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+CHRNA+3%2F5+and+the+HHIP+loci+make+a+significant+contribution+to+the+risk+of+COPD. assertion.
- assertion asSentence The+positional+candidate+gene+CHRNA7+at+the+juvenile+myoclonic+epilepsy+locus+%28EJM2%29+on+chromosome+15q13-14. assertion.
- assertion asSentence The+RIC-3e+protein+is+functionally+active+and+enables+surface+expression+of+mature+alpha7-nAChRs+in+cell+lines+not+otherwise+permissive+for+the+expression+of+this+receptor. assertion.
- assertion asSentence Cholinergic+axons+from+the+basal+forebrain+of+transgenic+mice+excite+a+specific+subset+of+cortical+interneurons+via+a+remarkably+slow%2C+non-alpha7+nicotinic+receptor-mediated+conductance. assertion.
- assertion asSentence Association+of+the+nicotinic+acetylcholine+receptor+beta1+subunit+%28CHRNB1%29+and+M1+muscarinic+acetylcholine+receptor+%28CHRM1%29+with+vulnerability+for+nicotine+dependence. assertion.
- assertion asSentence Sympathetic+alpha3beta2-nAChRs+mediate+basilar+artery+neurogenic+nitrergic+vasodilation+in+swine. assertion.
- assertion asSentence Variants+in+CHRNB3%2FCHRNA6+are+independently+associated+with+bipolar+disorder. assertion.
- assertion asSentence Genetic+variant+in+the+CHRNA5-CHRNA3-CHRNB4+gene+cluster+is+associated+with+smoking+cessation+during+pregnancy. assertion.
- assertion asSentence Missense+mutation+of+CHRNB4%2C+CHRNB3+and+CHRNA4+are+associated+with+sporadic+amyotrophic+lateral+sclerosis. assertion.
- assertion asSentence Single+nucleotide+polymorphism+%28SNP%29+CHRNB4+on+chromosome+15+is+not+associated+with+Parkinson%27s+disease+risk+in+the+overall+anaylsis+or+after+stratifying+on+smoking+status. assertion.
- assertion asSentence Single+Nucleotide+Polymorphisms+in+CHRNB4+is+associated+with+smoking+persistence+in+African+Americans. assertion.
- assertion asSentence alpha6beta4%2A+nAChRs+are+expressed+and+contribute+to+exocytosis+in+human+chromaffin+cells+of+the+adrenal+gland%2C+the+main+source+of+adrenaline+under+stressful+situations. assertion.
- assertion asSentence Compared+with+etomidate%2C+carboetomidate%27s+higher+hydrophobicity+is+associated+with+greater+inhibition+of+alpha4%2Fbeta2+neuronal+nicotinic+acetylcholine+receptors. assertion.
- assertion asSentence Increased+expression+of+stress-activated+kinases+and+IKK+and+their+phosphorylated+forms+in+omental+fat+occurs+in+obesity. assertion.
- assertion asSentence The+conformation+of+24P-IkappaBalpha+bound+to+beta-TrCP+presents+a+bend+corresponding+to+the+31DpSGLDpS36+motif+and+on+both+sides+N-+and+C-terminal+turn+regions+%28Lys22-Asp31+and+Met37-Glu43%29. assertion.
- assertion asSentence Atypical+protein+kinase+C+%28PKC-iota%2F-zeta%29+phosphorylates+IKKalphabeta+in+transformed+non-malignant+and+malignant+prostate+cell+survival. assertion.
- assertion asSentence p38alpha+collaborates+with+IKK2+to+protect+transgenic+liver+from+endotoxin%2Ftumor+necrosis+factor-induced+liver+failure+by+controlling+c-Jun+amino-terminal+kinase+%28JNK%29+activation. assertion.
- assertion asSentence IKK+alpha+phosphorylation+is+involved+in+decoy+receptor+3+expression+in+AsPC-1+pancreatic+adenocarcinoma+cells. assertion.
- assertion asSentence Overexpression+of+a+ubiquitin+%28Ub%29+G76A+mutant+leads+to+persistent+activation+of+the+IKK%2FNF-kappaB+pathway+in+the+absence+of+extra-cellular+stimuli. assertion.
- assertion asSentence Methylation+of+CpG+dinucleotides+in+the+promoter+of+IkappaBalpha+exerts+strong+influences+on+the+NF-kappaB+system+and+consequently+on+immune+functions+of+intestinal+epithelial+cells. assertion.
- assertion asSentence IKKalpha+rapidly+and+reversibly+translocates+to+the+nucleus+in+response+to+elevated+CO%282%29. assertion.
- assertion asSentence Cidea+and+other+lipid+droplet+proteins+define+a+novel%2C+highly+regulated+pathway+of+triglyceride+deposition+in+human+WAT. assertion.
- assertion asSentence CIDEA+binds+to+liver+X+receptors+and+regulates+their+activity+in+vitro. assertion.
- assertion asSentence Phosphocreatine+metabolism+in+the+normal+appearing+white+matter+in+multiple+sclerosis+is+impaired+due+to+decreased+CK-B+levels. assertion.
- assertion asSentence A+single+troponin+I+value+at+3+days+from+symptom+onset+is+a+better+predictor+of+infarct+size+compared+to+peak+values+and+CK-MB. assertion.
- assertion asSentence Cigarette+smoke+induced+carbonylation+and+subsequent+degradation+of+creatine+kinase+B+are+involved+in+the+regulation+of+senescence+in+bronchial+epithelial+cells. assertion.
- assertion asSentence Suppressors+of+both+cytokine+signaling+SOCS7+and+cytokine-inducible+SH2+protein+%28CIS%29+are+expressed+constitutively+at+higher+levels+in+LNCaP-S17+%28prostate+cancer%29+cells+than+in+LNCaP-C3+cells. assertion.
- assertion asSentence Muscle-type+creatine+kinase+physically+interacts+with+the+slow+skeletal+muscle-type+MyBPC1+%28myosin-binding+protein+C1%29. assertion.
- assertion asSentence The+Mutation+of+Cockayne+syndrome+type+A+can+also+cause+defective+transcription-coupled+repair+and+Cockayne+syndrome. assertion.
- assertion asSentence CKS2+is+one+of+the+gastric+cancer-related+genes+that+correlates+with+biological+aggressiveness+and+poor+prognosis+of+gastric+cancer. assertion.
- assertion asSentence V1H+can+function+as+an+adaptor+for+interactions+between+Nef+and+AP-2. assertion.
- assertion asSentence An+atypical+basic+motif+within+the+cytoplasmic+tails+of+AMPA-type+glutamate+receptors+directly+associates+with+mu2-adaptin+by+a+mechanism+similar+to+the+recognition+of+the+presynaptic+vesicle+protein+synaptotagmin+1+by+AP-2. assertion.
- assertion asSentence In+the+presence+of+physiological+concentrations+of+ATP%2C+reduction+of+the+intracellular+pH+inhibits+the+expressed+CLC-1%2C+mostly+by+decreasing+the+open+probability+of+the+common+gate+of+the+channel. assertion.
- assertion asSentence CLCN1+and+SCN4A+mutation+occurrence+is+associated+with+non-dystrophic+myotonia. assertion.
- assertion asSentence Recessive+CLCN1+mutation+presenting+in+a+Thomsen+disease. assertion.
- assertion asSentence CLCN5+gene+mutation+in+spanish+patients+with+Dent%27s+disease+is+associated+with+this+renal+tubulopathy. assertion.
- assertion asSentence CLCN5+mutation+should+be+considered+irrespective+of+the+presence+of+hypercalciuria+in+a+patient+with+low+molecular+weight+proteinuria. assertion.
- assertion asSentence Dent%27s+disease+is+an+inherited+tubulopathy+caused+by+CLCN5+gene+mutations. assertion.
- assertion asSentence Frameshift+mutation+in+CLCN5+protein+is+associated+with+Dent+disease. assertion.
- assertion asSentence Protonation+of+the+gating+glutamate+211+at+the+central+anion-binding+site+of+ClC-5+is+mediated+by+the+proton+glutamate+268. assertion.
- assertion asSentence Rat+G213R+ClC-7+is+the+analogue+of+human+G215R+ClC-7+responsible+for+autosomal+dominant+osteopetrosis+type+II. assertion.
- assertion asSentence CLCKB+expression+is+demonstrated+in+stria+vascularis%2C+spiral+ligament+and+limbal+fibrocytes%2C+interdental+cells+and+satellite+cells+of+spiral+ganglion+neurons+of+mice+harboring+enhanced+green+fluorescence+protein+gene+driven+by+the+human+CLCKB+promoter. assertion.
- assertion asSentence CLCNKB+mutations+are+associated+with+Bartter+syndrome. assertion.
- assertion asSentence Clusterin+%28SGP-2%29+transient+overexpression+decreases+proliferation+rate+of+SV40-immortalized+human+prostate+epithelial+cells+by+slowing+down+cell+cycle+progression. assertion.
- assertion asSentence Calcium+deprivation+causes+translocation+of+a+45kDa+CLU+isoform+to+the+nucleus+in+human+prostate+epithelial+cells%2C+leading+to+inhibition+of+cell+proliferation+and+caspase-cascade-dependent+anoikis. assertion.
- assertion asSentence The+Ectopic+overexpression+of+the+secreted+form+of+clusterin%2Fapoliporotein+J+the+sensitivity+of+HaCaT+cells+to+toxic+effects+of+ropivacaine+as+demonstrated+by+DNA+fragmentation. assertion.
- assertion asSentence TRPM2-mediated+Ca2%2Binflux+induces+chemokine+production+in+monocytes+that+aggravates+inflammatory+neutrophil+infiltration. assertion.
- assertion asSentence In+early-stage+lung+cancers+CLU+represents+a+positive+biomarker+correlating+with+better+overall+survival. assertion.
- assertion asSentence The+APOJ+single+nucleotide+polymorphism+%281598delT%29+is+associated+with+risk+factors+for+coronary+artery+disease+in+a+Chinese+population. assertion.
- assertion asSentence The+AD-protective+minor+rs11136000T+allele+is+associated+with+increased+clusterin+expression. assertion.
- assertion asSentence Cdc2-like+kinases+and+DNA+topoisomerase+I+regulate+alternative+splicing+of+tissue+factor+in+human+endothelial+cells. assertion.
- assertion asSentence AKT+activation+controls+cell+survival+to+ionizing+radiation+by+phosphorylating+CLK2%2C+revealing+an+important+regulatory+mechanism+required+for+promoting+cell+survival. assertion.
- assertion asSentence Co-operative+signal+structures+in+different+cytoplasmic+domains+of+CLN3+are+required+for+efficient+sorting+and+for+transport+to+the+lysosome. assertion.
- assertion asSentence S.+pombe+btn1%2C+the+orthologue+of+the+Batten+disease+gene+CLN3%2C+is+required+for+vacuole+protein+sorting+of+Cpy1p+and+Golgi+exit+of+Vps10p. assertion.
- assertion asSentence Syt+I+plays+a+pivotal+role+in+mediating+cAMP-+and+Ca%282%2B%29-induced+endocytosis+of+NHE3+%28but+not+in+inhibition+of+activity%29+through+cargo+recognition+of+NHE3+and+subsequent+recruitment+of+AP2-clathrin+assembly+required+for+membrane+endocytosis. assertion.
- assertion asSentence Nuclear+CHC+plays+a+role+distinct+from+clathrin-mediated+endocytosis. assertion.
- assertion asSentence The+assembly+efficiency+of+the+various+hepatitis+delta+virus+genotypes+correlates+well+with+the+clathrin+heavy+chain-binding+activity+of+their+HDAg-Ls+and+coincides+with+the+severity+of+disease+outcome. assertion.
- assertion asSentence CHC+functions+as+a+built-in+molecular+brake+that+ensures+a+tight+control+of+basal+NF-kappaB+activation+and+gene+expression+in+unstimulated+cells. assertion.
- assertion asSentence Chymase+rs1800875+polymorphism+is+associated+with+the+progression+of+immunoglobulin+A+%28IgA%29+nephropathy+in+Korean+patients. assertion.
- assertion asSentence Both+IgE+and+chymase+associate+with+diabetes+status. assertion.
- assertion asSentence The+expression+CCR1+in+colorectal+carcinoma+is+correlated+with+lymph+node+metastasis. assertion.
- assertion asSentence Methylation+of+CpG+sites+at+the+GATA+elements+in+the+regulatory+regions+fine-tunes+CCR3+transcription. assertion.
- assertion asSentence Regulatory+T+cells+recruited+through+CCL22%2FCCR4+are+selectively+activated+in+lymphoid+infiltrates+surrounding+primary+breast+tumors+and+lead+to+an+adverse+clinical+outcome. assertion.
- assertion asSentence YY1+transcription+factor+down-regulates+expression+of+this+chemokine+receptor%2C+a+major+coreceptor+for+HIV-1. assertion.
- assertion asSentence Early-+and+intermediate-stage+variants+of+simian+immunodeficiency+virus+replicate+efficiently+in+cells+lacking+CCR5. assertion.
- assertion asSentence Downregulation+and+intracellular+accumulation+mediated+by+binding+of+HCV+E2+to+CD81+which+induces+RANTES+secretion. assertion.
- assertion asSentence CCR5-Delta32+is+protective+against+the+development+of+rheumatoid+arthritis+. assertion.
- assertion asSentence CCR5+activation+in+HeLa-MAGI+cells+triggers+a+rapid+and+substantial+phosphatidylcholine-specific+phospholipase+D+activity%2C+as+assessed+by+mass+choline+production. assertion.
- assertion asSentence Condyloma+acuminata+are+not+associated+with+genetic+polymorphism+of+CCR5+delta32+gene. assertion.
- assertion asSentence Low+incidence+of+HIV-1+infection+in+Slovakia+population+is+not+associated+with+the+32+bp+deletion+in+the+the+CCR5+gene. assertion.
- assertion asSentence Presence+of+CCR5Delta32+is+associated+with+better+survival+in+type+2+diabetes+patients. assertion.
- assertion asSentence CCR5+and+its+ligands+play+important+roles+in+rheumatoid+arthritis+%28RA%29+and+systemic+lupus+erythematosus+%28SLE%29. assertion.
- assertion asSentence GBV-C+coinfection+in+HIV-1+disease+leads+to+reduced+expression+of+the+two+major+HIV-1+coreceptors%2C+CCR5+and+CXCR4%2C+on+CD4%28%2B%29+T-cells+in+patients+at+an+advanced+stage+of+immunodeficiency. assertion.
- assertion asSentence Functional+CCR5+receptor+protects+patients+with+arthritis+from+high+synovial+burden+of+infecting+Chlamydia+trachomatis. assertion.
- assertion asSentence Leucocyte+of+children+with+infectious+mononucleosis+expressed+higher+level+of+CCR3+and+lower+level+of+CCR5. assertion.
- assertion asSentence Delta32CCR5+polymorphism+does+not+associate+with+susceptibility+to+systemic+sclerosis. assertion.
- assertion asSentence UL33+and+UL78+heteromerize+with+host+CCR5+and+CXCR4+impairing+their+HIV+coreceptor+activity. assertion.
- assertion asSentence All+IL-17-producing+CD4%2B+T+cells+expressed+CCR6%2C+a+receptor+found+on+approximately+50%25+of+CD4%2B+memory+peripheral+blood+leukocytes. assertion.
- assertion asSentence CCL20+induces+MUC5AC+mucin+production+via+CCR6-+and+tumor+necrosis+factor+%28TNF%29-alpha-converting+enzyme+%28TACE%29-dependent+epidermal+growth+factor+receptor+%28EGFR%29+activation+in+human+airway+epithelial+%28NCI-H292%29+cells. assertion.
- assertion asSentence Rapamycin+selectively+up-regulates+CCR7+and+enhances+the+migration+of+differentiated+dendritic+cells+to+regional+lymph+nodes. assertion.
- assertion asSentence CXCR4+and+CCR7+provide+directional+migration+of+uveal+melanoma+cells+toward+the+liver%2C+the+most+common+site+for+the+formation+of+uveal+melanoma+metastases. assertion.
- assertion asSentence Low-expression+frequency+for+the+chemokine+receptor+CCR7+is+associated+with+mediastinal+large+B-cell+lymphoma. assertion.
- assertion asSentence PKCalpha+is+involved+in+the+CCR7%2FNF-kappaB+autocrine+signaling+loop+in+squamous+cell+carcinoma+of+head+and+neck. assertion.
- assertion asSentence The+autoantigen+DNA+topoisomerase+I+interacts+with+chemokine+receptor+7+and+exerts+cytokine-like+effects+on+dermal+fibroblasts. assertion.
- assertion asSentence CCR8-expressing+CD4-positive+T+lymphocytes+are+preferentially+recruited+from+the+periphery+into+the+lungs+of+asthmatic+individuals%2C+driven+by+elevated+CCL1+levels+produced+almost+exclusively+by+mast+cells+and+basophils. assertion.
- assertion asSentence The+combination+of+17beta-E%282%29+with+the+environmental+pollutant+TCDD+is+involved+in+the+pathogenesis+of+endometriosis+via+up-regulating+the+chemokine+CCR8-I-309. assertion.
- assertion asSentence D6+is+constitutively+internalized+via+a+ligand-independent%2C+phosphorylation-independent+association+with+beta-arrestin. assertion.
- assertion asSentence CMKLR1+is+expressed+by+circulating+pDC+in+normal+individuals+and+patients+suffering+from+skin+diseases%2C+such+as+psoriasis+and+atopic+dermatitis. assertion.
- assertion asSentence Introduction+of+a+metal-binding+site+connecting+the+third+and+sixth+transmembrane+domains+of+the+BLT1+receptor+stabilizes+its+ground+state. assertion.
- assertion asSentence The+role+of+multidrug+resistance+proteins+MRP1%2C+MRP2+and+MRP3+in+cellular+folate+homeostasis. assertion.
- assertion asSentence Posttranslational+regulation+of+Abcc2+expression+by+SUMOylation+system. assertion.
- assertion asSentence MRP2+genotype+of+the+donor+affects+kidney+graft+function. assertion.
- assertion asSentence ABCC2+polymorphism+is+an+important+predictor+for+the+prognosis+of+patients+with+breast+cancer+treated+with+tamoxifen. assertion.
- assertion asSentence Single-nucleotide+polymorphism+in+ABCC2+is+associated+with+small-cell+lung+cancer. assertion.
- assertion asSentence Downregulation+of+MRP2+contributes+to+increase+in+paclitaxel-induced+G2%2FM+arrest+and+apoptosis. assertion.
- assertion asSentence Plk3+is+in+a+pathway+linking+ATM%2C+Plk3%2C+Chk2%2C+Cdc25C+and+Cdc2+in+cellular+response+to+DNA+damage. assertion.
- assertion asSentence CB1+and+CB2+receptor+mRNA+expression+in+human+peripheral+blood+mononuclear+cells+%28PBMC%29+from+various+donor+types. assertion.
- assertion asSentence No+association+of+human+adipose+tissue+CNR1+mRNA+expression+with+measures+of+body+fat%2C+metabolic+parameters%2C+fat+cell+function%2C+or+adiponectin+expression. assertion.
- assertion asSentence CB1+is+densely+located+in+glucagon-secreting+alpha+cells+and+less+so+in+insulin-secreting+beta+cells. assertion.
- assertion asSentence Circular+dichroism+%28CD%29+spectroscopy+revealed+that+a+peptide+corresponding+to+the+full-length+C-tail+of+the+human+CB1+receptor+adopts+an+alpha-helical+conformation+in+negatively+charged+and+zwitterionic+detergents. assertion.